Review
Oncology
Antra, Palak Parashar, Hungharla Hungyo, Anuja Jain, Shandar Ahmad, Vibha Tandon
Summary: Head and neck squamous cell carcinomas (HNSCC) pose major challenges in treatment due to their heterogeneity, late-stage diagnosis, and high recurrence rate. Current biomarkers for diagnosis and prognosis of HNSCC mainly rely on smoking as the major risk factor. This review focuses on the differential environment and gene mutations of HNSCC in Indian patients who consume smokeless tobacco. It reveals frequent mutations in genes involved in DNA repair, cell proliferation, cell death, metastasis, lymphocyte proliferation, cell-cell adhesion, miRNA processing, and inflammatory responses in Indian HNSCC patients.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Review
Immunology
Huimin Liu, Dongxu Wang, Zhijing Yang, Shuangji Li, Han Wu, Jingcheng Xiang, Shaoning Kan, Ming Hao, Weiwei Liu
Summary: Epigenetic modifications play crucial roles in regulating the tumor microenvironment of head and neck tumors, influencing tumor development by altering gene expression and behavior of cells in TME.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Baptiste Colcombet-Cazenave, Florence Cordier, Yanlei Zhu, Guillaume Bouvier, Eleni Litsardaki, Louise Laserre, Marie S. Prevost, Bertrand Raynal, Celia Caillet-Saguy, Nicolas Wolff
Summary: Hearing relies on the transduction of sound-evoked vibrations into electrical signals, and the proteins ADGRV1 and PDZD7 are involved in the formation and function of stereocilia. PDZD7 inhibits the GPCR activity of ADGRV1 during hair cell development through an unknown mechanism. The N-terminal PDZ domains of PDZD7 interact with the cytoplasmic domain of ADGRV1, and their stability and binding properties are affected by deafness-causing mutations in PDZD7.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Pharmacology & Pharmacy
Xing-xing Huo, Shu-jie Wang, Hang Song, Ming-de Li, Hua Yu, Meng Wang, Hong-xiao Gong, Xiao-ting Qiu, Yong-fu Zhu, Jian-ye Zhang
Summary: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer malignancy worldwide and is known to have poor prognosis. RNA modifications play a role in various pathophysiological processes, including tumor development and inflammation. Adenosine-related RNA modifications have been linked to cancer and may play a role in cancer occurrence and development.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Oncology
Kenneth C. W. Wong, David Johnson, Edwin P. Hui, Rachel C. T. Lam, Brigette B. Y. Ma, Anthony T. C. Chan
Summary: The combination of radiotherapy and immune checkpoint inhibitors has potential for improving prognosis in locally advanced and recurrent/metastatic head and neck cancers, but the clinical trials have yielded largely negative results. Further investigation is needed to explore parameters such as dose fractionation, sequencing, irradiated volume, and predictive biomarkers.
