Mechanisms of Reciprocal Regulation of Gonadotropin-Releasing Hormone (GnRH)-Producing and Immune Systems: The Role of GnRH, Cytokines and Their Receptors in Early Ontogenesis in Normal and Pathological Conditions

Effect of Inflammation on Female Gonadotropin-Releasing Hormone (GnRH) Neurons: Mechanisms and Consequences

(2020) Klaudia Barabás et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Perinatal Inflammation Reprograms Neuroendocrine, Immune, and Reproductive Functions: Profile of Cytokine Biomarkers

(2020) Marina Izvolskaia et al.   INFLAMMATION

Testicular inflammation and infertility: Could chlamydial infections be contributing?

(2020) Emily R. Bryan et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

GnRH neurogenesis depends on embryonic pheromone receptor expression

(2020) Thomas Schmid et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Involvement of CXCR4 in Normal and Abnormal Development

(2019) Nanako Kawaguchi et al.   Cells

Effects of Vitamin D Supplementation During Pregnancy on Birth Size: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

(2019) Andrea Maugeri et al.   Nutrients

GnRH-1 Neural Migration From the Nose to the Brain Is Independent From Slit2, Robo3 and NELL2 Signaling

(2019) Ed Zandro M. Taroc et al.   Frontiers in Cellular Neuroscience

Differential CRE expression in Lhrh-Cre and Gnrh-Cre alleles and the impact on fertility in Otx2-flox mice

(2019) Hanne M. Hoffmann et al.   NEUROENDOCRINOLOGY

Sex-Dependent Effects of Perinatal Inflammation on the Brain: Implication for Neuro-Psychiatric Disorders

(2019) Maryam Ardalan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Prenatal maternal vaginal inflammation increases anxiety and alters HPA axis signalling in adult male mice

(2019) Huan-Li Wang et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Pax 6 Controls Neural Crest Potential of Limbal Niche Cells to Support Self-Renewal of Limbal Epithelial Stem Cells

(2019) Szu-Yu Chen et al.   Scientific Reports

Gonadotropin-Releasing Hormone in Regulation of Thymic Development in Rats: Profile of Thymic Cytokines

(2019) Victoria I. Melnikova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gli3 regulates vomeronasal neurogenesis, olfactory ensheathing cell formation and GnRH-1 neuronal migration

(2019) Ed Zandro M. Taroc et al.   JOURNAL OF NEUROSCIENCE

Dietary omega-3 deficiency exacerbates inflammation and reveals spatial memory deficits in mice exposed to lipopolysaccharide during gestation

(2018) V.F. Labrousse et al.   BRAIN BEHAVIOR AND IMMUNITY

Toll and Toll-like receptor signalling in development

(2018) Niki Anthoney et al.   DEVELOPMENT

IVIg Promote Cross-Tolerance against Inflammatory Stimuli In Vitro and In Vivo

(2018) Ángeles Domínguez-Soto et al.   JOURNAL OF IMMUNOLOGY

Gonadotropin regulation by pulsatile GnRH: Signaling and gene expression

(2018) George A. Stamatiades et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Therapeutic N-Acetyl-Cysteine (Nac) Following Initiation of Maternal Inflammation Attenuates Long-Term Offspring Cerebral Injury, as Evident in Magnetic Resonance Imaging (MRI)

(2018) Hila Sharabi et al.   NEUROSCIENCE

Protection Against Lipopolysaccharide-Induced Immunosuppression by IgG and IgM

(2018) Christiana Kyvelidou et al.   SHOCK

Abolition of prenatal lipopolysaccharide-induced reproductive disorders in rat male offspring by fulvestrant

(2018) Marina S. Izvolskaia et al.   ANDROLOGIA

Semaphorin signalling in GnRH neurons: from development to disease.

