Approaches for the discovery of new cell-penetrating peptides

Cell-penetrating peptide inhibits retromer-mediated human papillomavirus trafficking during virus entry

(2020) Pengwei Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polymer Cancerostatics Containing Cell-Penetrating Peptides: Internalization Efficacy Depends on Peptide Type and Spacer Length

(2020) Eliška Böhmová et al.   Pharmaceutics

Nanoparticles Modified with Cell-Penetrating Peptides: Conjugation Mechanisms, Physicochemical Properties, and Application in Cancer Diagnosis and Therapy

(2020) Isabel Gessner et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TargetCPP: accurate prediction of cell-penetrating peptides from optimized multi-scale features using gradient boost decision tree

(2020) Muhammad Arif et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

A Review on Applications of Computational Methods in Drug Screening and Design

(2020) Xiaoqian Lin et al.   MOLECULES

Computational Modeling of Realistic Cell Membranes

(2019) Siewert J. Marrink et al.   CHEMICAL REVIEWS

SignalP 5.0 improves signal peptide predictions using deep neural networks

(2019) José Juan Almagro Armenteros et al.   NATURE BIOTECHNOLOGY

Recent Advances in Cell Penetrating Peptide-Based Anticancer Therapies

(2019) Justine Habault et al.   MOLECULES

The carboxy-terminus, a key regulator of protein function

(2019) Surbhi Sharma et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Transportan-derived cell-penetrating peptide delivers siRNA to inhibit replication of influenza virus in vivo

(2019) Cuiling Zhang et al.   Drug Design Development and Therapy

Phage display screening of therapeutic peptide for cancer targeting and therapy

(2019) Phei Er Saw et al.   Protein & Cell

Synthetic evolution

(2019) Anna J. Simon et al.   NATURE BIOTECHNOLOGY

DRAMP 2.0, an updated data repository of antimicrobial peptides

(2019) Xinyue Kang et al.   Scientific Data

A C-terminal peptide of TFPI-1 facilitates cytosolic delivery of nucleic acid cargo into mammalian cells

(2019) Mobashar Hussain Urf Turabe Fazil et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Crossing the blood-brain-barrier with nanoligand drug carriers self-assembled from a phage display peptide

(2019) Lin-Ping Wu et al.   Nature Communications

A Novel Cell-Penetrating Antibody Fragment Inhibits the DNA Repair Protein RAD51

(2019) Landon Pastushok et al.   Scientific Reports

1D to 2D Self Assembly of Cyclic Peptides

(2019) Ignacio Insua et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In Vitro and MD Simulation Study to Explore Physicochemical Parameters for Antibacterial Peptide to Become Potent Anticancer Peptide

(2019) Rui Ma et al.   Molecular Therapy-Oncolytics

Molecular Dynamics Simulations Are Redefining Our View of Peptides Interacting with Biological Membranes

(2018) Jakob P. Ulmschneider et al.   ACCOUNTS OF CHEMICAL RESEARCH

Cell penetrating peptides: a comparative transport analysis for 474 sequence motifs

(2018) Katrin Ramaker et al.   DRUG DELIVERY

Machine-Learning-Based Prediction of Cell-Penetrating Peptides and Their Uptake Efficiency with Improved Accuracy

(2018) Balachandran Manavalan et al.   JOURNAL OF PROTEOME RESEARCH

Potent Macromolecule-Sized Poration of Lipid Bilayers by the Macrolittins, A Synthetically Evolved Family of Pore-Forming Peptides

(2018) Sijia Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Short BRCA2-Derived Cell-Penetrating Peptide Targets RAD51 Function and Confers Hypersensitivity toward PARP Inhibition

(2018) Anika Trenner et al.   MOLECULAR CANCER THERAPEUTICS

Cell Penetrating Capacity and Internalization Mechanisms Used by the Synthetic Peptide CIGB-552 and Its Relationship with Tumor Cell Line Sensitivity

(2018) Soledad Astrada et al.   MOLECULES

Synthetic molecular evolution of hybrid cell penetrating peptides

(2018) W. Berkeley Kauffman et al.   Nature Communications

Prediction of Cell-Penetrating Potential of Modified Peptides Containing Natural and Chemically Modified Residues

