Article
Biochemistry & Molecular Biology
Christian Macks, Daun Jeong, Sooneon Bae, Ken Webb, Jeoung Soo Lee
Summary: Dexamethasone-loaded hydrogels can reduce neuroinflammation, apoptosis, and lesion volume, as well as improve neuronal cell survival and motor function recovery in a rat mild-TBI model, making it a promising therapeutic intervention for TBI treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Ruihao Wang, Dafin Muresanu, Katharina Hoesl, Max J. Hilz
Summary: This study aimed to evaluate the association between cardiovascular autonomic regulation and cognitive function in patients with a history of traumatic brain injury (TBI). The results showed that decreased cardiovascular autonomic regulation was associated with impaired cognitive function in post-TBI patients. Therefore, monitoring both functions is important in post-TBI patients.
NEUROLOGICAL SCIENCES
(2023)
Review
Clinical Neurology
Kaila N. Parker, Michael H. Donovan, Kylee Smith, Linda J. Noble-Haeusslein
Summary: The article explores the impact of early life stress on recovery after early brain injury, highlighting the interaction between early life stress and subsequent brain injuries, and summarizing how early life stress affects the immune cell response to injury.
FRONTIERS IN NEUROLOGY
(2021)
Article
Immunology
Wende Xu, Shenglei Yue, Peng Wang, Bin Wen, Xiaojue Zhang
Summary: Patients with TBI exhibit higher levels of inflammatory cytokines, which are associated with worsening memory and predict poor cognitive performance.
IMMUNITY INFLAMMATION AND DISEASE
(2022)
Article
Critical Care Medicine
Mary Jo Pugh, Eamonn Kennedy, James J. Gugger, Jamie Mayo, David Tate, Alicia Swan, Jacob Kean, Hamada Altalib, Shaila Gowda, Alan Towne, Sidney Hinds, Anne Van Cott, Maria R. Lopez, Carlos A. Jaramillo, Blessen C. Eapen, Randall R. McCafferty, Martin Salinsky, Joyce Cramer, Katherine K. McMillan, Andrea Kalvesmaki, Ramon Diaz-Arrastia
Summary: Understanding the risk of epilepsy among those who experience mild traumatic brain injury (mTBI) is crucial for intervention and prevention, yet these cases are often undocumented in health records and pose challenges in population-based assessments. The MINUTE study revealed high rates of undocumented lifetime TBIs among veterans with epilepsy, highlighting the impact of epilepsy combined with TBI on physical functioning and health-related quality of life.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Clinical Neurology
Lindsay Ferguson, Christopher C. Giza, Rebecka O. Serpa, Tiffany Greco, Michael Folkerts, Mayumi L. Prins
Summary: Adolescents and young adults have the highest incidence of mild traumatic brain injury (mTBI), with sports activities being a major contributor. Utilizing voluntary exercise in adolescent rats can change the baseline functioning of the brain, and delayed return to activity helps improve cognitive recovery in those with repeated mTBI.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, General & Internal
Natascha Ekdahl, Alison K. Godbolt, Catharina Nygren Deboussard, Marianne Lannsjo, Britt-Marie Stalnacke, Maud Stenberg, Trandur Ulfarsson, Marika C. Moller
Summary: The study investigates the relationship between early global cognitive functioning and cognitive flexibility in severe traumatic brain injury patients. The results show a significant correlation between early global cognitive functioning, cognitive flexibility, and long-term outcome.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Critical Care Medicine
Olga Brawman-Mintzer, X. Charlene Tang, Marcel Bizien, Philip D. Harvey, Michael D. Horner, David B. Arciniegas, Murray Raskind, Lisa Johnson-Greene, R. Jared Martineau, Mark Hamner, Mercedes Rodriguez-Suarez, Ricardo E. Jorge, Suzanne McGarity, Hal S. Wortzel, Yongliang Wei, Tom Sindowski, Jacobo Mintzer, Arianne Z. Kindy, Keaveny Donovan, Domenic Reda
Summary: This study evaluated the efficacy and safety of rivastigmine transdermal patch treatment in veterans with TBI and post-traumatic memory impairment. Results showed no significant difference in treatment effects or changes in secondary outcomes between the rivastigmine and placebo groups. The trial provides the largest sample to date of veterans with TBI and post-traumatic memory deficits enrolled in a pharmacological trial.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Pharmacology & Pharmacy
Ibrahim Bulama, Suleiman Nasiru, Abubakar Bello, Abdullahi Yahaya Abbas, Jinjiri Ismail Nasiru, Yusuf Saidu, Musa Samaila Chiroma, Mohamad Aris Mohd Moklas, Che Norma Mat Taib, Ali Waziri, Bilbis Lawal Suleman
Summary: This study evaluated the antioxidative neuroprotective property and learning and memory-enhancing effects of dimethyl sulfoxide (DMSO) in a rat model after traumatic brain injury (TBI). The results showed that DMSO improved learning and memory, locomotor function, and decreased anxiety in rats with induced TBI. Additionally, DMSO decreased oxidative stress and S100B levels, while increasing the activity of antioxidant enzymes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Critical Care Medicine
