Review
Cell Biology
Ioannis Stouras, Maria Vasileiou, Panagiotis F. Kanatas, Eleni Tziona, Christina Tsianava, Stamatis Theocharis
Summary: In this review, the metabolic characteristics of cancer stem cells (CSCs) and normal stem cells are summarized, highlighting the significance and potential clinical value of CSC metabolism interventions.
Review
Immunology
Yen-Ju Lin, Alexandra Goretzki, Stefan Schuelke
Summary: Allergic disorders have been on the rise in recent decades, prompting the emergence of a new research field called immune metabolism. It has been found that metabolic changes in T and B cells may play a role in the development and maintenance of allergies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Joanna Kubik, Ewelina Humeniuk, Grzegorz Adamczuk, Barbara Madej-Czerwonka, Agnieszka Korga-Plewko
Summary: Cancer, the second leading cause of global death, necessitates the development of new treatment strategies that are highly effective and have few side effects. This review presents the changes in metabolic pathways in cancer cells and highlights the differences in metabolic phenotype between cancer cells and normal cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Emergency Medicine
Jue-xian Wei, Hui-lin Jiang, Xiao-hui Chen
Summary: This review investigated the role of endothelial cell metabolism in sepsis and found that dysregulation of metabolism may contribute to the progression of sepsis.
WORLD JOURNAL OF EMERGENCY MEDICINE
(2023)
Review
Oncology
Yuheng Yan, Lan Huang, Yiming Liu, Ming Yi, Qian Chu, Dechao Jiao, Kongming Wu
Summary: This article reviews the metabolic characteristics of Treg cells, discusses the differences in metabolism between Treg cells and other conventional T cells, and explores the critical roles of different metabolic programs in regulating Treg cell function. These studies provide new insights into Treg cell-targeted antitumor immunotherapies.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Review
Neurosciences
Sheng Yang, Chuan Qin, Zi-Wei Hu, Luo-Qi Zhou, Hai-Han Yu, Man Chen, Dale B. Bosco, Wei Wang, Long-Jun Wu, Dai-Shi Tian
Summary: Microglia can rapidly switch between pro-inflammatory and anti-inflammatory phenotypes in response to different types of stress, to maintain tissue homeostasis. Metabolic reprogramming is a key driver of microglial immune response, with pro-inflammatory cells favoring glycolysis for energy production, while anti-inflammatory cells mainly rely on oxidative phosphorylation and fatty acid oxidation.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Oncology
Yoshihiro Miyazaki, Nobuhito Mori, Yuka Akagi, Tatsuya Oda, Yasuyuki S. Kida
Summary: This study confirms that the intracellular metabolic pathway of normal tissue fibroblasts transitions from oxidative phosphorylation (OXPHOS) to glycolysis when differentiating into cancer-associated fibroblasts (CAFs). The study also identifies CAF-specific metabolites that could serve as potential biomarkers for pancreatic cancer.
Article
Biochemistry & Molecular Biology
Theodora Panagaki, Laszlo Pecze, Elisa B. Randi, Anni I. Nieminen, Csaba Szabo
Summary: Increased H2S generation in Down syndrome (DS) promotes pseudohypoxia and contributes to cellular metabolic dysfunction by causing a shift from oxidative phosphorylation to glycolysis.
Review
Oncology
Ziyi Zhao, Yong Mei, Ziyang Wang, Weiling He
Summary: Drug resistance in cancer patients significantly impacts their survival and quality of life, but targeting oxidative phosphorylation (OXPHOS) can eliminate cancer stem cells and delay the acquisition of drug resistance. Recent studies have shown that OXPHOS inhibitors can improve treatment responses to anticancer therapy in specific cancers, while also playing a complex role in cancer drug resistance.
