Review
Pharmacology & Pharmacy
Tayebeh Noori, Ahmad Reza Dehpour, Antoni Sureda, Eduardo Sobarzo-Sanchez, Samira Shirooie
Summary: Negative psychological and physiological consequences of neurodegenerative disorders, especially Alzheimer's disease, affect millions of people globally. Current treatments focus on symptom management, with natural products showing promise in preventing and alleviating symptoms of AD.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Clinical Neurology
Ya-Nan Lv, Yu Cui, Bo Zhang, Shu-Ming Huang
Summary: Sleep deficiency is associated with an increased risk for Alzheimer's disease, potentially through its effects on oxidative stress, protein deposition, neuroinflammation, and synaptic loss.
FRONTIERS IN NEUROLOGY
(2022)
Review
Neurosciences
Musa O. Iliyasu, Sunday A. Musa, Sunday B. Oladele, Abdullahi I. Iliya
Summary: Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by tau pathology and accumulation of amyloid-beta (Aβ). Aβ aggregation leads to oxidative stress, inflammatory cascade, and caspase activation, causing hyperphosphorylation of tau protein and formation of neurofibrillary tangles (NFTs). Acetylcholine degradation is accelerated, resulting in neurotransmitter deficiency and cognitive impairment. AD research is necessary to identify novel compounds for treatment and prevention, including those targeting Aβ, tau, neurotransmitter modulation, neuroinflammation, neuroprotection, and cognition enhancement.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Priyanka Rawat, Ujala Sehar, Jasbir Bisht, Ashley Selman, John Culberson, P. Hemachandra Reddy
Summary: This article summarizes the role of tau and phosphorylated tau (p-tau) in Alzheimer's disease (AD) and other tauopathies, highlighting current research on post-translational modifications and genetics of tau, tau pathology, the role of tau in tauopathies, and the development of new drugs targeting p-tau for therapeutics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Mahsa Pourhamzeh, Mohammad Taghi Joghataei, Soraya Mehrabi, Reza Ahadi, Seyed Mohammad Massood Hojjati, Nasrin Fazli, Seyed Massood Nabavi, Hossein Pakdaman, Koorosh Shahpasand
Summary: The research revealed the interplay between tauopathy and amyloidopathy processes in Alzheimer's disease. It was found that A beta(1-42) and pathogenic P-tau may induce each other and cause almost identical neurotoxicity in a time-dependent manner. Tauopathy appears to be more distributable than amyloidopathy in the neurodegenerative disorder.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Review
Cell Biology
Angelica Varesi, Adelaide Carrara, Vitor Gomes Pires, Valentina Floris, Elisa Pierella, Gabriele Savioli, Sakshi Prasad, Ciro Esposito, Giovanni Ricevuti, Salvatore Chirumbolo, Alessia Pascale
Summary: This narrative review discusses the potential of proteins, lipids, metabolites, oxidative-stress-related molecules, and cytokines as biomarkers for Alzheimer's Disease (AD). It also explores the emerging role of miRNAs, lncRNAs, vitamins, and gut-microbiome-related molecules as diagnostic tools, providing new insights into the diagnosis and progression of this devastating disease.
Review
Neurosciences
Mahmoud B. Maina, Youssra K. Al-Hilaly, Louise C. Serpell
Summary: Oxidative stress contributes to aging and Alzheimer's disease by causing damage to proteins. The covalent links between adjacent tyrosines, known as dityrosine (DiY) cross-linking, can serve as a biomarker of accumulated oxidative stress. Studies have shown the presence of DiY crosslinks in both A beta and tau deposits, but there is no consensus on their impact on A beta and tau function, aggregation, and toxicity. This review summarizes the current understanding of the role of DiY on A beta and tau, and discusses its potential as a biomarker for Alzheimer's disease.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Tharsius Raja William Raja, Veeramuthu Duraipandiyan, Savarimuthu Ignacimuthu, Udaiyappan Janakiraman, Soosaimanickam Maria Packiam
Summary: Alzheimer's Disease (AD) is a neurodegenerative disorder in the aged population, and polyphenols from various plant sources have been found to have antioxidant and anti-inflammatory properties, making them potential candidates for AD treatment. These polyphenols can protect neurons against oxidative stress and deposition of harmful proteins, thus inhibiting the progression of the disease. In this review, various polyphenols such as hesperidin, resveratrol, and curcumin are highlighted for their neuroprotective effects and potential as therapeutic agents for AD.
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Elena Tamagno, Michela Guglielmotto, Valeria Vasciaveo, Massimo Tabaton
Summary: The pathogenesis of Alzheimer's disease involves the accumulation of beta amyloid and vulnerability of the brain to oxidative stress, which are linked to each other. It is difficult to determine which comes first, Aβ or oxidative stress. Evidence suggests that oxidative stress occurs early in the development of Alzheimer's disease and plays a crucial role in the manifestation of clinical and pathological symptoms.
