Article
Biochemistry & Molecular Biology
Delu Che, Jiapan Gao, Xueshan Du, Yi Zheng, Yajing Hou, Bin Peng, Tao Jia, Songmei Geng, Langchong He
Summary: The study investigated the activation of MCs via MRGPRX2 by PPD, leading to immediate contact allergy and tryptase release without monoamine release.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Pharmacology & Pharmacy
Nan Wang, Jue Wang, Yongjing Zhang, Yingnan Zeng, Shiling Hu, Haoyun Bai, Yajing Hou, Cheng Wang, Huaizhen He, Langchong He
Summary: The study revealed that IMP can reduce SP-induced calcium flux and suppress MC degranulation. IMP can alleviate SP-induced mouse PCA and ASA, and mitigate lung inflammation in an OVA-induced asthma model by inhibitiing MC activation in lung tissue. Additionally, IMP binds well to MRGPRX2 protein, suggesting it is a novel inhibitor for treating allergic asthma.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Immunology
Zhao Wang, Xi Zhao, Hongmei Zhou, Delu Che, Xiaojie Du, Dan Ye, Weihui Zeng, Songmei Geng
Summary: Mast cell activation is associated with the pathogenesis of various immune dysregulatory skin disorders. Recent studies have shown that the activation of an IgE-independent pseudo-allergic route is mainly mediated through Mas-Related G protein-coupled receptor X2 (MRGPRX2) and regulated by Ryanodine receptor (RYR). This finding provides insights into the role of RYR in MRGPRX2-mediated pseudo-allergic dermatitis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Medicinal
Jiayu Lu, Xiangjun Wang, Shuai Ge, Yajing Hou, Yuexin Lv, Huaizhen He, Cheng Wang
Summary: This study synthesized two novel derivatives by integrating the active substructures of B10-S and mubritinib and evaluated their anti-allergic inhibitory effects. The results showed that both compounds effectively inhibited the release of beta-hexosaminidase and histamine in cells by targeting MRGPRX2 and reduced intracellular Ca2+ levels. Molecular docking analysis also revealed their binding sites on MRGPRX2. These findings may contribute to the development of synthetic molecules with anti-pseudo-allergic activity in the future.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Medicinal
Zhuoyin Xue, Yongjing Zhang, Yingnan Zeng, Shiling Hu, Haoyun Bai, Jue Wang, Huiling Jing, Nan Wang
Summary: Lico A demonstrates anti-pseudo-allergy effects by inhibiting MRGPRX2-mediated pseudo-allergic reactions through blocking NF-kappa B nuclear migration.
PHYTOTHERAPY RESEARCH
(2021)
Article
Cell Biology
Magda Babina, Zhao Wang, Kristin Franke, Torsten Zuberbier
Summary: TSLP is a novel factor that primes human skin MCs to support granule discharge, selectively cooperating with MRGPRX2 without impacting other pathways. TSLP prolongs granule opening by activating STAT5 and JNK in skin MCs, leading to reinforced degranulation.
Review
Allergy
Andrew W. Liu, Jacob E. Gillis, Tina L. Sumpter, Daniel H. Kaplan
Summary: The skin is populated by various immune cells and sensory neurons, and the interaction between the nervous and immune systems plays a crucial role in inflammatory skin diseases. Neurotransmitters secreted by nerve terminals mediate immune cell function, while immune factors derived from immune cells interact with neurons to induce itching. This review explores the effector functions of neurons on skin immune cells in mouse models of atopic and contact dermatitis, and discusses the contribution of specific neuronal subsets and immune factors to itch induction and inflammation. The findings also shed light on treatment strategies and the relationship between scratching and dermatitis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Lai-San Wong, Yu-Ta Yen, Chih-Hung Lee
Summary: Atopic dermatitis is a prototypic inflammatory disease characterized by intense itching, with multifactorial pathophysiology involving environmental factors, genetic susceptibility, skin barrier function, and immune responses. Recent research has shown that pruritogens not only trigger itch but also interact with immune cells and act as inflammatory mediators, worsening the severity of atopic dermatitis. Targeted therapies for atopic dermatitis focus on the interaction between pruritogens and inflammatory molecules.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Ju Hyun Lee, Linsha Dong, Hyeon Min Noh, Sung-Gu Park, Seung-Hyung Kim, Eun Heui Jo, Dong-Sung Lee, Min Cheol Park
