Safe Nanoparticles: Are We There Yet?

Drug Delivery with Polymeric Nanocarriers—Cellular Uptake Mechanisms

(2020) Levi Collin Nelemans et al.   Materials

Endocytosis: The Nanoparticle and Submicron Nanocompounds Gateway into the Cell

(2020) Darío Manzanares et al.   Pharmaceutics

Anti-PEG antibodies: Properties, formation, testing and role in adverse immune reactions to PEGylated nano-biopharmaceuticals

(2020) Gergely Tibor Kozma et al.   ADVANCED DRUG DELIVERY REVIEWS

Opsonins and Dysopsonins of Nanoparticles: Facts, Concepts, and Methodological Guidelines

(2020) Emanuele Papini et al.   Frontiers in Immunology

Degradability and Clearance of Inorganic Nanoparticles for Biomedical Applications

(2019) Guangbao Yang et al.   ADVANCED MATERIALS

Bactericidal and Cytotoxic Properties of Silver Nanoparticles

(2019) Chengzhu Liao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Development of cutaneous squamous cell carcinoma after prolonged exposure to pegylated liposomal doxorubicin and hand–foot syndrome: a newly recognized toxicity

(2019) Daniel F. Pease et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Subchronic and chronic toxicity evaluation of inorganic nanoparticles for delivery applications

(2019) Raziye Mohammadpour et al.   ADVANCED DRUG DELIVERY REVIEWS

Long-term pulmonary exposure to multi-walled carbon nanotubes promotes breast cancer metastatic cascades

(2019) Xuefei Lu et al.   Nature Nanotechnology

Current Applications of Nanoemulsions in Cancer Therapeutics

(2019) Elena Sánchez-López et al.   Nanomaterials

Redox interactions and genotoxicity of metal-based nanoparticles: A comprehensive review

(2019) Keywan Mortezaee et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Combinatorial Nano–Bio Interfaces

(2018) Pingqiang Cai et al.   ACS Nano

Nanoparticle-induced inflammation can increase tumor malignancy

(2018) Bella B. Manshian et al.   Acta Biomaterialia

Pharmacokinetics, Metabolism, Distribution and Permeability of Nanomedicine

(2018) Selvan Ravindran et al.   CURRENT DRUG METABOLISM

Coating Matters: Review on Colloidal Stability of Nanoparticles with Biocompatible Coatings in Biological Media, Living Cells and Organisms

(2018) Jonas Schubert et al.   CURRENT MEDICINAL CHEMISTRY

Early ecotoxic effects of ZnO nanoparticle chronic exposure in Mytilus galloprovincialis revealed by transcription of apoptosis and antioxidant-related genes

(2018) Jiji Li et al.   ECOTOXICOLOGY

Molecular and immunological toxic effects of nanoparticles

(2018) Rajan Kumar Pandey et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Nanoemulsion as pharmaceutical carrier for dermal and transdermal drug delivery: Formulation development, stability issues, basic considerations and applications

(2018) Vineet Kumar Rai et al.   JOURNAL OF CONTROLLED RELEASE

Toxicological interactions induced by chronic exposure to gold nanoparticles and microplastics mixtures in Daphnia magna

(2018) Alexandre Pacheco et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Influence of nanoparticle doping on the colloidal stability and toxicity of copper oxide nanoparticles in synthetic and natural waters

(2018) Adeyemi S. Adeleye et al.   WATER RESEARCH

Toxicological status of nanoparticles: What we know and what we don't know

(2018) Wided N. Missaoui et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Current approaches for safer design of engineered nanomaterials

(2018) Ruth Hwang et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Silver nanoparticles as an effective disinfectant: A review

(2018) S.P. Deshmukh et al.   Materials Science & Engineering C-Materials for Biological Applications

Understanding the nano-bio interactions using real-time surface plasmon resonance tool

(2018) Sonal S. Atale et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Copper doping enhanced the oxidative stress–mediated cytotoxicity of TiO2 nanoparticles in A549 cells

(2017) J Ahmad et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Superparamagnetic reconstituted high-density lipoprotein nanocarriers for magnetically guided drug delivery

(2017) Sarika Sabnis et al.   International Journal of Nanomedicine

Review of the effects of manufactured nanoparticles on mammalian target organs

(2017) Tianshu Wu et al.   JOURNAL OF APPLIED TOXICOLOGY

Advances in Magnetic Nanoparticles for Biomedical Applications

(2017) Vanessa Fernandes Cardoso et al.   Advanced Healthcare Materials

Two-Step Mechanism of Cellular Uptake of Cationic Gold Nanoparticles Modified by (16-Mercaptohexadecyl)trimethylammonium Bromide