Peter Ferrazzano, Benjamin Yeske, Jeanette Mumford, Gregory Kirk, Erin D. Bigler, Katherine Bowen, Nicole O'Brien, Bedda Rosario, Sue R. Beers, Paul Rathouz, Michael J. Bell, Andrew L. Alexander
Summary: Adolescent traumatic brain injury is a significant public health issue, with neuroimaging being a primary diagnostic tool. This study aimed to identify imaging biomarkers for long-term neurocognitive outcomes after severe adolescent TBI, finding associations between VBR and corpus callosum cross-sectional area with overall functional and neurocognitive outcomes.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Clinical Neurology
Henry W. Mahncke, Joseph DeGutis, Harvey Levin, Mary R. Newsome, Morris D. Bell, Chad Grills, Louis M. French, Katherine W. Sullivan, Sarah-Jane Kim, Annika Rose, Catherine Stasio, Michael M. Merzenich
Summary: This study evaluated the efficacy of self-administered plasticity-based cognitive training for individuals with a history of mild traumatic brain injury and cognitive impairment. The treatment group showed significant improvement in cognitive function compared to the active control group, with equivalent results in depressive and cognitive symptoms between the two groups.
Article
Critical Care Medicine
Lin F. Zou, Benjamin Pierce, Jessica L. Nielson
Summary: A study utilized new multi-variate outcome measures to assess cognitive recovery in traumatic brain injury (TBI) patients, which were found to better explain neuropsychiatric complications and cognitive speed and flexibility compared to the Glasgow Outcome Scale (GOSE). These new outcome measures provide a more accurate characterization of patients' functioning at six months post-TBI, especially in cases where gross impairment may be less evident.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Nutrition & Dietetics
Dora Brikou, Sokratis Charisis, Archontoula Drouka, Stavroula Myrto Christodoulakou, Eva Ntanasi, Eirini Mamalaki, Vasilios C. Constadinides, Nikolaos Scarmeas, Mary Yannakoulia
Summary: Cognitive disorders are a significant public health concern globally, but research on the association between cognitive decline and food timing is lacking. This study aimed to investigate the potential link between energy intake distribution during the day and cognitive performance in cognitively healthy and mildly cognitive impaired individuals. Data from the Albion study, which includes individuals aged 40 or older with a family history of cognitive disorders or concerns about their cognitive status, were analyzed. The findings show that individuals who consume low energy in the morning or high energy in the evening have better cognitive function. This association remains significant even after considering potential confounding factors (p = 0.043). The results suggest that meal patterns characterized by early eating or low energy intake in the evening may be markers of cognitive impairment.
Article
Biochemistry & Molecular Biology
Jiang Fang, Qiang Yuan, Zhuoying Du, Quan Zhang, Lei Yang, Meihua Wang, Weijian Yang, Cong Yuan, Jian Yu, Gang Wu, Jin Hu
Summary: We found that a distinct ferroptotic signature was detected in the injured hippocampus at the early stage of traumatic brain injury (TBI). Elevated levels of arachidonic acid (AA), ACLS4, and ALXO15, and deficiency of GPX4 were observed in the hippocampus after TBI, creating a pro-ferroptosis environment. Gpx4 overexpression alleviated TBI-induced cognitive deficits and reversed hippocampal ferroptosis and synaptic damage.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Clinical Neurology
Sihong Huang, Chuxin Huang, Mengjun Li, Huiting Zhang, Jun Liu
Summary: This study used three diffusion models (DTI, DKI, NODDI) to investigate complex white matter changes in the acute stage after mTBI. The results showed that mTBI patients had white matter abnormalities and cognitive deficits, and these two changes were positively correlated.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Martine Skumlien, Claire Mokrysz, Tom P. Freeman, Vincent Valton, Matthew B. Wall, Michael Bloomfield, Rachel Lees, Anna Borissova, Kat Petrilli, Manuela Giugliano, Denisa Clisu, Christelle Langley, Barbara J. Sahakian, H. Valerie Curran, Will Lawn
Summary: This study examined the association between cannabis use and anhedonia, apathy, pleasure, and effort-based decision-making for reward, and explored the moderating effect of age group.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Daphna Hoefnagel, Victor Volovici, Ellianne dos Santos J. Rubio, Anne Voor In't F. Holt, Clemens M. F. Dirven, Margreet C. Vos, Ruben Dammers
Summary: External ventricular drainage (EVD) is commonly used in neurosurgical procedures for cerebrospinal fluid drainage, but it is associated with high infection rates. This study aimed to measure the effect of a hospital-wide EVD handling protocol on the incidence of secondary EVD infections.
