Gene Therapy for Drug-Resistant Glioblastoma via Lipid-Polymer Hybrid Nanoparticles Combined with Focused Ultrasound

Theranostic Strategy of Focused Ultrasound Induced Blood-Brain Barrier Opening for CNS Disease Treatment

(2019) Ko-Ting Chen et al.   Frontiers in Pharmacology

Lipid-polymer hybrid nanoparticles: Synthesis strategies and biomedical applications

(2019) Vivek Dave et al.   JOURNAL OF MICROBIOLOGICAL METHODS

Lipid–polymer hybrid nanoparticles as a next-generation drug delivery platform: state of the art, emerging technologies, and perspectives

(2019) Anubhab Mukherjee et al.   International Journal of Nanomedicine

Targeted shRNA-loaded liposome complex combined with focused ultrasound for blood brain barrier disruption and suppressing glioma growth

(2018) Guanjian Zhao et al.   CANCER LETTERS

Safety evaluation of frequent application of microbubble-enhanced focused ultrasound blood-brain-barrier opening

(2018) Hong-Chieh Tsai et al.   Scientific Reports

Chemotherapy sensitization of glioblastoma by focused ultrasound-mediated delivery of therapeutic liposomes

(2018) Alexandros Papachristodoulou et al.   JOURNAL OF CONTROLLED RELEASE

iRGD-modified lipid–polymer hybrid nanoparticles loaded with isoliquiritigenin to enhance anti-breast cancer effect and tumor-targeting ability

(2017) Fei Gao et al.   International Journal of Nanomedicine

Polymer-lipid-PEG hybrid nanoparticles as photosensitizer carrier for photodynamic therapy

(2017) Sasivimon Pramual et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Blood-Brain Barrier Closure Time After Controlled Ultrasound-Induced Opening Is Independent of Opening Volume

(2017) Meaghan A. O'Reilly et al.   JOURNAL OF ULTRASOUND IN MEDICINE

Microinjection-based generation of mutant mice with a double mutation and a 0.5 Mb deletion in their genome by the CRISPR/Cas9 system

(2016) Satoshi HARA et al.   JOURNAL OF REPRODUCTION AND DEVELOPMENT

Engineered Viruses as Genome Editing Devices

(2016) Xiaoyu Chen et al.   MOLECULAR THERAPY

High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects

(2016) Benjamin P. Kleinstiver et al.   NATURE

Autocrine VEGFR1 and VEGFR2 signaling promotes survival in human glioblastoma models in vitro and in vivo

(2016) Emese Szabo et al.   NEURO-ONCOLOGY

Liposomal Drug Delivery: A Versatile Platform for Challenging Clinical Applications

(2016) Asadullah Madni et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

An alternative strategy for targeted gene replacement in plants using a dual-sgRNA/Cas9 design

(2016) Yongping Zhao et al.   Scientific Reports

The role of glioma stem cells in chemotherapy resistance and glioblastoma multiforme recurrence

(2015) Brenda Auffinger et al.   Expert Review of Neurotherapeutics

Pancreatic cancer modeling using retrograde viral vector delivery and in vivo CRISPR/Cas9-mediated somatic genome editing

(2015) Shin-Heng Chiou et al.   GENES & DEVELOPMENT

The role of glioma stem cells in chemotherapy resistance and glioblastoma multiforme recurrence

(2015) Brenda Auffinger et al.   Expert Review of Neurotherapeutics

Polymeric Nanoparticle Technologies for Oral Drug Delivery

(2014) Eric M. Pridgen et al.   Clinical Gastroenterology and Hepatology

Improving CRISPR-Cas nuclease specificity using truncated guide RNAs

(2014) Yanfang Fu et al.   NATURE BIOTECHNOLOGY

Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification

(2014) John P Guilinger et al.   NATURE BIOTECHNOLOGY

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

(2014) A. P. Patel et al.   SCIENCE

Combining Microbubbles and Ultrasound for Drug Delivery to Brain Tumors: Current Progress and Overview

(2014) Hao-Li Liu et al.   Theranostics

Single-Step Assembly of DOX/ICG Loaded Lipid–Polymer Nanoparticles for Highly Effective Chemo-photothermal Combination Therapy

(2013) Mingbin Zheng et al.   ACS Nano

Lipid–polymer hybrid nanoparticles as a new generation therapeutic delivery platform: A review

(2013) Kunn Hadinoto et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Paclitaxel-liposome–microbubble complexes as ultrasound-triggered therapeutic drug delivery carriers

(2013) Fei Yan et al.   JOURNAL OF CONTROLLED RELEASE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Engineering of lipid-coated PLGA nanoparticles with a tunable payload of diagnostically active nanocrystals for medical imaging

(2012) Aneta J. Mieszawska et al.   CHEMICAL COMMUNICATIONS

The Blood-Brain/Tumor Barriers: Challenges and Chances for Malignant Gliomas Targeted Drug Delivery

(2012) Changyou Zhan et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

Polymer therapeutics as nanomedicines: new perspectives

(2011) Ruth Duncan   CURRENT OPINION IN BIOTECHNOLOGY

Systemic delivery of siRNA with cationic lipid assisted PEG-PLA nanoparticles for cancer therapy

(2011) Xian-Zhu Yang et al.   JOURNAL OF CONTROLLED RELEASE

Focused ultrasound disruption of the blood-brain barrier: a new frontier for therapeutic delivery in molecular neurooncology

(2011) Arnold B. Etame et al.   Neurosurgical Focus

Downregulation of S100A4 expression by RNA interference suppresses cell growth and invasion in human colorectal cancer cells

(2011) LIYONG HUANG et al.   ONCOLOGY REPORTS

Temozolomide: Mechanisms of Action, Repair and Resistance

(2011) Jihong Zhang et al.   Current Molecular Pharmacology

Targeting O 6-methylguanine-DNA methyltransferase with specific inhibitors as a strategy in cancer therapy

(2010) Bernd Kaina et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Polymeric carriers: Preclinical safety and the regulatory implications for design and development of polymer therapeutics

(2009) Rogério Gaspar et al.   ADVANCED DRUG DELIVERY REVIEWS

Immunocompatibility properties of lipid–polymer hybrid nanoparticles with heterogeneous surface functional groups

(2009) Carolina Salvador-Morales et al.   BIOMATERIALS

Temozolomide in malignant gliomas: current use and future targets

(2009) J. Lee Villano et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

Self-Assembled Lipid−Polymer Hybrid Nanoparticles: A Robust Drug Delivery Platform

(2008) Liangfang Zhang et al.   ACS Nano

Mechanisms of Chemoresistance to Alkylating Agents in Malignant Glioma

(2008) J. N. Sarkaria et al.   CLINICAL CANCER RESEARCH