4.7 Article

In vitro and in vivo evaluation of gellan gum hydrogel films: Assessing the co impact of therapeutic oils and ofloxacin on wound healing

Journal

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 166, Issue -, Pages 483-495

Publisher

ELSEVIER
DOI: 10.1016/j.ijbiomac.2020.10.206

Keywords

Hydrogel films; Lavender oil; Tea tree oil; Ofloxacin; Gellan gum; Wound healing

Ask authors/readers for more resources

The study reported the co-encapsulation of ofloxacin with tea tree or lavender oil in gellan gum based hydrogel films using the solvent casting ionotropic gelation method, showing superior antibacterial and wound healing activity. In vitro release studies demonstrated controlled release of the drug and oils from the films over 48 hours.
Herein, we report co-encapsulation of ofloxacin with tea tree or lavender oil in gellan gum based hydrogel films by solvent casting ionotropic gelation method as wound dressing. Prepared films were transparent, flexible, and displayed antioxidant activity with superior antibacterial response against common inhabitants of wound i.e. gram positive and negative bacteria. Solid-state characterization of optimized formulation (OL3 and OT3) revealed successful incorporation of drug and oils in hydrogel structure without any noticeable interaction. In vitro release studies showed an initial burst release but remaining portion released in controlled manner over 48 h from the films and furthermore, presence of oils did not affected the ofloxacin release. Optimized formulation containing ofloxacin and 25% w/w lavender/tea tree oil showed 98% wound contraction in rats after ten days of treatment. Histological images displayed completely healed epidermis. Taken together, our prepared hydrogel films demonstrated favorable features with appreciable antibacterial, wound healing activity and could be useful for the treatment of full thickness wounds. (C) 2020 Elsevier B.V. All rights reserved.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Business

Digitalization and sustainable development: How could digital economy development improve green innovation in China?

Shiyue Luo, Nafisa Yimamu, Yueran Li, Haitao Wu, Muhammad Irfan, Yu Hao

Summary: In the context of sustainable development, the development of the digital economy can improve green innovation levels indirectly by boosting economic openness, optimizing industrial structure, and expanding market potential. The development of the digital economy has spatial effects on green innovation. However, the enhancement of green innovation in more developed regions may inhibit green innovation in less developed regions.

BUSINESS STRATEGY AND THE ENVIRONMENT (2023)

Article Environmental Sciences

How to improve total factor energy efficiency under climate change: does export sophistication matter?

Jianmin Liu, Yan Xue, Zehong Mao, Muhammad Irfan, Haitao Wu

Summary: This paper examines the relationship between export sophistication and total factor energy efficiency (TFEE) and finds that an improvement in export sophistication leads to higher TFEE. The findings have important implications for supporting China's export sophistication promotion strategy and for energy efficiency improvement and energy crisis response in the post-pandemic era.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2023)

Article Green & Sustainable Science & Technology

Assessment of renewable energy, financial growth and in accomplishing targets of China's cities carbon neutrality

Yuanxiong Lin, Muhammad Khalid Anser, Michael Yao-Ping Peng, Muhammad Irfan

Summary: Carbon emissions are harmful to the environment and expensive. The role of financial institutions is increasingly important as pollution emissions rise. By utilizing a novel econometric model, this study assessed the impact of green financing, renewable energy, trade openness, industrial upgradation, and financial development on carbon neutrality using data from Chinese cities between 2000 and 2020. The conclusions indicate that investments in green finance, renewable energy, and financial development can decrease CO2 emissions, while variables such as economic growth, energy consumption, trade, and foreign direct investment can increase CO2 emissions. Sustainable growth is crucial in helping China achieve its carbon neutrality goals. The immediate effects of green financing through renewable energy are temporary, but the direct impact of funding green initiatives is more long-lasting and critical for carbon neutrality.

