CRISPR/Cas9‐mediated genome editing of Schistosoma mansoni acetylcholinesterase

Programmed knockout mutation of liver fluke granulin attenuates virulence of infection-induced hepatobiliary morbidity

(2019) Patpicha Arunsan et al.   eLife

Programmed genome editing of the omega-1 ribonuclease of the blood fluke, Schistosoma mansoni

(2019) Wannaporn Ittiprasert et al.   eLife

CRISPResso2 provides accurate and rapid genome editing sequence analysis

(2019) Kendell Clement et al.   NATURE BIOTECHNOLOGY

Eosinophils and macrophages within the Th2-induced granuloma: Balancing killing and healing in a tight space

(2019) Anupama Ariyaratne et al.   INFECTION AND IMMUNITY

Delivering CRISPR: a review of the challenges and approaches

(2018) Christopher A. Lino et al.   DRUG DELIVERY

Schistosome-Induced Fibrotic Disease: The Role of Hepatic Stellate Cells

(2018) Jack P. Carson et al.   TRENDS IN PARASITOLOGY

Suppression of Schistosoma japonicum Acetylcholinesterase Affects Parasite Growth and Development

(2018) Hong You et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Kunitz type protease inhibitor EgKI-1 from the canine tapeworm Echinococcus granulosus as a promising therapeutic against breast cancer

(2018) Shiwanthi L. Ranasinghe et al.   PLoS One

CRISPR/Cas9-mediated gene modification and gene knock out in the human-infective parasite Trichomonas vaginalis

(2018) Brian D. Janssen et al.   Scientific Reports

Efficient homology-directed gene editing by CRISPR/Cas9 in human stem and primary cells using tube electroporation

(2018) Xiaoyun Xu et al.   Scientific Reports

Schistosomiasis

(2018) Donald P. McManus et al.   Nature Reviews Disease Primers

Schistosome Egg Migration: Mechanisms, Pathogenesis and Host Immune Responses

(2018) Alice H. Costain et al.   Frontiers in Immunology

Different populations of CD11b+ dendritic cells drive Th2 responses in the small intestine and colon

(2017) Johannes U. Mayer et al.   Nature Communications

Single-sex infection with female Schistosoma mansoni cercariae mitigates hepatic fibrosis after secondary infection

(2017) Nicole Koslowski et al.   PLoS Neglected Tropical Diseases

Targeted mutagenesis in a human-parasitic nematode

(2017) Spencer S. Gang et al.   PLoS Pathogens

Characterising granuloma regression and liver recovery in a murine model of schistosomiasis japonica

(2016) Candy Chuah et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Breaking-Cas—interactive design of guide RNAs for CRISPR-Cas experiments for ENSEMBL genomes

(2016) Juan C. Oliveros et al.   NUCLEIC ACIDS RESEARCH

Functional characterisation of Schistosoma japonicum acetylcholinesterase

(2016) Hong You et al.   Parasites & Vectors

Modulation of the Immune Response by Nematode Secreted Acetylcholinesterase Revealed by Heterologous Expression in Trypanosoma musculi

(2016) Rachel Vaux et al.   PLoS Pathogens

Genetic modification of the diarrhoeal pathogen Cryptosporidium parvum

(2015) Sumiti Vinayak et al.   NATURE

Evaluation of the immune response and protective efficacy of Schistosoma mansoni Cathepsin B in mice using CpG dinucleotides as adjuvant

(2015) Alessandra Ricciardi et al.   VACCINE

CRISPR-Cas9-Mediated Genome Editing in Leishmania donovani

(2015) Wen-Wei Zhang et al.   mBio

Of Monkeys and Men: Immunomic Profiling of Sera from Humans and Non-Human Primates Resistant to Schistosomiasis Reveals Novel Potential Vaccine Candidates

(2015) Mark S. Pearson et al.   Frontiers in Immunology

DNA Repair Mechanisms and Their Biological Roles in the Malaria Parasite Plasmodium falciparum

(2014) A. H. Lee et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Halting harmful helminths

(2014) K. F. Hoffmann et al.   SCIENCE

The new frontier of genome engineering with CRISPR-Cas9

(2014) J. A. Doudna et al.   SCIENCE

Cellular and chemokine-mediated regulation in schistosome-induced hepatic pathology

(2014) Candy Chuah et al.   TRENDS IN PARASITOLOGY

Omega-1 knockdown in Schistosoma mansoni eggs by lentivirus transduction reduces granuloma size in vivo

