Design and synthesis of novel pyrazole-phenyl semicarbazone derivatives as potential α-glucosidase inhibitor: Kinetics and molecular dynamics simulation study

Synthesis, in vitro and in silico screening of 2-amino-4-aryl-6-(phenylthio) pyridine-3,5-dicarbonitriles as novel α-glucosidase inhibitors

(2020) Muhammad Ali et al.   BIOORGANIC CHEMISTRY

Molecular characteristics of gallocatechin gallate affecting protein glycation

(2020) Xiaqing Wu et al.   FOOD HYDROCOLLOIDS

Design and synthesis of new imidazo[1,2-b]pyrazole derivatives, in vitro α-glucosidase inhibition, kinetic and docking studies

(2019) Fariba Peytam et al.   MOLECULAR DIVERSITY

Identification of essential 2D and 3D chemical features for discovery of the novel tubulin polymerization inhibitors

(2019) Fateme Azimi et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Novel C-2 Symmetric Molecules as α-Glucosidase and α-Amylase Inhibitors: Design, Synthesis, Kinetic Evaluation, Molecular Docking and Pharmacokinetics

(2019) Danish Shahzad et al.   MOLECULES

Biscoumarin-1,2,3-triazole hybrids as novel anti-diabetic agents: Design, synthesis, in vitro α-glucosidase inhibition, kinetic, and docking studies

(2019) Mohammad Sadegh Asgari et al.   BIOORGANIC CHEMISTRY

Design, synthesis, in vitro, and in silico studies of novel diarylimidazole-1,2,3-triazole hybrids as potent α-glucosidase inhibitors

(2019) Mina Saeedi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis, molecular modelling, ADME prediction and anti-hyperglycemic evaluation of new pyrazole-triazolopyrimidine hybrids as potent α-glucosidase inhibitors

(2019) Vinay Pogaku et al.   BIOORGANIC CHEMISTRY

Synthesis of benzotriazoles derivatives and their dual potential as α-amylase and α-glucosidase inhibitors in vitro: Structure-activity relationship, molecular docking, and kinetic studies

(2019) Shehryar Hameed et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Overview of recent developments of pyrazole derivatives as an anticancer agent in different cell line

(2019) Fatima Ezzahra Bennani et al.   BIOORGANIC CHEMISTRY

Update on Diabetic Nephropathy: Core Curriculum 2018

(2018) Kausik Umanath et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Synthesis of aryl pyrazole via Suzuki coupling reaction, in vitro mushroom tyrosinase enzyme inhibition assay and in silico comparative molecular docking analysis with Kojic acid

(2018) Pervaiz Ali Channar et al.   BIOORGANIC CHEMISTRY

Pathogenesis of Cardiovascular Disease in Diabetes

(2018) Andrea V. Haas et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Current anti-diabetic agents and their molecular targets: A review

(2018) Nagaraju Kerru et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Exploration of carboxy pyrazole derivatives: Synthesis, alkaline phosphatase, nucleotide pyrophosphatase/phosphodiesterase and nucleoside triphosphate diphosphohydrolase inhibition studies with potential anticancer profile

(2018) Pervaiz Ali Channar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New 6-amino-pyrido[2,3- d ]pyrimidine-2,4-diones as novel agents to treat type 2 diabetes: A simple and efficient synthesis, α -glucosidase inhibition, molecular modeling and kinetic study

(2018) Mehdi Adib et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New Insights into the Inhibition Mechanism of Betulinic Acid on α-Glucosidase

(2018) Huafang Ding et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Comparative α-glucosidase and α-amylase inhibition studies of rhodanine–pyrazole conjugates and their simple rhodanine analogues

(2018) Parvesh Singh et al.   MEDICINAL CHEMISTRY RESEARCH

A novel class of α-glucosidase and HMG-CoA reductase inhibitors from Ganoderma leucocontextum and the anti-diabetic properties of ganomycin I in KK-A y mice

(2017) Kai Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Diabetes and Stroke: Epidemiology, Pathophysiology, Pharmaceuticals and Outcomes

(2016) Rong Chen et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Prospective study on microangiopathy in type 2 diabetic foot ulcer

(2016) Fabio Fiordaliso et al.   DIABETOLOGIA

Syntheses of new 3-thiazolyl coumarin derivatives, in vitro α -glucosidase inhibitory activity, and molecular modeling studies

(2016) Uzma Salar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cinnamic acid amides from Tribulus terrestris displaying uncompetitive α-glucosidase inhibition

(2016) Yeong Hun Song et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The therapeutic voyage of pyrazole and its analogs: A review

(2016) Mohemmed Faraz Khan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Inhibitory kinetics and mechanism of kaempferol on α-glucosidase

(2016) Xi Peng et al.   FOOD CHEMISTRY

UniProt: the universal protein knowledgebase

(2016)   NUCLEIC ACIDS RESEARCH

The changing face of diabetes complications

(2016) Edward W Gregg et al.   Lancet Diabetes & Endocrinology

Long-Term Alcohol Consumption and Breast, Upper Aero-Digestive Tract and Colorectal Cancer Risk: A Systematic Review and Meta-Analysis