CANCER TREATMENT REVIEWS
(2022)
Review
Dentistry, Oral Surgery & Medicine
Cristina Valero, Ian Ganly
Summary: Paragangliomas are rare neuroendocrine tumors that can be found from the skull base to the pelvis. The management of head and neck paragangliomas has changed in recent years, with a trend toward a more conservative approach. Surgical resection is recommended for carotid body tumors, while non-surgical treatments such as observation and radiation therapy are usually preferred for non-carotid body tumors. Factors such as comorbidities, tumor type, and tumor growth rate should be considered when deciding the most appropriate treatment.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2022)
Article
Oncology
Elham Mohebbi, Maryam Hadji, Hamideh Rashidian, Abass Rezaianzadeh, Maryam Marzban, Ali Akbar Haghdoost, Ahmad Naghibzadeh Tahami, Abdolvahab Moradi, Mahin Gholipour, Farid Najafi, Roya Safari-Faramani, Reza Alizadeh-Navaei, Alireza Ansari-Moghaddam, Mahdieh Bakhshi, Azim Nejatizadeh, Masumeh Mahmoudi, Soodabeh Shahidsales, Saeideh Ahmadi-Simab, Ali Asghar Arabi Mianroodi, Monireh Sadat Seyyedsalehi, Bayan Hosseini, Vahideh Peyghambari, Mohammad Shirkhoda, Reza Shirkoohi, Elmira Ebrahimi, Soheila Manifar, Mohammad Ali Mohagheghi, Laura Rozek, Paul Brennan, Hossein Poustchi, Arash Etemadi, Eero Pukkala, Joachim Schuz, Reza Malekzadeh, Elisabete Weiderpass, Afarin Rahimi-Movaghar, Paolo Boffetta, Farin Kamanagar, Kazem Zendehdel
Summary: The study revealed an association between opium use and increased risk of multiple anatomical subsites of head and neck cancer, with this risk being influenced by smoking.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Review
Biochemistry & Molecular Biology
Daniela Pereira, Diana Martins, Fernando Mendes
Summary: This review explores the use of immunotherapy in the treatment of head and neck cancer (HNC) patients. Immune checkpoint inhibitors (ICI) as monotherapy or in combination with chemotherapy show promising results. Therapeutic vaccines targeting the Human Papilloma Virus also increase the anti-tumor response. However, toxicity remains a challenge.
Article
Oncology
Herbert Riechelmann, Daniel Dejaco, Teresa Bernadette Steinbichler, Anna Lettenbichler-Haug, Maria Anegg, Ute Ganswindt, Gabriele Gamerith, David Riedl
Summary: This study reported the functional outcomes of 681 newly diagnosed head and neck cancer (HNC) patients using the HNC-Functional InTegrity (FIT) Scales. The results showed that 61% of patients had normal or near-normal outcomes in all six functional domains, while clinically relevant impairment in at least one domain was observed in 30% of patients and loss of function in at least one domain was observed in 9% of patients. These findings suggest that clinically relevant persistent functional deficits should be expected in 40% of HNC patients. Treatment of these deficits is an important task of oncologic follow-up.
Article
Oncology
Yazan Abu-Shama, Julia Salleron, Florent Carsuzaa, Xu-Shan Sun, Carole Pflumio, Idriss Troussier, Claire Petit, Matthieu Caubet, Arnaud Beddok, Valentin Calugaru, Stephanie Servagi-Vernat, Joel Castelli, Jessica Miroir, Marco Krengli, Paul Giraud, Edouard Romano, Jonathan Khalifa, Melanie Dore, Nicolas Blanchard, Alexandre Coutte, Charles Dupin, Shakeel Sumodhee, Yungan Tao, Vincent Roth, Lionel Geoffrois, Bruno Toussaint, Duc Trung Nguyen, Jean-Christophe Faivre, Juliette Thariat
Summary: A retrospective multicentric study on 322 patients with head and neck cancers of unknown primary (HNCUP) found that neck dissection (ND) improved progression-free survival (PFS) regardless of nodal stage, but did not improve survival rates. The extent of ND did not affect the benefits of the procedure, and the benefits decreased with a more advanced nodal stage.
Article
Oncology
Theresa Tharakan, Gifty Marfowaa, Kenneth Akakpo, Ryan Jackson, Joseph Zenga, Sidharth V. Puram, Patrik Pipkorn
Summary: This study retrospectively analyzed the experience of two tertiary academic centers in using multiple simultaneous free flaps for complex head and neck defect reconstruction. The results showed that multiple simultaneous free flaps are a rare but reliable option for patients with defects involving multiple tissue types, functional areas, or large volumes.
