Mechanisms to reduce the cytotoxicity of pharmacological nicotinamide concentrations in the pathogenic fungus Candida albicans

Drug combinations: a strategy to extend the life of antibiotics in the 21st century

(2019) Mike Tyers et al.   NATURE REVIEWS MICROBIOLOGY

The microbiome, cancer, and cancer therapy

(2019) Beth A. Helmink et al.   NATURE MEDICINE

Review on Antifungal Resistance Mechanisms in the Emerging Pathogen Candida auris

(2019) Farid Chaabane et al.   Frontiers in Microbiology

Multisite Substrate Recognition in Asf1-Dependent Acetylation of Histone H3 K56 by Rtt109

(2018) Lin Zhang et al.   CELL

Candidemia and invasive candidiasis in adults: A narrative review

(2016) Spinello Antinori et al.   European Journal of Internal Medicine

Candida albicans Pathogenesis: Fitting within the Host-Microbe Damage Response Framework

(2016) Mary Ann Jabra-Rizk et al.   INFECTION AND IMMUNITY

Positive regulation of the Candida albicans multidrug efflux pump Cdr1p function by phosphorylation of its N-terminal extension

(2016) Sarah Tsao et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Revised Estimates for the Number of Human and Bacteria Cells in the Body

(2016) Ron Sender et al.   PLOS BIOLOGY

Fungal KATs/KDACs: A New Highway to Better Antifungal Drugs?

(2016) Karl Kuchler et al.   PLoS Pathogens

In vitro activity of a Hos2 deacetylase inhibitor, MGCD290, in combination with echinocandins against echinocandin-resistant Candida species

(2015) M.A. Pfaller et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

A Candida albicans CRISPR system permits genetic engineering of essential genes and gene families

(2015) V. K. Vyas et al.   Science Advances

Pneumocystis jirovecii Rtt109, a Novel Drug Target for Pneumocystis Pneumonia in Immunosuppressed Humans

(2014) Jayme L. Dahlin et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

YCL047C/POF1Is a Novel Nicotinamide Mononucleotide Adenylyltransferase (NMNAT) inSaccharomyces cerevisiae

(2014) Michiko Kato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigenetic and neurological effects and safety of high-dose nicotinamide in patients with Friedreich's ataxia: an exploratory, open-label, dose-escalation study

(2014) Vincenzo Libri et al.   LANCET

Deciphering key features in protein structures with the new ENDscript server

(2014) Xavier Robert et al.   NUCLEIC ACIDS RESEARCH

A Histone Deacetylase Complex Mediates Biofilm Dispersal and Drug Resistance in Candida albicans

(2014) C. J. Nobile et al.   mBio

A small molecule inhibitor of fungal histone acetyltransferase Rtt109

(2013) Jessica Lopes da Rosa et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Cell-Free Fluorometric High-Throughput Screen for Inhibitors of Rtt109-Catalyzed Histone Acetylation

(2013) Jayme L. Dahlin et al.   PLoS One

Use of Nicotinamide to Treat Hyperphosphatemia in Dialysis Patients

(2013) Aurélie Lenglet et al.   Drugs in research & development

TARGETED, LCMS-BASED METABOLOMICS FOR QUANTITATIVE MEASUREMENT OF NAD + METABOLITES

(2013) Samuel AJ Trammell et al.   Computational and Structural Biotechnology Journal

NAD+biosynthesis and salvage - a phylogenetic perspective

(2012) Toni I. Gossmann et al.   FEBS Journal

The metabolic response ofCandida albicansto farnesol under hyphae-inducing conditions

(2012) Ting-Li Han et al.   FEMS YEAST RESEARCH

Isonicotinamide Enhances Sir2 Protein-mediated Silencing and Longevity in Yeast by Raising Intracellular NAD+Concentration

(2012) Julie M. McClure et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Niacin: chemical forms, bioavailability, and health effects

(2012) Douglas MacKay et al.   NUTRITION REVIEWS

Structural and Kinetic Isotope Effect Studies of Nicotinamidase (Pnc1) from Saccharomyces cerevisiae

(2011) Brian C. Smith et al.   BIOCHEMISTRY

Chromatin-mediated Candida albicans virulence

(2011) Jessica Lopes da Rosa et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Hst3 and Hst4 histone deacetylases regulate replicative lifespan by preventing genome instability in Saccharomyces cerevisiae

(2011) Mayumi Hachinohe et al.   GENES TO CELLS

Candida albicans, a major human fungal pathogen

(2011) Joon Kim et al.   JOURNAL OF MICROBIOLOGY

Targeting chromatin in fungal pathogens as a novel therapeutic strategy: histone modification gets infectious

(2011) Denes Hnisz et al.   Epigenomics

Epidemiology of Invasive Mycoses in North America

(2010) Michael A. Pfaller et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Genomics-driven Reconstruction ofAcinetobacterNAD Metabolism

(2010) Leonardo Sorci et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of histone H3 lysine 56 acetylation as an antifungal therapeutic strategy

(2010) Hugo Wurtele et al.   NATURE MEDICINE

In vitro activity of nicotinamide/antileishmanial drug combinations

(2010) Elodie Gazanion et al.   PARASITOLOGY INTERNATIONAL

Histone acetyltransferase Rtt109 is required for Candida albicans pathogenesis

(2010) J. Lopes da Rosa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transformation of Candida albicans with a synthetic hygromycin B resistance gene

(2010) Luiz R. Basso et al.   YEAST

Activity of MGCD290, a Hos2 Histone Deacetylase Inhibitor, in Combination with Azole Antifungals against Opportunistic Fungal Pathogens

(2009) M. A. Pfaller et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Nicotinic Acid, Nicotinamide, and Nicotinamide Riboside: A Molecular Evaluation of NAD+ Precursor Vitamins in Human Nutrition

(2008) Katrina L Bogan et al.   Annual Review of Nutrition

Identification of Formyl Kynurenine Formamidase and Kynurenine Aminotransferase fromSaccharomyces cerevisiaeUsing Crystallographic, Bioinformatic and Biochemical Evidence‡

(2008) Mark Wogulis et al.   BIOCHEMISTRY

Structural Insights into Intermediate Steps in the Sir2 Deacetylation Reaction

(2008) William F. Hawse et al.   STRUCTURE

A proteomic view of Candida albicans yeast cell metabolism in exponential and stationary growth phases

(2007) Harald Kusch et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY