Revisiting the Complexity of GLP-1 Action from Sites of Synthesis to Receptor Activation

Single-Cell Transcriptome Atlas of Murine Endothelial Cells

(2020) Joanna Kalucka et al.   CELL

GABA neurons in the nucleus tractus solitarius express GLP-1 receptors and mediate anorectic effects of liraglutide in rats

(2020) Samantha M. Fortin et al.   Science Translational Medicine

Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics

(2020) Julia Ast et al.   Nature Communications

High-Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells

(2020) Joep Beumer et al.   CELL

Patch-Seq Links Single-Cell Transcriptomes to Human Islet Dysfunction in Diabetes

(2020) Joan Camunas-Soler et al.   Cell Metabolism

PPG neurons in the nucleus of the solitary tract modulate heart rate but do not mediate GLP-1 receptor agonist-induced tachycardia in mice

(2020) Marie K. Holt et al.   Molecular Metabolism

Discordance between GLP-1R gene and protein expression in mouse pancreatic islet cells

(2020) Sarah M Gray et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Labeling and Characterization of Human GLP-1-Secreting L-cells in Primary Ileal Organoid Culture

(2020) Deborah A. Goldspink et al.   Cell Reports

Intestine-selective reduction of Gcg expression reveals the importance of the distal gut for GLP-1 secretion

(2020) Brandon L. Panaro et al.   Molecular Metabolism

Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist

(2020) Francis S. Willard et al.   JCI Insight

The Human and Mouse Enteric Nervous System at Single-Cell Resolution

(2020) Eugene Drokhlyansky et al.   CELL

Type 2 diabetes is associated with impaired jejunal enteroendocrine GLP-1 cell lineage in human obesity

(2020) Céline Osinski et al.   INTERNATIONAL JOURNAL OF OBESITY

Gs/Gq signaling switch in β cells defines incretin effectiveness in diabetes

(2020) Okechi S. Oduori et al.   JOURNAL OF CLINICAL INVESTIGATION

A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis

(2020) Philip N. Newsome et al.   NEW ENGLAND JOURNAL OF MEDICINE

Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons

(2019) Van B. Lu et al.   Nature Communications

Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease

(2019) Shun He et al.   NATURE

Comparison of Human and Murine Enteroendocrine Cells by Transcriptomic and Peptidomic Profiling

(2019) Geoffrey P. Roberts et al.   DIABETES

Identification of Enteroendocrine Regulators by Real-Time Single-Cell Differentiation Mapping

(2019) Helmuth Gehart et al.   CELL

Epicardial adipose tissue GLP-1 receptor is associated with genes involved in fatty acid oxidation and white-to-brown fat differentiation: A target to modulate cardiovascular risk?

(2019) Elena Dozio et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Role of adipose tissue GLP-1R expression in metabolic improvement after bariatric surgery in patients with type 2 diabetes

(2019) Miriam Ejarque et al.   Scientific Reports

Distinct Neural Sites of GLP-1R Expression Mediate Physiological versus Pharmacological Control of Incretin Action

(2019) Elodie M. Varin et al.   Cell Reports

Gut-Proglucagon-Derived Peptides Are Essential for Regulating Glucose Homeostasis in Mice

(2019) Youngmi Song et al.   Cell Metabolism

β Cell–intrinsic β-arrestin 1 signaling enhances sulfonylurea-induced insulin secretion

(2019) Luiz F. Barella et al.   JOURNAL OF CLINICAL INVESTIGATION

New Insights into Beta-Cell GLP-1 Receptor and cAMP Signaling

(2019) Alejandra Tomas et al.   JOURNAL OF MOLECULAR BIOLOGY

The GLP1R Agonist Liraglutide Reduces Hyperglucagonemia Induced by the SGLT2 Inhibitor Dapagliflozin via Somatostatin Release

(2019) Chiara Saponaro et al.   Cell Reports

Glucagon-like peptide 1 (GLP-1)

(2019) T.D. Müller et al.   Molecular Metabolism

Glucagon-Like Peptide-1 Receptor Agonism Improves Nephrotoxic Serum Nephritis by Inhibiting T-Cell Proliferation

