Article
Biochemistry & Molecular Biology
Mahmuda Akter, A. K. M. Atique Ullah, Subrata Banik, Md. Tajuddin Sikder, Toshiyuki Hosokawa, Takeshi Saito, Masaaki Kurasaki
Summary: Green synthesized silver nanoparticles (Ag-NPs) show promising cytotoxic and anticancer effects in different cell lines. The study on autophagy-regulated cytotoxic effect of Ag-NPs against human epithelial colorectal adenocarcinoma cells (Caco-2 cells) found that Ag-NPs induced cell death through NF-kappa B mediated autophagy, oxidative stress, and DNA damage, leading to apoptosis and necrosis.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Chemistry, Inorganic & Nuclear
Manikandan Elumalai, Gopinath Nagaraj, Jayapalan Kasthuri, Elangovan Vellaichamy, Nagappan Rajendiran
Summary: The use of biocompatible templates for the synthesis of noble metal nanoparticles (MNPs) provides a safe and cost-effective approach for biomedical applications. This study reports the synthesis of gold and silver nanoparticles (Au and Ag NPs) using N-cholyl D-penicilamine (NCPA) as a reducing and stabilizing agent at concentrations below the critical micellar concentration (CMC) under sunlight exposure. The size and stability of the synthesized NPs were optimized by adjusting the concentration of NCPA and the pH of the medium. The results showed that the prepared NPs exhibited low toxicity on human erythrocytes (RBCs) even at higher concentrations and showed potent cytotoxicity on A549 cells in a dose-dependent manner, with AgNPs exhibiting better cytotoxicity compared to AuNPs.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Review
Materials Science, Multidisciplinary
Shazina Jabeen, Rahmatullah Qureshi, Mehmooda Munazir, Muhammad Maqsood, Mubashrah Munir, Syed Sabir Hussain Shah, Bakht Zareen Rahim
Summary: With advances in technology, researchers are exploring green synthesis of metallic nanoparticles using plant secondary metabolites for cancer control. This method offers advantages such as cost-effectiveness, energy efficiency, and biocompatibility.
MATERIALS RESEARCH EXPRESS
(2021)
Article
Engineering, Biomedical
Widadh Klein, Enas Ismail, Ernest Maboza, Ahmed A. A. Hussein, Razia Z. Z. Adam
Summary: The aim of this study was to investigate the cytotoxic and antifungal properties of silver nanoparticles (AgNPs) produced using three different natural extracts. The results showed that the synthesized AgNPs from Berzelia lanuginose, Helichrysum cymosum, and Searsia crenata exhibited surface plasmonic resonance (SPR) peaks at 430, 440, and 428 nm, respectively. The AgNPs demonstrated concentration- and size-dependent antifungal activity.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Multidisciplinary Sciences
R. Padmini, V. Uma Maheshwari Nallal, M. Razia, S. Sivaramakrishnan, Hissah Abdulrahman Alodaini, Ashraf Atef Hatamleh, Munirah Abdullah Al-Dosary, Venkatalakshmi Ranganathan, Woo Jin Chung
Summary: The study aimed to synthesize Ag NPs from garlic extract and evaluate their cytotoxicity on human lung adenocarcinoma cells. Spectroscopic and microscopic analyses confirmed the formation and morphology of the particles, while in-vitro MTT assay showed significant cytotoxic potential against A549 cells. The study suggests a cost-effective method for synthesizing Ag NPs with potential anti-cancer properties.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Paulkumar Kanniah, Parvathiraja Chelliah, Jesi Reeta Thangapandi, Gnanajobitha Gnanadhas, Vanaja Mahendran, Marshan Robert
Summary: In this study, the seed extract of P. nigrum was utilized as a reducing agent to synthesize silver nanoparticles and silver based chitosan nanocomposite. The synthesized silver nanoparticles showed effective antibacterial activity and cytotoxicity against various cancer cell lines. The Ag/CS NC coated cotton fabric also exhibited remarkable antibacterial activity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Vajravathi Lakkim, Madhava C. Reddy, VijayaDurga V. V. Lekkala, Veeranjaneya Reddy Lebaka, Mallikarjuna Korivi, Dakshayani Lomada
Summary: Developing an efficient and cost-effective wound-healing substance is urgently needed. Silver nanoparticles synthesized from Azadirachta indica and Catharanthus roseus leaf extracts showed rapid wound healing, increased collagen deposition, and improved antioxidant status in mice. These nanoparticles could be potential natural antioxidants for treating wounds.
Article
Biochemistry & Molecular Biology
Priyanka Jayachandran, Suganya Ilango, Vivekananthan Suseela, Ramalingam Nirmaladevi, Mohammed Rafi Shaik, Mujeeb Khan, Merajuddin Khan, Baji Shaik
Summary: Silver nanoparticles loaded in liposomes were developed for effective cancer management. The prepared liposomes were characterized and showed high encapsulation efficiency and suitable particle size. In vitro drug release experiments revealed a higher release of silver nanoparticles at pH 5.5, indicating their potential for targeted delivery to cancer cells.
