The p21-activated kinase (PAK1) is involved in diet-induced beta cell mass expansion and survival in mice and human islets

Activation of cAMP Signaling Attenuates Impaired Hepatic Glucose Disposal in Aged Male p21-Activated Protein Kinase-1 Knockout Mice

(2014) Yu-ting Alex Chiang et al.   ENDOCRINOLOGY

Divergent compensatory responses to high-fat diet between C57BL6/J and C57BLKS/J inbred mouse strains

(2013) Emily K. Sims et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Depletion of PAK1 enhances Ubiquitin-mediated Survivin degradation in pancreatic β-cells

(2013) Yi-Chun Chen et al.   Islets

A p21-activated kinase (PAK1) signaling cascade coordinately regulates F-actin remodeling and insulin granule exocytosis in pancreatic β cells

(2012) Michael A. Kalwat et al.   BIOCHEMICAL PHARMACOLOGY

Saturated Fatty Acid and TLR Signaling Link β Cell Dysfunction and Islet Inflammation

(2012) Kosei Eguchi et al.   Cell Metabolism

Doc2b Is a Key Effector of Insulin Secretion and Skeletal Muscle Insulin Sensitivity

(2012) L. Ramalingam et al.   DIABETES

Pancreatic diabetes manifests when beta cell area declines by approximately 65% in humans

(2012) J. J. Meier et al.   DIABETOLOGIA

P21-Activated Protein Kinase 1 (Pak1) Mediates the Cross Talk between Insulin and β-Catenin on Proglucagon Gene Expression and Its Ablation Affects Glucose Homeostasis in Male C57BL/6 Mice

(2012) Yuting Alex Chiang et al.   ENDOCRINOLOGY

Munc18-1 Regulates First-phase Insulin Release by Promoting Granule Docking to Multiple Syntaxin Isoforms

(2012) Eunjin Oh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines

(2012) Décio L. Eizirik et al.   PLoS Genetics

PAK1 limits the expression of the pro-apoptotic protein Bad in pancreatic islet β-cells

(2012) Zhanxiang Wang et al.   FEBS Open Bio

Inhibition or Ablation of p21-activated Kinase (PAK1) Disrupts Glucose Homeostatic Mechanismsin Vivo

(2011) Zhanxiang Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid-induced pancreatic β-cell dysfunction: focus on in vivo studies

(2010) Adria Giacca et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The unique hypusine modification of eIF5A promotes islet β cell inflammation and dysfunction in mice

(2010) Bernhard Maier et al.   JOURNAL OF CLINICAL INVESTIGATION

p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics

(2009) J. D. Allen et al.   BLOOD

The Rho Guanosine 5′-Triphosphatase, Cell Division Cycle 42, Is Required for Insulin-Induced Actin Remodeling and Glucagon-Like Peptide-1 Secretion in the Intestinal Endocrine L Cell

(2009) Gareth E. Lim et al.   ENDOCRINOLOGY

Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic β-cells

(2008) Elida Lai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Glucolipotoxicity: Fuel Excess and β-Cell Dysfunction

(2008) Vincent Poitout et al.   ENDOCRINE REVIEWS

Regulation of Insulin Granule Turnover in Pancreatic β-Cells by Cleaved ICA512

(2008) Mirko Trajkovski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

P21-activated kinase is required for mitotic progression and regulates Plk1

(2008) B Maroto et al.   ONCOGENE

Ileal brake: A sensible food target for appetite control. A review

(2008) P.W.J. Maljaars et al.   PHYSIOLOGY & BEHAVIOR