Article
Endocrinology & Metabolism
Wen Zhang, Tingting Liang, Bing Han, Rui Yang, Shuo Yang, Yan Yang, Jiajia Zhang, Xiaoying Zheng, Jie Yan, Caihong Ma, Xueling Song, Jie Qiao
Summary: Unstimulated IVM-surgery provides the opportunity for both spontaneous pregnancy and assisted reproductive technology in patients with refractory PCOS. Basal FSH and LH are significantly associated with oocyte maturation rate and blastocyst formation of unstimulated IVM-surgery.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Obstetrics & Gynecology
Xueqi Gong, Hemei Li, Yiqing Zhao
Summary: In recent years, significant improvements have been made in in vitro maturation (IVM) technology, particularly with the establishment of biphasic IVM. The efficiency of the CNP-mediated pre-IVM culturing system has shown promising results for non/minimally stimulated immature oocytes. This advancement has the potential to improve the efficiency of fertility preservation and expand the use of IVM worldwide in the future.
REPRODUCTIVE SCIENCES
(2022)
Article
Obstetrics & Gynecology
Robert B. Gilchrist, Johan Smitz
Summary: Oocyte in vitro maturation (IVM) is a minimally invasive technique involving the collection and culture of immature oocytes to maturity outside the body. It is now classified as nonexperimental and is primarily indicated for patients with a high antral follicle count and for fertility preservation in cancer patients. Significant advances in IVM culture methods have been made based on animal studies and a simplified patient treatment protocol, leading to its routine practice in specialized centers worldwide.
FERTILITY AND STERILITY
(2023)
Article
Medicine, General & Internal
Wei Guo, Yalan Xu, Tian Tian, Shuo Yang, Rong Li, Jie Qiao, Xiaoying Zheng
Summary: This study compared the impact of in vitro maturation (IVM) treatment on subsequent in vitro fertilization (IVF) cycles in women with polycystic ovary syndrome (PCOS). The results showed that even if the first IVM attempt failed, comparable cumulative live birth rates were observed in the subsequent IVF cycle. IVM treatment does not adversely affect the subsequent IVF cycle.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Reproductive Biology
Rebecca L. Krisher
Summary: This review examines the current use of in vitro oocyte maturation in clinical settings, including its different definitions in practice. It discusses the role of in vitro oocyte maturation in patient care and the challenges for implementation, as well as exploring its efficiency and safety. The review also discusses the role of in vitro oocyte maturation in oncofertility and provides an outlook for its future in clinical settings.
BIOLOGY OF REPRODUCTION
(2022)
Article
Biochemistry & Molecular Biology
Huixia Yang, Thomas Kolben, Sarah Meister, Corinna Paul, Julia van Dorp, Sibel Eren, Christina Kuhn, Martina Rahmeh, Sven Mahner, Udo Jeschke, Viktoria von Schoenfeldt
Summary: In vitro maturation of oocytes is considered a simple and safe assisted reproductive technology, mainly used for patients with impaired oocyte maturation and women at risk of losing fertility. However, its underperformance limits its widespread clinical use. Factors such as the IVM system, culture medium, and supplementation significantly affect the outcomes of oocyte IVM, but further research is needed to fully clarify their roles.
Review
Medicine, General & Internal
Chloe De Roo, Kelly Tilleman
Summary: In vitro maturation of ovarian tissue oocytes is an effective assisted reproductive treatment, but further validation and research are needed for its effectiveness. The introduction of biphasic IVM (CAPA-IVM) has shown significant improvement in the maturation protocol for oocytes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Zhenni Mu, Sinan Shen, Lei Lei
Summary: Resistant ovary syndrome is a rare and difficult gynecological endocrine disorder that poses a serious risk to women's reproductive health. The pathogenesis of the disease is still poorly understood, and effective clinical management strategies are yet to be determined.
FRONTIERS IN MEDICINE
(2022)
Review
Genetics & Heredity
Paul Pirtea, Estelle Haggerty, Estelle Hagege, Chloe Tran, Dominique de Ziegler, Clemence Farabet, Meryem Filali, Marine Poulain, Jean Marc Ayoubi
Summary: McCune-Albright syndrome (MAS) is a rare genetic disease that affects multiple organs, including the endocrine tissues, and can cause infertility. This case report presents the infertility journey of a 22-year-old female with MAS, who underwent various infertility treatments before achieving a live birth through ovarian stimulation and in vitro fertilization.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Article
Cell Biology
Yongzhi Cao, Zhao Wang, Changming Zhang, Yuehong Bian, Xin Zhang, Xin Liu, Wendi Chen, Yueran Zhao
Summary: The addition of metformin to the culture medium of oocytes from aged mice significantly improved oocyte maturation and early embryonic development. Metformin reduced meiotic defects, maintained normal distribution of cortical granules, improved mitochondrial function, reduced apoptosis, increased autophagy, and decreased mitochondrial ROS in oocytes from aged mice. This finding demonstrates the protective effect of metformin on the quality of oocytes from aged mice and provides a potential strategy to improve ART success rates and delay reproductive aging.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Genetics & Heredity
Ho Long Le, Vu Ngoc Anh Ho, Tam Thi Ngan Le, Van Thi Thu Tran, Mai Pham Que Ma, Anh Hoang Le, Linh Khanh Nguyen, Tuong Manh Ho, Lan Ngoc Vuong
