Review
Pharmacology & Pharmacy
Liu Yang, Yawen Hao, Joost Boeckmans, Robim M. Rodrigues, Yong He
Summary: Nonalcoholic fatty liver disease (NAFLD) is a major global cause of chronic liver disease. Despite extensive research and clinical trials, there are no FDA-approved treatments for severe forms of NAFLD due to its complex etiology and pathogenesis. Inflammation and the role of immune cells and extracellular vesicles (EVs) derived from inflammatory cells and hepatocytes are key factors in NAFLD progression. This review focuses on the involvement of immune cells, microRNA-enriched EVs, and potential drug targets in the treatment of NAFLD.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Engineering, Biomedical
T. F. Hady, B. Hwang, R. L. Waworuntu, B. D. Ratner, J. D. Bryers
Summary: Precision porous templated scaffolds (PTS) are hydrogel constructs that induce pro-healing response when the pores are 30-40 μm in diameter. Tregs play a role in maintaining the pore size specific differences in CD4+ T cell phenotype. Proteomic analyses suggest that integrin signaling, monocytes/macrophages, cytoskeletal remodeling, inflammatory cues, and vesicule endocytosis are involved in Treg activation and CD4+ T cell equilibrium modulated by PTS resident cell-derived small extracellular vesicles (sEVs). The role of TLR4 signaling in PTS cell-derived sEV-to-T cell signaling is investigated.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Multidisciplinary
Lan Li, Jiasong Cao, Sheng Li, Tianyi Cui, Jingyu Ni, Han Zhang, Yan Zhu, Jingyuan Mao, Xiumei Gao, Adam C. Midgley, Meifeng Zhu, Guanwei Fan
Summary: Tissue-resident cardiac macrophage subsets play important roles in cardiac tissue inflammation and repair after acute myocardial infarction (AMI). CC chemokine receptor 2 (CCR2)-expressing macrophages recruit circulating monocytes to infarcted myocardium and promote inflammation. However, small extracellular vesicles (sEV) derived from CCR2 macrophages, which resemble M2-polarized macrophages, have anti-inflammatory effects and contribute to cardiac repair.
Article
Chemistry, Multidisciplinary
Guan Huang, Ying Zhu, Shihui Wen, Haoqi Mei, Yongtao Liu, Dejiang Wang, Mahnaz Maddahfar, Qian Peter Su, Gungun Lin, Yinghui Chen, Dayong Jin
Summary: The study demonstrates a single-sEV enumeration platform using UCNPs, which has high sensitivity and specificity, suitable for evaluating the heterogeneous antigen expression of sEV and can be adapted for biomarker discoveries and disease diagnosis.
Article
Chemistry, Multidisciplinary
Kohei Suzuki, Masataka Nakano, Shimon Nakashima, Tatsuki Fukami, Miki Nakajima
Summary: This study aimed to examine whether cancer cell-derived sEV fractions prepared by different isolation methods show similar responses for the induction of inflammatory cytokines in macrophages.
PHARMACEUTICAL RESEARCH
(2023)
Review
Cell Biology
Theodore Reed, Jeffrey Schorey, Crislyn D'Souza-Schorey
Summary: Extracellular vesicles are a diverse population of membrane-bound particles that can induce various effects on recipient cells. In the tumor microenvironment, EVs released by tumor cells play a crucial role in influencing the functional plasticity of macrophages in tumor progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mauro Finicelli, Filomena Anna Digilio, Umberto Galderisi, Gianfranco Peluso
Summary: This review discusses the role of macrophages in COPD and their impact on inflammatory and oxidative stress processes. Macrophages exhibit plasticity by responding to stimuli from the surrounding tissue, which is crucial in COPD. The regulatory influence of extracellular vesicles (EVs) in cell-to-cell communications is also explored.
Article
Cell Biology
Younggap Lim, Hyun Young Kim, Dohyun Han, Bong-Kyu Choi
Summary: This study analyzed the proteome and inflammatory response of extracellular vesicles (EVs) released from macrophages infected with the periodontal pathogen Tannerella forsythia. The results showed that T. forsythia infection enriched macrophage-derived EVs with pro-inflammatory cytokines and inflammatory mediators associated with periodontitis progression, while T. forsythia-derived vesicles carried various virulence factors and induced pro-inflammatory responses.