RENEWABLE ENERGY (2023)

Article Chemistry, Physical

Facile Synthesis of Poly(o-anisidine)/Graphitic Carbon Nitride/Zinc Oxide Composite for Photo-Catalytic Degradation of Congo Red Dye

Mohammed Jalalah, Zubair Nabi, Muhammad Naveed Anjum, Mirza Nadeem Ahmad, Atta Ul Haq, Muhammad Bilal Qadir, Mohd Faisal, Mabkhoot Alsaiari, Muhammad Irfan, Farid A. Harraz

Summary: The growing industry and its effluents, such as toxic dyes and volatile organic compounds, pose a serious environmental concern due to their non-biodegradable nature and high chemical stability. Recently, using photo-catalysts to degrade toxic dyes and drugs has become an important and successful approach. This study presents the synthesis of a poly(o-anisidine)-based composite with graphitic carbon nitride and zinc oxide (POA/g-C3N4/ZnO) and its utilization as a photo-catalyst.

CATALYSTS (2023)

Article Green & Sustainable Science & Technology

How does digital infrastructure construction affect low-carbon development? A multidimensional interpretation of evidence from China

Jin Hu, Hong Zhang, Muhammad Irfan

Summary: Digital infrastructure construction and low-carbon development are two important drivers for sustainable growth. This study comprehensively analyzes the relationship between the two, using China as an example to empirically examine the role of digital infrastructure construction in low-carbon development. The results show that digital infrastructure construction actively encourages low-carbon growth and has a positive spatial spillover impact. The study also highlights the non-linear trend of increasing marginal effect and the need for industrial upgrading in low-carbon development.

JOURNAL OF CLEANER PRODUCTION (2023)

Article Respiratory System

GRADE-ADOLOPMENT of clinical practice guidelines and creation of clinical pathways for the primary care management of chronic respiratory conditions in Pakistan

Russell Seth Martins, Hawra Hussain, Maryam Chaudry, Nashia Ali Rizvi, Mohsin Ali Mustafa, Bushra Ayub, Salima Saleem Aamdani, Alina Abdul Rehman, Alina Pervez, Sarah Nadeem, Rameesha Khalid, Akbar Shoukat Ali, Shayan Shahid, Ali Bin Sarwar Zubairi, Adil H. H. Haider, Muhammad Irfan

Summary: This study developed evidence-based clinical practice guidelines and clinical pathways for the management of chronic respiratory conditions in Pakistan, aiming to improve the primary care management of these diseases.

BMC PULMONARY MEDICINE (2023)

Correction Environmental Sciences

Adoption of digital money (e-wallet) in the post COVID-19 era: The moderating role of low distribution charges and low transit time in impulsive buying: A developing country perspective (vol 10, 984316, 2023)

Qing Wei, Wendong Xiao, Rana Muhammad Shahid Yaqub, Muhammad Irfan, Muhammad Murad, Muhammad Zafar Yaqub

FRONTIERS IN ENVIRONMENTAL SCIENCE (2023)

Article Water Resources

Effects of climate anomaly on rainfall, groundwater depth, and soil moisture on peatlands in South Sumatra, Indonesia

Muhammad Irfan, Sri Safrina, Erry Koriyanti, Netty Kurniawati, Khairul Saleh, Iskhaq Iskandar

Summary: This study aims to investigate the impact of climate anomalies in 2019 and 2020, as well as factors such as rainfall, groundwater level, and soil moisture on peatland natural disasters in South Sumatra. The results show that in the 2019 dry season, there was minimal rainfall, the lowest groundwater table depth was -1.14 m, and the lowest soil moisture was 3.4%. In the 2020 dry season, rainfall exceeded the monthly average of 100 mm, with the lowest groundwater level at -0.44 m and the lowest soil moisture at 26.64%. There is a strong correlation between soil moisture and groundwater table depth, especially when there is less rainfall.

JOURNAL OF GROUNDWATER SCIENCE AND ENGINEERING (2023)

Article Biodiversity Conservation

Has the ecological civilization pilot promoted the transformation of industrial structure in China?

Jin Hu, Yuntao Wu, Muhammad Irfan, Mingjun Hu

Summary: This study evaluates the impact of the ecological civilization pilot policy (ECPP) on industrial structure transformation and explores the mechanism channels and spatial effects using the difference-in-differences method, three-stage mediating effect method, and spatial spillover analysis method. The research findings show that the ECPP has promoted the rationalization of industrial structure but has had a negative impact on industrial structure advancement. Positive central-local relationships enhance the trend toward industrial structure rationalization. Moreover, the effect of the ECPP varies depending on population density and environmental pollution.

ECOLOGICAL INDICATORS (2023)

Article Environmental Sciences

Testing of Magnetic ZnO/MgFe2O4 Heterostructures for Photocatalytic Removal of Synthetic Dye Pollutants from Wastewater

Muhammad Shoaib, Muhammad Adnan Munir, Muhammad Yasin Naz, Ghulam Abbas, Muhammad Irfan, Saifur Rahman, Abdulnour Ali Jazem Ghanim

Summary: The limited availability of clean water due to worldwide population growth and pollution necessitates the development of rapid water purification techniques. Photocatalytic degradation using the ZnO/MgFe2O4 heterostructure photocatalyst demonstrates high efficiency in eliminating water pollutants. The presence of magnetic ferrite in the heterostructure promotes radiation absorption, reduces electron-hole recombination, and improves charge transfer. The heterostructure photocatalyst also exhibits high stability and easy removal.

WATER AIR AND SOIL POLLUTION (2023)

Article Environmental Sciences

Can fiscal decentralization and farmers' use of internent be the route to the digitalization performance in China? A novel approach towards unlocking the role of online marketing behavior and performance of agricultural products

Changying Song, Shaofeng Zheng, Qingsong Zhang, Jiajing Wei, Yuehan Chen, Muhammad Irfan

Summary: The purpose of this study is to investigate the theoretical effects of the digital revolution on environmental behavior and performance, and to analyze the role of digitalization in fiscal decentralization. Using research data collected from 1338 pear farmers in China, a structural equation model was developed and analyzed using partial least squares and bootstrapping methods. The results show that the use of the Internet by farmers has a significant positive effect on improving their information literacy, which in turn promotes online sales of pears.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2023)

Article Social Sciences, Interdisciplinary

The Image of Pious Wife in the Malay Islamic Hikayat: Application of Preaching Method via Pengkaedahan Melayu Theory

Muhd Norizam Jamian, Muhammad Irfan, Waqiuddin Hasanudin, Aulia Sari Torodji

Summary: The Malay-Islamic hikayat texts have served as an important means of conveying Islamic teachings in the Malay world since the 15th century. These narrative works focused on promoting Islamic morality and family values, particularly emphasizing the role of the pious wife in creating a happy household. This paper analyzes the portrayal of the pious wife in two Malay-Islamic hikayat texts, namely Hikayat Darmata'siah and Hikayat Perempuan Bernama Latifah, based on the Pengkaedahan Melayu Theory by Hashim Awang. The study finds that these texts highlight the characteristics of a pious wife, including strong religious belief, obedience to her husband, treating him like a king, and lifelong loyalty. Overall, these hikayat texts still hold relevance as a guide for contemporary women.

AKADEMIKA (2023)

Article Chemistry, Analytical

Molecular simulation-guided aptasensor design of robust and sensitive lateral flow strip for cadmium ion detection

Muhammad Irfan, Ghulam Murtaza, Shangnan Fu, Ailiang Chen, Feng Qu, Xin Su

Summary: Molecular simulations were used to optimize the sensitivity of lateral flow fluorescence strip (LFFS) aptasensors by optimizing the length and sequence of the DNA probes. The simulations revealed that a 30 nt probe maximized hybridization yield and reduced background signals. Based on these findings, a sensitive aptamer-based fluorescent lateral flow strip was developed for rapid detection of Cd2+.