(2019) Foteini Moschovaki Filippidou et al.   AMERICAN JOURNAL OF PATHOLOGY

Genetic Identification of Vagal Sensory Neurons That Control Feeding

(2019) Ling Bai et al.   CELL

Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine

(2019) Yalong Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Synaptic Inputs to the Mouse Dorsal Vagal Complex and Its Resident Preproglucagon Neurons

(2019) Marie K. Holt et al.   JOURNAL OF NEUROSCIENCE

A unique olfactory bulb microcircuit driven by neurons expressing the precursor to glucagon-like peptide 1

(2019) Nicolas Thiebaud et al.   Scientific Reports

Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials

(2019) Søren L Kristensen et al.   Lancet Diabetes & Endocrinology

Single cell transcriptomic profiling of large intestinal enteroendocrine cells in mice – Identification of selective stimuli for insulin-like peptide-5 and glucagon-like peptide-1 co-expressing cells

(2019) Lawrence J. Billing et al.   Molecular Metabolism

Endothelial GLP-1 (Glucagon-Like Peptide-1) Receptor Mediates Cardiovascular Protection by Liraglutide In Mice With Experimental Arterial Hypertension

(2019) Johanna Helmstädter et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Glucagon-Like Peptide-1 Receptor Agonists and Prevention of Stroke Systematic Review of Cardiovascular Outcome Trials With Meta-Analysis

(2019) Giuseppe Bellastella et al.   STROKE

Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1

(2018) Daniel J. Drucker   Cell Metabolism

New Understanding of β-Cell Heterogeneity and In Situ Islet Function

(2018) Richard K.P. Benninger et al.   DIABETES

Liraglutide Modulates Appetite and Body Weight Through Glucagon-Like Peptide 1 Receptor–Expressing Glutamatergic Neurons

(2018) Jessica M. Adams et al.   DIABETES

Glucagon-like peptide-1 receptor expression in the human eye

(2018) Josephine B. Hebsgaard et al.   DIABETES OBESITY & METABOLISM

GLP-1 action in the mouse bed nucleus of the stria terminalis

(2018) Diana L. Williams et al.   NEUROPHARMACOLOGY

Glucagon-like peptide 1 receptor (GLP-1R) expression by nerve fibres in inflammatory bowel disease and functional effects in cultured neurons

(2018) Uma Anand et al.   PLoS One

Down-regulation of vascular GLP-1 receptor expression in human subjects with obesity

(2018) Tomohiko Kimura et al.   Scientific Reports

Loss of dorsomedial hypothalamic GLP-1 signaling reduces BAT thermogenesis and increases adiposity

(2018) Shin J. Lee et al.   Molecular Metabolism

Integrated Brain Atlas for Unbiased Mapping of Nervous System Effects Following Liraglutide Treatment

(2018) Casper Bo Gravesen Salinas et al.   Scientific Reports

Circulating Levels of Soluble Dipeptidyl Peptidase-4 Are Dissociated from Inflammation and Induced by Enzymatic DPP4 Inhibition

(2018) Elodie M. Varin et al.   Cell Metabolism

Preproglucagon Neurons in the Nucleus of the Solitary Tract Are the Main Source of Brain GLP-1, Mediate Stress-Induced Hypophagia, and Limit Unusually Large Intakes of Food

(2018) Marie K. Holt et al.   DIABETES

GLP-1 Receptor in Pancreatic α-Cells Regulates Glucagon Secretion in a Glucose-Dependent Bidirectional Manner

(2018) Yanqing Zhang et al.   DIABETES

Exendin-4 overcomes cytokine-induced decreases in gap junction coupling via protein kinase A and Epac2 in mouse and human islets

(2018) Nikki L. Farnsworth et al.   JOURNAL OF PHYSIOLOGY-LONDON

Insulin Secretion Depends on Intra-islet Glucagon Signaling

(2018) Berit Svendsen et al.   Cell Reports

GLP‐1 Is a Coronary Artery Vasodilator in Humans

(2018) Sophie J. Clarke et al.   Journal of the American Heart Association

Identification of expression and function of the glucagon-like peptide-1 receptor in colonic smooth muscle

(2018) Alexander T. May et al.   PEPTIDES

Human Epicardial Fat Expresses Glucagon-Like Peptide 1 and 2 Receptors Genes

(2017) Gianluca Iacobellis et al.   HORMONE AND METABOLIC RESEARCH

Glucagon-Like Peptide-1 Inhibits Prandial Gastrointestinal Motility Through Myenteric Neuronal Mechanisms in Humans

