Article
Biochemistry & Molecular Biology
Bo Li, Yue Zhou, Jing Chen, Tingting Wang, Zhijuan Li, Yili Fu, Aixia Zhai, Changlong Bi
Summary: Aberrant expressions of lncRNA H19 and miR-29b have been implicated in the complications of diabetes mellitus, specifically in diabetic foot ulcer (DFU). Upregulation of lncRNA H19 in DFU tissues competitively binds to miR-29b, leading to increased expression of FBN1, which enhances fibroblast proliferation and migration while inhibiting apoptosis, ultimately facilitating wound healing in DFU.
Article
Cardiac & Cardiovascular Systems
Xueting Fan, Kai Feng, Yonghui Liu, Leixi Yang, Yizhuo Zhao, Liping Tian, Yiqun Tang, Xiaozhi Wang
Summary: This study investigated the function and regulatory network of miR-135a in atrial fibrillation (AF). It was found that miR-135a expression was significantly decreased in AF patients and AF rats. MiR-135a regulates AF through the Smad3/TRPM7 pathway, indicating it as a potential therapeutic target for AF.
CARDIOVASCULAR THERAPEUTICS
(2023)
Article
Cell Biology
Yu-Rui Duan, Bao-Ping Chen, Fang Chen, Su-Xia Yang, Chao-Yang Zhu, Ya-Li Ma, Yang Li, Jun Shi
Summary: The study showed that lncRNA lnc-ISG20 is up-regulated in the glomerular of patients with diabetic nephropathy (DN). Silencing lnc-ISG20 alleviated fibrosis in kidney cells and delayed renal fibrosis in DN mice. The downstream miRNA of lnc-ISG20, miR-486-5p, was found to inhibit NFAT5 expression by binding to its 3'UTR.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Urology & Nephrology
Taoxia Wang, Shubei Cui, Xiaoli Liu, Li Han, Xiaoting Duan, Shuning Feng, Sen Zhang, Guiying Li
Summary: This study explores the role of long noncoding RNA taurine-up-regulated gene 1 (TUG1) in tubular fibrosis caused by high glucose and its target genes. Results show that downregulation of TUG1 contributes to renal injury and fibrosis, while overexpression of TUG1 alleviates these effects through the miR-145-5p/DUSP6 axis. These findings provide insights into the mechanism of diabetic nephropathy and potential therapeutic targets.
Article
Endocrinology & Metabolism
Claudia Silva Souza, Amanda Lima Deluque, Beatriz Magalhaes Oliveira, Ana Livia Dias Maciel, Cleonice Giovanini, Patricia Aline Boer, Francisco Jose Albuquerque de Paula, Roberto Silva Costa, Heloisa Della Colleta Franscecato, Lucas Ferreira de Almeida, Terezila Machado Coimbra
Summary: This study aimed to investigate the impact of vitamin D deficiency on the progression of diabetic kidney disease (DKD). The results demonstrated that vitamin D deficiency accelerates the development of DKD and contributes to renal structural and functional impairment, possibly through the occurrence of epithelial-mesenchymal transition.
NUTRITION & DIABETES
(2023)
Article
Medicine, Research & Experimental
Qiuer Liang, Tianhao Liu, Tingting Guo, Wencong Tao, Xudong Chen, Weihao Chen, Liguo Chen, Ya Xiao
Summary: The study showed that inhibiting ATF4 can improve renal damage and fibrosis in DN mice, as well as restore autophagy. In cell experiments, inhibition of ATF4 can increase autophagosome numbers, improve autophagic flux, and decrease Collagen type 4 (Col-IV) levels.
Article
Biochemistry & Molecular Biology
Zheli Niu, Guangwei Ren, Lijing Huang, Liqin Mu
Summary: A study found that circ_0008529 plays a key role in the progression of diabetic nephropathy (DN), regulating DN development through the miR-185-5p/SMAD2 signaling pathway. Additionally, the expression of circ_0008529 was upregulated in urinary exosomes of DN patients and showed diagnostic value.