ANALYST (2023)

Article Environmental Sciences

Vertical decentralization, environmental regulation, and enterprise pollution: An evolutionary game analysis

Yuntao Wu, Jin Hu, Muhammad Irfan, Mingjun Hu

Summary: Achieving sustainable economic development and mitigating climate change require effective green transformation management, including incentivizing industrial enterprises to adopt green transformation practices through increased environmental taxes, and providing financial incentives from the central government to local governments.

JOURNAL OF ENVIRONMENTAL MANAGEMENT (2024)

Article Computer Science, Information Systems

Liver Ailment Prediction Using Random Forest Model

Fazal Muhammad, Bilal Khan, Rashid Naseem, Abdullah A. Asiri, Hassan A. Alshamrani, Khalaf A. Alshamrani, Samar M. Alqhtani, Muhammad Irfan, Khlood M. Mehdar, Hanan Talal Halawani

Summary: Liver disease is common worldwide, especially among young people. Researchers have used machine learning to analyze models for predicting liver disease in its early stages. The study found that the Random Forest classifier performs well in early diagnosis of liver disease.

CMC-COMPUTERS MATERIALS & CONTINUA (2023)

Article Biochemistry & Molecular Biology

Effects of aging and diabetes on the deformation mechanisms and molecular structural characteristics of collagen fibrils under daily activity

Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang

Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)

Article Biochemistry & Molecular Biology

Tea polyphenols protect against Flavobacterium columnare-induced gill injury via suppression of oxidative stress, inflammation, and apoptosis in grass carp

Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng

Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)

Article Biochemistry & Molecular Biology

Neddylation-dependent LSD1 destabilization inhibits the stemness and chemoresistance of gastric cancer

Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng

Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)

Review Biochemistry & Molecular Biology

Cellular and physiological roles of sigma factors in Vibrio spp.: A comprehensive review

Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim

Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)

Article Biochemistry & Molecular Biology

An eco-friendly composite hydrogel based on covalently crosslinked cellulose/poly (glycerol citrate) for thallium (І) removal from aqueous solutions

Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati

Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)

Article Biochemistry & Molecular Biology

Enzyme-triggered approach to reduce water bodies' contamination using peroxidase-immobilized ZnO/SnO2/alginate nanocomposite

Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal

Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)

Article Biochemistry & Molecular Biology

Bacterial cellulose microfiber reinforced hollow chitosan beads decorated with cross-linked melamine plates for the removal of the Congo red

Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri

Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)

Article Biochemistry & Molecular Biology

Necrotic activity of ExhC from Mammaliicoccus sciuri is mediated by specific amino acid residues

Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti

Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)

Article Biochemistry & Molecular Biology

Silk-hydrogel functionalized with human decellularized Wharton's jelly extracellular matrix as a minimally invasive injectable hydrogel system for potential nucleus pulposus tissue replacement therapy

Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal

Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)

Article Biochemistry & Molecular Biology

A uniform-unsaturated crosslinking strategy to construct injectable alginate hydrogel

Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma

Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)

Article Biochemistry & Molecular Biology

α-Tocopherol-loaded multi-layer nanoemulsion using chitosan, and dextran sulfate: Cellular uptake, antioxidant activity, and in vitro bioaccessibility

Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee

Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)

Article Biochemistry & Molecular Biology

Stabilization of oil-in-water high internal phase emulsions with octenyl succinic acid starch and beeswax oleogel

Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao

Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)

Review Biochemistry & Molecular Biology

A review for the correlation between optic atrophy 1-dependent mitochondrial fusion and cardiovascular disorders

Bi-Feng Yao, Xiu-Ju Luo, Jun Peng

Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)

Review Biochemistry & Molecular Biology

Nanomaterials for detection of biomolecules and delivering therapeutic agents in theragnosis: A review

Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park

Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)

Article Biochemistry & Molecular Biology

Preparation and characterization of hemicellulose films reinforced with amino polyhedral oligomeric silsesquioxane for biodegradable packaging

Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan

Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)