(2018) Anna Cariboni et al.   NEUROENDOCRINOLOGY

Disruptions in the reproductive system of female rats after prenatal lipopolysaccharide-induced immunological stress: role of sex steroids

(2018) V. M. Ignatiuk et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Defective signaling through plexin-A1 compromises the development of the peripheral olfactory system and neuroendocrine reproductive axis in mice

(2017) Séverine Marcos et al.   HUMAN MOLECULAR GENETICS

The role of peripheral immune cells in the CNS in steady state and disease

(2017) Marco Prinz et al.   NATURE NEUROSCIENCE

Prenatal developmental origins of behavior and mental health: The influence of maternal stress in pregnancy

(2017) Bea R.H. Van den Bergh et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Definition of the hypothalamic GnRH pulse generator in mice

(2017) Jenny Clarkson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of active immunization against GnRH versus surgical castration on hypothalamic-pituitary function in boars

(2017) Xingfa Han et al.   THERIOGENOLOGY

Mechanisms of action of intravenous immunoglobulin

(2017) Benjamin Chaigne et al.   TRANSFUSION AND APHERESIS SCIENCE

Tocilizumab (Actemra)

(2017) Martin Sheppard et al.   Human Vaccines & Immunotherapeutics

The Immune System and Neuroinflammation as Potential Sources of Blood-Based Biomarkers for Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease

(2016) Lorraine F. Clark et al.   ACS Chemical Neuroscience

Maternal magnesium sulfate fetal neuroprotective effects to the fetus: inhibition of neuronal nitric oxide synthase and nuclear factor kappa-light-chain-enhancer of activated B cells activation in a rodent model

(2016) Ron Beloosesky et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Cell migration in the developing rodent olfactory system

(2016) Dhananjay Huilgol et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The inhibition of dopamine synthesis in fetuses changes the pattern of T-lymphocyte maturation in the thymus of adult rats

(2016) N. V. Lifantseva et al.   Doklady Biochemistry and Biophysics

Physiological interactions between the hypothalamic-pituitary-gonadal axis and spleen in rams actively immunized against GnRH

(2016) Xingfa Han et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Targeted next generation sequencing approach identifies eighteen new candidate genes in normosmic hypogonadotropic hypogonadism and Kallmann syndrome

(2016) Samuel D. Quaynor et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Disruptions in the hypothalamic–pituitary–gonadal axis in rat offspring following prenatal maternal exposure to lipopolysaccharide

(2016) Marina S. Izvolskaia et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Kisspeptin signaling in the amygdala modulates reproductive hormone secretion

(2015) Alexander N. Comninos et al.   Brain Structure & Function

Conditional Viral Tract Tracing Delineates the Projections of the Distinct Kisspeptin Neuron Populations to Gonadotropin-Releasing Hormone (GnRH) Neurons in the Mouse

(2015) Siew Hoong Yip et al.   ENDOCRINOLOGY

The pre-vertebrate origins of neurogenic placodes

(2015) Philip Barron Abitua et al.   NATURE

Urinary Tract Infection and Bacteriuria in Pregnancy

(2015) Alexander P. Glaser et al.   UROLOGIC CLINICS OF NORTH AMERICA

Maternal zinc deficiency during pregnancy elevates the risks of fetal growth restriction: a population-based birth cohort study

(2015) Hua Wang et al.   Scientific Reports

Lipopolysaccharide-Induced Maternal Inflammation Affects the Gonadotropin-Releasing Hormone Neuron Development in Fetal Mice

(2015) Victoria S. Sharova et al.   NEUROIMMUNOMODULATION

The spatiotemporal segregation of GAD forms defines distinct GABA signaling functions in the developing mouse olfactory system and provides novel insights into the origin and migration of GnRH neurons

(2014) Csaba Vastagh et al.   Developmental Neurobiology

Gonadotropin-releasing hormone agonist selectively augments thymopoiesis and prevents cell apoptosis in LPS induced thymic atrophy model independent of gonadal steroids

(2014) Meenal P. Ullewar et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Mutation screening of SEMA3A and SEMA7A in patients with congenital hypogonadotropic hypogonadism

(2014) Johanna Känsäkoski et al.   PEDIATRIC RESEARCH

LPS alters placental inflammatory and endocrine mediators and inhibits fetal neurite growth in affected offspring during late gestation

(2014) M.E. Straley et al.   PLACENTA

A Critical Point of Male Gonad Development: Neuroendocrine Correlates of Accelerated Testicular Growth in Rats during Early Life