(2017) Md Abdul Halim et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Discovery, characterization, and clinical development of the glucagon-like peptides

(2017) Daniel J. Drucker et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of murine pre-proglucagon–producing neurons reduces food intake and body weight

(2017) Ronald P. Gaykema et al.   JOURNAL OF CLINICAL INVESTIGATION

A hippocampus to prefrontal cortex neural pathway inhibits food motivation through glucagon-like peptide-1 signaling

(2017) T M Hsu et al.   MOLECULAR PSYCHIATRY

A single-cell survey of the small intestinal epithelium

(2017) Adam L. Haber et al.   NATURE

Enhanced AMPA Receptor Trafficking Mediates the Anorexigenic Effect of Endogenous Glucagon-like Peptide-1 in the Paraventricular Hypothalamus

(2017) Ji Liu et al.   NEURON

Glucagon-Like Peptide-1 Receptor Signaling in the Lateral Dorsal Tegmental Nucleus Regulates Energy Balance

(2017) David J Reiner et al.   NEUROPSYCHOPHARMACOLOGY

Chemogenetics revealed: DREADD occupancy and activation via converted clozapine

(2017) Juan L. Gomez et al.   SCIENCE

Expression of GLP-1 receptor and CD26 in human thyroid C-cells: The association of thyroid C-cell tumorigenesis with incretin-based medicine

(2017) Yuejia Song et al.   Oncology Letters

β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions

(2017) Lu Zhu et al.   Nature Communications

Pancreatic α Cell-Derived Glucagon-Related Peptides Are Required for β Cell Adaptation and Glucose Homeostasis

(2017) Shuyang Traub et al.   Cell Reports

Enteroendocrine L Cells Sense LPS after Gut Barrier Injury to Enhance GLP-1 Secretion

(2017) Lorène J. Lebrun et al.   Cell Reports

Acute activation of GLP-1-expressing neurons promotes glucose homeostasis and insulin sensitivity

(2017) Xuemei Shi et al.   Molecular Metabolism

The autonomic nervous system and cardiac GLP-1 receptors control heart rate in mice

(2017) Laurie L. Baggio et al.   Molecular Metabolism

Single-cell RNA-sequencing reveals a distinct population of proglucagon-expressing cells specific to the mouse upper small intestine

(2017) Leslie L. Glass et al.   Molecular Metabolism

Appetite-Controlling Endocrine Systems in Teleosts

(2017) Ivar Rønnestad et al.   Frontiers in Endocrinology

Glucagon-like peptide-1 receptor is present in pancreatic acinar cells and regulates amylase secretion through cAMP

(2016) Yanan Hou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Hindbrain glucagon-like peptide-1 neurons track intake volume and contribute to injection stress-induced hypophagia in meal-entrained rats

(2016) Alison D. Kreisler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Glucagon-related peptides and the regulation of food intake in chickens

(2016) Kazuhisa Honda   ANIMAL SCIENCE JOURNAL

Sensory Neurons that Detect Stretch and Nutrients in the Digestive System

(2016) Erika K. Williams et al.   CELL

Never Waste a Good Crisis: Confronting Reproducibility in Translational Research

(2016) Daniel J. Drucker   Cell Metabolism

iNKT Cells Induce FGF21 for Thermogenesis and Are Required for Maximal Weight Loss in GLP1 Therapy

(2016) Lydia Lynch et al.   Cell Metabolism

Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes

(2016) Åsa Segerstolpe et al.   Cell Metabolism

The Hypothalamic Glucagon-Like Peptide 1 Receptor Is Sufficient but Not Necessary for the Regulation of Energy Balance and Glucose Homeostasis in Mice

(2016) Melissa A. Burmeister et al.   DIABETES

Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets

(2016) Alice E. Adriaenssens et al.   DIABETOLOGIA

GLP-1 Induces Barrier Protective Expression in Brunnerʼs Glands and Regulates Colonic Inflammation

(2016) Claus H. Bang-Berthelsen et al.   INFLAMMATORY BOWEL DISEASES

Evolving Concepts and Translational Relevance of Enteroendocrine Cell Biology

(2016) Daniel J. Drucker   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The incretin hormone glucagon-like peptide 1 increases mitral cell excitability by decreasing conductance of a voltage-dependent potassium channel

