Article
Biochemistry & Molecular Biology
Eva Konkolova, Monika Hudacova, Slavka Hamulakova, Rastislav Jendzelovsky, Jana Vargova, Juraj Sevc, Peter Fedorocko, Maria Kozurkova
Summary: A series of new drugs with tacrine and coumarin pharmacophores were studied for their ability to inhibit human lung carcinoma cell growth and topoisomerase I and II activity. All compounds were found to completely inhibit topoisomerase I activity, with derivatives 1c and 1d displaying the highest activity, likely due to their longer chain length between tacrine and coumarin moieties.
Article
Pharmacology & Pharmacy
Boris Rodenak-Kladniew, Rocio Gambaro, Jose S. Cisneros, Cristian Huck-Iriart, Gisel Padula, Guillermo R. Castro, Cecilia Y. Chain, German A. Islan
Summary: Geraniol (GOH), a monoterpene alcohol found in essential oils, was encapsulated into nanostructured lipid carriers (NLC) to improve its anticancer activity. The NLC/GOH exhibited high stability and low dispersity, and showed increased release of GOH at acidic pH. The NLC/GOH were safe, absorbed serum proteins, and preferentially interacted with human serum albumin. A time-dependent cellular uptake of NLC/GOH was observed in A549 cells, leading to increased cytotoxicity, mitochondrial membrane depolarization, and cell death. NLC/GOH showed highly cytotoxic concentrations against A549 cells but was non-toxic to normal lung fibroblasts. Additionally, GOH nanoencapsulation into NLC potentiated the inhibition of A549 cell migration.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Physical
Liana Ghasemi, Maryam Hasanzadeh Esfahani, Unes Sahebi, Adeleh Divsalar, Alireza Abbasi, Mahdi Behzad
Summary: This study synthesized and characterized a series of new mixed-ligand Cu(II) complexes, and investigated their anticancer activity. Through experimental and computational analysis, the complexes showed potent cytotoxic effects on three human carcinoma cell lines. The highest cytotoxicity was observed in complex (2), making it a promising candidate for developing new anticancer drugs.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Environmental Sciences
Lin Diao, Ning Tang, Cheng Zhang, Jiagao Cheng, Zhenhai Zhang, Siyu Wang, Can Wu, Lutong Zhang, Liming Tao, Zhong Li, Yang Zhang
Summary: The study found that Avermectin (AVM) has significant cytotoxic effects on human lung A549 cells, posing a potential threat to human health by inducing DNA damage and programmed cell death.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Qingying Shi, Jingchun Tang, Lan Wang, Rutao Liu, John P. Giesy
Summary: The combined toxicity of exposure to nanoplastics and phthalate esters on human lung cells was investigated in this study, with oxidative stress and inflammatory reactions identified as mechanisms. Lower concentrations of nanoparticles resulted in decreased toxicity and bioavailability on the cells.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Medicine, Research & Experimental
Davide Campoccia, Stefano Ravaioli, Spartaco Santi, Valentina Mariani, Cristina Santarcangelo, Anna De Filippis, Lucio Montanaro, Carla Renata Arciola, Maria Daglia
Summary: Propolis exhibits antimicrobial, antioxidant, anti-inflammatory, and anticancer activities, influenced by various factors. The Multi Dynamic Extraction Method (MED) can improve the reproducibility of propolis extracts. The study shows that propolis has mild cytotoxicity towards cancer cells, with some selective activity observed, highlighting the importance of assessing selectivity when screening for anticancer drug candidates.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Chellasamy Panneerselvam, Adel I. Alalawy, Karma Albalawi, Hamza S. Al-Shehri, Humaira Parveen, Hatem A. Al-Aoh, Noha Said Bedowr, Fahad J. Mujammami, Mohammed Nusari, Sahar Khateeb
Summary: This study investigates the anti-cancer efficacy of the bioactive compound chavicol against lung cancer cells. The treatment with chavicol inhibits cancer cell growth, survival, migration, and invasion, while showing no significant adverse effects on normal cells. The findings suggest the potential therapeutic use of chavicol in lung cancer treatment.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Qingying Shi, Jingchun Tang, Xiaomei Liu, Rutao Liu
Summary: The study investigated the aging of polystyrene (PS) NPs through photodegradation under ultraviolet irradiation for 2 months, comparing the toxicities of pristine and aged NPs on human lung epithelial A549 cells. The results showed changes in physicochemical properties, with a reduction in NPs size and the formation of abundant oxygen-containing groups on the surface. The toxic effects of aged NPs on A549 cells exhibited greater cytotoxicity than pristine NPs and were positively correlated with aging time, highlighting the importance of photodegradation in assessing the risk of NPs on human health.
ENVIRONMENTAL SCIENCE-NANO
(2021)
Article
Biochemistry & Molecular Biology
Turgut Keles, Burak Barut, Arzu Ozel, Zekeriya Biyiklioglu
Summary: In this study, a series of silicon phthalocyanines and naphthalocyanines compounds were synthesized and characterized, among which SiPc1a showed the highest cytotoxicity. Cell cycle analysis indicated that it could inhibit cell proliferation by arresting cells in the G(0)/G(1) phase.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Physical
Ala Manohar, S. V. Prabhakar Vattikuti, Panchanathan Manivasagan, Eue-Soon Jang, Heba Taha M. Abdelghani, Ki Hyeon Kim
Summary: This study investigates the effect of size variation in CeO2/MgFe2O4 nanocomposites on their electrochemical performance and cytotoxicity. The nanocomposites were synthesized using a combustion process and different calcined temperatures to adjust the particle size. The results show that the nanocomposites exhibit good biocompatibility and favorable electrochemical performance, suggesting their potential for biological applications.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Toxicology
Farzaneh Motafeghi, Romina Shahsavari, Parham Mortazavi, Mohammad Shokrzadeh
Summary: This study for the first time investigated the anticancer effects of paroxetine and amitriptyline, as well as their combination treatment, on HT29 and A549 cell lines. The results showed that both drugs alone inhibited the growth of cancer cells, and the inhibitory effect increased with the dose. The simultaneous exposure of these two drugs had a much greater inhibitory effect compared to single drug exposure. Additionally, these drugs caused LDH leakage and induction of apoptosis. In conclusion, paroxetine and amitriptyline have the ability to inhibit the growth of cancer cells by inducing apoptosis, LDH leakage, and oxidative stress.
TOXICOLOGY IN VITRO
(2023)
Article
Chemistry, Inorganic & Nuclear
Mohammad Usman, Rais Ahmad Khan, Mohammad Rashid Khan, Mohammad Abul Farah, Ibtisam I. BinSharfan, Walaa Alharbi, Jilani. P. Shaik, Narasimha Reddy Parine, Ali Alsalme, Sartaj Tabassum
Summary: Copper compounds show potential as next-generation metal anticancer drugs, with a newly synthesized polymer displaying high DNA binding propensity and selective cytotoxicity against A549 cancer cells. In vitro studies also revealed the polymer's ability to cleave DNA and its impact on gene expression in various cell lines.
DALTON TRANSACTIONS
(2021)
Article
Nanoscience & Nanotechnology
Sangiliyandi Gurunathan, Min-Hee Kang, Muniyandi Jeyaraj, Jin-Hoi Kim
Summary: Several studies have demonstrated the molecular mechanisms involved in the biogenesis and release of exosomes. PtNPs were shown to enhance exosome secretion in A549 cells by inducing oxidative stress and the ceramide pathway. Pre-treatment with NAC could inhibit the PtNPs-induced exosome biogenesis and release.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Wei-Zhi Huang, Ting-Ming Liu, Shu-Ting Liu, Ssu-Yu Chen, Shih-Ming Huang, Gunng-Shinng Chen
Summary: Oral squamous cell carcinoma (OSCC) is a complex disease involving genetic mutations and altered levels of various molecules. Platinum-based drugs are commonly used to treat OSCC, but severe side-effects and resistance are issues. In this study, the cytotoxic effects of ascorbate on two oral cell lines were investigated. The results showed that both free and sodium forms of ascorbate had higher sensitivity to one cell line compared to the other. Ascorbate-induced cytotoxicity was mediated by the generation of reactive oxygen species (ROS) in the mitochondria. The combination of ascorbate and cisplatin had a synergistic effect on one cell line, suggesting its potential as a sensitizer for platinum-based treatment of OSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sun-Ok Kim, Bo Yeon Kim, Kyung Ho Lee