BIOCHEMICAL GENETICS
(2023)
Article
Medicine, Research & Experimental
Xiaohan Wu, He Li, Zhijie Wan, Ran Wang, Jing Liu, Qingfeng Liu, Haiyun Zhao, Zhehuan Wang, Huiru Zhang, Hui Guo, Caihong Qi, Xiangyue Jiao, Xiaotian Li
Summary: This study investigates the combined effects of ursolic acid and empagliflozin in treating diabetic nephropathy using a diabetic rat model. The results showed that the combination treatment was more effective in improving blood glucose, renal function indicators, inflammation levels, oxidative stress responses, and renal fibrosis compared to monotherapy.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Zhanchi Xu, Meng Zhang, Yu Wang, Rui Chen, Shiyue Xu, Xiaohong Sun, Yan Yang, Zeyuan Lin, Shaogui Wang, Heqing Huang
Summary: Gentiopicroside (GPS) alleviates renal tubulointerstitial fibrosis (TIF) in diabetes by inhibiting inflammatory response and regulating protein expressions.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Endocrinology & Metabolism
Shengju Wang, Shuai Qin, Baochao Cai, Jihong Zhan, Qiu Chen
Summary: Diabetic nephropathy (DN) is a serious complication of diabetes mellitus, characterized by renal fibrosis. The exact mechanism of renal fibrosis in DN is still unclear, hindering its treatment. Chinese herbal medicine (CHM) has shown effectiveness in improving inflammation and albuminuria in diabetic patients. This review outlines the underlying mechanisms of renal fibrosis in DN, including oxidative stress generation and ASK1-p38/JNK activation, and summarizes the current status of CHM in treating DN by improving renal fibrosis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
DongWei Liu, FengXun Liu, ZhengYong Li, ShaoKang Pan, JunWei Xie, ZiHao Zhao, ZhenJie Liu, JiaHui Zhang, ZhangSuo Liu
Summary: This study found that miR-483-5p is decreased in kidney tissues of diabetic mice and in tubular epithelial cells stimulated with high glucose, but increased in exosomes derived from diabetic mouse kidney tissues. miR-483-5p inhibits fibrosis-related gene expressions by binding to TIMP2 and MAPK1, thus alleviating the progression of DN-induced renal interstitial fibrosis.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Bojin Xu, Qianqian Wang, Wenyi Li, Lili Xia, Xiaoxu Ge, Lisha Shen, Zhen Cang, Wenfang Peng, Kan Shao, Shan Huang
Summary: circEIF4G2 plays a role in promoting renal tubular epithelial cell fibrosis in diabetic nephropathy, through the miR-218/SERBP1 pathway.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Endocrinology & Metabolism
Lei Du, Yibing Chen, Jiasen Shi, Xiujuan Yu, Jieling Zhou, Xue Wang, Liu Xu, Junjie Liu, Jian Gao, Xiaoke Gu, Tao Wang, Zeyuan Yin, Chenglin Li, Meng Yan, Jianyun Wang, Xiaoxing Yin, Qian Lu
Summary: S100A8 and S100A9 expression is increased in diabetic kidneys, and their abnormal expression promotes the epithelial to mesenchymal transition (EMT) process and renal interstitial fibrosis (RIF) through the TLR4/NF-?B signal pathway. Inhibiting the abnormal expressions of S100A8/A9 with the compound AB38b may be a potential therapeutic strategy for treating DN.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Article
Cell Biology
Jing Ren, Hanping Qi, Chao Song, Lina Ba, Renling Liu, Xiang Feng, Lixin Wang, Meitian Zhang, Yawen Xie, Hongli Sun
Summary: This study identified lncRNA4930473A02Rik as a key regulator in cardiac hypertrophy, promoting its development by modulating miR-135a levels and TCF7 activity. Inhibition of lncRNAA02Rik may serve as a novel potential therapeutic strategy for cardiac hypertrophy.
CELL DEATH DISCOVERY
(2021)
Article
Pharmacology & Pharmacy
Haozi Huang, Guowei Zhang, Zhenying Ge
Summary: The overexpression of MALAT1 in diabetic rats and HG-treated cells may exacerbate renal fibrosis and cell damage via the miR-2355-3p/IL6ST axis.
FRONTIERS IN PHARMACOLOGY
(2021)