(2016) Monika Zarska et al.   BIOCONJUGATE CHEMISTRY

PSMA targeted docetaxel-loaded superparamagnetic iron oxide nanoparticles for prostate cancer

(2016) Prashanth K.B. Nagesh et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Submicron Emulsions and Their Applications in Oral Delivery

(2016) Veenu Mundada et al.   CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS

The toxicology of ion-shedding zinc oxide nanoparticles

(2016) Jia Liu et al.   CRITICAL REVIEWS IN TOXICOLOGY

Oxidative stress, inflammation, and DNA damage in multiple organs of mice acutely exposed to amorphous silica nanoparticles

(2016) Abderrahim Nemmar et al.   International Journal of Nanomedicine

The effect of exposure to nanoparticles and nanomaterials on the mammalian epigenome

(2016) Marta I. Sierra et al.   International Journal of Nanomedicine

Biodistribution of polyacrylic acid-coated iron oxide nanoparticles is associated with proinflammatory activation and liver toxicity

(2016) Diana Couto et al.   JOURNAL OF APPLIED TOXICOLOGY

Where does the toxicity of metal oxide nanoparticles come from: The nanoparticles, the ions, or a combination of both?

(2016) Dali Wang et al.   JOURNAL OF HAZARDOUS MATERIALS

Carbon Nanotubes in Biomedical Applications: Factors, Mechanisms, and Remedies of Toxicity

(2016) Reem Alshehri et al.   JOURNAL OF MEDICINAL CHEMISTRY

Investigation and Mathematical Description of the Real Driving Force of Passive Transport of Drug Molecules from Supersaturated Solutions

(2016) Enikő Borbás et al.   MOLECULAR PHARMACEUTICS

Low-dose, subchronic exposure to silver nanoparticles causes mitochondrial alterations in Sprague–Dawley rats

(2016) João Soeiro Teodoro et al.   Nanomedicine

The effect of nanoparticle size on in vivo pharmacokinetics and cellular interaction

(2016) Nazanin Hoshyar et al.   Nanomedicine

Liposome-mediated delivery of the p21 activated kinase-1 (PAK-1) inhibitor IPA-3 limits prostate tumor growth in vivo

(2016) Ahmad Al-Azayzih et al.   Nanomedicine-Nanotechnology Biology and Medicine

Designed synthesis and surface engineering strategies of magnetic iron oxide nanoparticles for biomedical applications

(2016) Wei Wu et al.   Nanoscale

On the contribution of the phagocytosis and the solubilization to the iron oxide nanoparticles retention in and elimination from lungs under long-term inhalation exposure

(2016) M.P. Sutunkova et al.   TOXICOLOGY

Preparation, characterization, and potential application of chitosan, chitosan derivatives, and chitosan metal nanoparticles in pharmaceutical drug delivery

(2016) Tarek Ahmed et al.   Drug Design Development and Therapy

A novel covalent approach to bio-conjugate silver coated single walled carbon nanotubes with antimicrobial peptide

(2016) Atul A. Chaudhari et al.   JOURNAL OF NANOBIOTECHNOLOGY

Manufacturing Techniques and Surface Engineering of Polymer Based Nanoparticles for Targeted Drug Delivery to Cancer

(2016) Yichao Wang et al.   Nanomaterials

Can Carbon Nanotubes Deliver on Their Promise in Biology? Harnessing Unique Properties for Unparalleled Applications

(2016) Christopher J. Serpell et al.   ACS Central Science

Reduction of Acute Inflammatory Effects of Fumed Silica Nanoparticles in the Lung by Adjusting Silanol Display through Calcination and Metal Doping

(2015) Bingbing Sun et al.   ACS Nano

Tailored functionalization of iron oxide nanoparticles for MRI, drug delivery, magnetic separation and immobilization of biosubstances

(2015) Katerina Hola et al.   BIOTECHNOLOGY ADVANCES

Nanoparticles in food. Epigenetic changes induced by nanomaterials and possible impact on health

(2015) Bozena Smolkova et al.   FOOD AND CHEMICAL TOXICOLOGY

Liposomes as nanomedical devices

(2015) Giuseppina Bozzuto et al.   International Journal of Nanomedicine

Influence of the surface charge of PLGA nanoparticles on theirin vitrogenotoxicity, cytotoxicity, ROS production and endocytosis

