Hydroxyethylamine Based Phthalimides as New Class of Plasmepsin Hits: Design, Synthesis and Antimalarial Evaluation

Optimization of plasmepsin inhibitor by focusing on similar structural feature with chloroquine to avoid drug-resistant mechanism of Plasmodium falciparum

(2014) Takuya Miura et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and In Vivo Antimalarial Evaluation of Novel Hydroxyethylamine Derivatives

(2014) Mariana Conceicao de Souza et al.   Medicinal Chemistry

Plasmepsin Inhibitory Activity and Structure-Guided Optimization of a Potent Hydroxyethylamine-Based Antimalarial Hit

(2014) Kristaps Jaudzems et al.   ACS Medicinal Chemistry Letters

Functionalized hydroxyethylamine based peptide nanostructures as potential inhibitors of falcipain-3, an essential proteases of Plasmodium falciparum

(2013) Brijesh Rathi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Protein complex directs hemoglobin-to-hemozoin formation in Plasmodium falciparum

(2013) M. Chugh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel in vivo active anti-malarials based on a hydroxy-ethyl-amine scaffold

(2012) Claire-Lise Ciana et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Potent Inhibitors of Malarial Aspartic Proteases, the Plasmepsins, by Hydroformylation of Substituted 7-Azanorbornenes

(2012) Valentina Aureggi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Recent Advances in Plasmepsin Medicinal Chemistry and Implications for Future Antimalarial Drug Discovery Efforts

(2012) Marvin J. Meyers et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Structural studies of vacuolar plasmepsins

(2011) Prasenjit Bhaumik et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Aryl piperazine and pyrrolidine as antimalarial agents. Synthesis and investigation of structure–activity relationships

(2011) Adela Mendoza et al.   EXPERIMENTAL PARASITOLOGY

Antimalarial Pyrido[1,2-a]benzimidazoles

(2011) Albert J. Ndakala et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Research Agenda to Underpin Malaria Eradication

(2011) Pedro L. Alonso et al.   PLOS MEDICINE

Recent Advances in the Chemistry of Phthalimide Analogues and their Therapeutic Potential

(2010) U. Sharma et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

That Was Then But This Is Now: Malaria Research in the Time of an Eradication Agenda

(2010) S. H. I. Kappe et al.   SCIENCE

Microwave irradiation: A facile, scalable and convenient method for synthesis of N-phthaloylamino acids

(2010) Hassan M. Al-Hazimi et al.   Arabian Journal of Chemistry

Role of Plasmodium falciparum Digestive Vacuole Plasmepsins in the Specificity and Antimalarial Mode of Action of Cysteine and Aspartic Protease Inhibitors

(2009) P. A. Moura et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthesis, antimalarial evaluation and molecular modeling studies of hydroxyethylpiperazines, potential aspartyl protease inhibitors, Part 2

(2009) Wilson Cunico et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Artemisinin Resistance inPlasmodium falciparumMalaria

(2009) Arjen M. Dondorp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting the Plasmepsin 4 Orthologs of Plasmodium sp. with “Double Drug” Inhibitors

(2008) Linda Janka et al.   PROTEIN AND PEPTIDE LETTERS

Predicting functional residues in Plasmodium falciparum plasmepsins by combining sequence and structural analysis with molecular dynamics simulations

(2008) Pedro A. Valiente et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS