Review
Oncology
Kevin Truskowski, Sarah R. Amend, Kenneth J. Pienta
Summary: Metastasis is the main cause of cancer mortality, and many cancer cells can enter a dormant state before reactivating and causing lethal relapse. Understanding the similarities and differences between cellular senescence and quiescence and their role in cancer dormancy is crucial for studying dormant cancer cells.
CANCER AND METASTASIS REVIEWS
(2023)
Review
Oncology
Hye-Young Min, Ho-Young Lee
Summary: Cancer is a major cause of disease-related mortality worldwide, with drug resistance being a primary reason for treatment failure. Novel mechanisms such as genetic/epigenetic modifications, microenvironmental factors, and tumor heterogeneity contribute to anticancer drug resistance. Researchers have recently discovered the ability of cancer to enter a dormant state due to drug resistance, tumor relapse, and progression. Understanding the biology of cancer dormancy is critical for developing effective anticancer therapies.
CANCER RESEARCH AND TREATMENT
(2023)
Review
Cell Biology
Bowen Li, Yichun Huang, Hui Ming, Edouard C. Nice, Rongrong Xuan, Canhua Huang
Summary: After cancer treatment, some cancer cells may survive through dormancy, leading to tumor recurrence and worsened outcomes. Dormancy is when most cancer cells in a tumor population are quiescent with little to no proliferation. Recent research suggests that redox mechanisms control the life cycle of dormant cancer cells, including entrance, long-term dormancy, and metastatic relapse.
Article
Biochemistry & Molecular Biology
Xiangdong Tian, Yuchao He, Lisha Qi, Dongming Liu, Dejun Zhou, Yun Liu, Wenchen Gong, Zhiqiang Han, Yuren Xia, Hua Li, Jiefu Wang, Kangwei Zhu, Lu Chen, Hua Guo, Qiang Zhao
Summary: Dormant cancer cells in colorectal cancer (CRC) have negative effects on prognosis, leading to cancer recurrence, metastasis, and drug resistance. A recent study revealed that autophagy plays a crucial role in the survival of dormant tumor cells. In this study, the researchers found that downregulation of polo-like kinases 4 (PLK4) induced dormancy and inhibited migration and invasion in CRC cell lines. They also discovered a correlation between PLK4 expression and dormancy markers in clinical samples. Mechanistically, downregulation of PLK4 induced autophagy through the MAPK signaling pathway, contributing to the restoration of aggressive tumor cells to a dormant state.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Oncology
Scott Sauer, Damon R. Reed, Michael Ihnat, Robert E. Hurst, David Warshawsky, Dalit Barkan
Summary: Cancer recurrence is a great fear for many survivors, as metastasis accounts for a majority of cancer deaths. New strategies are needed to prevent metastatic recurrence, including targeting dormant disseminated tumor cells.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Lang Xie, Renli Huang, Hongyun Huang, Xiaoxia Liu, Jinlong Yu
Summary: This study identified the characteristics of colorectal cancer (CRC) cell dormancy and predicted key factors associated with cell dormancy using transcriptome data and clinical data. The study found that dormant CRC is associated with high glutamine metabolism and synergizes with cancer-associated fibroblasts.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Dina Hermawaty, John A. Considine, Michael J. Considine
Summary: In this study, the application of flow cytometry (FCM) to measure the cell cycle status in mature dormant buds of grapevine was demonstrated. The protocol describes the optimization and validation of FCM data analysis and provides strategies to avoid pitfalls in data analysis.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Cell Biology
Nelson K. Y. Wong, Xin Dong, Yen-Yi Lin, Hui Xue, Rebecca Wu, Dong Lin, Colin Collins, Yuzhuo Wang
Summary: Androgen deprivation therapy is the standard treatment for advanced prostate cancer, but most patients eventually relapse. The study of the dormant phase of prostate cancer progression is hindered by limited clinical tissue and preclinical models. This study uses unique patient-derived xenograft models to investigate the immune evasion mechanisms of dormant prostate cancer cells, providing a framework for further research and immune-based therapies.