Summary: Primary cilia, regulated by cellular signaling pathways including Wnt, are cellular sensor structures that play a role in anticancer drug resistance. This study found that anticancer drug resistance and Wnt3a stimulation synergistically affect primary ciliogenesis, suggesting a potential new strategy for overcoming drug resistance.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Editorial Material
Plant Sciences
S. I. Ismail, K. Ahmad Dahlan, S. Abdullah, D. Zulperi
Editorial Material
Plant Sciences
Dan Su, Wenhao Zhang, Rui Sun, Zhuting Zhang, Guozhong Lyu
Review
Environmental Sciences
N. A. Umor, S. Ismail, S. Abdullah, M. H. R. Huzaifah, N. M. Huzir, N. A. N. Mahmood, A. Y. Zahrim
Summary: Edible mushrooms are commercially grown using lignocellulosic waste through a biological process. After harvesting season, about 70% of the substrate remains as spent mushroom compost (SMC). SMC can be utilized for value-added products, supporting a zero waste approach. The major uses of SMC include in agriculture, as mushroom media, animal feed, plant compost, and fertilizer, with potential for extended usage in second cultivation and renewable energy production.
JOURNAL OF MATERIAL CYCLES AND WASTE MANAGEMENT
(2021)
Editorial Material
Plant Sciences
Muhammad Ziaur Rahman, Khairulmazmi Ahmad, Yasmeen Siddiqui, Norsazilawati Saad, Tan Geok Hun, Erneeza Mohd Hata, Osamah Rashed, Md Imam Hossain
Article
Agronomy
Nurul Kamaliah, Sabiha Salim, Sumaiyah Abdullah, Frisco Nobilly, Sapari Mat, Ahmad R. Norhisham, Kamil Azmi Tohiran, Raja Zulkifli, Alex M. Lechner, Badrul Azhar
Summary: The study found that factors such as bed humidity, bed temperature, harvesting week, harvesting month, and replication significantly affected the production of V. volvacea, while bed pH and orientation did not have an impact. Variations in temperature and humidity, especially during incubation, were found to be crucial for mycelial growth and fruiting body development, affecting mushroom production. Further research is needed to explore the potential of cultivating V. volvacea in different tropical agroforestry settings and its ability to contribute to climate change mitigation and circular economy by recycling oil palm wastes.
AGROFORESTRY SYSTEMS
(2022)
Review
Environmental Sciences
Jameel R. Al-Obaidi, Mohammed Yahya Allawi, Bilal Salim Al-Taie, Khalid H. Alobaidi, Jameel M. Al-Khayri, Sumaiyah Abdullah, E. Ahmad-Kamil
Summary: Desertification is a global concern that has threatened Iraq and many other parts of the Middle East in the past two decades. The main causes of desertification include vegetation loss, overgrazing, deforestation during war, poor irrigation practices, and water scarcity. Combating desertification requires cooperative efforts involving innovative practices, biotechnological approaches, oasis restoration, continuous reforestation, and agricultural land rehabilitation.
ENVIRONMENTAL MONITORING AND ASSESSMENT
(2022)
Editorial Material
Plant Sciences
A. Z. Md-Zali, Y. Ja'afar, K. Paramisparan, S. I. Ismail, N. Saad, E. M. Hata, D. Zulperi, M. R. Ismail, M. A. Md Hatta, M. T. Yusof
Article
Biochemistry & Molecular Biology
Suzziyana Hosni, Siti Salwa Abd Gani, Valerie Orsat, Masriana Hassan, Sumaiyah Abdullah
Summary: This study presents modeling and optimization of ultrasound-assisted extraction (UAE) of Melastoma malabathricum to evaluate its phytochemical properties. Through an OFAT procedure and response surface methodology, optimum conditions were established for maximum antioxidant extraction. The results showed that UAE at 37 kHz, X-ET 32 degrees C for X-UT 16 min, X-SC 70% ethanol concentration, and X-SLR 1:10 ratio yielded high scavenging effects on DPPH, as well as significant levels of total phenolic and flavonoid contents. GC-MS analysis confirmed the presence of important phytochemical compounds. This study provides valuable insights for further validation of the medicinal and cosmeceutical uses of Melastoma malabathricum.