(2014) Jana Hagen et al.   Nature Communications

Paeoniflorin attenuates amyloid-beta peptide-induced neurotoxicity by ameliorating oxidative stress and regulating the NGF-mediated signaling in rats

(2013) Zhou Lan et al.   BRAIN RESEARCH

One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering

(2013) Haoyi Wang et al.   CELL

Transgene-Free Genome Editing in Caenorhabditis elegans Using CRISPR-Cas

(2013) Hui Chiu et al.   GENETICS

Heritable Gene Knockout in Caenorhabditis elegans by Direct Injection of Cas9–sgRNA Ribonucleoproteins

(2013) Seung Woo Cho et al.   GENETICS

Spatial and temporal transcriptomics of Schistosoma japonicum -induced hepatic granuloma formation reveals novel roles for neutrophils

(2013) Candy Chuah et al.   JOURNAL OF LEUKOCYTE BIOLOGY

RNA-guided editing of bacterial genomes using CRISPR-Cas systems

(2013) Wenyan Jiang et al.   NATURE BIOTECHNOLOGY

Heritable genome editing in C. elegans via a CRISPR-Cas9 system

(2013) Ari E Friedland et al.   NATURE METHODS

Malaria parasites utilize both homologous recombination and alternative end joining pathways to maintain genome integrity

(2013) Laura A. Kirkman et al.   NUCLEIC ACIDS RESEARCH

Schistosoma japonicum Eggs Induce a Proinflammatory, Anti-Fibrogenic Phenotype in Hepatic Stellate Cells

(2013) Barrie J. Anthony et al.   PLoS One

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Transcriptional Responses of In Vivo Praziquantel Exposure in Schistosomes Identifies a Functional Role for Calcium Signalling Pathway Member CamKII

(2013) Hong You et al.   PLoS Pathogens

Whole-genome sequence of Schistosoma haematobium

(2012) Neil D Young et al.   NATURE GENETICS

Role of resident liver cells in the pathogenesis of schistosomiasis

(2012) Barrie J. Anthony et al.   TRENDS IN PARASITOLOGY

Germline Transgenesis and Insertional Mutagenesis in Schistosoma mansoni Mediated by Murine Leukemia Virus

(2012) Gabriel Rinaldi et al.   PLoS Pathogens

Type II Toxoplasma gondii KU80 Knockout Strains Enable Functional Analysis of Genes Required for Cyst Development and Latent Infection

(2011) Barbara A. Fox et al.   EUKARYOTIC CELL

Macrophage activation governs schistosomiasis-induced inflammation and fibrosis

(2011) Luke Barron et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

New insights into gastrointestinal and hepatic granulomatous disorders

(2011) Majid A. Almadi et al.   Nature Reviews Gastroenterology & Hepatology

Differential Expression of Chemokine and Matrix Re-Modelling Genes Is Associated with Contrasting Schistosome-Induced Hepatopathology in Murine Models

(2011) Carly R. Perry et al.   PLoS Neglected Tropical Diseases

Cloning and Characterisation of Schistosoma japonicum Insulin Receptors

(2010) Hong You et al.   PLoS One

Temporal Expression of Chemokines Dictates the Hepatic Inflammatory Infiltrate in a Murine Model of Schistosomiasis

(2010) Melissa L. Burke et al.   PLoS Neglected Tropical Diseases

The embryonic development of Schistosoma mansoni eggs: proposal for a new staging system

(2009) Arnon D. Jurberg et al.   DEVELOPMENT GENES AND EVOLUTION

Efficient Gene Replacements inToxoplasma gondiiStrains Deficient for Nonhomologous End Joining

(2009) Barbara A. Fox et al.   EUKARYOTIC CELL

Tagging of Endogenous Genes in aToxoplasma gondiiStrain Lacking Ku80

(2009) My-Hang Huynh et al.   EUKARYOTIC CELL

Transcriptional profiles of adult male and female Schistosoma japonicum in response to insulin reveal increased expression of genes involved in growth and development

(2009) Hong You et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Alternatively activated macrophage-derived RELM-α is a negative regulator of type 2 inflammation in the lung

(2009) Meera G. Nair et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Schistosoma japonicum genome reveals features of host–parasite interplay

(2009)   NATURE

The genome of the blood fluke Schistosoma mansoni

(2009) Matthew Berriman et al.   NATURE

Culture for genetic manipulation of developmental stages of Schistosoma mansoni

(2009) VICTORIA H. MANN et al.   PARASITOLOGY

Identification of the amino-acetonitrile derivative monepantel (AAD 1566) as a new anthelmintic drug development candidate

(2008) R. Kaminsky et al.   PARASITOLOGY RESEARCH