Review
Immunology
Akanksha Verma, Antara Ghoshal, Ved Prakash Dwivedi, Ashima Bhaskar
Summary: Mycobacterium tuberculosis is an intracellular pathogen that induces dormancy, counteracting host stress responses, and can resuscitate when conditions are favorable. Understanding key bacterial proteins can lead to novel therapies.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Oncology
Robert Wieder
Summary: Breast cancer cells can travel to the bone before being detectable in the breast, and these disseminated cells are resistant to treatment. They can remain dormant for over 20 years before recurring and causing incurable diseases. Various factors can wake up dormant cancer cells, including aging, inflammation, trauma, surgery, and psychological conditions. Efforts have been made to kill or maintain these disseminated cells, with some entering clinical trials.
Article
Engineering, Chemical
Raghu Vamsi Kondapaneni, Rachel Warren, Shreyas S. Rao
Summary: This study investigated the impact of chemotherapy drug paclitaxel on brain metastatic breast cancer spheroids and found that lower doses of the drug induced a dormant state and decreased proliferation, and withdrawal of the drug led to the resumption of growth, indicating the reversibility of the observed dormant state.
Review
Oncology
Yunus Akkoc, Nesibe Peker, Arzu Akcay, Devrim Gozuacik
Summary: Metastasis and relapse are the main causes of cancer-related deaths. Dormant cancer cells are able to evade conventional treatments, with autophagy playing a crucial role in the adaptation, survival, and reactivation of these cells.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Qihao Ren, Weng Hua Khoo, Alexander P. Corr, Tri Giang Phan, Peter Croucher, Sheila A. Stewart
Summary: Dormant breast cancer cells exhibit a distinct gene expression signature that may have predictive value in determining recurrence and treatment strategies.
BREAST CANCER RESEARCH
(2022)
Article
Oncology
Amanda M. Clark, Haley L. Heusey, Linda G. Griffith, Douglas. A. Lauffenburger, Alan Wells
Summary: Metastatic breast cancer with liver involvement is a largely incurable and fatal disease, with a subset of disseminated tumor cells potentially lying dormant for years before re-emerging. IP-10, a CXCR3 ligand, has been found to be elevated in metastatic TNBC breast cancer cells, triggering their emergence within the liver metastatic niche. This pathway could be a target for maintaining dormancy in breast cancer treatment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Frank C. Cackowski, Elisabeth I. Heath
Summary: Prostate cancer has the unique ability to lie dormant and recur long after treatment, with important reservoirs for dormant tumor cells in the bone marrow, lymph nodes, and the prostate bed. The induction of cellular dormancy in prostate cancer cells involves complex signaling pathways and interactions with the microenvironment, and current adjuvant therapies are only modestly successful in preventing recurrence, indicating the need for further advancements in systemic adjuvant therapy.
Article
Medicine, Research & Experimental
Anne C. Rios, Jacco van Rheenen, Colinda L. G. J. Scheele
Summary: Breast cancer is a highly heterogeneous condition, both in terms of morphology and molecular characteristics. To understand its evolution within the complex tumor micro-environment, it is essential to analyze breast cancer cells, co-evolving cells, and structures in space and time. This review discusses recent advances in three-dimensional and intravital imaging techniques for breast cancer research, highlighting the new insights obtained through these innovative imaging technologies. Finally, the integration of multidimensional imaging technologies with molecular profiling is discussed as a means to understand the full complexity of breast cancer and its tumor micro-environment.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE
(2023)
Article
Multidisciplinary Sciences
Julia M. Houthuijzen, Roebi de Bruijn, Eline van der Burg, Anne Paulien Drenth, Ellen Wientjens, Tamara Filipovic, Esme Bullock, Chiara S. Brambillasca, Emilia M. Pulver, Marja Nieuwland, Iris de Rink, Frank van Diepen, Sjoerd Klarenbeek, Ron Kerkhoven, Valerie G. Brunton, Colinda L. G. J. Scheele, Mirjam C. Boelens, Jos Jonkers