(2018) Vinod Kumar et al.   Frontiers in Microbiology

Cell-Penetrating Peptide Mediates Intracellular Membrane Passage of Human Papillomavirus L2 Protein to Trigger Retrograde Trafficking

(2018) Pengwei Zhang et al.   CELL

Highly efficient cellular uptake of a cell-penetrating peptide (CPP) derived from the capsid protein of porcine circovirus type 2

(2018) Wanting Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

KELM-CPPpred: Kernel Extreme Learning Machine Based Prediction Model for Cell-Penetrating Peptides

(2018) Poonam Pandey et al.   JOURNAL OF PROTEOME RESEARCH

A platform for discovery of functional cell-penetrating peptides for efficient multi-cargo intracellular delivery

(2018) Katrin Hoffmann et al.   Scientific Reports

UniProt: a worldwide hub of protein knowledge

(2018)   NUCLEIC ACIDS RESEARCH

The BioGRID interaction database: 2019 update

(2018) Rose Oughtred et al.   NUCLEIC ACIDS RESEARCH

Arginine-rich cell-penetrating peptides induce membrane multilamellarity and subsequently enter via formation of a fusion pore

(2018) Christoph Allolio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Empirical comparison and analysis of web-based cell-penetrating peptide prediction tools

(2018) Ran Su et al.   BRIEFINGS IN BIOINFORMATICS

A novel amphipathic cell-penetrating peptide based on the N-terminal glycosaminoglycan binding region of human apolipoprotein E

(2018) Takashi Ohgita et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Characterization of DNA Condensation by Conformationally Restricted Dipeptides and Gene Delivery

(2017) Anjali Khatri et al.   Journal of Biomedical Nanotechnology

CPPred-RF: A Sequence-based Predictor for Identifying Cell-Penetrating Peptides and Their Uptake Efficiency

(2017) Leyi Wei et al.   JOURNAL OF PROTEOME RESEARCH

NLSdb—major update for database of nuclear localization signals and nuclear export signals

(2017) Michael Bernhofer et al.   NUCLEIC ACIDS RESEARCH

Combinatorial Library Screening with Liposomes for Discovery of Membrane Active Peptides

(2017) Randy P. Carney et al.   ACS Combinatorial Science

Effects of N-terminal and C-terminal modification on cytotoxicity and cellular uptake of amphiphilic cell penetrating peptides

(2017) Mehdi Soleymani-Goloujeh et al.   Artificial Cells Nanomedicine and Biotechnology

The Formation of Nanoparticles between Small Interfering RNA and Amphipathic Cell-Penetrating Peptides

(2017) Ly Pärnaste et al.   Molecular Therapy-Nucleic Acids

Effective in vivo gene delivery with reduced toxicity, achieved by charge and fatty acid -modified cell penetrating peptide

(2017) Kaido Kurrikoff et al.   Scientific Reports

Cargo Capture and Bulk Flow in the Early Secretory Pathway

(2016) Charles Barlowe et al.   Annual Review of Cell and Developmental Biology

Prediction of cell-penetrating peptides with feature selection techniques

(2016) Hua Tang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PinaColada: peptide–inhibitor ant colony ad-hoc design algorithm

(2016) Daniel Zaidman et al.   BIOINFORMATICS

Conjugates of HA2 with octaarginine-grafted HPMA copolymer offer effective siRNA delivery and gene silencing in cancer cells

(2016) Moran Golan et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Optimization of in vivo DNA delivery with NickFect peptide vectors

(2016) Krista Freimann et al.   JOURNAL OF CONTROLLED RELEASE

Molecular sled sequences are common in mammalian proteins

(2016) Kan Xiong et al.   NUCLEIC ACIDS RESEARCH

Effective Design of Multifunctional Peptides by Combining Compatible Functions

(2016) Christian Diener et al.   PLoS Computational Biology

Prediction and analysis of cell-penetrating peptides using pseudo-amino acid composition and random forest models

(2015) Lei Chen et al.   AMINO ACIDS

CPPsite 2.0: a repository of experimentally validated cell-penetrating peptides

(2015) Piyush Agrawal et al.   NUCLEIC ACIDS RESEARCH

DBAASP v.2: an enhanced database of structure and antimicrobial/cytotoxic activity of natural and synthetic peptides

