Journal
DEVELOPMENTAL BIOLOGY
Volume 333, Issue 2, Pages 312-323Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2009.06.043
Keywords
Cap mesenchyme; Metanephros; Kidney; Progenitor; Transcription factor; Nephrogenesis
Categories
Funding
- National Kidney Foundation
- HSCI Seed Grant
- GUDMAP [U01 DK070181]
- NIH [R37 DK054364]
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The functional unit of the kidney is the nephron. During its organogenesis, the mammalian metanephric kidney generates thousands of nephrons over a protracted period of fetal life. All nephrons are derived from a population of self-renewing multi-potent progenitor cells, termed the cap mesenchyme. However, our understanding of the molecular and cellular mechanisms underlying nephron development is at an early stage. In order to identify factors involved in nephrogenesis, we performed a high-resolution, spatial pro. ling of a number of transcriptional regulators expressed within the cap mesenchyme and early developing nephron. Our results demonstrate novel, stereotypic, spatially defined cellular sub-domains within the cap mesenchyme, which may, in part, reflect induction of nephron precursors. These results suggest a hitherto unappreciated complexity of cell states that accompany the assembly of the metanephric kidney, likely reflecting diverse regulatory actions such as the maintenance and induction of nephron progenitors. (C) 2009 Elsevier Inc. All rights reserved.
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