Summary: The increase of atopic dermatitis has led to higher socio-economic cost and raised a need for alternative medicine. This study evaluated the inhibitory effects of Donkey Hide Gelatin (DHG) water extract on atopic dermatitis and investigated its underlying mechanisms. The results showed that DHG reduced skin symptoms, immune cell numbers, allergic reactions, and levels of neutrophils and eosinophils. In addition, DHG inhibited pro-inflammatory cytokines and chemokines in keratinocytes, and suppressed NF-kappa B and MAPK signaling pathway activation. DHG may be a potential therapeutic agent or supplement for atopic dermatitis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Baowen Dang, Shiting Hu, Yonghui Zhang, Yihan Huang, Tao Zhang, Hongli An
Summary: In this study, myricetin was identified as an exogenous ligand for CD300f, which negatively regulates MRGPRX2-mediated MCs activation to inhibit MCs degranulation and pseudo-allergic reactions.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Feng Yuan, Chi Zhang, Maji Sun, Dongying Wu, Lin Cheng, Bin Pan, Ting Li, Delu Che
Summary: The study showed that Iohexol induces immediate-type pseudo-allergic reactions via MRGPRX2-mediated activation of mast cells. Structural modifications can reduce the effects of Iohexol-induced reactions, highlighting the importance of preventing allergic reactions to Iohexol.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Monica Thapaliya, Hydar Ali
Summary: This article investigates the role of GRK2 in mouse mast cells. It is found that GRK2 inhibits the responses mediated by MRGPRX2/B2 for C48/80 and SP, but not for LL-37. It is also discovered that GRK2 plays a role in IgE-mediated PCA and itch, but not in PSA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Franz J. Legat
Summary: Atopic dermatitis is a common inflammatory skin disease affecting up to 20% of children and 10% of adults in higher income countries, with chronic pruritus as a major symptom causing significant impact on quality of life. New systemic and topical treatments targeting specific cytokines and receptors have ushered in a new era in atopic dermatitis and pruritus therapy.
FRONTIERS IN MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Yoshie Umehara, Chanisa Kiatsurayanon, Juan Valentin Trujillo-Paez, Panjit Chieosilapatham, Ge Peng, Hainan Yue, Hai Le Thanh Nguyen, Pu Song, Ko Okumura, Hideoki Ogawa, Francois Niyonsaba
Summary: Itch or pruritus is a hallmark of atopic dermatitis and is believed to be a signal of danger from various environmental factors or physiological abnormalities. While histamine is a well-known substance inducing itch, H-1-antihistamines may not be fully effective against intractable itch in patients with atopic dermatitis. Treatment of the underlying conditions that cause itch is necessary to improve the quality of life of patients with atopic dermatitis.
Article
Medicine, General & Internal
Kjell Lussmann, Kerry Montgomery, Andrew Thompson, Uwe Gieler, Christoph Zick, Joerg Kupfer, Christina Schut
Summary: Itch intensity is positively correlated with itch catastrophizing, while mindfulness is negatively correlated with itch catastrophizing. Increasing acting with awareness may buffer itch catastrophizing and lead to lower itch intensity in patients with AD.
FRONTIERS IN MEDICINE
(2021)
Review
Neurosciences
Auriane Corbiere, Hubert Vaudry, Philippe Chan, Marie-Laure Walet-Balieu, Thierry Lecroq, Arnaud Lefebvre, Charles Pineau, David Vaudry
FRONTIERS IN NEUROSCIENCE
(2019)
Article
Immunology
Nadine Serhan, Lilian Basso, Riccardo Sibilano, Camille Petitfils, James Meixiong, Chrystelle Bonnart, Laurent L. Reber, Thomas Marichal, Philipp Starkl, Nicolas Cenac, Xinzhong Dong, Mindy Tsai, Stephen J. Galli, Nicolas Gaudenzio
Review
Allergy
Fatma Jendoubi, Nicolas Gaudenzio, Adeline Gallini, Mathilde Negretto, Carle Paul, Cristina Livideanu
CLINICAL AND EXPERIMENTAL ALLERGY
(2020)
Article
Biochemical Research Methods
Jelle Folkerts, Nicolas Gaudenzio, Marcus Maurer, Rudi W. Hendriks, Ralph Stadhouders, See-Ying Tam, Stephen J. Galli
Editorial Material
Neurosciences
James Meixiong, Lilian Basso, Xinzhong Dong, Nicolas Gaudenzio
TRENDS IN NEUROSCIENCES
(2020)
Review
Immunology
Stephen J. Galli, Nicolas Gaudenzio, Mindy Tsai
ANNUAL REVIEW OF IMMUNOLOGY, VOL 38
(2020)
Article
Peripheral Vascular Disease
Marc Clement, Fabien Lareyre, Alexia Loste, Aurelie Sannier, Fanny Burel-Vandenbos, Nicolas Massiot, Joseph Carboni, Elixene Jean-Baptiste, Giuseppina Caligiuri, Antonino Nicoletti, Juliette Raffort
Summary: The study identified histological features of SAAs, showing characteristics such as atherosclerotic lesions, calcifications, and intraluminal thrombus. SAAs were characterized by intense vascular remodeling, loss of VSMCs, elastin degradation, fibrosis, enhanced apoptosis, and increased matrix metalloproteinase 9 expression. Immune cell infiltration was observed, but lymphoid neogenesis in SAAs appeared to be incomplete.