(2015) Malak Pirtskhalava et al.   NUCLEIC ACIDS RESEARCH

Cell-Penetrating Antimicrobial Peptides – Prospectives for Targeting Intracellular Infections

(2015) Jesper S. Bahnsen et al.   PHARMACEUTICAL RESEARCH

X-pep, a novel cell-penetrating peptide motif derived from the hepatitis B virus

(2014) Kristopher Montrose et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Modular analysis of hipposin, a histone-derived antimicrobial peptide consisting of membrane translocating and membrane permeabilizing fragments

(2014) Maria E. Bustillo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Prolongation of Life in Rats with Malignant Glioma by Intranasal siRNA/Drug Codelivery to the Brain with Cell-Penetrating Peptide-Modified Micelles

(2014) Takanori Kanazawa et al.   MOLECULAR PHARMACEUTICS

Peptide-Based Glioma-Targeted Drug Delivery Vector gHoPe2

(2013) Elo Eriste et al.   BIOCONJUGATE CHEMISTRY

CPPpred: prediction of cell penetrating peptides

(2013) Thérèse A. Holton et al.   BIOINFORMATICS

Delivery of siRNA to the brain using a combination of nose-to-brain delivery and cell-penetrating peptide-modified nano-micelles

(2013) T. Kanazawa et al.   BIOMATERIALS

In silico approaches for designing highly effective cell penetrating peptides

(2013) Ankur Gautam et al.   Journal of Translational Medicine

A Novel Cell-Penetrating Peptide Derived from Human Eosinophil Cationic Protein

(2013) Shun-lung Fang et al.   PLoS One

Effects of Tryptophan Content and Backbone Spacing on the Uptake Efficiency of Cell-Penetrating Peptides

(2012) Hanna A. Rydberg et al.   BIOCHEMISTRY

Bioportide: an emergent concept of bioactive cell-penetrating peptides

(2012) John Howl et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Tuning the Activity of Mitochondria-Penetrating Peptides for Delivery or Disruption

(2012) Kristin L. Horton et al.   CHEMBIOCHEM

Cell penetrating peptides fused to a thermally targeted biopolymer drug carrier improve the delivery and antitumor efficacy of an acid-sensitive doxorubicin derivative

(2012) Leslie Walker et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Self-Assembled BolA-like Amphiphilic Peptides as Viral-Mimetic Gene Vectors for Cancer Cell Targeted Gene Delivery

(2012) Jing-Xiao Chen et al.   MACROMOLECULAR BIOSCIENCE

Cell-penetrating peptides released from thermosensitive nanoparticles suppress pro-inflammatory cytokine response by specifically targeting inflamed cartilage explants

(2012) Rush L. Bartlett et al.   Nanomedicine-Nanotechnology Biology and Medicine

CyLoP-1: A Novel Cysteine-Rich Cell-Penetrating Peptide for Cytosolic Delivery of Cargoes

(2011) Deepti Jha et al.   BIOCONJUGATE CHEMISTRY

PepCrawler: a fast RRT-based algorithm for high-resolution refinement and binding affinity estimation of peptide inhibitors

(2011) E. Donsky et al.   BIOINFORMATICS

Screening of cell-penetrating peptides using mRNA display

(2011) Jae-Hun Lee et al.   Biotechnology Journal

Prediction of Cell Penetrating Peptides by Support Vector Machines

(2011) William S. Sanders et al.   PLoS Computational Biology

Secondary structure of cell-penetrating peptides controls membrane interaction and insertion

(2010) Emelía Eiríksdóttir et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Prediction of Cell-Penetrating Peptides Using Artificial Neural Networks

(2010) Dimitar A. Dobchev et al.   Current Computer-Aided Drug Design

Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fluorescence and MR imaging of proteases

(2010) E. S. Olson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue-Penetrating Delivery of Compounds and Nanoparticles into Tumors

(2009) Kazuki N. Sugahara et al.   CANCER CELL

Predicting cell-penetrating peptides

(2007) Mats Hansen et al.   ADVANCED DRUG DELIVERY REVIEWS

Design of a Tumor-Homing Cell-Penetrating Peptide

(2007) Helena Myrberg et al.   BIOCONJUGATE CHEMISTRY