(2015) Anne Platel et al.   JOURNAL OF APPLIED TOXICOLOGY

Stability, Pharmacokinetics, Biodistribution and Safety Assessment of Folate-Conjugated Pullulan Acetate Nanoparticles as Cervical Cancer Targeted Drug Carriers

(2015) Hongbo Tang et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Gold nanoparticle surface functionalization: a necessary requirement in the development of novel nanotherapeutics

(2015) James R Nicol et al.   Nanomedicine

Principles of nanoparticle design for overcoming biological barriers to drug delivery

(2015) Elvin Blanco et al.   NATURE BIOTECHNOLOGY

Tissue distribution and acute toxicity of silver after single intravenous administration in mice: nano-specific and size-dependent effects

(2015) Camilla Recordati et al.   Particle and Fibre Toxicology

Recent progress on magnetic iron oxide nanoparticles: synthesis, surface functional strategies and biomedical applications

(2015) Wei Wu et al.   SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS

Spectral investigations on undoped and Cu2+ doped ZnO–CdS composite nanopowders

(2015) G. Thirumala Rao et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Multi-walled carbon nanotube induced frustrated phagocytosis, cytotoxicity and pro-inflammatory conditions in macrophages are length dependent and greater than that of asbestos

(2015) Matthew S.P. Boyles et al.   TOXICOLOGY IN VITRO

Epigenetic mechanisms in nanomaterial-induced toxicity

(2015) Sukanya Shyamasundar et al.   Epigenomics

Nanotechnology in the real world: Redeveloping the nanomaterial consumer products inventory

(2015) Marina E Vance et al.   Beilstein Journal of Nanotechnology

Nanotoxicity: An Interplay of Oxidative Stress, Inflammation and Cell Death

(2015) Puja Khanna et al.   Nanomaterials

Nanoemulsions in Translational Research—Opportunities and Challenges in Targeted Cancer Therapy

(2014) Srinivas Ganta et al.   AAPS PHARMSCITECH

Gold nanoparticles with different amino acid surfaces: Serum albumin adsorption, intracellular uptake and cytotoxicity

(2014) Huanxin Cai et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Toxicity of Nanoparticles

(2014) Maria Zoroddu et al.   CURRENT MEDICINAL CHEMISTRY

Toxicity and efficacy of carbon nanotubes and graphene: the utility of carbon-based nanoparticles in nanomedicine

(2014) Yongbin Zhang et al.   DRUG METABOLISM REVIEWS

Toxicity of quantum dots on respiratory system

(2014) Tianshu Wu et al.   INHALATION TOXICOLOGY

Nanodrugs: pharmacokinetics and safety

(2014) Satomi Onoue et al.   International Journal of Nanomedicine

Zwitteration: Coating Surfaces with Zwitterionic Functionality to Reduce Nonspecific Adsorption

(2014) Joseph B. Schlenoff   LANGMUIR

Zwitterionic-Coated “Stealth” Nanoparticles for Biomedical Applications: Recent Advances in Countering Biomolecular Corona Formation and Uptake by the Mononuclear Phagocyte System

(2014) Karina Pombo García et al.   Small

In Vitro Safety Evaluation of Nanomaterials^|^mdash;Cellular Response to Metal Oxide Nanoparticles^|^mdash;

(2014) Kazuo Isama   YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN

Engineered nanoparticles interacting with cells: size matters

(2014) Li Shang et al.   JOURNAL OF NANOBIOTECHNOLOGY

Nanoemulsion: an advanced mode of drug delivery system

(2014) Manjit Jaiswal et al.   3 Biotech

Surface Charge and Cellular Processing of Covalently Functionalized Multiwall Carbon Nanotubes Determine Pulmonary Toxicity

(2013) Ruibin Li et al.   ACS Nano

Molecular mechanism of titanium dioxide nanoparticles-induced oxidative injury in the brain of mice

(2013) Yuguan Ze et al.   CHEMOSPHERE

Effects of sub-acute exposure to TiO2, ZnO and Al2O3nanoparticles on oxidative stress and histological changes in mouse liver and brain