Article
Critical Care Medicine
Lennart Riemann, Ana Mikolic, Andrew Maas, Andreas Unterberg, Alexander Younsi
Summary: We investigated the relationship between the presence of intracranial traumatic CT pathologies and the global functional outcome one year after mTBI in young patients. The study included all patients with mTBI (GCS: 13-15) aged <=24 years from the CENTER-TBI study. The results showed that patients with CT abnormalities were less likely to achieve complete recovery 12 months post-injury.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Clinical Neurology
Roxanne W. Hook, Masanori Isobe, George Savulich, Jon E. Grant, Konstantinos Ioannidis, David Christmas, Barbara J. Sahakian, Trevor W. Robbins, Samuel R. Chamberlain
Summary: This study found that single-dose istradefylline can impact human cognition, particularly in the social information preference task with emotional loading. This indicates the under-studied role of the adenosine neurochemical system in human cognition, which requires further exploration.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Critical Care Medicine
Brecht Decraene, Samuel P. Klein, Ian Piper, Barbara Gregson, Per Enblad, Arminas Ragauskas, Giuseppe Citerio, Iain Chambers, Jan-Oliver Neumann, Juan Sahuquillo, Karl Kiening, Laura Moss, Pelle Nilsson, Rob Donald, Tim Howells, Milly Lo, Bart Depreitere
Summary: This study investigated the outcomes of decompressive craniectomy (DC) in a non-randomized controlled setting. The results showed that DC reduced mortality and had similar rates of favorable outcomes compared to medical management. The findings highlight the important role of DC in managing severe traumatic brain injury (TBI).
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2023)
Correction
Critical Care Medicine
Emanuele Rezoagli, Matteo Petrosino, Paola Rebora, David Menon, Stefania Mondello, D. James Cooper, Andrew I. R. Maas, Eveline J. A. Wiegers, Stefania Galimberti, Giuseppe Citerio, Cecilia Ackerlund, Krisztina Amrein, Nada Andelic, Lasse Andreassen, Audny Anke, Gerard Audibert, Philippe Azouvi, Maria Luisa Azzolini, Ronald Bartels, Ronny Beer, Bo-Michael Bellander, Habib Benali, Maurizio Berardino, Luigi Beretta, Erta Beqiri, Morten Blaabjerg, Stine Borgen Lund, Camilla Brorsson, Andras M. Buki, Manuel Cabeleira, Alessio Caccioppola, Emiliana Calappi, Maria Rosa Calvi, Peter Cameron, Guillermo Carbayo Lozano, Marco Carbonara, Ana D. Castano-Leon, Simona Cavallo, Giorgio Chevallard, Arturo Chieregato, Hans Clusmann, Mark Steven Coburn, Jonathan Coles, Jamie Cooper, Marta Correia, Endre Czeiter, Marek Czosnyka, Claire Dahyot-Fizelier, Paul Dark, Veronique Keyser, Vincent Degos, Francesco Della Corte, Hugo Boogert, Bart Depreitere, Dula Dilvesi, Abhishek Dixit, Jens Dreier, Guy-Loup Duliere, Ari Ercole, Erzsebet Ezer, Martin Fabricius, Kelly Foks, Shirin A. Frisvold, Alex Furmanov, Damien Galanaud, Dashiell Gantner, Alexandre Ghuysen, Lelde Giga, Jagos Golubovic, Pedro Gomez, Benjamin J. Gravesteijn, Francesca Grossi, Deepak Gupta, Iain Haitsma, Raimund G. Helbok, Eirik