SNF–CVAE: Computational method to predict drug–disease interactions using similarity network fusion and collective variational autoencoder

Estimated Research and Development Investment Needed to Bring a New Medicine to Market, 2009-2018

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Anserine and glucosamine supplementation attenuates the levels of inflammatory markers in rats with rheumatoid arthritis

(2020) Jiang Minghao Zhao et al.   AMB Express

Atomoxetine improves memory and other components of executive function in young-adult rats and aged rhesus monkeys

(2019) Patrick M. Callahan et al.   NEUROPHARMACOLOGY

Realizing drug repositioning by adapting a recommendation system to handle the process

(2018) Makbule Guclin Ozsoy et al.   BMC BIOINFORMATICS

Sequential drug treatment algorithm for agitation and aggression in Alzheimer’s and mixed dementia

(2018) Simon JC Davies et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Alzheimer’s disease master regulators analysis: search for potential molecular targets and drug repositioning candidates

(2018) D. M. Vargas et al.   Alzheimers Research & Therapy

DrugBank 5.0: a major update to the DrugBank database for 2018

(2017) David S Wishart et al.   NUCLEIC ACIDS RESEARCH

Alzheimer’s disease and cigarette smoke components: effects of nicotine, PAHs, and Cd(II), Cr(III), Pb(II), Pb(IV) ions on amyloid-β peptide aggregation

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Evaluating the Effectiveness of GTM-1, Rapamycin, and Carbamazepine on Autophagy and Alzheimer Disease

(2017) Lijuan Zhang et al.   MEDICAL SCIENCE MONITOR

Generating Focused Molecule Libraries for Drug Discovery with Recurrent Neural Networks

(2017) Marwin H. S. Segler et al.   ACS Central Science

DrugQuest - a text mining workflow for drug association discovery

(2016) Nikolas Papanikolaou et al.   BMC BIOINFORMATICS

Pharmacotherpy and Alzheimer's Disease: The M-Drugs (Melatonin, Minocycline, Modafinil, and Memantine) Approach

(2016) Mak Adam Daulatzai   CURRENT PHARMACEUTICAL DESIGN

Clozapine Improves Memory Impairment and Reduces Aβ Level in the Tg-APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease

(2016) Yura Choi et al.   MOLECULAR NEUROBIOLOGY

Public Health and Rare Diseases: Oxymoron No More

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Large-Scale Off-Target Identification Using Fast and Accurate Dual Regularized One-Class Collaborative Filtering and Its Application to Drug Repurposing

(2016) Hansaim Lim et al.   PLoS Computational Biology

The SIDER database of drugs and side effects

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PubChem Substance and Compound databases

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Methotrexate for the treatment of juvenile idiopathic arthritis: process to approval for JIA indication in Japan

(2014) Masaaki Mori et al.   Modern Rheumatology

Similarity network fusion for aggregating data types on a genomic scale

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Safety of celecoxib and nonselective nonsteroidal anti-inflammatory drugs in juvenile idiopathic arthritis: results of the phase 4 registry

(2014) Rachel E Sobel et al.   Pediatric Rheumatology

Safety and Efficacy of Methylphenidate for Apathy in Alzheimer’s Disease

(2013) Paul B. Rosenberg et al.   JOURNAL OF CLINICAL PSYCHIATRY

Non-Steroidal Anti-Inflammatory Drugs and Gastroprotection with Proton Pump Inhibitors

(2012) Antonio Gigante et al.   CLINICAL DRUG INVESTIGATION

Gaussian interaction profile kernels for predicting drug–target interaction

(2011) Twan van Laarhoven et al.   BIOINFORMATICS

Exploiting drug-disease relationships for computational drug repositioning

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What Do Medicinal Chemists Actually Make? A 50-Year Retrospective

(2011) W. Patrick Walters et al.   JOURNAL OF MEDICINAL CHEMISTRY

Repositioning of an existing drug for the neglected tropical disease Onchocerciasis

(2010) Christian Gloeckner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of drug mode of action and drug repositioning from transcriptional responses

(2010) F. Iorio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systematic Evaluation of Drug–Disease Relationships to Identify Leads for Novel Drug Uses

(2009) A P Chiang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Predicting new molecular targets for known drugs

(2009) Michael J. Keiser et al.   NATURE

Human Disease-Drug Network Based on Genomic Expression Profiles

(2009) Guanghui Hu et al.   PLoS One