Article
Medicine, Research & Experimental
Guoshu Bi, Yunyi Bian, Jiaqi Liang, Jiacheng Yin, Runmei Li, Mengnan Zhao, Yiwei Huang, Tao Lu, Cheng Zhan, Hong Fan, Qun Wang
Summary: This study analyzed the metabolic characteristics of glycolysis and oxidative phosphorylation in 9668 patients across 33 tumor types, identifying four metabolic subtypes. Patients with high glycolysis and low oxidative phosphorylation were consistently associated with worse prognosis. Common dysregulated molecular features were found between different metabolic subgroups, with their mutual interfering relationships investigated.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Orthopedics
X. Wu, C. Liyanage, M. Plan, T. Stark, T. McCubbin, R. A. Barrero, J. Batra, R. Crawford, Y. Xiao, I. Prasadam
Summary: This study aims to identify the changes in energy metabolism in osteoarthritis (OA) cartilage. Metabolomics, proteomics, and transcriptomics analyses were conducted to investigate the global alterations in OA metabolism. The results showed increased lactate production and decreased mitochondrial respiratory rates in OA chondrocytes. This study provides a basis for targeting metabolism as a therapeutic approach for OA.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Biochemistry & Molecular Biology
Croi E. Buckley, Xiaofei Yin, Sebastian Meltzer, Anne Hansen Ree, Kathrine Roe Redalen, Lorraine Brennan, Jacintha O'Sullivan, Niamh Lynam-Lennon
Summary: Resistance to neoadjuvant chemoradiation therapy in rectal cancer is a challenge, and there is a need to identify its underlying mechanisms and develop predictive biomarkers and novel treatment strategies. This study identified an in vitro model of radioresistant rectal cancer and found significant alterations in multiple molecular pathways, including cell cycle, DNA repair, and oxidative phosphorylation-related genes. Metabolomic profiling of pre-treatment serum samples from rectal cancer patients identified metabolites significantly associated with treatment response and overall survival. This study highlights metabolic reprogramming as a role in radioresistance of rectal cancer and suggests altered metabolites as potential circulating predictive markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Srinath Muralidharan, Sarthak Sahoo, Aryamaan Saha, Sanjay Chandran, Sauma Suvra Majumdar, Susmita Mandal, Herbert Levine, Mohit Kumar Jolly
Summary: Research analysis reveals diverse associations between cancer cells' EMT status and metabolic pathways, showing that EMT is generally positively correlated with glycolysis but negatively correlated with oxidative phosphorylation and fatty acid metabolism. Additionally, higher levels of EMT and glycolysis predict a worse prognosis in many cancers.
Review
Oncology
Priyanka S. Rana, Krishna Goparaju, James J. Driscoll
Summary: The deregulation of cellular bioenergetic pathways is a characteristic feature of tumor cells. Tumor cells can reprogram the pathways that control nutrient acquisition and metabolism to promote their growth and survival. This reprogramming is also observed in surrounding cell types that contribute to anti-tumor immunity. Multiple myeloma (MM) cells undergo metabolic pathway disruption to support their proliferation, survival, metastasis, drug resistance, and evasion of the immune system. Understanding these metabolic events may lead to the development of more effective therapeutic strategies.
FRONTIERS IN ONCOLOGY
(2023)
Review
Allergy
Alexandra Goretzki, Yen-Ju Lin, Stefan Schulke
Summary: This review highlights the metabolic changes in immune cells during allergic responses, with a focus on key cell types involved in allergy. Different immune cell types exhibit distinct metabolic phenotypes upon activation, indicating the relevance of immune metabolism in allergic diseases. Further understanding of immune cell metabolism could potentially lead to new treatment targets/strategies for allergic diseases.
Article
Microbiology
Max Kolton, David J. Weston, Xavier Mayali, Peter K. Weber, Karis J. McFarlane, Jennifer Pett-Ridge, Mark M. Somoza, Jory Lietard, Jennifer B. Glass, Erik A. Lilleskov, A. Jonathan Shaw, Susannah Tringe, Paul J. Hanson, Joel E. Kostka
Summary: The microbiome of Sphagnum mosses in North America shows remarkable consistency, with nitrogen-fixing methanotrophs playing a key role in the coupling of carbon and nitrogen cycles.
Article
Biochemistry & Molecular Biology
Moran Frenkel-Pinter, Anton S. Petrov, Kavita Matange, Michael Travisano, Jennifer B. Glass, Loren Dean Williams
Summary: Evolution occurs through adaptation and exaptation, which can be observed at various levels, from organismal to molecular. Adenosine and its variants are examples of how molecules have been adapted and exapted for different functions throughout biological evolution.
JOURNAL OF MOLECULAR EVOLUTION
(2022)
Article
Multidisciplinary Sciences
Moran Frenkel-Pinter, Marcos Bouza, Facundo M. Fernandez, Luke J. Leman, Loren Dean Williams, Nicholas Hud, Aikomari Guzman-Martinez
Summary: In this study, the authors report the synthesis of thiodepsipeptides and HS-peptides under mild temperatures and various pH conditions, suggesting that they could have formed on early prebiotic Earth.
