Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis

Serine Catabolism Feeds NADH when Respiration Is Impaired

(2020) Lifeng Yang et al.   Cell Metabolism

T cells with dysfunctional mitochondria induce multimorbidity and premature senescence

(2020) Gabriela Desdín-Micó et al.   SCIENCE

Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function

(2019) Will Bailis et al.   NATURE

Requirement of Mitochondrial Transcription Factor A in Tissue-Resident Regulatory T Cell Maintenance and Function

(2019) Zheng Fu et al.   Cell Reports

Manipulation of Gut Microbiota Influences Immune Responses, Axon Preservation, and Motor Disability in a Model of Progressive Multiple Sclerosis

(2019) Leyre Mestre et al.   Frontiers in Immunology

Antibiotics-Driven Gut Microbiome Perturbation Alters Immunity to Vaccines in Humans

(2019) Thomas Hagan et al.   CELL

Linezolid: a review of its properties, function, and use in critical care

(2018) Seyed MohammadReza Hashemian et al.   Drug Design Development and Therapy

The Immunomodulatory Effects of Macrolides—A Systematic Review of the Underlying Mechanisms

(2018) Petra Zimmermann et al.   Frontiers in Immunology

The risk factors of linezolid-induced lactic acidosis

(2018) Yiyang Mao et al.   MEDICINE

Mitochondrial transcription factor A (TFAM) shapes metabolic and invasion gene signatures in melanoma

(2018) L. F. Araujo et al.   Scientific Reports

Pathways to balance mitochondrial translation and protein import

(2018) Chantal Priesnitz et al.   GENES & DEVELOPMENT

Azithromycin and Chloramphenicol Diminish Neutrophil Extracellular Traps (NETs) Release

(2017) Weronika Bystrzycka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Anemia inducida por linezolid

(2017) José María Prieto de Paula et al.   MEDICINA CLINICA

Pharmacologic concentrations of linezolid modify oxidative phosphorylation function and adipocyte secretome

(2017) Laura Llobet et al.   Redox Biology

Antibiotics impair murine hematopoiesis by depleting the intestinal microbiota

(2016) Kamilla S. Josefsdottir et al.   BLOOD

Mitochondrial Networking in T Cell Memory

(2016) Marc Liesa et al.   CELL

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

(2016) Michael D. Buck et al.   CELL

Mitochondrial Protein Synthesis Adapts to Influx of Nuclear-Encoded Protein

(2016) Ricarda Richter-Dennerlein et al.   CELL

Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation

(2016) Noga Ron-Harel et al.   Cell Metabolism

Resurrecting the intestinal microbiota to combat antibiotic-resistant pathogens

(2016) Eric G. Pamer   SCIENCE

Metabolic pathways in T cell activation and lineage differentiation

(2016) Luís Almeida et al.   SEMINARS IN IMMUNOLOGY

Mutations in the two ribosomal RNA genes in mitochondrial DNA among Finnish children with hearing impairment

(2015) Sanna Häkli et al.   BMC Medical Genetics

Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells

(2015) Lucas B. Sullivan et al.   CELL

Mitochondrial Respiration Controls Lysosomal Function during Inflammatory T Cell Responses

(2015) Francesc Baixauli et al.   Cell Metabolism

Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: Treating cancer like an infectious disease

(2015) Rebecca Lamb et al.   Oncotarget

Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research

(2015) Norman Moullan et al.   Cell Reports

Computational Inhibition Studies of the Human Proteasome by Argyrin-Based Analogues with Subunit Specificity

(2014) Eriketi Z. Loizidou et al.   Chemical Biology & Drug Design

Mechanisms of vancomycin resistance in Staphylococcus aureus

(2014) Susana Gardete et al.   JOURNAL OF CLINICAL INVESTIGATION

Evolution of Mitochondria Reconstructed from the Energy Metabolism of Living Bacteria

(2014) Mauro Degli Esposti et al.   PLoS One

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling

(2013) Laura A. Sena et al.   IMMUNITY

Mitonuclear protein imbalance as a conserved longevity mechanism

(2013) Riekelt H. Houtkooper et al.   NATURE

TGF-β Signalling Is Required for CD4+ T Cell Homeostasis But Dispensable for Regulatory T Cell Function

(2013) Anna Śledzińska et al.   PLOS BIOLOGY

The 12S rRNA A1555G mutation in the mitochondrial haplogroup D5a is responsible for maternally inherited hypertension and hearing loss in two Chinese pedigrees

(2012) Hong Chen et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Mitochondrial antibiograms in personalized medicine

(2012) D. Pacheu-Grau et al.   HUMAN MOLECULAR GENETICS

Identification of Elongation Factor G as the Conserved Cellular Target of Argyrin B

(2012) Beat Nyfeler et al.   PLoS One

The Structure and Function of the Eukaryotic Ribosome

(2012) D. N. Wilson et al.   Cold Spring Harbor Perspectives in Biology

Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid Leukemia

(2011) Marko Škrtić et al.   CANCER CELL

PI3Kγ deficiency delays the onset of experimental autoimmune encephalomyelitis and ameliorates its clinical outcome

(2011) Luciana Berod et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

A conditional knockout resource for the genome-wide study of mouse gene function

(2011) William C. Skarnes et al.   NATURE

How antibiotics kill bacteria: from targets to networks

(2010) Michael A. Kohanski et al.   NATURE REVIEWS MICROBIOLOGY

Influence of mtDNA genetic variation on antibiotic therapy

(2010) David Pacheu-Grau et al.   PHARMACOGENOMICS

The Bacterial Cell Envelope

(2010) T. J. Silhavy et al.   Cold Spring Harbor Perspectives in Biology

Role of Gut Commensal Microflora in the Development of Experimental Autoimmune Encephalomyelitis

(2009) J. Ochoa-Reparaz et al.   JOURNAL OF IMMUNOLOGY

EF-G2mt Is an Exclusive Recycling Factor in Mammalian Mitochondrial Protein Synthesis

(2009) Masafumi Tsuboi et al.   MOLECULAR CELL

Argyrin A Reveals a Critical Role for the Tumor Suppressor Protein p27kip1 in Mediating Antitumor Activities in Response to Proteasome Inhibition

(2008) Irina Nickeleit et al.   CANCER CELL

Complicated Skin and Skin‐Structure Infections and Catheter‐Related Bloodstream Infections: Noninferiority of Linezolid in a Phase 3 Study

(2008) Mark H. Wilcox et al.   CLINICAL INFECTIOUS DISEASES

Benefit-Risk Assessment of Linezolid for Serious Gram-Positive Bacterial Infections

(2008) Matthew E Falagas et al.   DRUG SAFETY

Effect of Antibiotics on Vulvovaginal Candidiasis: A MetroNet Study

(2008) J. Xu et al.   Journal of the American Board of Family Medicine

Mapping and quantifying mammalian transcriptomes by RNA-Seq

(2008) Ali Mortazavi et al.   NATURE METHODS