(2016) Nicolas Thiebaud et al.   JOURNAL OF PHYSIOLOGY-LONDON

Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study

(2016) Matthew James Armstrong et al.   LANCET

Glucagon-like Peptide 1 Receptor Signaling in Acinar Cells Causes Growth-Dependent Release of Pancreatic Enzymes

(2016) Nicolai J. Wewer Albrechtsen et al.   Cell Reports

Comprehensive alpha, beta and delta cell transcriptomes reveal that ghrelin selectively activates delta cells and promotes somatostatin release from pancreatic islets

(2016) Michael R. DiGruccio et al.   Molecular Metabolism

GLP-1R Agonists Modulate Enteric Immune Responses Through the Intestinal Intraepithelial Lymphocyte GLP-1R

(2015) Bernardo Yusta et al.   DIABETES

Bile Acids Trigger GLP-1 Release Predominantly by Accessing Basolaterally Located G Protein–Coupled Bile Acid Receptors

(2015) Cheryl A. Brighton et al.   ENDOCRINOLOGY

GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation

(2015) Makoto Shigeto et al.   JOURNAL OF CLINICAL INVESTIGATION

Exenatide exerts a PKA-dependent positive inotropic effect in human atrial myocardium

(2015) Markus Wallner et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Septal Glucagon-Like Peptide 1 Receptor Expression Determines Suppression of Cocaine-Induced Behavior

(2015) Anne E Harasta et al.   NEUROPSYCHOPHARMACOLOGY

Spinally projecting preproglucagon axons preferentially innervate sympathetic preganglionic neurons

(2015) I.J. Llewellyn-Smith et al.   NEUROSCIENCE

Physiology of Proglucagon Peptides: Role of Glucagon and GLP-1 in Health and Disease

(2015) Darleen A. Sandoval et al.   PHYSIOLOGICAL REVIEWS

Beta cell specific probing with fluorescent exendin-4 is progressively reduced in type 2 diabetic mouse models

(2015) Janne Lehtonen et al.   Islets

Rapid, high efficiency isolation of pancreatic ß-cells

(2015) Susan M. Clardy et al.   Scientific Reports

Oxyntomodulin regulates resetting of the liver circadian clock by food

(2015) Dominic Landgraf et al.   eLife

Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain

(2015) Simon C. Cork et al.   Molecular Metabolism

Distribution of glucagon-like peptide 1-immunopositive neurons in human caudal medulla

(2014) Huiyuan Zheng et al.   Brain Structure & Function

Glutamatergic phenotype of glucagon-like peptide 1 neurons in the caudal nucleus of the solitary tract in rats

(2014) H. Zheng et al.   Brain Structure & Function

The Role of β Cell Glucagon-like Peptide-1 Signaling in Glucose Regulation and Response to Diabetes Drugs

(2014) Eric P. Smith et al.   Cell Metabolism

Glucagon-Like Peptide-1 Receptor Agonists Increase Pancreatic Mass by Induction of Protein Synthesis

(2014) Jacqueline A. Koehler et al.   DIABETES

Pharmacology, Physiology, and Mechanisms of Action of Dipeptidyl Peptidase-4 Inhibitors

(2014) Erin E. Mulvihill et al.   ENDOCRINE REVIEWS

GLP-1 Receptor Localization in Monkey and Human Tissue: Novel Distribution Revealed With Extensively Validated Monoclonal Antibody

(2014) Charles Pyke et al.   ENDOCRINOLOGY

The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss

(2014) Anna Secher et al.   JOURNAL OF CLINICAL INVESTIGATION

Neuronal GLP1R mediates liraglutide’s anorectic but not glucose-lowering effect

(2014) Stephanie Sisley et al.   JOURNAL OF CLINICAL INVESTIGATION

Exogenous glucagon-like peptide 1 reduces contractions in human colon circular muscle

(2014) Antonella Amato et al.   JOURNAL OF ENDOCRINOLOGY

Glucagon-like-peptide-1 receptor expression in normal and diseased human thyroid and pancreas

(2014) Beatrice Waser et al.   MODERN PATHOLOGY

Hippocampal GLP-1 Receptors Influence Food Intake, Meal Size and Effort-Based Responding for Food through Volume Transmission