(2015) Harindra Jayasekara et al.   ALCOHOL AND ALCOHOLISM

Microangiopathy of common carotid vasa vasorum in type 1 diabetes mellitus

(2015) Esther Rubinat et al.   ATHEROSCLEROSIS

Oxidative stress, mitochondrial damage and diabetic retinopathy

(2015) Renu A. Kowluru et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Novel 5-functionalized-pyrazoles: Synthesis, characterization and pharmacological screening

(2015) Shridevi D. Doddaramappa et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Diabetes, Lower-Extremity Amputation, and Death

(2015) Ole Hoffstad et al.   DIABETES CARE

Antioxidant activity and inhibition of α-glucosidase by hydroxyl-functionalized 2-arylbenzo[b]furans

(2015) Jung-Feng Hsieh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of novel flavone hydrazones: In-vitro evaluation of α-glucosidase inhibition, QSAR analysis and docking studies

(2015) Syahrul Imran et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of novel inhibitors of α-glucosidase based on the benzothiazole skeleton containing benzohydrazide moiety and their molecular docking studies

(2015) Muhammad Taha et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of phenyl thiazole hydrazones and their activity against glycation of proteins

(2015) Khalid Mohammed Khan et al.   MEDICINAL CHEMISTRY RESEARCH

1,3-Oxazine as a chiral building block used in the total synthesis of (+)-1-deoxynojirimycin and (2R,5R)-dihydroxymethyl-(3R,4R)-dihydroxypyrrolidine

(2015) Seok-Hwi Park et al.   TETRAHEDRON-ASYMMETRY

Pleiotropic effects of type 2 diabetes management strategies on renal risk factors

(2015) Marcel H A Muskiet et al.   Lancet Diabetes & Endocrinology

(1,3-Diphenyl-1H-Pyrazol-4-yl)-Methylamine Analogues as Inhibitors of Dipeptidyl Peptidases

(2015) Tsu Hsu et al.   JOURNAL OF THE CHINESE CHEMICAL SOCIETY

Metformin Treatment in the Period After Stroke Prevents Nitrative Stress and Restores Angiogenic Signaling in the Brain in Diabetes

(2014) Mohammed Abdelsaid et al.   DIABETES

Synthesis of indole-2-hydrazones in search of potential leishmanicidal agents

(2014) Muhammad Taha et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis of Novel Bisindolylmethane Schiff bases and Their Antibacterial Activity

(2014) Syahrul Imran et al.   MOLECULES

Synthesis, hypoglycemic activity and molecular modeling studies of pyrazole-3-carbohydrazides designed by a CoMFA model

(2013) Eduardo Hernández-Vázquez et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Spirolactam-Based Acetyl-CoA Carboxylase Inhibitors: Toward Improved Metabolic Stability of a Chromanone Lead Structure

(2013) David A. Griffith et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Highly Potent, Selective, and Brain-Penetrant Aminopyrazole Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors

(2013) Anthony A. Estrada et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Spiropiperidine Lactam Acetyl-CoA Carboxylase Inhibitors

(2012) Kim Huard et al.   JOURNAL OF ORGANIC CHEMISTRY

2,4,6-Trichlorophenylhydrazine Schiff Bases as DPPH Radical and Super Oxide Anion Scavengers

(2012) Khalid Mohammed Khan et al.   Medicinal Chemistry

A new class of non-thiazolidinedione, non-carboxylic-acid-based highly selective peroxisome proliferator-activated receptor (PPAR) γ agonists: Design and synthesis of benzylpyrazole acylsulfonamides

(2011) Kentaro Rikimaru et al.   BIOORGANIC & MEDICINAL CHEMISTRY

16. The fraction of cancer attributable to lifestyle and environmental factors in the UK in 2010

(2011) D M Parkin et al.   BRITISH JOURNAL OF CANCER

Toward potent α-glucosidase inhibitors based on xanthones: A closer look into the structure–activity correlations

(2011) Gai-Li Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of novel, potent, selective, and orally active human glucagon receptor antagonists containing a pyrazole core

(2010) Dong-Ming Shen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Crystal structures of isomaltase from Saccharomyces cerevisiae and in complex with its competitive inhibitor maltose

(2010) Keizo Yamamoto et al.   FEBS Journal

Synthesis and biological evaluation of new 3-trifluoromethylpyrazolesulfonyl-urea and thiourea derivatives as antidiabetic and antimicrobial agents

(2010) Hassan M. Faidallah et al.   JOURNAL OF FLUORINE CHEMISTRY

Management of type 2 diabetes: evolving strategies for the treatment of patients with type 2 diabetes

(2010) Ebenezer A. Nyenwe et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Synthesis and pharmacological screening of some novel chalconyl derivatives of substituted phenyl semicarbazide

(2009) Hemendra Pratap Singh et al.   MEDICINAL CHEMISTRY RESEARCH