Helseth, Jilske Huijben, Peter Hutchinson, Stefan Jankowski, Faye Johnson, Mladen Karan, Angelos Kolias, Daniel Kondziella, Evgenios Kornaropoulos, Lars-Owe Koskinen, Noemi Kovacs, Ana Kowark, Alfonso Lagares, Steven Laureys, Aurelie Lejeune, Fiona Lecky, Didier Ledoux, Roger Lightfoot, Hester Lingsma, Alex Manara, Hugues Marechal, Costanza Martino, Julia Mattern, Catherine McMahon, Tomas Menovsky, Benoit Misset, Visakh Muraleedharan, Lynnette Murray, Ancuta Negru, David Nelson, Virginia Newcombe, Jozsef Nyiradi, Fabrizio Ortolano, Jean-Francois Payen, Vincent Perlbarg, Paolo P. Persona, Wilco Peul, Anna Piippo-Karjalainen, Horia Ples, Inigo Pomposo, Jussi Posti, Louis Puybasset, Andreea Radoi, Arminas Ragauskas, Rahul Raj, Jonathan Rhodes, Sophie Richter, Saulius Rocka, Cecilie Roe, Olav Roise, Jeffrey Rosenfeld, Christina Rosenlund, Guy Rosenthal, Rolf Rossaint, Sandra Rossi, Juan Sahuquillo, Oliver Sakowitz, Renan Sanchez-Porras, Oddrun Sandrod, Kari Schirmer-Mikalsen, Rico Frederik W. Schou, Charlie Sewalt, Peter Smielewski, Abayomi Sorinola, Emmanuel Stamatakis, Ewout Steyerberg, Nino Stocchetti, Nina Sundstroem, Riikka Takala, Viktoria Tamas, Tomas Tamosuitis, Olli Tenovuo, Matt Thomas, Dick Tibboel, Christos Tolias, Tony Trapani, Cristina Maria Tudora, Andreas Unterberg, Peter Vajkoczy, Egils A. Valeinis, Shirley Vallance, Zoltan Vamos, Gregory Steen, T. J. M. van Dijck Jeroen, Thomas Essen, Roel Wijk, Alessia Vargiolu, Emmanuel Vega, Anne Vik, Rimantas Vilcinis, Victor Volovici, Peter Vulekovic, Eveline A. Wiegers, Guy Williams, Stefan Winzeck, Stefan Wolf, Alexander Younsi, Frederick Zeiler, Agate Ziverte, Tommaso V. Zoerle, Russel Gruen, Lynette Murray, Dinesh Varma, Christopher MacIsaac, Andrea Jordan
INTENSIVE CARE MEDICINE
(2023)
Article
Multidisciplinary Sciences
Nicole von Steinbuechel, Katrin Rauen, Amra Covic, Ugne Krenz, Fabian W. Bockhop, Isabelle Mueller, Katrin Cunitz, Suzanne Polinder, Ewout Steyerberg, Johannes Vester, Marina Zeldovich
Summary: Traumatic brain injury (TBI) can have negative effects on patients' lives. This study examined the sensitivity of different outcome instruments for evaluating TBI outcomes and found that the Glasgow Outcome Scale Extended (GOSE) had the highest sensitivity. However, GOSE may not capture the multidimensional nature of outcomes.
Article
Clinical Neurology
Toni J. U. Niiranen, Anne-Cecile Chiollaz, Riikka S. K. Takala, Miko Voutilainen, Olli Tenovuo, Virginia F. J. Newcombe, Henna-Riikka Maanpaa, Jussi Tallus, Mehrbod Mohammadian, Iftakher Hossain, Mark van Gils, David K. Menon, Peter J. Hutchinson, Jean-Charles Sanchez, Jussi P. Posti
Summary: This study aimed to investigate the blood levels of interleukin 10 (IL-10) and heart fatty acid-binding protein (H-FABP) in patients with moderate-to-severe traumatic brain injury (TBI), and their correlations with inflammation/infection markers and cardiac injury markers. The results showed that increased IL-10 levels were associated with the inflammatory/infection status, while elevated H-FABP levels were related to cardiac injury in TBI patients.