Summary: This study reports successful live births in two women with Gonadotropin-resistant ovary syndrome (GROS) who underwent fertility treatment with in vitro maturation (IVM). The results suggest that IVM may be a first-line therapeutic option for patients with GROS.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Review
Endocrinology & Metabolism
Mausumi Das, Weon-Young Son
Summary: In vitro maturation (IVM) is a viable option for specific patients, including those at risk of ovarian hyperstimulation syndrome (OHSS), in need of urgent fertility preservation, or when controlled ovarian stimulation is not possible. The clinical applications of IVM are expanding rapidly and it is now classified as a non-experimental technique. IVM offers advantages over conventional IVF, such as reduced stimulation and risk of OHSS, shorter treatment times, and lower costs. However, challenges remain in terms of technical expertise and lower success rates compared to traditional IVF. Ongoing research aims to refine protocols and improve the efficiency and effectiveness of IVM.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Mohd Faizal Ahmad, Marjanu Hikmah Elias, Norazilah Mat Jin, Muhammad Azrai Abu, Saiful Effendi Syafruddin, Ani Amelia Zainuddin, Nao Suzuki, Abdul Kadir Abdul Karim
Summary: In vitro oocyte maturation (IVM) has been implemented worldwide, but it is not widely adopted in current in vitro fertilization (IVF) due to the lack of synchronization in protocols and definition criteria, resulting in difficulty in collecting proper outcome data and understanding the exact procedure. This review aims to consolidate the current clinical practice of IVM and explore its theoretical basis, as well as discuss potential future uses and the importance of collaboration among IVM centers for better clinical data collection and safety purposes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Emmi Rotgers, Barbara Nicol, Karina Rodriguez, Saniya Rattan, Jodi A. Flaws, Humphrey Hung-Chang Yao
Summary: The study found that overexpression of NR5A1 in female mice leads to reproductive dysfunction and metabolic imbalance, resulting in premature infertility. These results provide a new model for studying not only the molecular actions of NR5A1, but also the crosstalk between endocrine, reproductive, and metabolic systems.
Review
Oncology
Yalan Xu, Jie Qiao
Summary: This study found that there were no significant differences between IVM and IVF in terms of fertilization rate, clinical pregnancy rate, and miscarriage among PCOS patients. However, the IVF group had a significantly higher live birth rate than the IVM group. IVM may be a more suitable option for the treatment of PCOS in terms of cost and successful pregnancy rate.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Pavel Yakovlev, Svetlana Vyatkina, Alex Polyakov, Marina Pavlova, Victor Volkomorov, Maksim Yakovlev, Sergey Filimonov, Liya Kazaryn, Asia Aizikovich, Nikolay Kornilov
Summary: This study compared the clinical and neonatal outcomes between mosaic embryo transfers (MET) and euploid embryo transfers (EET). The results showed that EET had a higher implantation rate and live birth rate (LBR) compared to MET and whole chromosome mosaic (WCM) embryos. Segmental mosaic embryos had similar outcomes to euploid embryos, while mosaic embryos with a high percentage of aneuploid cells had a lower LBR and higher risk of miscarriage.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Orthopedics
Dmitrii Chugaev, Nikita S. Konovalchuk, Pavel G. Kogan, Nikolai N. Kornilov, Evgenii P. Sorokin, Daniil N. Glaznyov
Summary: The study aimed to evaluate the effect of using absorbent wound dressings containing silver ions on the quality of rehabilitation and the rate of superficial infection occurrence in patients undergoing total knee joint arthroplasty. The results showed that the type and duration of wound dressings did not have a significant impact on pain syndrome intensity or Knee Society Score. However, the use of adhesive dressings with silver impregnation reduced the rate of blistering.
TRAVMATOLOGIYA I ORTOPEDIYA ROSSII
(2022)
Article
Obstetrics & Gynecology
Ermanno Greco, Pavel Yakovlev, Nikolay Kornilov, Svetlana Vyatkina, Daria Bogdanova, Marina Ermakova, Yulia Tarasova, Andrei Tikhonov, Anna Pendina, Anil Biricik, Maria Teresa Sessa, Ilaria Listorti, Carlo Ronsini, Pier Francesco Greco, Andrea Victor, Frank Barnes, Christo Zouves, Francesca Spinella, Manuel Viotti
Summary: The health risks of transferring mosaic embryos identified by preimplantation genetic testing for aneuploidies (PGT-A) are currently unknown. Two cases of persisting mosaicism from the embryonic stage to established pregnancy were reported, raising concerns about the resolution of embryonic mosaicism and potential clinical effects.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
Manuel Viotti, Ermanno Greco, James A. Grifo, Mitko Madjunkov, Clifford Librach, Murat Cetinkaya, Semra Kahraman, Pavel Yakovlev, Nikolay Kornilov, Laura Corti, Anil Biricik, En-Hui Cheng, Ching-Ya Su, Maw-Sheng Lee, Michael D. Bonifacio, Amber R. Cooper, Darren K. Griffin, Diane Y. Tran, Purvi Kaur, Frank L. Barnes, Christo G. Zouves, Andrea R. Victor, Andria G. Besser, Svetlana Madjunkova, Francesca Spinella
Summary: The study found that embryos classified as euploid had a lower risk of spontaneous abortion compared to mosaic embryos, but infants born from mosaic embryo transfers were similar to those born from euploid transfers. Most prenatal tests conducted on pregnancies from mosaic embryo transfers showed normal results, and mosaicism resolved during most pregnancies.
FERTILITY AND STERILITY
(2023)