Theanine, Antistress Amino Acid in Tea Leaves, Causes Hippocampal Metabolic Changes and Antidepressant Effects in Stress-Loaded Mice

Theanine, the Main Amino Acid in Tea, Prevents Stress-Induced Brain Atrophy by Modifying Early Stress Responses

(2020) Keiko Unno et al.   Nutrients

Kynurenine regulates NLRP2 inflammasome in astrocytes and its implications in depression

(2020) Qingyu Zhang et al.   BRAIN BEHAVIOR AND IMMUNITY

Peripheral and cerebral abnormalities of the tryptophan metabolism in the depression-like rats induced by chronic unpredicted mild stress

(2020) Chen-Chen Li et al.   NEUROCHEMISTRY INTERNATIONAL

Involvement of kynurenine pathway in depressive-like behaviour induced by nandrolone decanoate in mice

(2020) Leandro Cattelan Souza et al.   STEROIDS

Altered brain arginine metabolism in a mouse model of tauopathy

(2019) Pranav Vemula et al.   AMINO ACIDS

Psychotropic effects of L-theanine and its clinical properties: From the management of anxiety and stress to a potential use in schizophrenia

(2019) Filipe Lopes Sakamoto et al.   PHARMACOLOGICAL RESEARCH

Regulation of lifespan by neural excitation and REST

(2019) Joseph M. Zullo et al.   NATURE

Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial

(2019) Hidese et al.   Nutrients

Widely targeted metabolomics of Alzheimer's disease postmortem cerebrospinal fluid based on 9-fluorenylmethyl chloroformate derivatized ultra-high performance liquid chromatography tandem mass spectrometry

(2018) Yoshio Muguruma et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

L-theanine ameliorate depressive-like behavior in a chronic unpredictable mild stress rat model via modulating the monoamine levels in limbic-cortical-striatal-pallidal-thalamic-circuit related brain regions

(2018) Manjun Shen et al.   PHYTOTHERAPY RESEARCH

Depletion of adult neurogenesis exacerbates cognitive deficits in Alzheimer’s disease by compromising hippocampal inhibition

(2017) Carolyn Hollands et al.   Molecular Neurodegeneration

Adult hippocampal neurogenesis and cognitive flexibility — linking memory and mood

(2017) Christoph Anacker et al.   NATURE REVIEWS NEUROSCIENCE

n-3 Polyunsaturated fatty acid supplementation restored impaired memory and GABAergic synaptic efficacy in the hippocampus of stressed rats

(2017) Miguel Ángel Pérez et al.   NUTRITIONAL NEUROSCIENCE

Effects of l-theanine on anxiety-like behavior, cerebrospinal fluid amino acid profile, and hippocampal activity in Wistar Kyoto rats

(2017) Shintaro Ogawa et al.   PSYCHOPHARMACOLOGY

Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study

(2016) Shinsuke Hidese et al.   ACTA NEUROPSYCHIATRICA

Tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase 1 make separate, tissue-specific contributions to basal and inflammation-induced kynurenine pathway metabolism in mice

(2016) Paul B. Larkin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Hippocampal adult neurogenesis: Its regulation and potential role in spatial learning and memory

(2016) Claudia Lieberwirth et al.   BRAIN RESEARCH

Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior

(2016) J. Tiago Gonçalves et al.   CELL

GABAergic Regulation of Adult Hippocampal Neurogenesis

(2016) Mirjam Sibbe et al.   MOLECULAR NEUROBIOLOGY

Macrophages are essential for maintaining a M2 protective response early after ischemic brain injury

(2016) Carlo Perego et al.   NEUROBIOLOGY OF DISEASE

Mouse model of imiquimod-induced psoriatic itch

(2016) Kent Sakai et al.   PAIN

Anti-stress effects of drinking green tea with lowered caffeine and enriched theanine, epigallocatechin and arginine on psychosocial stress induced adrenal hypertrophy in mice

(2016) Keiko Unno et al.   PHYTOMEDICINE

Lipocalin-2 as a therapeutic target for brain injury: An astrocentric perspective

