Journal
GENOMICS
Volume 113, Issue 1, Pages 944-956Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygeno.2020.10.028
Keywords
Common carp; Aphanomyces invadans; RNA sequencing; Head kidney; Disease resistance; Immune response
Funding
- Department of Biotechnology, Ministry of Science and Technology, Government of India [BT/IN/Indo-UK/BBSRC-qua/38/MSS/2015-16]
- UK BBSRC, UK ESRC [BB/N005058/1]
- BBSRC [BB/N005058/1] Funding Source: UKRI
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The study revealed that common carp exhibit resistance mechanisms against Aphanomyces invadans infection, involving efficient processing and presentation of antigens, enhanced phagocytosis, recognition of pathogen-associated molecular patterns, and increased leukocyte recruitment.
Infection with Aphanomyces invadans is a serious fish disease with major global impacts. Despite affecting over 160 fish species, some of the species like the common carp Cyprinus carpio are resistant to A. invadans infection. In the present study, we investigated the transcriptomes of head kidney of common carp experimentally infected with A. invadans. In time course analysis, 5288 genes were found to be differentially expressed (DEGs), of which 731 were involved in 21 immune pathways. The analysis of immune-related DEGs suggested that efficient processing and presentation of A. invadans antigens, enhanced phagocytosis, recognition of pathogen-associated molecular patterns, and increased recruitment of leukocytes to the sites of infection contribute to resistance of common carp against A. invadans. Herein, we provide a systematic understanding of the disease resistance mechanisms in common carp at molecular level as a valuable resource for developing disease management strategies for this devastating fish-pathogenic oomycete.
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