The Aryl Hydrocarbon Receptor in Asthma: Friend or Foe?

Activation of aryl hydrocarbon receptor (AhR) in mesenchymal stem cells modulates macrophage polarization in asthma

(2020) Zhuang Cui et al.   Journal of Immunotoxicology

Ozone-Induced Aryl Hydrocarbon Receptor Activation Controls Lung Inflammation via Interleukin-22 Modulation

(2020) Chloé Michaudel et al.   Frontiers in Immunology

Epithelial cell dysfunction, a major driver of asthma development

(2020) Irene H. Heijink et al.   ALLERGY

Microbiota-Derived Metabolites Suppress Arthritis by Amplifying Aryl-Hydrocarbon Receptor Activation in Regulatory B Cells

(2020) Elizabeth C. Rosser et al.   Cell Metabolism

Role of airway epithelial cells in the development of different asthma phenotypes

(2020) Daniel P. Potaczek et al.   CELLULAR SIGNALLING

Activation of aryl hydrocarbon receptor by benzo[a]pyrene increases interleukin 33 expression and eosinophil infiltration in a mouse model of allergic airway inflammation

(2020) Hitoshi Tajima et al.   JOURNAL OF APPLIED TOXICOLOGY

Efficacy and Patient-Reported Outcomes from a Phase IIb, Randomized Clinical Trial of Tapinarof Cream for the Treatment of Adolescents and Adults with Atopic Dermatitis

(2020) Amy S. Paller et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Benzo(a)pyrene Facilitates Dermatophagoides Group 1 (Der f 1)‐Induced Epithelial Cytokine Release through Aryl Hydrocarbon Receptor in Asthma

(2019) E. Wang et al.   ALLERGY

TET1 contributes to allergic airway inflammation and regulates interferon and aryl hydrocarbon receptor signaling pathways in bronchial epithelial cells

(2019) J. D. Burleson et al.   Scientific Reports

Dietary natural flavonoids treating cancer by targeting aryl hydrocarbon receptor

(2019) Tian Yang et al.   CRITICAL REVIEWS IN TOXICOLOGY

2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced aryl hydrocarbon receptor activation enhanced the suppressive function of mesenchymal stem cells against splenocyte proliferation

(2019) Guorui Zhang et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Particulate matter of 2.5 μm or less in diameter disturbs the balance of TH17/regulatory T cells by targeting glutamate oxaloacetate transaminase 1 and hypoxia-inducible factor 1α in an asthma model

(2019) Licheng Sun et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Aryl Hydrocarbon Receptor Contributes to the Transcriptional Program of IL-10-Producing Regulatory B Cells

(2019) Christopher J.M. Piper et al.   Cell Reports

Aryl Hydrocarbon Receptor activation by diesel exhaust particles mediates epithelium-derived cytokines expression in severe allergic asthma

(2018) Chih-Ming Weng et al.   ALLERGY

Aryl hydrocarbon receptor signaling promotes ORMDL3-dependent generation of sphingosine-1-phosphate by inhibiting sphingosine-1-phosphate lyase

(2018) Hsueh-Chun Wang et al.   Cellular & Molecular Immunology

Regulation of the Immune Response by the Aryl Hydrocarbon Receptor

(2018) Cristina Gutiérrez-Vázquez et al.   IMMUNITY

IL-17–producing ST2 + group 2 innate lymphoid cells play a pathogenic role in lung inflammation

(2018) Ting Cai et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A Jagged 1–Notch 4 molecular switch mediates airway inflammation induced by ultrafine particles

(2018) Mingcan Xia et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A Phase 2, Randomized Dose-Finding Study of Tapinarof (GSK2894512 Cream) for the Treatment of Atopic Dermatitis

(2018) Johnny Peppers et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Variation in doses and duration of particulate matter exposure in bronchial epithelial cells results in upregulation of different genes associated with airway disorders

(2018) Priya Tripathi et al.   TOXICOLOGY IN VITRO

Ambient particulate matter activates the aryl hydrocarbon receptor in dendritic cells and enhances Th17 polarization

(2018) Alejandro R. Castañeda et al.   TOXICOLOGY LETTERS

A prominent air pollutant, Indeno[1,2,3-cd]pyrene, enhances allergic lung inflammation via aryl hydrocarbon receptor

(2018) Tzu-Hsuan Wong et al.   Scientific Reports

Understanding Asthma Phenotypes, Endotypes, and Mechanisms of Disease

(2018) Merin E. Kuruvilla et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Aryl Hydrocarbon Receptor Signaling Cell Intrinsically Inhibits Intestinal Group 2 Innate Lymphoid Cell Function

(2018) Shiyang Li et al.   IMMUNITY

Aryl Hydrocarbon Receptor Controls Monocyte Differentiation into Dendritic Cells versus Macrophages

(2017) Christel Goudot et al.   IMMUNITY

Dysregulation of type 2 innate lymphoid cells and T H 2 cells impairs pollutant-induced allergic airway responses