(2014) Ted M Hsu et al.   NEUROPSYCHOPHARMACOLOGY

Neural integration of satiation and food reward: Role of GLP-1 and orexin pathways

(2014) Diana L. Williams   PHYSIOLOGY & BEHAVIOR

Differential activation of chemically identified neurons in the caudal nucleus of the solitary tract in non-entrained rats after intake of satiating vs. non-satiating meals

(2014) Alison D. Kreisler et al.   PHYSIOLOGY & BEHAVIOR

Inactivation of the cardiomyocyte glucagon-like peptide-1 receptor (GLP-1R) unmasks cardiomyocyte-independent GLP-1R-mediated cardioprotection

(2014) John R. Ussher et al.   Molecular Metabolism

Fluorescent Exendin-4 Derivatives for Pancreatic β-Cell Analysis

(2013) Susan M. Clardy et al.   BIOCONJUGATE CHEMISTRY

Incretin Action in the Pancreas: Potential Promise, Possible Perils, and Pathological Pitfalls

(2013) D. J. Drucker   DIABETES

Identification and Characterization of GLP-1 Receptor-Expressing Cells Using a New Transgenic Mouse Model

(2013) P. Richards et al.   DIABETES

β-Arrestin2 plays a key role in the modulation of the pancreatic beta cell mass in mice

(2013) Magalie A. Ravier et al.   DIABETOLOGIA

Lipotoxicity disrupts incretin-regulated human β cell connectivity

(2013) David J. Hodson et al.   JOURNAL OF CLINICAL INVESTIGATION

GLP-1 Receptor Is Expressed in Human Stomach Mucosa

(2013) Efrat Broide et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

The protective roles of GLP-1R signaling in diabetic nephropathy: possible mechanism and therapeutic potential

(2013) Hiroki Fujita et al.   KIDNEY INTERNATIONAL

GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure

(2013) Minsuk Kim et al.   NATURE MEDICINE

SSTR2 is the functionally dominant somatostatin receptor in human pancreatic β- and α-cells

(2012) Balrik Kailey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Glucagon-like peptide-1 (GLP-1) induces M2 polarization of human macrophages via STAT3 activation

(2012) Daisuke Shiraishi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Direct Control of Brown Adipose Tissue Thermogenesis by Central Nervous System Glucagon-Like Peptide-1 Receptor Signaling

(2012) S. H. Lockie et al.   DIABETES

Predominant role of active versus facilitative glucose transport for glucagon-like peptide-1 secretion

(2012) H. E. Parker et al.   DIABETOLOGIA

A local glucagon-like peptide 1 (GLP-1) system in human pancreatic islets

(2012) P. Marchetti et al.   DIABETOLOGIA

GLP-1 Receptor Agonists and the Thyroid: C-Cell Effects in Mice Are Mediated via the GLP-1 Receptor and not Associated with RET Activation

(2012) Lars Wichmann Madsen et al.   ENDOCRINOLOGY

GLP-1 Receptor Activation Indirectly Reduces Hepatic Lipid Accumulation But Does Not Attenuate Development of Atherosclerosis in Diabetic MaleApoE−/−Mice

(2012) Naim Panjwani et al.   ENDOCRINOLOGY

The Glucagon-Like Peptide-1 Receptor—or Not?

(2012) Charles Pyke et al.   ENDOCRINOLOGY

Glucagon-like peptide-1 in the rat brain: Distribution of expression and functional implication

(2012) Guibao Gu et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Optogenetic silencing strategies differ in their effects on inhibitory synaptic transmission

(2012) Joseph V Raimondo et al.   NATURE NEUROSCIENCE

The enteric nervous system and neurogastroenterology

(2012) John B. Furness   Nature Reviews Gastroenterology & Hepatology

Preproglucagon (PPG) neurons innervate neurochemicallyidentified autonomic neurons in the mouse brainstem

(2012) I.J. Llewellyn-Smith et al.   NEUROSCIENCE

The brainstem preproglucagon system in a non-human primate (Macaca mulatta)

(2011) Niels Vrang et al.   BRAIN RESEARCH

CCK Stimulation of GLP-1 Neurons Involves α 1 -Adrenoceptor–Mediated Increase in Glutamatergic Synaptic Inputs

