Recent advance of spleen tyrosine kinase in diseases and drugs

Inhibition of the deubiquitinase USP10 induces degradation of SYK

(2020) Jing Yang et al.   BRITISH JOURNAL OF CANCER

Effects of the multi‐kinase inhibitor midostaurin in combination with chemotherapy in models of acute myeloid leukaemia

(2020) Ellen Weisberg et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Spleen tyrosine kinase inhibition is an effective treatment for established vasculitis in a pre-clinical model

(2020) Stephen P. McAdoo et al.   KIDNEY INTERNATIONAL

Protein‐Tyrosine Kinase, Syk Accelerates Phagosome Maturation by Depolymerizing F‐Actin in Complement‐Mediated Phagocytosis

(2020) Hiroyuki Tabata et al.   FASEB JOURNAL

Role of spleen tyrosine kinase in liver diseases

(2020) Dhadhang Wahyu Kurniawan et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Inhibition of SYK kinase does not confer a pro-proliferative or pro-invasive phenotype in breast epithelium or breast cancer cells

(2020) David J. Lamb et al.   Oncotarget

Ranunculus bulumei Methanol Extract Exerts Anti-Inflammatory Activity by Targeting Src/Syk in NF-κB Signaling

(2020) Yo Han Hong et al.   Biomolecules

Anti-Inflammatory Functions of Alverine via Targeting Src in the NF-κB Pathway

(2020) Chae Young Lee et al.   Biomolecules

Structural optimization and anti-allergic activity of nucleotide aptamers target to Cε3-Cε4

(2019) Yanlei Yang et al.   BIOCHEMICAL PHARMACOLOGY

Hematopoietic or Osteoclast-Specific Deletion of Syk Leads to Increased Bone Mass in Experimental Mice

(2019) Dániel Csete et al.   Frontiers in Immunology

New treatments for chronic urticaria

(2019) Pavel Kolkhir et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

IL-17A Increases Multiple Myeloma Cell Viability by Positively Regulating Syk Expression

(2019) Shunye Wang et al.   Translational Oncology

Identifying regulatory pathways of spleen tyrosine kinase expression in human basophils

(2019) Xia Peng et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Alveolar Bone Protection by Targeting the SH3BP2‐SYK Axis in Osteoclasts

(2019) Mizuho Kittaka et al.   JOURNAL OF BONE AND MINERAL RESEARCH

New treatments for atopic dermatitis targeting beyond IL-4/IL-13 cytokines

(2019) Yael Renert-Yuval et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

The Syk Kinase Promotes Mammary Epithelial Integrity and Inhibits Breast Cancer Invasion by Stabilizing the E-Cadherin/Catenin Complex

(2019) Toufic Kassouf et al.   Cancers

Multidomain Control Over TEC Kinase Activation State Tunes the T Cell Response

(2018) Amy H. Andreotti et al.   Annual Review of Immunology

Discovery of Novel Syk/PDGFR-α/c-Kit Inhibitors as Multi-targeting Drugs to Treat Rheumatoid Arthritis

(2018) Xiaokang Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Syk inhibitor R406 downregulates inflammation in an in vitro model of Pseudomonas aeruginosa infection

(2018) Alaa Alhazmi et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Furaltadone suppresses IgE-mediated allergic response through the inhibition of Lyn/Syk pathway in mast cells

(2018) Seung Taek Nam et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Splenic tyrosine kinase (SYK) inhibitors and their possible use in acute myeloid leukemia

(2018) Sushma Bartaula-Brevik et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Autoantibodies to IgE and FcεRI and the natural variability of spleen tyrosine kinase expression in basophils

(2018) Donald MacGlashan   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Phosphorylated immunoreceptor tyrosine-based activation motifs and integrin cytoplasmic domains activate spleen tyrosine kinase via distinct mechanisms

(2018) Lina Antenucci et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DOK3 Modulates Bone Remodeling by Negatively Regulating Osteoclastogenesis and Positively Regulating Osteoblastogenesis

(2017) Xiaofeng Cai et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Timescale Separation of Positive and Negative Signaling Creates History-Dependent Responses to IgE Receptor Stimulation