Summary: The origin of cancer-associated fibroblasts (CAFs) in cancer is still unclear. Single-cell transcriptomics, in vivo and in vitro studies suggest that CD26+ and CD26- normal fibroblasts transform into distinct CAF subpopulations in mouse models of breast cancer.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Maria Fankhaenel, Farahnaz S. Golestan Hashemi, Larissa Mourao, Emily Lucas, Manal M. Hosawi, Paul Skipp, Xavier Morin, Colinda L. G. J. Scheele, Salah Elias
Summary: Oriented cell divisions, crucial for structured epithelial formation and maintenance, rely on polarised anchoring of force generators to the cell cortex. This anchoring is regulated by the interaction between the G(alpha i) subunit, LGN, and the nuclear mitotic apparatus protein. Annexin A1 is identified as an interactor of LGN, able to instruct cortical accumulation of LGN and the nuclear mitotic apparatus protein for proper spindle alignment. Loss of Annexin A1 disrupts spindle orientation, resulting in epithelial architectural and luminogenic defects in mammary epithelial cells in three-dimensional cultures.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Stefan J. Hutten, Roebi de Bruijn, Catrin Lutz, Madelon Badoux, Timo Eijkman, Xue Chao, Marta Ciwinska, Michael Sheinman, Hendrik Messal, Andrea Herencia-Ropero, Petra Kristel, Lennart Mulder, Rens van der Waal, Joyce Sanders, Mathilde M. Almekinders, Alba Llop-Guevara, Helen R. Davies, Matthijs J. van Haren, Nathaniel I. Martin, Fariba Behbod, Serena Nik-Zainal, Violeta Serra, Jacco van Rheenen, Esther H. Lips, Lodewyk F. A. Wessels, Jelle Grand Challenge PRECISION Consortium, Jelle Wesseling, Colinda L. G. J. Scheele, Jos Jonkers
Summary: DCIS is a non-obligate precursor of invasive breast cancer, but it is treated similarly to early IBC due to a lack of biomarkers. In this study, MIND DCIS models were used to identify prognostic factors for high-risk DCIS and a multiclonal evolution model for DCIS. Additionally, a collection of distributable DCIS-MIND models spanning all molecular subtypes was provided.
Article
Multidisciplinary Sciences
Carla Riera-Domingo, Eduarda Leite-Gomes, Iris Charatsidou, Peihua Zhao, Giovanna Carra, Federica Cappellesso, Larissa Mourao, Maxim De Schepper, Dana Liu, Jens Serneels, Mohamad-Gabriel Alameh, Vladimir V. Shuvaev, Tatjana Geukens, Edoardo Isnaldi, Hans Prenen, Drew Weissman, Vladimir R. Muzykantov, Stefaan Soenen, Christine Desmedt, Colinda L. G. J. Scheele, Anna Sablina, Mario Di Matteo, Rosa Martin-Perez, Massimiliano Mazzone
Summary: In the premetastatic niche, endothelial cells express tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its cognate death receptor 5 (DR5). TRAIL interacts with DR5 intracellularly to prevent its signaling and maintain a quiescent vascular phenotype. Absence of endothelial TRAIL leads to DR5 activation, causing endothelial cell death and compromising vascular integrity, thereby promoting cancer cell metastasis.
Article
Multidisciplinary Sciences
James R. W. Conway, Sean C. Warren, Young-Kyung Lee, Andrew T. McCulloch, Astrid Magenau, Victoria Lee, Xanthe L. Metcalf, Janett Stoehr, Katharina Haigh, Lea Abdulkhalek, Cristian S. Guaman, Daniel A. Reed, Kendelle J. Murphy, Brooke A. Pereira, Pauline Melenec, Cecilia Chambers, Sharissa L. Latham, Helen Lenthall, Elissa K. Deenick, Yuanqing Ma, Tri Phan, Elgene Lim, Anthony M. Joshua, Stacey Walters, Shane T. Grey, Yan-Chuan Shi, Lei Zhang, Herbert Herzog, David R. Croucher, Andy Philp, Colinda L. G. J. Scheele, David Herrmann, Owen J. Sansom, Jennifer P. Morton, Antonella Papa, Jody J. Haigh, Max Nobis, Paul Timpson
Summary: Aberrant AKT activation is implicated in various diseases, and therefore targeting AKT has become a significant approach for disease treatment. In this study, we developed an Akt-FRET biosensor mouse that enables the monitoring of AKT activity in live tissues. We demonstrated the sensitivity of this biosensor mouse in different cancer models and showed its suitability for evaluating drug response. Additionally, we observed real-time dynamics of AKT activation in diverse tissues, indicating the broad preclinical applications of this biosensor mouse for studying AKT dynamics in vivo.