(2017) Katrien C. De Grove et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Activin-A co-opts IRF4 and AhR signaling to induce human regulatory T cells that restrain asthmatic responses

(2017) Sofia Tousa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TCDD, FICZ, and Other High Affinity AhR Ligands Dose-Dependently Determine the Fate of CD4+ T Cell Differentiation

(2017) Allison K Ehrlich et al.   TOXICOLOGICAL SCIENCES

Cockroach allergen exposure and risk of asthma

(2016) D. C. Do et al.   ALLERGY

Innate lymphoid cells contribute to allergic airway disease exacerbation by obesity

(2016) Laetitia Everaere et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Group 2 innate lymphoid cells mediate ozone-induced airway inflammation and hyperresponsiveness in mice

(2016) Qi Yang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Ten-eleven translocation 1 (TET1) methylation is associated with childhood asthma and traffic-related air pollution

(2016) Hari K. Somineni et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Current concepts of severe asthma

(2016) Anuradha Ray et al.   JOURNAL OF CLINICAL INVESTIGATION

The aryl hydrocarbon receptor controls cell-fate decisions in B cells

(2016) Bharat Vaidyanathan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The aryl hydrocarbon receptor AhR links atopic dermatitis and air pollution via induction of the neurotrophic factor artemin

(2016) Takanori Hidaka et al.   NATURE IMMUNOLOGY

TCDD-Induced Activation of Aryl Hydrocarbon Receptor Inhibits Th17 Polarization and Regulates Non-Eosinophilic Airway Inflammation in Asthma

(2016) Xiao-ming Li et al.   PLoS One

Aryl hydrocarbon receptor–ligand axis mediates pulmonary fibroblast migration and differentiation through increased arachidonic acid metabolism

(2016) Hsiang-Han Su et al.   TOXICOLOGY

Childhood asthma is associated with mutations and gene expression differences ofORMDLgenes that can interact

(2015) A. A. Toncheva et al.   ALLERGY

Aryl hydrocarbon receptor mediates both proinflammatory and anti-inflammatory effects in lipopolysaccharide-activated microglia

(2015) Yi-Hsuan Lee et al.   GLIA

Endogenous ligands of the aryl hydrocarbon receptor regulate lung dendritic cell function

(2015) Thomas H. Thatcher et al.   IMMUNOLOGY

Vehicular exhaust particles promote allergic airway inflammation through an aryl hydrocarbon receptor–notch signaling cascade

(2015) Mingcan Xia et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Polymorphisms related to ORMDL3 are associated with asthma susceptibility, alterations in transcriptional regulation of ORMDL3, and changes in TH2 cytokine levels

(2015) Michaela Schedel et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

T cell metabolism drives immunity

(2015) Michael D. Buck et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Aryl Hydrocarbon Receptor Protects Lungs from Cockroach Allergen–Induced Inflammation by Modulating Mesenchymal Stem Cells

(2015) Ting Xu et al.   JOURNAL OF IMMUNOLOGY

Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation

(2015) Nicola Gagliani et al.   NATURE

Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α

(2015) Ivan D Mascanfroni et al.   NATURE MEDICINE

Polycyclic Aromatic Hydrocarbons Reciprocally Regulate IL-22 and IL-17 Cytokines in Peripheral Blood Mononuclear Cells from Both Healthy and Asthmatic Subjects

(2015) Coline Plé et al.   PLoS One

The Aryl Hydrocarbon Receptor: Multitasking in the Immune System

(2014) Brigitta Stockinger et al.   Annual Review of Immunology

AhR and Arnt differentially regulate NF-κB signaling and chemokine responses in human bronchial epithelial cells

(2014) Johan Øvrevik et al.   Cell Communication and Signaling

Functional Effects of TGF- 1 on Mesenchymal Stem Cell Mobilization in Cockroach Allergen-Induced Asthma

(2014) P. Gao et al.   JOURNAL OF IMMUNOLOGY

An aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress the Th17 response in allergic rhinitis patients

(2014) Ping Wei et al.   LABORATORY INVESTIGATION

Aryl Hydrocarbon Receptor (AhR) Modulates Cockroach Allergen-Induced Immune Responses through Active TGFβ1 Release

(2014) Yufeng Zhou et al.   MEDIATORS OF INFLAMMATION

AhR sensing of bacterial pigments regulates antibacterial defence

(2014) Pedro Moura-Alves et al.   NATURE

A common environmental pollutant, 4-nonylphenol, promotes allergic lung inflammation in a murine model of asthma

(2013) J. L. Suen et al.   ALLERGY

Mesenchymal Stromal Cells: Sensors and Switchers of Inflammation

(2013) Maria Ester Bernardo et al.   Cell Stem Cell

Environmental and genetic contribution in airway epithelial barrier in asthma pathogenesis

(2013) Anne Tsicopoulos et al.   Current Opinion in Allergy and Clinical Immunology

Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22

(2013) Teresa Zelante et al.   IMMUNITY

Differential Roles of CXCL2 and CXCL3 and Their Receptors in Regulating Normal and Asthmatic Airway Smooth Muscle Cell Migration

(2013) L. A. Al-Alwan et al.   JOURNAL OF IMMUNOLOGY

Contribution of Lung Macrophages to the Inflammatory Responses Induced by Exposure to Air Pollutants

(2013) Kunihiko Hiraiwa et al.   MEDIATORS OF INFLAMMATION

Interleukin-17–producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity

(2013) Hye Young Kim et al.   NATURE MEDICINE

Khellin and Visnagin Differentially Modulate AHR Signaling and Downstream CYP1A Activity in Human Liver Cells

(2013) Radim Vrzal et al.   PLoS One

Exposure to Atmospheric Particulate Matter Enhances Th17 Polarization through the Aryl Hydrocarbon Receptor

(2013) Michael van Voorhis et al.   PLoS One

The Aryl Hydrocarbon Receptor Antagonist StemRegenin 1 Promotes Human Plasmacytoid and Myeloid Dendritic Cell Development from CD34+ Hematopoietic Progenitor Cells

(2013) Soley Thordardottir et al.   STEM CELLS AND DEVELOPMENT

Uremic toxin indoxyl 3-sulfate regulates the differentiation of Th2 but not of Th1 cells to lessen allergic asthma

(2013) You-Jung Hwang et al.   TOXICOLOGY LETTERS

The AhR twist: ligand-dependent AhR signaling and pharmaco-toxicological implications

(2012) Erwan Guyot et al.   DRUG DISCOVERY TODAY

FICZ, a Tryptophan photoproduct, suppresses pulmonary eosinophilia and Th2-type cytokine production in a mouse model of ovalbumin-induced allergic asthma

(2012) Kyu-Tae Jeong et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The Aryl Hydrocarbon Receptor Modulates Acute and Late Mast Cell Responses

(2012) R. Sibilano et al.   JOURNAL OF IMMUNOLOGY

Induction and molecular signature of pathogenic TH17 cells

(2012) Youjin Lee et al.   NATURE IMMUNOLOGY

DNA methylation: a promising landscape for immune system-related diseases

(2012) Beatriz Suarez-Alvarez et al.   TRENDS IN GENETICS

Suppression of allergic airway inflammation in a mouse model of asthma by exogenous mesenchymal stem cells

(2011) Hai-Feng Ou-Yang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

The Aryl Hydrocarbon Receptor Regulates Gut Immunity through Modulation of Innate Lymphoid Cells

(2011) Ju Qiu et al.   IMMUNITY

AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch

(2011) Jacob S Lee et al.   NATURE IMMUNOLOGY

Activation of Aryl Hydrocarbon Receptor (AhR) Leads to Reciprocal Epigenetic Regulation of FoxP3 and IL-17 Expression and Amelioration of Experimental Colitis

(2011) Narendra P. Singh et al.   PLoS One

Natural Aryl Hydrocarbon Receptor Ligands Control Organogenesis of Intestinal Lymphoid Follicles

(2011) E. A. Kiss et al.   SCIENCE

Ambient air pollution impairs regulatory T-cell function in asthma

(2010) Kari Nadeau et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells

(2010) J. D. Mezrich et al.   JOURNAL OF IMMUNOLOGY

The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27

(2010) Lionel Apetoh et al.   NATURE IMMUNOLOGY

Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell–like and Foxp3+ regulatory T cells

(2010) Roopali Gandhi et al.   NATURE IMMUNOLOGY

CH223191 Is a Ligand-Selective Antagonist of the Ah (Dioxin) Receptor

(2010) Bin Zhao et al.   TOXICOLOGICAL SCIENCES

Arylhydrocarbon Receptor Activation in NCI-H441 Cells and C57BL/6 Mice

(2009) Patrick S. Wong et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells

(2009) Sara Trifari et al.   NATURE IMMUNOLOGY

Activation of the aryl hydrocarbon receptor is essential for mediating the anti-inflammatory effects of a novel low-molecular-weight compound

(2008) B. P. Lawrence et al.   BLOOD

12(R)-Hydroxy-5(Z),8(Z),10(E),14(Z)-eicosatetraenoic Acid [12(R)-HETE], an Arachidonic Acid Derivative, Is an Activator of the Aryl Hydrocarbon Receptor

(2008) Christopher. R. Chiaro et al.   MOLECULAR PHARMACOLOGY

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

(2008) Marc Veldhoen et al.   NATURE

Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

(2008) Francisco J. Quintana et al.   NATURE

Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells

(2008) A. Kimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-8 induction by the environmental contaminant benzo(a)pyrene is aryl hydrocarbon receptor-dependent and leads to lung inflammation

(2008) Normand Podechard et al.   TOXICOLOGY LETTERS