Editorial Material
Multidisciplinary Sciences
Jasper B. J. Kamphuis, William P. M. Worrall, Julien Stackowicz, Aurelie Mougel, Emilie Maure, Eva Conde, Pierre Bruhns, Laurent Guilleminault, Nicolas Gaudenzio, Jinmiao Chen, Rebecca Gentek, Laurent L. Reber
Summary: The researchers found that interleukin-33 can induce accumulation of tumor-associated macrophages expressing the Fc epsilon RI receptor, but raised concerns about the specificity of the anti-Fc epsilon RI antibody used in the study.
Article
Multidisciplinary Sciences
Eva Conde, Romain Bertrand, Bianca Balbino, Jonathan Bonnefoy, Julien Stackowicz, Noemie Caillot, Fabien Colaone, Samir Hamdi, Raissa Houmadi, Alexia Loste, Jasper B. J. Kamphuis, Francois Huetz, Laurent Guilleminault, Nicolas Gaudenzio, Aurelie Mougel, David Hardy, John N. Snouwaert, Beverly H. Koller, Vincent Serra, Pierre Bruhns, Geraldine Grouard-Vogel, Laurent L. Reber
Summary: The study developed vaccines targeting IL-4 and IL-13, demonstrating promising prophylactic and therapeutic effects in mouse models of asthma. Vaccines specific for human IL-4 and IL-13 also showed efficient neutralization of these cytokines in mice, suggesting a potential long-term therapeutic strategy for allergic asthma.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Julien Stackowicz, Nicolas Gaudenzio, Nadine Serhan, Eva Conde, Ophelie Godon, Thomas Marichal, Philipp Starkl, Bianca Balbino, Axel Roers, Pierre Bruhns, Friederike Jonsson, Philippe Moguelet, Sophie Georgin-Lavialle, Lori Broderick, Hal M. Hoffman, Stephen J. Galli, Laurent L. Reber
Summary: Gain-of-function mutations in NLRP3 gene cause CAPS, with neutrophils potentially being the main cellular drivers of CAPS pathology.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Review
Immunology
Marie Tauber, Fang Wang, Brian Kim, Nicolas Gaudenzio
Summary: Peripheral neurons play a crucial role in transmitting sensations and regulating type 2 immune responses and allergic inflammation. Neurons can express receptors previously thought to be exclusive to the immune system, and interact with immune cells to modulate their activation status during allergic inflammation.
CURRENT OPINION IN IMMUNOLOGY
(2021)
Article
Immunology
Marie Tauber, Lilian Basso, Jeremy Martin, Luciana Bostan, Marlene Magalhaes Pinto, Guilhem R. Thierry, Raissa Houmadi, Nadine Serhan, Alexia Loste, Camille Bleriot, Jasper B. J. Kamphuis, Mirjana Grujic, Lena Kjellen, Gunnar Pejler, Carle Paul, Xinzhong Dong, Stephen J. Galli, Laurent L. Reber, Florent Ginhoux, Marc Bajenoff, Rebecca Gentek, Nicolas Gaudenzio
Summary: By combining whole-tissue imaging and single-cell RNA sequencing datasets, this study provides a comprehensive analysis of mast cells in mice and humans. The results reveal the presence of two distinct mast cell populations in mice and seven different mast cell subsets in humans, with specific transcriptomic signatures. This study sheds light on the natural diversity of mast cell subtypes and provides valuable insights for studying mast cell functions and diseases.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Dermatology
Matthew J. Davis, Gokul Srinivasan, Rachael Chacko, Sophie Chen, Anish Suvarna, Louis J. Vaickus, Veronica C. Torres, Sassan Hodge, Eunice Y. Chen, Sarah Preum, Kimberley S. Samkoe, Brock C. Christensen, Matthew R. Leboeuf, Joshua J. Levy
Summary: The development and application of AI algorithms are of great significance for the removal of cSCC, as they can improve operational efficiency and accuracy, especially for moderately and poorly differentiated tumors/ neoplasms. Further improvement is needed to maintain sensitivity to surrounding tissue and determine anatomical positioning.
EXPERIMENTAL DERMATOLOGY
(2024)
Article
Dermatology
Lingjing Chen, Qing Yu, Feiying Guo, Xuewen Wang, Zhenying Cai, Qiang Zhou
Summary: This study investigated the role and mechanisms of NTS in stress-induced hair growth inhibition. The results demonstrated that NTS effectively counteracted hair growth inhibition caused by stress and regulated the expression of multiple genes related to hair growth at the transcriptional level.
EXPERIMENTAL DERMATOLOGY
(2024)