Review
Pharmacology & Pharmacy
Jaana van Gastel, Hanne Leysen, Jan Boddaert, Laura Vangenechten, Louis M. Luttrell, Bronwen Martin, Stuart Maudsley
Summary: Aging is a complex molecular process that affects almost all tissue systems in humans and is the primary risk factor for neurodegenerative disorders, cardiovascular disease, and Type 2 diabetes. With the current focus on GPCR-targeted therapeutics dominating the pharmacopeia, searching for effective anti-aging treatments in this area may be beneficial. A nuanced understanding of GPCR signaling diversity could lead to the development of therapeutics with selective signaling activities to impact the complex aberrations of the aging process.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Medicine, General & Internal
Mario Perez-Sayans, Cintia M. Chamorro-Petronacci, Fatima Baltazar, Fabio Ramoa Pires, Angel Insua, Juan A. Suarez-Quintanilla, Jose M. Suarez-Penaranda
Summary: The study indicates that nestin immunohistochemical expression has clinical significance in the diagnosis and prognosis of head and neck lesions, and may serve as a useful marker for detecting the presence of stem cells in tumors.
Review
Endocrinology & Metabolism
Lyndsey Sandow, Rajat Thawani, Myung Sun Kim, Michael C. Heinrich
Summary: This article reviews the epidemiology, presentation, diagnosis, and management of head and neck paragangliomas. The majority of head and neck paragangliomas are benign, but a small percentage can metastasize and significantly impact patient survival. Diagnosis and management methods include biochemical testing, imaging modalities, and surgical intervention. Prognosis of head and neck paragangliomas varies depending on the pathology, location, and aggressiveness of the tumor.
ENDOCRINE PRACTICE
(2023)
Article
Oncology
Liye Zhou, Zexian Zeng, Ann Marie Egloff, Fan Zhang, Fei Guo, Katie M. Campbell, Peter Du, Jingxin Fu, Paul Zolkind, Xiaojing Ma, Zhe Zhang, Yi Zhang, Xiaoqing Wang, Shengqing Gu, Rachel Riley, Yasutaka Nakahori, Joshua Keegan, Robert Haddad, Jonathan D. Schoenfeld, Obi Griffith, Robert T. Manguso, James A. Lederer, X. Shirley Liu, Ravindra Uppaluri
Summary: This study reveals critical aspects of CD8+TIL heterogeneity and differentiation, and suggests the facilitation of CD8+TIL differentiation as a strategy to improve HNSCC ICB response.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Endocrinology & Metabolism
Min Liu, Mohammed Alharbi, Dana Graves, Shuying Yang
JOURNAL OF BONE AND MINERAL RESEARCH
(2020)
Article
Medicine, Research & Experimental
Wei Yu, Leilei Zhong, Lutian Yao, Yulong Wei, Tao Gui, Ziqing Li, Hyunsoo Kim, Nicholas Holdreith, Xi Jiang, Wei Tong, Nathaniel Dyment, X. Sherry Liu, Shuying Yang, Yongwon Choi, Jaimo Ahn, Ling Qin
Summary: Our study identified marrow adipogenic lineage precursors (MALPs) as a critical player in controlling bone remodeling during normal bone metabolism and pathological bone loss in a RANKL-dependent fashion.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Lutian Yao, Elisia D. Tichy, Leilei Zhong, Sarthak Mohanty, Luqiang Wang, Emily Ai, Shuying Yang, Foteini Mourkioti, Ling Qin
Summary: Gli1+ FAPs play a crucial role in skeletal muscle repair by relying on Hh signaling to promote the growth of regenerating myofibers. These cells demonstrate superior clonogenicity and reduced adipogenic differentiation ability, enhancing myogenesis and reducing adipogenesis after injury.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yang Li, Min Liu, Shuting Yang, Ashley M. Fuller, T. S. Karin Eisinger-Mathason, Shuying Yang
Summary: This study identifies RGS12 as a novel tumor suppressor in osteosarcoma through inhibiting the YAP-TEAD1-Ezrin signaling pathway and provides evidence that targeting RGS12 may be a therapeutic strategy for osteosarcoma.