(2016) Kyoungho Suk   PROGRESS IN NEUROBIOLOGY

Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study

(2016) Shinsuke Hidese et al.   ACTA NEUROPSYCHIATRICA

Principal component analysis for designed experiments

(2015) Tomokazu Konishi   BMC BIOINFORMATICS

Neuromodulation and metamodulation by adenosine: Impact and subtleties upon synaptic plasticity regulation

(2015) Ana M. Sebastião et al.   BRAIN RESEARCH

A Review on GABA/Glutamate Pathway for Therapeutic Intervention of ASD and ADHD

(2015) Priyanka Purkayastha et al.   CURRENT MEDICINAL CHEMISTRY

Tryptophan-kynurenine pathway is dysregulated in inflammation and immune activation

(2015) Ming-Hui Zou   Frontiers in Bioscience-Landmark

In Search of a Safe Natural Sleep Aid

(2015) Theertham P. Rao et al.   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

Unpredictable Chronic Stress Alters Adenosine Metabolism in Zebrafish Brain

(2015) F. F. Zimmermann et al.   MOLECULAR NEUROBIOLOGY

Possible Benefit of Dietary Carnosine towards Depressive Disorders

(2015) Alan R. Hipkiss   Aging and Disease

Npas4 Regulates Excitatory-Inhibitory Balance within Neural Circuits through Cell-Type-Specific Gene Programs

(2014) Ivo Spiegel et al.   CELL

Metabolic profiling of Alzheimer's disease brains

(2013) Koichi Inoue et al.   Scientific Reports

Ingestion of theanine, an amino acid in tea, suppresses psychosocial stress in mice

(2012) Keiko Unno et al.   EXPERIMENTAL PHYSIOLOGY

Neuronal Per Arnt Sim (PAS) Domain Protein 4 (NPAS4) Regulates Neurite Outgrowth and Phosphorylation of Synapsin I

(2012) Jaesuk Yun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Long lasting effects of early-life stress on glutamatergic/GABAergic circuitry in the rat hippocampus

(2012) Eva Martisova et al.   NEUROPHARMACOLOGY

Aging affects l-arginine and its metabolites in memory-associated brain structures at the tissue and synaptoneurosome levels

(2012) M. Rushaidhi et al.   NEUROSCIENCE

Npas4: A Neuronal Transcription Factor with a Key Role in Social and Cognitive Functions Relevant to Developmental Disorders

(2012) Laurence Coutellier et al.   PLoS One

Microarray test results should not be compensated for multiplicity of gene contents

(2011) Tomokazu Konishi   BMC Systems Biology

Theanine intake improves the shortened lifespan, cognitive dysfunction and behavioural depression that are induced by chronic psychosocial stress in mice

(2011) Keiko Unno et al.   FREE RADICAL RESEARCH

Antidepressant-like Effects of L-theanine in the Forced Swim and Tail Suspension Tests in Mice

(2011) Cui Yin et al.   PHYTOTHERAPY RESEARCH

Modulation and metamodulation of synapses by adenosine

(2010) J. A. Ribeiro et al.   Acta Physiologica

Chronic restraint stress impairs neurogenesis and hippocampus-dependent fear memory in mice: possible involvement of a brain-specific transcription factor Npas4

(2010) Jaesuk Yun et al.   JOURNAL OF NEUROCHEMISTRY

Histamine in the regulation of wakefulness

(2010) Mahesh M. Thakkar   SLEEP MEDICINE REVIEWS

Central l-arginine reduced stress responses are mediated by l-ornithine in neonatal chicks

(2008) R. Suenaga et al.   AMINO ACIDS

Carnosine-induced antidepressant-like activity in rats

(2008) Shozo Tomonaga et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Perinatal exposure to 5-metoxytryptamine, behavioural-stress reactivity and functional response of 5-HT1A receptors in the adolescent rat

(2007) C. Cannizzaro et al.   BEHAVIOURAL BRAIN RESEARCH