Complement activation and endothelial perturbation parallel COVID-19 severity and activity

Abnormal Coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia

(2020) Ning Tang et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Vascular endothelial cells evade complement‐mediated membrane injury via Weibel‐Palade body mobilization

(2020) Magdalena Riedl Khursigara et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Complement activation in patients with COVID-19: A novel therapeutic target

(2020) Massimo Cugno et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Clinical and immunological features of severe and moderate coronavirus disease 2019

(2020) Guang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypercoagulability of COVID‐19 patients in Intensive Care Unit. A Report of Thromboelastography Findings and other Parameters of Hemostasis

(2020) Mauro Panigada et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy

(2020) Ning Tang et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Fibrinolytic abnormalities in acute respiratory distress syndrome (ARDS) and versatility of thrombolytic drugs to treat COVID‐19

(2020) Claire S Whyte et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Endothelial cell infection and endotheliitis in COVID-19

(2020) Zsuzsanna Varga et al.   LANCET

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

(2020) Maximilian Ackermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: a report of five cases

(2020) Cynthia Magro et al.   Translational Research

On the Alert for Cytokine Storm: Immunopathology in COVID ‐19

(2020) Lauren A. Henderson et al.   Arthritis & Rheumatology

Tackling COVID‐19 infection through complement‐targeted immunotherapy

(2020) Sonata Jodele et al.   BRITISH JOURNAL OF PHARMACOLOGY

Association of COVID-19 inflammation with activation of the C5a–C5aR1 axis

(2020) Julien Carvelli et al.   NATURE

Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection

(2020) Vijendra Ramlall et al.   NATURE MEDICINE

SARS-CoV-2 viral load predicts COVID-19 mortality

(2020) Elisabet Pujadas et al.   Lancet Respiratory Medicine

Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study

(2020) George Goshua et al.   Lancet Haematology

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

(2020) Qian Zhang et al.   SCIENCE

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

(2020) Paul Bastard et al.   SCIENCE

Complement Receptor C5aR1 Inhibition Reduces Pyroptosis in hDPP4-Transgenic Mice Infected with MERS-CoV

(2019) Yuting Jiang et al.   Viruses-Basel

Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis

(2018) Lisa E. Gralinski et al.   mBio

Complement and Its Receptors: New Insights into Human Disease

(2014) V. Michael Holers   Annual Review of Immunology

Spectrum of Complement-Mediated Thrombotic Microangiopathies: Pathogenetic Insights Identifying Novel Treatment Approaches

(2014) Magdalena Riedl et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Thrombomodulin and the vascular endothelium: insights into functional, regulatory, and therapeutic aspects

(2013) Fiona A. Martin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Degos Disease

(2011) Cynthia M. Magro et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Patients with antiphospholipid syndrome display endothelial perturbation

(2009) Massimo Cugno et al.   JOURNAL OF AUTOIMMUNITY