(2017) Brooke Harmon et al.   Scientific Reports

Reconstruction and signal propagation analysis of the Syk signaling network in breast cancer cells

(2017) Aurélien Naldi et al.   PLoS Computational Biology

Resveratrol inhibits IgE binding and down-regulates intracellular phosphorylation of Syk following IgE aggregation on human basophils

(2017) Sayaka Arakawa et al.   ALLERGOLOGY INTERNATIONAL

The kinase inhibitors R406 and GS-9973 impair T cell functions and macrophage-mediated anti-tumor activity of rituximab in chronic lymphocytic leukemia patients

(2016) Ana Colado et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Signal transduction and chemotaxis in mast cells

(2016) Petr Draber et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inhibition of BCR signaling using the Syk inhibitor TAK-659 prevents stroma-mediated signaling in chronic lymphocytic leukemia cells

(2016) Noelia Purroy et al.   Oncotarget

CLEC-2 expression is maintained on activated platelets and on platelet microparticles

(2014) E. Gitz et al.   BLOOD

Expression of Variant Isoforms of the Tyrosine Kinase SYK Determines the Prognosis of Hepatocellular Carcinoma

(2014) Jian Hong et al.   CANCER RESEARCH

Differential Expression and Molecular Associations of Syk in Systemic Lupus Erythematosus T Cells

(2014) S. Krishnan et al.   JOURNAL OF IMMUNOLOGY

The Role of the Syk/Shp-1 Kinase-Phosphatase Equilibrium in B Cell Development and Signaling

(2014) A. Alsadeq et al.   JOURNAL OF IMMUNOLOGY

Increased Syk phosphorylation leads to overexpression of TRAF6 in peripheral B cells of patients with systemic lupus erythematosus

(2014) S Iwata et al.   LUPUS

Arctigenin suppresses receptor activator of nuclear factor κB ligand (RANKL)-mediated osteoclast differentiation in bone marrow-derived macrophages

(2012) A-Ram Kim et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The role of the TRAF-interacting protein in proliferation and differentiation

(2012) Christophe Chapard et al.   EXPERIMENTAL DERMATOLOGY

IgE-dependent signaling as a therapeutic target for allergies

(2012) Donald W. MacGlashan   TRENDS IN PHARMACOLOGICAL SCIENCES

Kinase inhibitors: a new class of antirheumatic drugs

(2012) Vasileios Kyttaris   Drug Design Development and Therapy

The protein-tyrosine kinase Syk interacts with the C-terminal region of tensin2

(2011) Kyung D. Moon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development

(2011) B. A. Finney et al.   BLOOD

ER stress is implicated in mitochondrial dysfunction-induced apoptosis of pancreatic beta cells

(2011) June Woo Lee et al.   MOLECULES AND CELLS

SYK regulates B-cell migration by phosphorylation of the F-actin interacting protein SWAP-70

(2010) G. Pearce et al.   BLOOD

Immunotherapy for allergies and asthma: present and future

(2010) Shyam S Mohapatra et al.   CURRENT OPINION IN PHARMACOLOGY

Mast cell signaling: The role of protein tyrosine kinase Syk, its activation and screening methods for new pathway participants

(2010) Reuben P. Siraganian et al.   FEBS LETTERS

Syk is a dual-specificity kinase that self-regulates the signal output from the B-cell antigen receptor

(2010) B. Heizmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autoinhibition and adapter function of Syk

(2009) Yogesh Kulathu et al.   IMMUNOLOGICAL REVIEWS

FcɛRI-induced activation by low antigen concentrations results in nuclear signals in the absence of degranulation

(2009) Ana Cristina G. Grodzki et al.   MOLECULAR IMMUNOLOGY

The protein-tyrosine kinase Syk interacts with TRAF-interacting protein TRIP in breast epithelial cells

(2009) Q Zhou et al.   ONCOGENE

An orally bioavailable spleen tyrosine kinase inhibitor delays disease progression and prolongs survival in murine lupus

(2008) Frances Rena Bahjat et al.   ARTHRITIS AND RHEUMATISM

The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development

(2008) Yogesh Kulathu et al.   EMBO JOURNAL

Tyr130 phosphorylation triggers Syk release from antigen receptor by long-distance conformational uncoupling

(2008) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA