Evading antimicrobial resistance using boron-containing therapeutics

Design and discovery of boronic acid drugs

(2020) Jessica Plescia et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

First time in human (FTIH) study and prediction of early bactericidal activity for GSK3036656, a potent Leucyl - tRNA synthetase inhibitor for tuberculosis treatment

(2019) David Tenero et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Profiling Interactions of Vaborbactam with Metallo-β-Lactamases

(2019) Gareth W. Langley et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections

(2019) Bin Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

In Vitro and In Vivo Activities of DS86760016, a Novel Leucyl-tRNA Synthetase Inhibitor for Gram-Negative Pathogens

(2018) Kedar P. Purnapatre et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656)

(2017) Xianfeng Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting Antibiotic Resistance

(2016) Mathieu F. Chellat et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery of potent anti-tuberculosis agents targeting leucyl-tRNA synthetase

(2016) Olga I. Gudzera et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Challenges and Opportunities for the Application of Boron Clusters in Drug Design

(2016) Zbigniew J. Leśnikowski   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a Cyclic Boronic Acid β-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases

(2015) Scott J. Hecker et al.   JOURNAL OF MEDICINAL CHEMISTRY

Genetic Mutations Associated with Isoniazid Resistance in Mycobacterium tuberculosis: A Systematic Review

(2015) Marva Seifert et al.   PLoS One

Boron-containing compounds: chemico-biological properties and expanding medicinal potential in prevention, diagnosis and therapy

(2014) Marvin A Soriano-Ursúa et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Discovery of a Novel Class of Boron-Based Antibacterials with Activity against Gram-Negative Bacteria

(2013) Vincent Hernandez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Therapeutic potential of boron-containing compounds

(2009) Stephen J Baker et al.   Future Medicinal Chemistry

Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

(2008) Helen W. Boucher et al.   CLINICAL INFECTIOUS DISEASES