Article
Oncology
Gongsheng Yuan, Shuting Yang, Mayank Gautam, Wenqin Luo, Shuying Yang
Summary: The study showed that deletion of RGS12 in macrophages attenuated inflammatory pain, likely due to impaired regulation of the COX2/PGE2 signaling pathway.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Cell & Tissue Engineering
Xinhua Li, Shuting Yang, Ling Qin, Shuying Yang
Summary: The basic mechanism of spine development is not well understood. Col2+ cells play a crucial role in spine development and are vital for intervertebral disc repair and regeneration, with their numbers and differentiation ability decreasing with age.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Xinhua Li, Shuting Yang, Vishwa Deepk, Zahra Chinipardaz, Shuying Yang
Summary: This study provides evidence for the presence of cilia in chondrocytes and throughout bone cells in vivo, as well as revealing the distribution of cilia and centrioles in different tissues and organs.
Article
Dentistry, Oral Surgery & Medicine
G. Yuan, C. Fu, S. T. Yang, D. Y. Yuh, G. Hajishengallis, S. Yang
Summary: Ablation of RGS12 in hematopoietic cells was shown to prevent bone loss in a periodontitis model, inhibit osteoclast formation and activity, and reduce inflammatory cytokine production in periodontal tissue. In vitro experiments also demonstrated that overexpression of RGS12 promoted proinflammatory macrophage reprogramming and enhanced migration ability, while knockdown of RGS12 inhibited inflammatory cytokine production and macrophage migration in response to stimuli like lipopolysaccharide. The results suggest that targeting RGS12 in macrophages could be a promising therapeutic approach for periodontitis.
JOURNAL OF DENTAL RESEARCH
(2022)
Letter
Oncology
Gongsheng Yuan, Yan Huang, Shu-ting Yang, Andrew Ng, Shuying Yang
CANCER COMMUNICATIONS
(2022)
Article
Cell Biology
Yang Li, Shuting Yang, Shuying Yang
Summary: This study demonstrated that verteporfin (VP) can delay osteosarcoma progression and improve survival rate in mice by inhibiting the YAP/TAZ signaling pathway. In vitro experiments also showed the inhibitory effects of VP on osteosarcoma cells. Therefore, targeting the Hippo pathway with VP may be a potential therapeutic strategy for osteosarcoma.
Article
Biology
Hyeran Helen Jeon, Jessica Kang, Jiahui (Madelaine) Li, Douglas Kim, Gongsheng Yuan, Nicolette Almer, Min Liu, Shuying Yang
Summary: The effects of IFT80 deletion in osteocytes on orthodontic and physiological bone remodeling were investigated, and it was found that the deletion did not significantly impact these processes.
Article
Dentistry, Oral Surgery & Medicine
Gongsheng Yuan, Shuting Yang, Shuying Yang
Summary: Tumor-associated macrophages (TAMs) have significant roles in tumor progression and immune responses. This study investigates the mechanism of driving TAMs towards antitumor function and finds that regulator of G protein signaling 12 (RGS12) regulates pathologic processes and immune-related pathways in human oral cancer tissues. The knockout of RGS12 in macrophages leads to decreased M1 TAMs, increased proliferation and invasion of oral cancer cells. RGS12 increases M1 macrophages with features of increased ciliated cell number and cilia length by associating with and activating MYC binding protein 2 (MYCBP2) to degrade the cilia protein kinesin family member 2A (KIF2A) in TAMs.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Gongsheng Yuan, Shuting Yang, Shuying Yang
Summary: This study identifies the role of ubiquitination in osteoarthritis (OA) and reveals the mechanism involving the protein RGS12 in promoting inflammation. The findings demonstrate that RGS12 enhances the association between ubiquitin and IKB, leading to the degradation of IKB through ubiquitination. Additionally, the increased ubiquitination inhibits the expression of MTAP, indirectly activating the phosphorylation of IKB. These processes ultimately result in the translocation of NF-KB to the nucleus and the upregulation of cytokine gene expression during inflammation.