(2013) Rupal Shrivastava et al.   DRUG AND CHEMICAL TOXICOLOGY

Gold nanoparticles: an era in bionanotechnology

(2013) Deepak Kumar et al.   Expert Opinion on Drug Delivery

Interactive threats of nanoparticles to the biological system

(2013) Ruchi Roy et al.   IMMUNOLOGY LETTERS

Magnetic Iron Oxide Nanoparticles for Multimodal Imaging and Therapy of Cancer

(2013) Reju Thomas et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics

(2013) Martin A Maier et al.   MOLECULAR THERAPY

Therapeutic nanoparticles in clinics and under clinical evaluation

(2013) Catherine A Schütz et al.   Nanomedicine

Modulation of the pharmacokinetics of zinc oxide nanoparticles and their fates in vivo

(2013) Hee-Jeong Paek et al.   Nanoscale

Titanium dioxide nanoparticles: a review of current toxicological data

(2013) Hongbo Shi et al.   Particle and Fibre Toxicology

Carbon Nanotubes: Present and Future Commercial Applications

(2013) M. F. L. De Volder et al.   SCIENCE

Challenges in Development of Nanoparticle-Based Therapeutics

(2012) Neil Desai   AAPS Journal

Physicochemical Properties Determine Nanomaterial Cellular Uptake, Transport, and Fate

(2012) Motao Zhu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Surface functionalization of nanoparticles for nanomedicine

(2012) Rubul Mout et al.   CHEMICAL SOCIETY REVIEWS

Lipid-Based Nanoparticles as Pharmaceutical Drug Carriers: From Concepts to Clinic

(2012) Anu Puri et al.   CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS

Evidence for distinct mechanisms of uptake and antitumor activity of secretory phospholipase A2responsive liposome in prostate cancer

(2012) J. N. Mock et al.   Integrative Biology

Short- and long-term toxicities of multi-walled carbon nanotubesin vivoandin vitro

(2012) Shaoxian Tang et al.   JOURNAL OF APPLIED TOXICOLOGY

Pluronic F108 Coating Decreases the Lung Fibrosis Potential of Multiwall Carbon Nanotubes by Reducing Lysosomal Injury

(2012) Xiang Wang et al.   NANO LETTERS

In vivo toxicity, biodistribution, and clearance of glutathione-coated gold nanoparticles

(2012) Carrie A. Simpson et al.   Nanomedicine-Nanotechnology Biology and Medicine

Epigenetic effects of nano-sized materials

(2012) Andrea Stoccoro et al.   TOXICOLOGY

Decreased Dissolution of ZnO by Iron Doping Yields Nanoparticles with Reduced Toxicity in the Rodent Lung and Zebrafish Embryos

(2011) Tian Xia et al.   ACS Nano

Dispersal State of Multiwalled Carbon Nanotubes Elicits Profibrogenic Cellular Responses That Correlate with Fibrogenesis Biomarkers and Fibrosis in the Murine Lung

(2011) Xiang Wang et al.   ACS Nano

Toxicology of nanoparticles

(2011) Andreas Elsaesser et al.   ADVANCED DRUG DELIVERY REVIEWS

Toxicity of nanomaterials

(2011) Shahriar Sharifi et al.   CHEMICAL SOCIETY REVIEWS

Surface modified nevirapine nanosuspensions for viral reservoir targeting: In vitro and in vivo evaluation

(2011) Ranjita Shegokar et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Surface-modified silica nanoparticles for tumor-targeted delivery of camptothecin and its biological evaluation

(2011) Pablo Botella et al.   JOURNAL OF CONTROLLED RELEASE

In vivobiodistribution of nanoparticles

(2011) Joao Paulo Mattos Almeida et al.   Nanomedicine

Targeted photodynamic therapy of breast cancer cells using antibody–phthalocyanine–gold nanoparticle conjugates

(2011) Tanya Stuchinskaya et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Characterization of quaternized chitosan-stabilized iron oxide nanoparticles as a novel potential magnetic resonance imaging contrast agent for cell tracking

(2011) Chia-Rui Shen et al.   POLYMER INTERNATIONAL

Aggravating Impact of Nanoparticles on Immune-Mediated Pulmonary Inflammation

(2011) Ken-Ichiro Inoue et al.   TheScientificWorldJOURNAL

Nanotoxicology and in vitro studies: The need of the hour

(2011) Sumit Arora et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Use of a Rapid Cytotoxicity Screening Approach To Engineer a Safer Zinc Oxide Nanoparticle through Iron Doping

(2010) Saji George et al.   ACS Nano

PET/NIRF/MRI triple functional iron oxide nanoparticles

(2010) Jin Xie et al.   BIOMATERIALS

Nanomedicine: Magnetic Nanoparticles and their Biomedical Applications

(2010) R. Banerjee et al.   CURRENT MEDICINAL CHEMISTRY

TiO2 Nanoparticles Co-Doped with Silver and Nitrogen for Antibacterial Application