Review
Biochemistry & Molecular Biology
Pasquale Picone, Tiziana Sanfilippo, Sonya Vasto, Sara Baldassano, Rossella Guggino, Domenico Nuzzo, Donatella Bulone, Pier Luigi San Biagio, Emanuela Muscolino, Roberto Monastero, Clelia Dispenza, Daniela Giacomazza
Summary: Alzheimer's disease is the most common neurodegenerative disorder in the elderly, characterized by senile plaques and neurofibrillary tangles. There is currently a lack of treatment options aside from symptomatic medications. This review presents research results on the use of peptides of different sizes for the treatment of Alzheimer's disease.
Article
Chemistry, Multidisciplinary
Xin Chen, Santosh Pandit, Lei Shi, Vaishnavi Ravikumar, Julie Bonne Kohler, Ema Svetlicic, Zhejian Cao, Abhroop Garg, Dina Petranovic, Ivan Mijakovic
Summary: Alzheimer's disease is a common neurodegenerative disease characterized by the aggregation of misfolded amyloid-beta peptides in the brain. Graphene oxide nanoflakes have been found to effectively inhibit A beta aggregation in vitro. In this study using yeast as a model, it is shown that graphene oxide can penetrate yeast cells and reduce A beta 42 toxicity. The findings provide insights for designing graphene oxide-based therapies for attenuating cytotoxicity of A beta 42 and other misfolded proteins involved in neurodegenerative pathology.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Food Science & Technology
Wenli Ruan, Shuoheng Shen, Yang Xu, Na Ran, Heng Zhang
Summary: As the global population ages, more patients are diagnosed with neurodegenerative diseases, for which curative drugs or treatments are still lacking. Procyanidins, found in plants like grapes, blackberries, and hawthorn leaves, show potential protective roles in reducing oxidative stress, inhibiting neuroinflammation, and decreasing abnormal protein aggregation in Alzheimer's disease, highlighting a promising new therapeutic strategy for neurodegenerative diseases.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Review
Biochemistry & Molecular Biology
Zdenek Fisar
Summary: Damage or loss of brain cells and impaired neurochemistry, neurogenesis, and synaptic and nonsynaptic plasticity of the brain lead to dementia in neurodegenerative diseases, such as Alzheimer's disease (AD). Injury to synapses and neurons and accumulation of extracellular amyloid plaques and intracellular neurofibrillary tangles are considered the main morphological and neuropathological features of AD. Age, genetic and epigenetic factors, environmental stressors, and lifestyle contribute to the risk of AD onset and progression. These risk factors are associated with structural and functional changes in the brain, leading to cognitive decline. Biomarkers of AD reflect or cause specific changes in brain function, especially changes in pathways associated with neurotransmission, neuroinflammation, bioenergetics, apoptosis, and oxidative and nitrosative stress. Even in the initial stages, AD is associated with A beta neurotoxicity, mitochondrial dysfunction, and tau neurotoxicity. The integrative amyloid-tau-mitochondrial hypothesis assumes that the primary cause of AD is the neurotoxicity of A beta oligomers and tau oligomers, mitochondrial dysfunction, and their mutual synergy. For the development of new efficient AD drugs, targeting the elimination of neurotoxicity, mutual potentiation of effects, and unwanted protein interactions of risk factors and biomarkers (mainly A beta oligomers, tau oligomers, and mitochondrial dysfunction) in the early stage of the disease seems promising.
Article
Biochemistry & Molecular Biology
Jiang Chen, Anran Fan, Song Li, Yan Xiao, Yanlin Fu, Jun-Sheng Chen, Dan Zi, Ling-Hui Zeng, Jun Tan
Summary: Alzheimer's disease (AD), the most common type of dementia, is characterized by the presence of extracellular senile plaques composed of beta-amyloid peptides and intracellular neurofibrillary tangles containing phosphorylated-tau protein. This study has demonstrated the interaction between soluble tau and the N-terminal of amyloid precursor protein (APP) in vitro and in vivo, as well as the involvement of APP in the cellular uptake of tau through endocytosis. Targeting the pathological interaction between N-terminal APP and tau could be a promising therapeutic strategy for AD.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Geriatrics & Gerontology
Maryam Hamid, Sumaiya Mansoor, Sanila Amber, Saadia Zahid
Summary: This meta-analysis and systematic review found that AD patients have significantly lower plasma levels of vitamin C, suggesting that vitamin C deficiency is involved in disease progression and supplementation may be an effective strategy for preventing and treating AD.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)