NATURE COMMUNICATIONS
(2022)
Editorial Material
Microbiology
Jennifer B. Glass
ENVIRONMENTAL MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Marcin Biesiada, Michael Y. Hu, Loren Dean Williams, Katarzyna J. Purzycka, Anton S. Petrov
Summary: The ribosomal core is conserved across all species, but eukaryotic ribosomes have diverse rRNA expansion segments (ESs) on their surfaces. ES7 is one of the most diverse regions of the ribosome and contains a distinct signature fold. Through experimental and modeling approaches, the secondary and full-atom 3D structures of ES7 have been determined, revealing a potential atomic-level accretion path for rRNA growth. The non-monophyletic distribution of some ES7 features suggests acquisition through convergent processes.
NUCLEIC ACIDS RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Jennifer B. Glass, Claire E. Elbon, Loren Dean Williams
Summary: Aerobic respiration evolved through bricolage, combining modules from microbial biochemistry and Earth's geochemistry. The mitochondrial electron transport chain has a patchwork of modules inherited from various pathways, reflecting Earth's redox environment over its history. The anoxic early Earth can be seen in Complex I's iron-sulfur cofactors, while the advent of oxygen as an electron acceptor led to the use of heme and copper cofactors. Supercomplexes formed for improved electron transfer efficiency in some organisms, and accessory subunits evolved for better assembly and stability. Environmental microbes with "fossil" proteins similar to ancestral forms of respiratory complexes could provide insights on aerobic respiration evolution.
TRENDS IN MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Claudia Alvarez-Carreno, Rohan J. Gupta, Anton S. Petrov, Loren Dean Williams
Summary: The mechanisms of emergence and divergence of protein folds are important questions in biological sciences. This study presents evidence of common ancestry between three distinct protein folds and proposes a mechanism of fold evolution called creative destruction. Creative destruction involves the fusion of ancestral domains, allowing the fused polypeptide to explore new folding landscapes and potentially acquire new functions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Rebecca Guth-Metzler, Ahmad Mohyeldin Mohamed, Elizabeth T. Cowan, Ashleigh Henning, Chieri Ito, Moran Frenkel-Pinter, Roger M. Wartell, Jennifer B. Glass, Loren Dean Williams
Summary: Magnesium, as the most abundant divalent cation in cells, plays a dual role in catalyzing RNA cleavage and promoting RNA folding. Through simulation and experiment, it has been discovered that structured RNAs can exhibit "Goldilocks" behavior, with a local maximum in RNA lifetime at specific magnesium concentrations. This behavior can be finely controlled by various folding and cleavage parameters, allowing for precise regulation of RNA chemical lifetime.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Hyojung Kim, Courtney M. Moore, Santi Mestre-Fos, David A. Hanna, Loren Dean Williams, Amit R. Reddi, Matthew P. Torres
Summary: In this study, a quantitative mass spectrometry-based chemoproteomics strategy was used to identify hemoproteins that interact with heme specifically. The results showed that heme is involved in various cellular processes, such as genome integrity and protein trafficking.
Article
Multidisciplinary Sciences
Dustin J. E. Huard, Abigail M. Johnson, Zixing Fan, Lydia G. Kenney, Manlin Xu, Ran Drori, James C. Gumbart, Sheng Dai, Raquel L. Lieberman, Jennifer B. Glass
Summary: This study reports the discovery of new methane clathrate-binding proteins (CbpAs) of bacterial origin in ocean sediments. These proteins show similar suppression of methane clathrate growth as commercial inhibitors and exhibit selectivity for clathrate over ice. The study also reveals the specific interaction between CbpAs and methane clathrate, highlighting the potential importance of native sediment bacteria in clathrate stability and habitability.
Article
Chemistry, Multidisciplinary
C. Martin, Moran Frenkel-Pinter, Kelvin H. Smith, Victor F. Rivera-Santana, Alyssa B. Sargon, Kaitlin C. Jacobson, Aikomari Guzman-Martinez, Loren Dean Williams, Luke J. Leman, Charles L. Liotta, Martha A. Grover, Nicholas Hud
Summary: The high kinetic barrier to amide bond formation limits its utility in reversible chemistry applications, but the use of depsipeptides can overcome the challenges associated with dynamic peptide chemistry and achieve reversible polymerization and depolymerization.
Article
Microbiology
Max Kolton, David J. Weston, Xavier Mayali, Peter K. Weber, Karis J. McFarlane, Jennifer Pett-Ridge, Mark M. Somoza, Jory Lietard, Jennifer B. Glass, Erik A. Lilleskov, A. Jonathan Shaw, Susannah Tringe, Paul J. Hanson, Joel E. Kostka
Summary: The study reveals that diazotrophic methanotrophs play a crucial role in the core Sphagnum microbiome, coupling the carbon and nitrogen cycles in nutrient-poor peatlands.