Article
Multidisciplinary Sciences
Ibrahim Sani, Syari Jamian, Norsazilawati Saad, Sumaiyah Abdullah, Erneeza Mohd Hata, Johari Jalinas, Siti Izera Ismail
Summary: In this study, two entomopathogenic fungal species, Isaria javanica and Purpureocillium lilacinum, were found to act as endophytes in tomato plants, benefiting the plants and causing significant mortality of the whitefly pests. This indicates that they have potential as biocontrol agents and plant growth promoters.
Article
Multidisciplinary Sciences
Ibrahim Sani, Syari Jamian, Siti Izera Ismail, Norsazilawati Saad, Sumaiyah Abdullah, Erneeza Mohd Hata, Johari Jalinas
Summary: This article reports the temperature influence on the growth and efficacy of M. anisopliae in Malaysia. The results showed that the isolates of M. anisopliae had growth and virulence capabilities against B. tabaci on vegetables planted in a tropical climate. However, further research is still needed.
Article
Entomology
Ibrahim Sani, Syari Jamian, Norsazilawati Saad, Sumaiyah Abdullah, Erneeza Mohd Hata, Johari Jalinas, Siti Izera Ismail
Summary: Three entomopathogenic fungi, Isaria javanica (Cjc-03 and Cjw-01) and Purpureocillium lilacinum (TS-01), were discovered infecting whiteflies naturally on chili and tomato plants. The virulence of these isolates against nymphs and adults of Bemisia tabaci was evaluated at different concentrations in laboratory and glasshouse conditions. Isaria javanica showed the highest virulence against both nymphs and adults of B. tabaci.
EGYPTIAN JOURNAL OF BIOLOGICAL PEST CONTROL
(2023)
Article
Agriculture, Dairy & Animal Science
Mohamad Zaihan Zailan, Suraya Mohamad Salleh, Sumaiyah Abdullah, Halimatun Yaakub
Summary: This study evaluated the effect of feeding P. pulmonarius-treated empty fruit bunch (FTEFB) on the nutrient intakes, digestibility, milk yield and milk profiles of lactating Saanen goats. The results showed that the replacement of Napier grass with FTEFB did not adversely affect nutrient intake, fiber digestibility, milk yield, milk composition and milk fatty acid profiles in lactating goats.
TROPICAL ANIMAL HEALTH AND PRODUCTION
(2023)
Article
Biochemistry & Molecular Biology
Siti-Nurhuda Mohammad Yusof, Siva Raseetha, Vikineswary Sabaratnam, Sumaiyah Abdullah, Razifah Mohd Razali, Asrul Bahar
Summary: The effects of different storage temperatures (4, 25, and 35 degrees C) on the quality and microbial counts of oven-dried black jelly mushroom were investigated. The results showed that a storage temperature of 4 degrees C was the most effective in maintaining the quality and reducing microbial counts.
INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS
(2022)
Article
Entomology
Muhammad Amali Kamarudin, Sumaiyah Abdullah, Wei Hong Lau
Summary: This study isolated and identified 11 potential entomopathogenic fungi with insecticidal activity against C. curvignathus. Among them, UPM-A2C-1 M. anisopliae var anisopliae showed the best efficacy and had high virulence score and mycelia formation rate against the subterranean termite.
EGYPTIAN JOURNAL OF BIOLOGICAL PEST CONTROL
(2022)
Article
Microbiology
Ibrahim Sani, Syari Jamian, Siti Izera Ismail, Norsazilawati Saad, Sumaiyah Abdullah, Erneeza Mohd Hata, Muhammad Amali Kamarudin, Johari Jalinas
Summary: This study aimed to identify novel indigenous isolates of entomopathogenic fungi (EPF) in oil palm soil as part of integrated pest management (IPM) of oil palm insect pests. Seven Metarhizium anisopliae and two Purpureocillium lilacinum isolates were identified and could be potentially considered as biological control candidates for major insect pests in oil palm.
MALAYSIAN JOURNAL OF MICROBIOLOGY
(2022)
