Journal
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
Volume 36, Issue 8, Pages 2107-2115Publisher
WILEY
DOI: 10.1111/jgh.15410
Keywords
Abdominal pain; Colon; FODMAP; Food; Gastrointestinal; Nutrition
Categories
Funding
- Department of Gastroenterology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India
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The study aimed to evaluate the efficacy and acceptability of short-term strict low FODMAP diet and long-term modified FODMAP diet in diarrhea-dominant IBS patients, finding a significant improvement in symptoms in the LFD group.
Background and Aim Low fermentable oligosaccharide, disaccharide, monosaccharide, and polyol (FODMAP) diet improves irritable bowel syndrome (IBS) symptoms. Data on long-term modified FODMAP diet are emerging. We aimed to assess efficacy and acceptability of short-term strict low FODMAP diet (LFD) and long-term modified FODMAP diet in patients with diarrhea-predominant IBS (IBS-D). Methods This prospective randomized trial included patients with IBS-D (Rome IV) and IBS severity scoring system (IBS-SSS) >= 175. In phase I (4 weeks), patients were randomized to strict LFD and traditional dietary advice (TDA) groups. From 4 to 16 weeks, LFD group was advised systematic reintroduction of FODMAPs (modified FODMAP diet). Response was defined as > 50-point reduction in IBS-SSS. Results Of the total 166 patients with IBS-D screened, 101 (mean age 41.9 +/- 17.1 years, 58% male) were randomized to LFD (n = 52) and TDA (n = 49) groups. Both at 4 and 16 weeks, total IBS-SSS and IBS quality of life score reduced significantly in both groups, but there was significantly greater reduction in LFD group. By intention-to-treat analysis, responders in LFD group were significantly higher than TDA group (4 weeks-62.7% [32/51] vs 40.8% [20/49], respectively, P = 0.0448; 16 weeks-52.9% [27/51] vs 30.6% [15/49], respectively; P = 0.0274). Compliance to LFD was 93% at 4 weeks and 64% at 16 weeks. Energy, carbohydrate, fat, and fiber intake showed reduction in LFD group at 4 weeks, which improved till 16 weeks. Conclusions Strict LFD for short-term and modified LFD for long term in IBS-D patients is acceptable and leads to significant improvement in symptoms and quality of life.
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