The complement C3‐C3aR pathway mediates microglia–astrocyte interaction following status epilepticus

Constitutive deletion of astrocytic connexins aggravates kainate-induced epilepsy

(2020) Tushar Deshpande et al.   GLIA

Microglial calcium signaling is attuned to neuronal activity in awake mice

(2020) Anthony D Umpierre et al.   eLife

Neuron–glia interactions in the pathophysiology of epilepsy

(2019) Dipan C. Patel et al.   NATURE REVIEWS NEUROSCIENCE

Epilepsy in adults

(2019) Roland D Thijs et al.   LANCET

Microglial proliferation and monocyte infiltration contribute to microgliosis following status epilepticus

(2019) Lijie Feng et al.   GLIA

Status epilepticus triggers long-lasting activation of complement C1q-C3 signaling in the hippocampus that correlates with seizure frequency in experimental epilepsy

(2018) Nicole D. Schartz et al.   NEUROBIOLOGY OF DISEASE

Cortical Circuit Activity Evokes Rapid Astrocyte Calcium Signals on a Similar Timescale to Neurons

(2018) Jillian L. Stobart et al.   NEURON

RNAseq analysis of hippocampal microglia after kainic acid-induced seizures

(2018) Dale B. Bosco et al.   Molecular Brain

Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer’s Disease

(2018) Alexandra Litvinchuk et al.   NEURON

Enhanced classical complement pathway activation and altered phagocytosis signaling molecules in human epilepsy

(2017) Season K. Wyatt et al.   EXPERIMENTAL NEUROLOGY

Reactive Astrocytes: Production, Function, and Therapeutic Potential

(2017) Shane A. Liddelow et al.   IMMUNITY

Mechanisms and Therapeutic Relevance of Neuro-immune Communication

(2017) Sangeeta S. Chavan et al.   IMMUNITY

Chemokine CCL2–CCR2 Signaling Induces Neuronal Cell Death via STAT3 Activation and IL-1β Production after Status Epilepticus

(2017) Dai-Shi Tian et al.   JOURNAL OF NEUROSCIENCE

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Complement: A primer for the coming therapeutic revolution

(2017) Scott R. Barnum   PHARMACOLOGY & THERAPEUTICS

Regulation of astrocyte glutamate transporter-1 (GLT1) and aquaporin-4 (AQP4) expression in a model of epilepsy

(2016) Jacqueline A. Hubbard et al.   EXPERIMENTAL NEUROLOGY

Microglia-Neuron Communication in Epilepsy

(2016) Ukpong B. Eyo et al.   GLIA

Intracellular Activation of Complement 3 Is Responsible for Intestinal Tissue Damage during Mesenteric Ischemia

(2016) Abhigyan Satyam et al.   JOURNAL OF IMMUNOLOGY

Astroglial Scarring and Seizures

(2016) Stefanie Robel   NEUROSCIENTIST

Infiltrating monocytes promote brain inflammation and exacerbate neuronal damage after status epilepticus

(2016) Nicholas H. Varvel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multifaceted interactions between adaptive immunity and the central nervous system

(2016) J. Kipnis   SCIENCE

Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke

(2016) Gergely Szalay et al.   Nature Communications

Infections, inflammation and epilepsy

(2015) Annamaria Vezzani et al.   ACTA NEUROPATHOLOGICA

Astrocyte uncoupling as a cause of human temporal lobe epilepsy

(2015) Peter Bedner et al.   BRAIN

Modulation of Microglial Process Convergence Toward Neuronal Dendrites by Extracellular Calcium

(2015) U. B. Eyo et al.   JOURNAL OF NEUROSCIENCE

Reactive Astrogliosis Causes the Development of Spontaneous Seizures

(2015) S. Robel et al.   JOURNAL OF NEUROSCIENCE

NFκB-Activated Astroglial Release of Complement C3 Compromises Neuronal Morphology and Function Associated with Alzheimer’s Disease

(2015) Hong Lian et al.   NEURON

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Neuronal Hyperactivity Recruits Microglial Processes via Neuronal NMDA Receptors and Microglial P2Y12 Receptors after Status Epilepticus

(2014) U. B. Eyo et al.   JOURNAL OF NEUROSCIENCE

Norepinephrine Controls Astroglial Responsiveness to Local Circuit Activity

(2014) Martin Paukert et al.   NEURON

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

MRI changes and complement activation correlate with epileptogenicity in a mouse model of temporal lobe epilepsy

(2013) Irina Kharatishvili et al.   Brain Structure & Function

Complement in animal development: Unexpected roles of a highly conserved pathway

(2013) Jonathan D. Leslie et al.   SEMINARS IN IMMUNOLOGY

The “quad-partite” synapse: Microglia-synapse interactions in the developing and mature CNS

(2012) Dorothy P. Schafer et al.   GLIA

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Neuron–astrocyte signaling and epilepsy

(2011) Gerald Seifert et al.   EXPERIMENTAL NEUROLOGY

Rapid astrocyte and microglial activation following pilocarpine-induced seizures in rats

(2010) Lee A. Shapiro et al.   EPILEPSIA

Role for Complement in the Development of Seizures following Acute Viral Infection

(2010) J. E. Libbey et al.   JOURNAL OF VIROLOGY

Astrogliosis in CNS Pathologies: Is There A Role for Microglia?

(2010) Dan Zhang et al.   MOLECULAR NEUROBIOLOGY

Enhanced synaptic connectivity and epilepsy in C1q knockout mice

(2010) Yunxiang Chu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Therapeutic potential of complement modulation

(2009) Eric Wagner et al.   NATURE REVIEWS DRUG DISCOVERY

Molecular dissection of reactive astrogliosis and glial scar formation

(2009) Michael V. Sofroniew   TRENDS IN NEUROSCIENCES