(2014) Nikolay N. Dygalo et al.   PLoS One

Maternal LPS Exposure during Pregnancy Impairs Testicular Development, Steroidogenesis and Spermatogenesis in Male Offspring

(2014) Hua Wang et al.   PLoS One

The efficacy of intravenous immunoglobulin on lipopolysaccharide-induced fetal brain inflammation in preterm rats

(2013) Aslı İnci et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Tumor Necrosis Factor gene polymorphism results in high TNF level in sepsis and septic shock

(2013) Nikhil Kothari et al.   CYTOKINE

Intravenous immunoglobulin preparation attenuates LPS-induced production of pro-inflammatory cytokines in human monocytic cells by modulating TLR4-mediated signaling pathways

(2013) Kazuki Murakami et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Slit2 and Robo3 modulate the migration of GnRH-secreting neurons

(2012) A. Cariboni et al.   DEVELOPMENT

Altered Expression of Alzheimer's Disease-Related Proteins in Male Hypogonadal Mice

(2012) Eleanor S. Drummond et al.   ENDOCRINOLOGY

SDF and GABA interact to regulate axophilic migration of GnRH neurons

(2012) F. Casoni et al.   JOURNAL OF CELL SCIENCE

Suppression of  1-Integrin in Gonadotropin-Releasing Hormone Cells Disrupts Migration and Axonal Extension Resulting in Severe Reproductive Alterations

(2012) J. Parkash et al.   JOURNAL OF NEUROSCIENCE

Electrophysiological and Morphological Evidence for Synchronized GnRH Pulse Generator Activity Among Kisspeptin/neurokinin B/dynorphin A (KNDy) Neurons in Goats

(2012) Yoshihiro WAKABAYASHI et al.   JOURNAL OF REPRODUCTION AND DEVELOPMENT

Epigenetic regulation of Kiss1 gene expression mediating estrogen-positive feedback action in the mouse brain

(2012) J. Tomikawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sex differences in developmental programming models

(2012) Catherine E Aiken et al.   REPRODUCTION

The role of immunological system in the regulation of gonadoliberin and gonadotropin secretion

(2012) Dorota Tomaszewska-Zaremba et al.   Reproductive Biology

Inflammation during fetal and neonatal life: Implications for neurologic and neuropsychiatric disease in children and adults

(2011) Henrik Hagberg et al.   ANNALS OF NEUROLOGY

Prenatal exposure to lipopolysaccharide results in neurodevelopmental damage that is ameliorated by zinc in mice

(2011) Joanne S.C. Chua et al.   BRAIN BEHAVIOR AND IMMUNITY

Prenatal exposure to bacterial endotoxin reduces the number of GAD67- and reelin-immunoreactive neurons in the hippocampus of rat offspring

(2011) Dominique Nouel et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Expanding the Phenotype and Genotype of Female GnRH Deficiency

(2011) Natalie D. Shaw et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Hypothalamic Dysregulation and Infertility in Mice Lacking the Homeodomain Protein Six6

(2011) R. Larder et al.   JOURNAL OF NEUROSCIENCE

Neural Crest and Ectodermal Cells Intermix in the Nasal Placode to Give Rise to GnRH-1 Neurons, Sensory Neurons, and Olfactory Ensheathing Cells

(2011) P. E. Forni et al.   JOURNAL OF NEUROSCIENCE

Isolated GnRH deficiency: A disease model serving as a unique prism into the systems biology of the GnRH neuronal network

(2011) Ravikumar Balasubramanian et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Developmentally regulated IL6-type cytokines signal to germ cells in the human fetal ovary

(2011) S. L. Eddie et al.   MOLECULAR HUMAN REPRODUCTION

Signaling of Cytokines is Important in Regulation of GnRH Neurons

(2011) Sheng Wu et al.   MOLECULAR NEUROBIOLOGY

A stereological comparison of GAD67 and reelin expression in the hippocampal stratum oriens of offspring from two mouse models of maternal inflammation during pregnancy

(2011) Louise Harvey et al.   NEUROPHARMACOLOGY

Prenatal LPS exposure reduces olfactory perception in neonatal and adult rats

(2011) Thiago Berti Kirsten et al.   PHYSIOLOGY & BEHAVIOR

Effect of bacterial endotoxin on migration of gonadotropin-releasing hormone-producing neurons in rat embryogenesis

(2011) V. S. Sharova et al.   Russian Journal of Developmental Biology

Effect of endotoxin on the expression of GnRH and GnRHR genes in the hypothalamus and anterior pituitary gland of anestrous ewes

(2010) Andrzej Przemysław Herman et al.   ANIMAL REPRODUCTION SCIENCE

Minireview: Kisspeptin/Neurokinin B/Dynorphin (KNDy) Cells of the Arcuate Nucleus: A Central Node in the Control of Gonadotropin-Releasing Hormone Secretion

(2010) Michael N. Lehman et al.   ENDOCRINOLOGY

Maternal Leukemia Inhibitory Factor (LIF) Promotes Fetal Neurogenesis via a LIF-ACTH-LIF Signaling Relay Pathway

(2010) Eriko Simamura et al.   ENDOCRINOLOGY

The kisspeptin system of the human hypothalamus: sexual dimorphism and relationship with gonadotropin-releasing hormone and neurokinin B neurons

(2010) E. Hrabovszky et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

TAC3/TACR3Mutations Reveal Preferential Activation of Gonadotropin-Releasing Hormone Release by Neurokinin B in Neonatal Life Followed by Reversal in Adulthood

(2010) Elena Gianetti et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Removal of Polysialic Acid Triggers Dispersion of Subventricularly Derived Neuroblasts into SurroundingCNS Tissues

(2010) D. Battista et al.   JOURNAL OF NEUROSCIENCE

Neonatal programming by immunological challenge: effects on ovarian function in the adult rat

(2010) Xue-Qing Wu et al.   REPRODUCTION

Dopaminergic and serotoninergic deficiencies in young adult rats prenatally exposed to the bacterial lipopolysaccharide

(2009) Sabrina Wang et al.   BRAIN RESEARCH

Leptin, Ciliary Neurotrophic Factor, Leukemia Inhibitory Factor and Interleukin- 6: Class-I Cytokines Involved in the Neuroendocrine Regulation of the Reproductive Function

(2009) E. Dozio et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Neonatal Lipopolysaccharide Exposure Delays Puberty and Alters HypothalamicKiss1andKiss1rmRNA Expression in the Female Rat

(2009) A. M. I. Knox et al.   JOURNAL OF NEUROENDOCRINOLOGY

GnRH signaling in intrauterine tissues

(2009) Hsien-Ming Wu et al.   REPRODUCTION

The influence of catecholamine on the migration of gonadotropin-releasing hormone-producing neurons in the rat foetuses

(2008) M. Izvolskaia et al.   Brain Structure & Function

Maternal regulation of estrogen receptor α methylation

(2008) F CHAMPAGNE et al.   CURRENT OPINION IN PHARMACOLOGY

CXCR4/SDF-1 system modulates development of GnRH-1 neurons and the olfactory system

(2008) Yoko Toba et al.   Developmental Neurobiology

Luteinizing Hormone-Releasing Hormone I (LHRH-I) and Its Metabolite in Peripheral Tissues

(2008) Kathryn Walters et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Adverse trends in male reproductive health: we may have reached a crucial ‘tipping point’

(2008) A.-M. Andersson et al.   INTERNATIONAL JOURNAL OF ANDROLOGY

Semaphorin 4D regulates gonadotropin hormone–releasing hormone-1 neuronal migration through PlexinB1–Met complex

(2008) Paolo Giacobini et al.   JOURNAL OF CELL BIOLOGY

Epigenetic Programming of Phenotypic Variations in Reproductive Strategies in the Rat Through Maternal Care

(2008) N. M. Cameron et al.   JOURNAL OF NEUROENDOCRINOLOGY

Specific GATA-Binding Elements in the GnRH Promoter Are Required for Gene Expression Pulse Activity: Role of GATA-4 and GATA-5 in This Intermittent Process

(2008) Gilles M. Leclerc et al.   NEUROENDOCRINOLOGY