FRONTIERS IN NEUROLOGY
(2023)
Article
Medicine, General & Internal
Marina Zeldovich, Katrin Cunitz, Sven Greving, Holger Muehlan, Fabian Bockhop, Ugne Krenz, Dagmar Timmermann, Inga K. Koerte, Philine Rojczyk, Maike Roediger, Michael Lendt, Nicole von Steinbuechel
Summary: The aim of this study was to examine the psychometric characteristics of the newly developed QOLIBRI-KID/ADO questionnaire for assessing TBI-specific HRQOL in children and adolescents. The study used an item response theory (IRT) framework and investigated 152 children (8-12 years) and 148 adolescents (13-17 years). The results showed that the QOLIBRI-KID/ADO questionnaire demonstrated satisfactory psychometric properties according to both classical test theoretical and IRT analyses.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Critical Care Medicine
Brian L. Edlow, Varina L. Boerwinkle, Jitka Annen, Melanie Boly, Olivia Gosseries, Steven Laureys, Pratik Mukherjee, Louis Puybasset, Robert D. Stevens, Zachary D. Threlkeld, Virginia F. J. Newcombe, Davinia Fernandez-Espejo, Curing Coma Campaign
Summary: Advances in neuroimaging have provided insights into the mechanisms causing disorders of consciousness in patients with severe brain injuries. Neuroimaging techniques have improved diagnosis and prognosis, leading to endorsement of fMRI for clinical evaluation. However, standardized reporting is needed for research and collaboration.
NEUROCRITICAL CARE
(2023)
Article
Critical Care Medicine
Aleksandra Yakhkind, Naomi Niznick, Yelena Bodien, Flora M. Hammond, Douglas Katz, Jacques Luaute, Molly McNett, Lionel Naccache, Katherine O'Brien, Caroline Schnakers, Tarek Sharshar, Beth S. Slomine, Joseph T. Giacino
Summary: The recent publication of practice guidelines for management of patients with disorders of consciousness (DoC) has contributed significantly to improving accuracy and consistency in the field. However, there is still a need for a more precise classification system that combines clinical symptoms with neuroimaging, electrophysiology, and other biomarker data. In response to this need, the National Institute of Neurological Disorders and Stroke launched the Common Data Elements (CDEs) initiative, which has been expanded to include DoC. This paper presents CDE recommendations for behavioral phenotyping of DoC patients, which will facilitate international harmonization of studies and improve characterization of study cohorts.
NEUROCRITICAL CARE
(2023)
Article
Critical Care Medicine
Elisa R. Zanier, Francesca Pischiutta, Eliana Rulli, Alessia Vargiolu, Francesca Elli, Paolo Gritti, Giuseppe Gaipa, Daniela Belotti, Gianpaolo Basso, Tommaso Zoerle, Nino Stocchetti, Giuseppe Citerio
Summary: Mesenchymal stromal cell (MSC)-based therapy shows promise in improving functional and structural outcomes for traumatic brain injury (TBI) patients. This study aims to evaluate the safety and efficacy of intravenous administration of allogeneic bone marrow-derived MSCs for severe TBI patients within 48 hours of injury. The results could potentially lead to a breakthrough in TBI treatment.
INTENSIVE CARE MEDICINE EXPERIMENTAL
(2023)
Article
Medicine, General & Internal
Thomas A. van Essen, Inge A. M. van Erp, Hester F. Lingsma, Dana Pisica, John K. Yue, Ranjit D. Singh, Jeroen T. J. M. van Dijck, Victor Volovici, Alexander Younsi, Angelos Kolias, Lianne D. Peppel, Majanka Heijenbrok-Kal, Gerard M. Ribbers, David K. Menon, Peter J. A. Hutchinson, Geoffrey T. Manley, Bart Depreitere, Ewout W. Steyerberg, Andrew I. R. Maas, Godard C. W. de Ruiter, Wilco C. Peul
Summary: This study aimed to analyze current clinical practice patterns and compare outcomes of patients with traumatic acute subdural hematoma who underwent decompressive craniectomy or craniotomy. The findings showed substantial variation in the use of decompressive craniectomy, but this variation did not result in different functional outcomes.
Article
Clinical Neurology
Agnieszka Uryga, Arkadiusz Ziolkowski, Agnieszka Kazimierska, Agata Pudelko, Cyprian Mataczynski, Erhard W. Lang, Marek Czosnyka, Magdalena Kasprowicz
Summary: This study aimed to analyze cerebrospinal pressure-volume compensation in traumatic brain injury (TBI) patients using intracranial pressure (ICP) pulse waveform analysis. The results showed that the pulse amplitude of ICP (AMP), high frequency centroid (HFC), and higher harmonics centroid (HHC) could predict mortality, while the pulse shape index (PSI) could potentially serve as an early warning sign of intracranial hypertension. Among patients with low ICP, elevated AMP, PSI, and HFC were associated with poor outcome.
JOURNAL OF NEUROSURGERY
(2023)