Article
Environmental Sciences
Ahmed Th. A. Ibrahim
Summary: The study indicates that silver nanoparticles synthesized by Moringa oleifera leaf extract have negative impacts on oxidative stress biomarkers of Oreochromis niloticus, while selenium nanoparticles can counteract this toxicity. Selenium nanoparticles and selenium bulk show positive roles in detoxification of silver nanoparticles, with selenium nanoparticles having better recovery of oxidative biomarkers compared to selenium bulk.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Thi Thanh Huong Le, Thu Ha Ngo, Thi Huong Nguyen, Van Hung Hoang, Van Hao Nguyen, Phu Hung Nguyen
Summary: The use of Ardisia gigantifolia extract for synthesizing silver nanoparticles with anticancer activity is reported in this study. The green synthesized silver nanoparticles (Arg-AgNPs) showed inhibitory effects on gastric cancer cells, causing cell cycle arrest, inhibition of cell migration, and induction of senescence and reactive oxygen species (ROS) production. Therefore, Arg-AgNPs could be a promising candidate for targeting human gastric cancer cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Crystallography
Murad A. Mubaraki, Kashif Mustafa, Fozia Fozia, Madeeha Aslam, Ijaz Ahmad, Nisar Ahmad
Summary: This study synthesized silver nanoparticles (Ag NPs) using an aqueous plant extract as a reducing and stabilizing agent. The Ag NPs were characterized using various techniques, and their crystalline morphology, size, and chemical composition were determined. The synthesized Ag NPs showed antimicrobial activity and potential anti-asthma properties.
Article
Pharmacology & Pharmacy
Amgad I. M. Khedr, Abdelaziz F. S. Farrag, Ali M. Nasr, Shady A. Swidan, Mohamed S. Nafie, Maged S. Abdel-Kader, Marwa S. Goda, Jihan M. Badr, Reda F. A. Abdelhameed
Summary: Green synthesized flower extract AgNPs exhibited cytotoxicity in A549 and PC-3 cells through apoptosis-induction. They increased gene and protein expression of pro-apoptotic markers while decreasing expression of anti-apoptotic genes, indicating their potential role in anti-cancer therapy.
Article
Chemistry, Physical
Byron Mubaiwa, Mookho S. Lerata, Nicole R. S. Sibuyi, Mervin Meyer, Toufiek Samaai, John J. Bolton, Edith M. Antunes, Denzil R. Beukes
Summary: The conjugation of three compounds extracted from a South African sponge with gold nanoparticles retains their strong cytotoxic activity against breast cancer cells, providing a new avenue for overcoming issues in the development of anticancer drugs.
Article
Chemistry, Physical
Oznur Yildirim, Dogukan Tunay, Bestami Ozkaya, Ahmet Demir
Summary: This study investigated the effect of green synthesized silver oxide nanoparticles on bio-hydrogen yield and found that the addition of 400 mg/L nanoparticles increased the production of dark fermentative bio-hydrogen by 17%.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2022)
Article
Chemistry, Inorganic & Nuclear
S. Rathish Kumar, R. Anusha, S. Sathish, R. Rugmini, K. C. Sekhar, A. Sulthan Ibrahim
Summary: This study investigated the effect of green synthesized silver nanoparticles (AR-AgNPs) using aqueous extract of Actiniopteris radiata on gentamicin induced nephrotoxicity. The results showed that AR-AgNPs exhibited good nanoparticle properties and antioxidant and anti-nephrotoxic activity.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Review
Oncology
Joana Liz-Pimenta, Valeria Tavares, Beatriz Vieira Neto, Joana M. O. Santos, Catarina Brandao Guedes, Antonio Araujo, Alok A. Khorana, Rui Medeiros
Summary: Among cancer patients, thrombosis and cachexia are major causes of morbidity and mortality. Little is known about their possible relationship. Cancer-associated thrombosis (CAT) and cancer-associated cachexia (CAC) seem to share several risk factors. Inflammation and metabolic/endocrine derangement may be the missing link between CAT, CAC, and cancer. Many specific pro-inflammatory cytokines, immune cells, and hormones are implicated in both thrombosis and cachexia, suggesting potential therapeutic targets. Further epidemiological studies are needed to explore this potential relationship and better manage cancer patients.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jani Silva, Valeria Tavares, Ana Afonso, Juliana Garcia, Fatima Cerqueira, Rui Medeiros
Summary: Prostate cancer (PCa) is a common malignancy and advanced PCa leads to metastatic castration-resistant prostate cancer (mCRPC). This study evaluated the prognostic potential of miRNAs in liquid biopsies of mCRPC patients treated with ARAT agents. Low expression levels of miR-16-5p and miR-145-5p were associated with lower PFS in patients treated with abiraterone acetate. Low miR-20a-5p levels were associated with worse OS in patients with Gleason scores of <8.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Virology
Andreia Rosario, Ana Sousa, Tatiana Varandas, Joana Marinho-Dias, Rui Medeiros, Gabriela Martins, Paula Monteiro, Hugo Sousa
Summary: This study aims to investigate the vaginal microbiome in relation to Human Papillomavirus (HPV) infections and found that certain microorganisms are associated with cervical abnormalities, while others are protective. These findings are important for future risk stratification in high-risk HPV-positive women.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Bruno Horta, Joana Freitas-Silva, Jani Silva, Francisca Dias, Ana Luisa Teixeira, Rui Medeiros, Honorina Cidade, Madalena Pinto, Fatima Cerqueira
Summary: Chalcones have been extensively studied as anticancer agents. Among them, chalcone 16 showed the highest inhibitory effect on tumor cell viability and was selected for further investigation. The results suggest that chalcone 16 may influence macrophage polarization to inhibit cancer.