(2010) Yali Yuan et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Gold Nanoparticles for the Improved Anticancer Drug Delivery of the Active Component of Oxaliplatin

(2010) Sarah D. Brown et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Surface-Mediated Production of Hydroxyl Radicals as a Mechanism of Iron Oxide Nanoparticle Biotoxicity

(2010) Maxim A. Voinov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pulmonary Inflammation After Intraperitoneal Administration of Ultrafine Titanium Dioxide (TiO2) At Rest or in Lungs Primed with Lipopolysaccharide

(2010) Changsuk Moon et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Multiscale observation of biological interactions of nanocarriers: From nano to macro

(2010) Su-Eon Jin et al.   MICROSCOPY RESEARCH AND TECHNIQUE

Biocompatible Nanoscale Dispersion of Single-Walled Carbon Nanotubes Minimizes in vivo Pulmonary Toxicity

(2010) Gökhan M. Mutlu et al.   NANO LETTERS

Flame spray pyrolysis: An enabling technology for nanoparticles design and fabrication

(2010) Wey Yang Teoh et al.   Nanoscale

Lung deposition and extrapulmonary translocation of nano-ceria after intratracheal instillation

(2010) Xiao He et al.   NANOTECHNOLOGY

Emulsion Design to Improve the Delivery of Functional Lipophilic Components

(2010) David Julian McClements   Annual Review of Food Science and Technology

Antibacterial activity and mechanism of silver nanoparticles on Escherichia coli

(2009) Wen-Ru Li et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Size dependence of the translocation of inhaled iridium and carbon nanoparticle aggregates from the lung of rats to the blood and secondary target organs

(2009) Wolfgang G. Kreyling et al.   INHALATION TOXICOLOGY

Inhibition of Macrophage Phagocytotic Activity by a Receptor-targeted Polymer Vesicle-based Drug Delivery Formulation of Pravastatin

(2009) Pavel Broz et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Safety assessment for nanotechnology and nanomedicine: concepts of nanotoxicology

(2009) G. Oberdörster   JOURNAL OF INTERNAL MEDICINE

Understanding biophysicochemical interactions at the nano–bio interface

(2009) Andre E. Nel et al.   NATURE MATERIALS

Evaluation of nanoparticle immunotoxicity

(2009) Marina A. Dobrovolskaia et al.   Nature Nanotechnology

Uptake and Intracellular Fate of Surface-Modified Gold Nanoparticles

(2008) Paola Nativo et al.   ACS Nano

Comparison of the Mechanism of Toxicity of Zinc Oxide and Cerium Oxide Nanoparticles Based on Dissolution and Oxidative Stress Properties

(2008) Tian Xia et al.   ACS Nano

Copper Oxide Nanoparticles Are Highly Toxic: A Comparison between Metal Oxide Nanoparticles and Carbon Nanotubes

(2008) Hanna L. Karlsson et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Magnetic Iron Oxide Nanoparticles: Synthesis and Surface Functionalization Strategies

(2008) Wei Wu et al.   Nanoscale Research Letters

Surface-structure-regulated cell-membrane penetration by monolayer-protected nanoparticles

(2008) Ayush Verma et al.   NATURE MATERIALS

The asbestos analogy revisited

(2008) Agnes B. Kane et al.   Nature Nanotechnology

Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study

(2008) Craig A. Poland et al.   Nature Nanotechnology

Shape Induced Inhibition of Phagocytosis of Polymer Particles

(2008) Julie A. Champion et al.   PHARMACEUTICAL RESEARCH

Methods for the Preparation and Manufacture of Polymeric Nanoparticles

(2008) Christine Vauthier et al.   PHARMACEUTICAL RESEARCH

Liposomal Nanomedicines: An Emerging Field

(2008) David B. Fenske et al.   TOXICOLOGIC PATHOLOGY

Potential neurological lesion after nasal instillation of TiO2 nanoparticles in the anatase and rutile crystal phases

(2008) J WANG et al.   TOXICOLOGY LETTERS

Multifunctional nanoparticles – properties and prospects for their use in human medicine

(2008) Nuria Sanvicens et al.   TRENDS IN BIOTECHNOLOGY

Cytotoxicity of Nanoparticles

(2007) Nastassja Lewinski et al.   Small