Article
Biochemical Research Methods
Stefan J. Hutten, Fariba Behbod, Colinda L. G. J. Scheele, Jos Jonkers
Summary: Mouse intraductal modeling is a valuable technique for studying early-stage breast cancer and creating patient-derived tumor xenograft models. This protocol provides detailed steps for processing and injecting primary ductal carcinoma in situ (DCIS) tissues, as well as procedures for imaging and transplantation of intraductal lesions.
Meeting Abstract
Oncology
Tatjana Geukens, Maxim De Schepper, Karen Van Baelen, Francois Richard, Marion Maetens, Amena Mahdami, Ha-Linh Nguyen, Edoardo Isnaldi, Anirudh Pabba, Sophia Leduc, Imane Bachir, Maysam Hajipirloo, Emily Vanden Berghe, Sigrid Hatse, Eleonora Leucci, Maria Francesca Baietti, Georgios Sflomos, Cathrin Brisken, Patrick Derksen, Colinda Scheele, Vincent Vandecaveye, Ann Smeets, Ines Nevelsteen, Kevin Punie, Patrick Neven, Elia Biganzoli, Hans Wildiers, Wouter Van Den Bogaert, Giuseppe Floris, Christine Desmedt
Meeting Abstract
Oncology
Catrin Lutz, Madelon Badoux, Timo Eijkman, Bim de Klein, Ji-Ying Song, Linda Henneman, Colinda Scheele, Jelle Wesseling, Jos Jonkers
CANCER PREVENTION RESEARCH
(2022)
Meeting Abstract
Oncology
Catrin Lutz, Madelon Badoux, Timo Eijkman, Bim de Klein, Ji-Ying Song, Linda Henneman, Colinda Scheele, Jelle Wesseling, Jos Jonkers
CANCER PREVENTION RESEARCH
(2022)
Meeting Abstract
Oncology
Hendrik Messal, Colinda Scheele, Esther Lips, Catrin Lutz, Stefan Hutten, Petra Kristel, Carmen Vlahu, Jos Jonkers, Jelle Wesseling, Jacco van Rheenen
CANCER PREVENTION RESEARCH
(2022)
Meeting Abstract
Oncology
Hendrik Messal, Colinda Scheele, Esther Lips, Catrin Lutz, Stefan Hutten, Petra Kristel, Carmen Vlahu, Jos Jonkers, Jelle Wesseling, Jacco van Rheenen
CANCER PREVENTION RESEARCH
(2022)
Meeting Abstract
Oncology
Stefan J. Hutten, Roebi de Bruijn, Catrin Lutz, Madelon Badoux, Timo Eijkman, Xue Chao, Marta Ciwinska, Andrea Herencia-Ropero, Petra Kristel, Lennart Mulder, Joyce Sanders, Mathilde Almekinders, Alba Llop-Gueverra, Helen R. Davies, Fariba Behbod, Serena Nik-Zainal, Violeta Serra, Jacco van Rheenen, Esther H. Lips, Lodewyk F. A. Wessels, Jelle Wesseling, Colinda Scheele, Jos Jonkers
CANCER PREVENTION RESEARCH
(2022)
Meeting Abstract
Oncology
Stefan J. Hutten, Roebi de Bruijn, Catrin Lutz, Madelon Badoux, Timo Eijkman, Xue Chao, Marta Ciwinska, Andrea Herencia-Ropero, Petra Kristel, Lennart Mulder, Joyce Sanders, Mathilde Almekinders, Alba Llop-Gueverra, Helen R. Davies, Fariba Behbod, Serena Nik-Zainal, Violeta Serra, Jacco van Rheenen, Esther H. Lips, Lodewyk F. A. Wessels, Jelle Wesseling, Colinda Scheele, Jos Jonkers
CANCER PREVENTION RESEARCH
(2022)
Meeting Abstract
Oncology
Catrin Lutz, Madelon Badoux, Timo Eijkman, Bim de Klein, Ji-Ying Song, Linda Henneman, Colinda Scheele, Jelle Wesseling, Jos Jonkers
CANCER PREVENTION RESEARCH
(2022)