DOK3 Modulates Bone Remodeling by Negatively Regulating Osteoclastogenesis and Positively Regulating Osteoblastogenesis

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

SHIP1 Regulates MSC Numbers and Their Osteolineage Commitment by Limiting Induction of the PI3K/Akt/β-Catenin/Id2 Axis

(2014) Sonia Iyer et al.   STEM CELLS AND DEVELOPMENT

DOK3 Negatively Regulates LPS Responses and Endotoxin Tolerance

(2012) Qisheng Peng et al.   PLoS One

B Cell Receptor-Mediated Antigen Gathering Requires Ubiquitin Ligase Cbl and Adaptors Grb2 and Dok-3 to Recruit Dynein to the Signaling Microcluster

(2011) Tim Schnyder et al.   IMMUNITY

Dok-1 and Dok-2 deficiency induces osteopenia via activation of osteoclasts

(2011) Aya Kawamata et al.   JOURNAL OF CELLULAR PHYSIOLOGY

OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice

(2011) Alexander David Barrow et al.   JOURNAL OF CLINICAL INVESTIGATION

Erk1 Positively Regulates Osteoclast Differentiation and Bone Resorptive Activity

(2011) Yongzheng He et al.   PLoS One

Guidelines for assessment of bone microstructure in rodents using micro-computed tomography

(2010) Mary L Bouxsein et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Mice lacking Dok-1, Dok-2 and Dok-3 succumb to aggressive histiocytic sarcoma

(2010) Ryuichi Mashima et al.   LABORATORY INVESTIGATION

Identification of DOK genes as lung tumor suppressors

(2010) Alice H Berger et al.   NATURE GENETICS

TREM2- and DAP12-Dependent Activation of PI3K Requires DAP10 and Is Inhibited by SHIP1

(2010) Q. Peng et al.   Science Signaling

The roles of Dok family adapters in immunoreceptor signaling

(2009) Ryuichi Mashima et al.   IMMUNOLOGICAL REVIEWS

Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and β-catenin

(2009) Karel Otero et al.   NATURE IMMUNOLOGY

DAP12 Couples c-Fms Activation to the Osteoclast Cytoskeleton by Recruitment of Syk

(2008) Wei Zou et al.   MOLECULAR CELL