JOURNAL OF EXTRACELLULAR VESICLES
(2023)
Review
Pharmacology & Pharmacy
Jana Zarubova, Mohammad M. Hasani-Sadrabadi, Reza Ardehali, Song Li
Summary: Immune cells play a crucial role in vascularization and tissue regeneration, including not only macrophages but also other cells of the innate and adaptive immune system. The spatiotemporal regulation of immune cells has a significant impact on the speed of regeneration and functional recovery. This review summarizes the contribution of different immune cell types to the healing process and discusses strategies to manipulate and control immune cells for vascularization and tissue regeneration.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Medicine, Research & Experimental
Zhizhen He, Johannes Greven, Yulong Shi, Kang Qin, Qun Zhao, Xing Zhang, Eva Miriam Buhl, Joerg Eschweiler, Frank Hildebrand, Elizabeth Rosado Balmayor
Summary: Extracellular vesicles (EVs) are involved in cell-to-cell communication by transferring biological materials. A study found that pathogen-associated molecular patterns, such as lipopolysaccharide (LPS), can stimulate the secretion of specific types of EVs (E-LPS-EVs) from endothelial cells. These E-LPS-EVs can modulate macrophage phenotype and activation, promoting inflammatory response. This discovery enhances our understanding of the importance of EVs in regulating macrophages under inflammatory conditions.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Editorial Material
Oncology
Ernesto Gargiulo, Elodie Viry, Etienne Moussay, Jerome Paggetti
Summary: Recently, small extracellular vesicles (sEVs) secreted from chronic lymphocytic leukemia (CLL) preclinical murine models were studied and found to selectively target CD8(+) T-cells, inducing cell exhaustion and inhibiting anti-tumor immune response. Furthermore, the gene expression of sEVs was correlated with patient treatment-free survival, overall survival, and clinical parameters.
Review
Cell Biology
Oxana E. Musatova, Yury P. Rubtsov
Summary: This review summarizes the effects of glioblastoma-derived extracellular vesicles (GBM-EVs) on immune cells and their potential use in diagnostics and treatment of glioblastoma.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Immunology
Hannah J. Loghry, Noelle A. Sondjaja, Sarah J. Minkler, Michael J. Kimber
Summary: Lymphatic filariasis (LF) is a mosquito-borne disease caused by filarial nematodes including Brugia malayi. Current control strategies rely on mass drug administration programs, but established infections are incurable. This study found that parasite-derived galectins have immunomodulatory effects and induce immune phenotypes consistent with chronic LF infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Zhiguo Lin, Wenjing Li, Yanli Wang, Xueying Lang, Wentian Sun, Xiaoying Zhu, Rui Bian, Yeye Ma, Xuemin Wei, Juan Zhang, Maolin Chu, Zhiyi Zhang
Summary: This study found that abnormal synovial fibroblast proliferation was observed in rheumatoid arthritis (RA). It was also discovered that Erastin-sEV could exacerbate synovial angiogenesis and promote the progression of arthritis, while administration of miR-433-3p-SMSCs-sEV may serve as a potential therapeutic method to counteract Erastin-sEV.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Zhong-Wei Luo, Kun Xia, Yi-Wei Liu, Jiang-Hua Liu, Shan-Shan Rao, Xiong-Ke Hu, Chun-Yuan Chen, Ran Xu, Zhen-Xing Wang, Hui Xie
Summary: The study demonstrated that Akkermansia muciniphila-derived extracellular vesicles (Akk-EVs) have significant anti-tumor effects on prostate cancer by modulating immune cell activation and macrophage polarization, inhibiting tumor cell proliferation and invasion, with minimal toxicity to normal cells.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Farhood Farjah, David K. Madtes, Douglas E. Wood, David R. Flum, Megan E. Zadworny, Rachel Waworuntu, Billanna Hwang, Michael S. Mulligan
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2015)
Article
Critical Care Medicine
Stephen W. Standage, Rachel L. Waworuntu, Martha A. Delaney, Sara M. Maskal, Brock G. Bennion, Jeremy S. Duffield, William C. Parks, W. Conrad Liles, John K. McGuire
CRITICAL CARE MEDICINE
(2016)
Article
Cardiac & Cardiovascular Systems
Billanna Hwang, W. Conrad Liles, Rachel Waworuntu, Michael S. Mulligan
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2016)
Article
Cardiac & Cardiovascular Systems
Lucas W. Thornblade, Michael S. Mulligan, Katherine Odem-Davis, Billanna Hwang, Rachel L. Waworuntu, Erika M. Wolff, Larry Kessler, Douglas E. Wood, Farhood Farjah
ANNALS OF THORACIC SURGERY
(2018)
Article
Cardiac & Cardiovascular Systems
Francys C. Verdial, David K. Madtes, Billanna Hwang, Michael S. Mulligan, Katherine Odem-Davis, Rachel Waworuntu, Douglas E. Wood, Farhood Farjah
ANNALS OF THORACIC SURGERY
(2019)