Article
Chemistry, Physical
Rosa M. F. Baptista, Clara S. B. Gomes, Bruna Silva, Joao Oliveira, Bernardo Almeida, Cidalia Castro, Pedro V. Rodrigues, Ana Machado, Ruben B. Freitas, Manuel J. L. F. Rodrigues, Etelvina de Matos Gomes, Michael Belsley
Summary: A polymorph of glycyl-L-alanine HI.H2O is synthesized from chiral cyclo-glycyl-L-alanine dipeptide, which exhibits polar space group and shows pyroelectricity, optical second harmonic generation, thermal memory effect, and piezoelectric properties. It has a high pyroelectric coefficient and a nonlinear optical effective coefficient, making it suitable for energy harvesting applications.
Article
Chemistry, Physical
Daniela Santos, Rosa M. F. Baptista, Adelino Handa, Bernardo Almeida, Pedro V. Rodrigues, Ana R. Torres, Ana Machado, Michael Belsley, Etelvina de Matos Gomes
Summary: This work presents the fabrication of hybrid systems based on chiral cyclic dipeptide L-Tryptophan-L-Tryptophan incorporated into biopolymer electrospun fibers. The micro/nanofibers contain self-assembled nano-spheres embedded into the polymer matrix, exhibiting wide-band gap semiconductors with a 4.0 eV band gap energy, blue photoluminescence, and significant piezoelectric and pyroelectric properties. These hybrid mats have potential applications in thermal sensing and energy harvesting.
Review
Biology
Cristina Almeida, Ana Luisa Teixeira, Francisca Dias, Mariana Morais, Rui Medeiros
Summary: Extracellular vesicles (EVs) are vehicles of cell communication that can carry various biomolecules derived from parent cells, which may represent oncogenic behavior in a cancer context, delivering them to recipient cells. EVs have advantageous features such as biocompatibility and high stability, making them useful as delivery systems for potential anticancer drugs. This review highlights the potential application of EVs as drug delivery systems and their clinical applications.
Review
Veterinary Sciences
Tiago Ferreira, Adelina Gama, Fernanda Seixas, Ana I. I. Faustino-Rocha, Carlos Lopes, Vitor M. Gaspar, Joao F. Mano, Rui Medeiros, Paula A. A. Oliveira
Summary: This review compares the anatomy, epidemiology, and histopathological features of mammary glands and breast cancer in women, female dogs, and female rats. It discusses the advantages and limitations of using these models and highlights their translational potential. Female dogs and female rats have contributed significantly to breast cancer research and can provide valuable insights for human medicine.
VETERINARY SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ines Soares Marques, Valeria Tavares, Beatriz Vieira Neto, Ines N. R. Mota, Deolinda Pereira, Rui Medeiros
Summary: Venous thromboembolism (VTE), a common cardiovascular disorder in Western countries, is caused by haemostatic irregularities leading to thrombus formation in veins. Long non-coding RNAs (lncRNAs) may play a role in VTE pathogenesis, but their clinical usefulness as biomarkers and therapeutic targets for VTE management is still unclear. This article reviewed the current evidence on lncRNAs associated with VTE and the coagulation system, highlighting the need for further investigation in this field for disease prediction, prevention, and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Beatriz Almeida, Tania R. Dias, Ana Luisa Teixeira, Francisca Dias, Rui Medeiros
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic known as coronavirus disease (COVID-19), resulting in millions of deaths worldwide. However, there are still unanswered questions regarding its impact on public health, such as the effect of vaccination on vulnerable populations like cancer patients. Immunosuppression in these individuals can lead to a dysfunctional antiviral response to viral infection and compromised vaccination response. This review focuses on the role of extracellular vesicle-derived microRNAs in COVID-19 infection and their potential as prognostic biomarkers for vaccination response in cancer patients.
Article
Biotechnology & Applied Microbiology
Joana M. O. Santos, Valeria Tavares, Rui M. Gil da Costa, Rui Medeiros
Summary: By analyzing transgenic mouse and clinical data, it was found that miR-150 and miR-155 may potentially serve as prognostic biomarkers in cervical cancer patients.
