Integration of the Transcriptome and Genome-Wide Landscape of BRD2 and BRD4 Binding Motifs Identifies Key Superenhancer Genes and Reveals the Mechanism of Bet Inhibitor Action in Rheumatoid Arthritis Synovial Fibroblasts
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Integration of the Transcriptome and Genome-Wide Landscape of BRD2 and BRD4 Binding Motifs Identifies Key Superenhancer Genes and Reveals the Mechanism of Bet Inhibitor Action in Rheumatoid Arthritis Synovial Fibroblasts
Authors
Keywords
-
Journal
JOURNAL OF IMMUNOLOGY
Volume 206, Issue 2, Pages 422-431
Publisher
The American Association of Immunologists
Online
2020-12-08
DOI
10.4049/jimmunol.2000286
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The emerging role of epigenetics in human autoimmune disorders
- (2019) Roberta Mazzone et al. Clinical Epigenetics
- Current Therapeutic Options in the Treatment of Rheumatoid Arthritis
- (2019) Köhler et al. Journal of Clinical Medicine
- Effectiveness, Tolerability, and Safety of Tofacitinib in Rheumatoid Arthritis: A Retrospective Analysis of Real-World Data from the St. Gallen and Aarau Cohorts
- (2019) Mueller et al. Journal of Clinical Medicine
- Immune checkpoint inhibitor PD-1 pathway is down-regulated in synovium at various stages of rheumatoid arthritis disease progression
- (2018) Yanxia Guo et al. PLoS One
- Rheumatoid arthritis
- (2018) Josef S. Smolen et al. Nature Reviews Disease Primers
- Targeting IL-6 or IL-6 Receptor in Rheumatoid Arthritis: What’s the Difference?
- (2018) Ali Berkant Avci et al. BIODRUGS
- CD40L-Dependent Pathway Is Active at Various Stages of Rheumatoid Arthritis Disease Progression
- (2017) Yanxia Guo et al. JOURNAL OF IMMUNOLOGY
- Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression
- (2017) Bing Zhou et al. JOURNAL OF MEDICINAL CHEMISTRY
- Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation
- (2017) Ka Lung Cheung et al. MOLECULAR CELL
- Enhancement of CCL2 expression and monocyte migration by CCN1 in osteoblasts through inhibiting miR-518a-5p: implication of rheumatoid arthritis therapy
- (2017) Cheng-Yu Chen et al. Scientific Reports
- GREM1 Is a Key Regulator of Synoviocyte Hyperplasia and Invasiveness
- (2016) E.-J. Han et al. JOURNAL OF RHEUMATOLOGY
- Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone loss
- (2015) Akilan Krishnamurthy et al. ANNALS OF THE RHEUMATIC DISEASES
- Targeting bromodomain-containing protein 4 (BRD4) benefits rheumatoid arthritis
- (2015) Qing-gang Zhang et al. IMMUNOLOGY LETTERS
- limma powers differential expression analyses for RNA-sequencing and microarray studies
- (2015) Matthew E. Ritchie et al. NUCLEIC ACIDS RESEARCH
- Bromodomain and extra-terminal domain bromodomain inhibition prevents synovial inflammation via blocking IκB kinase–dependent NF-κB activation in rheumatoid fibroblast-like synoviocytes
- (2015) Youjun Xiao et al. RHEUMATOLOGY
- The bromodomain protein inhibitor I-BET151 suppresses expression of inflammatory genes and matrix degrading enzymes in rheumatoid arthritis synovial fibroblasts
- (2014) Kerstin Klein et al. ANNALS OF THE RHEUMATIC DISEASES
- Stimulatory Role of Lysophosphatidic Acid in Cyclooxygenase-2 Induction by Synovial Fluid of Patients with Rheumatoid Arthritis in Fibroblast-Like Synovial Cells
- (2014) H. Nochi et al. JOURNAL OF IMMUNOLOGY
- BRD4 assists elongation of both coding and enhancer RNAs by interacting with acetylated histones
- (2014) Tomohiko Kanno et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- ChIP-Enrich: gene set enrichment testing for ChIP-seq data
- (2014) Ryan P. Welch et al. NUCLEIC ACIDS RESEARCH
- Sonic hedgehog signalling pathway regulates apoptosis through Smo protein in human umbilical vein endothelial cells
- (2014) S.-l. Zhu et al. RHEUMATOLOGY
- Lysophosphatidic acid receptor inhibition as a new multipronged treatment for rheumatoid arthritis
- (2013) Beatriz Orosa et al. ANNALS OF THE RHEUMATIC DISEASES
- Necessity of Lysophosphatidic Acid Receptor 1 for Development of Arthritis
- (2013) Yoshishige Miyabe et al. ARTHRITIS AND RHEUMATISM
- Discovery and Characterization of Super-Enhancer-Associated Dependencies in Diffuse Large B Cell Lymphoma
- (2013) Bjoern Chapuy et al. CANCER CELL
- Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position
- (2013) Jason D Buenrostro et al. NATURE METHODS
- Treating inflammation by blocking interleukin-1 in humans
- (2013) Charles A. Dinarello et al. SEMINARS IN IMMUNOLOGY
- Differential oestrogen receptor binding is associated with clinical outcome in breast cancer
- (2012) Caryn S. Ross-Innes et al. NATURE
- Fast gapped-read alignment with Bowtie 2
- (2012) Ben Langmead et al. NATURE METHODS
- Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors
- (2012) Nunzio Bottini et al. Nature Reviews Rheumatology
- A novel autoantibody against fibronectin leucine-rich transmembrane protein 2 expressed on the endothelial cell surface identified by retroviral vector system in systemic lupus erythematosus
- (2012) Tsuyoshi Shirai et al. ARTHRITIS RESEARCH & THERAPY
- ChIPpeakAnno: a Bioconductor package to annotate ChIP-seq and ChIP-chip data
- (2010) Lihua J Zhu et al. BMC BIOINFORMATICS
- Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities
- (2010) Sven Heinz et al. MOLECULAR CELL
- Suppression of inflammation by a synthetic histone mimic
- (2010) Edwige Nicodeme et al. NATURE
- Selective inhibition of BET bromodomains
- (2010) Panagis Filippakopoulos et al. NATURE
- High-density lipoproteins downregulate CCL2 production in human fibroblast-like synoviocytes stimulated by urate crystals
- (2010) Anna Scanu et al. ARTHRITIS RESEARCH & THERAPY
- Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: Results of two randomized, double-blind, placebo-controlled clinical studies
- (2009) Nemanja Damjanov et al. ARTHRITIS AND RHEUMATISM
- The Sequence Alignment/Map format and SAMtools
- (2009) H. Li et al. BIOINFORMATICS
- Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis
- (2009) Beatrix Bartok et al. IMMUNOLOGICAL REVIEWS
- Treatment options in patients with rheumatoid arthritis failing initial TNF inhibitor therapy: a critical review
- (2009) Andrea Rubbert-Roth et al. ARTHRITIS RESEARCH & THERAPY
- High mobility group box-1 protein as a tumor necrosis factor-independent therapeutic target in rheumatoid arthritis
- (2008) Richard S Goldstein ARTHRITIS RESEARCH & THERAPY
- Model-based Analysis of ChIP-Seq (MACS)
- (2008) Yong Zhang et al. GENOME BIOLOGY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now