(2011) Kazunari Hisadome et al.   DIABETES

Glucagon-like peptide-1 (GLP-1) and the regulation of human invariant natural killer T cells: lessons from obesity, diabetes and psoriasis

(2011) A. E. Hogan et al.   DIABETOLOGIA

Stromal cell-derived factor-1 (SDF-1)/chemokine (C-X-C motif) receptor 4 (CXCR4) axis activation induces intra-islet glucagon-like peptide-1 (GLP-1) production and enhances beta cell survival

(2011) Z. Liu et al.   DIABETOLOGIA

Glucagon Like Peptide-1 Receptor Expression in the Human Thyroid Gland

(2011) Belinda Gier et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Pancreatic GLP-1 receptor activation is sufficient for incretin control of glucose metabolism in mice

(2011) Benjamin J. Lamont et al.   JOURNAL OF CLINICAL INVESTIGATION

Hyperphagia and Increased Fat Accumulation in Two Models of Chronic CNS Glucagon-Like Peptide-1 Loss of Function

(2011) J. G. Barrera et al.   JOURNAL OF NEUROSCIENCE

Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis

(2011) Gianluca Svegliati-Baroni et al.   LIVER INTERNATIONAL

Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells

(2011) Helga Ellingsgaard et al.   NATURE MEDICINE

Preproglucagon neurons project widely to autonomic control areas in the mouse brain

(2011) I.J. Llewellyn-Smith et al.   NEUROSCIENCE

Nutrient detection by incretin hormone secreting cells

(2011) Eleftheria Diakogiannaki et al.   PHYSIOLOGY & BEHAVIOR

GLP-1-derived nonapeptide GLP-1(28–36)amide targets to mitochondria and suppresses glucose production and oxidative stress in isolated mouse hepatocytes

(2011) Eva Tomas et al.   REGULATORY PEPTIDES

A Novel Human-Based Receptor Antagonist of Sustained Action Reveals Body Weight Control by Endogenous GLP-1

(2010) James T. Patterson et al.   ACS Chemical Biology

GLP-1 Inhibits and Adrenaline Stimulates Glucagon Release by Differential Modulation of N- and L-Type Ca2+ Channel-Dependent Exocytosis

(2010) Yang Z. De Marinis et al.   Cell Metabolism

Inhibition of Monocyte Adhesion to Endothelial Cells and Attenuation of Atherosclerotic Lesion by a Glucagon-like Peptide-1 Receptor Agonist, Exendin-4

(2010) M. Arakawa et al.   DIABETES

Leptin Directly Depolarizes Preproglucagon Neurons in the Nucleus Tractus Solitarius

(2010) Kazunari Hisadome et al.   DIABETES

Glucagon-like peptide-1 receptor signalling selectively regulates murine lymphocyte proliferation and maintenance of peripheral regulatory T cells

(2010) I. Hadjiyanni et al.   DIABETOLOGIA

Glucagon-Like Peptide-1 Receptor Agonists Activate Rodent Thyroid C-Cells Causing Calcitonin Release and C-Cell Proliferation

(2010) Lotte Bjerre Knudsen et al.   ENDOCRINOLOGY

Immune challenge and satiety-related activation of both distinct and overlapping neuronal populations in the brainstem indicate parallel pathways for viscerosensory signaling

(2009) Ronald PA Gaykema et al.   BRAIN RESEARCH

GLP-1R Agonist Liraglutide Activates Cytoprotective Pathways and Improves Outcomes After Experimental Myocardial Infarction in Mice

(2009) M. H. Noyan-Ashraf et al.   DIABETES

Roles of cAMP signalling in insulin granule exocytosis

(2009) S. Seino et al.   DIABETES OBESITY & METABOLISM

The Extrapancreatic Effects of Glucagon-Like Peptide-1 and Related Peptides

(2009) Rania Abu-Hamdah et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Glucose Sensing in L Cells: A Primary Cell Study

(2008) Frank Reimann et al.   Cell Metabolism

Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas

(2008) J. de Heer et al.   DIABETOLOGIA

Expression of the GLP-1 Receptor in Mouse, Rat, and Human Pancreas

(2008) Ditte Tornehave et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

The Murine Glucagon-Like Peptide-1 Receptor Is Essential for Control of Bone Resorption

(2007) Chizumi Yamada et al.   ENDOCRINOLOGY