CNS macrophages differentially rely on an intronic Csf1r enhancer for their development

Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis

(2020) David Schafflick et al.   Nature Communications

Early Fate Defines Microglia and Non-parenchymal Brain Macrophage Development

(2020) Sebastian G. Utz et al.   CELL

Single-cell RNA-seq analysis of human CSF microglia and myeloid cells in neuroinflammation

(2020) Ekaterina Esaulova et al.   Neurology-Neuroimmunology & Neuroinflammation

Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation

(2019) Marta Joana Costa Jordão et al.   SCIENCE

Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution

(2019) Takahiro Masuda et al.   NATURE

Bi-allelic CSF1R Mutations Cause Skeletal Dysplasia of Dysosteosclerosis-Pyle Disease Spectrum and Degenerative Encephalopathy with Brain Malformation

(2019) Long Guo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Homozygous Mutations in CSF1R Cause a Pediatric-Onset Leukoencephalopathy and Can Result in Congenital Absence of Microglia

(2019) Nynke Oosterhof et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment

(2019) Hannah Van Hove et al.   NATURE NEUROSCIENCE

Phenotypic impacts of CSF1R deficiencies in humans and model organisms

(2019) David A. Hume et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Macrophages at CNS interfaces: ontogeny and function in health and disease

(2019) Katrin Kierdorf et al.   NATURE REVIEWS NEUROSCIENCE

Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations

(2019) Rocío Rojo et al.   Nature Communications

High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease

(2018) Dunja Mrdjen et al.   IMMUNITY

Histology Atlas of the Developing Prenatal and Postnatal Mouse Central Nervous System, with Emphasis on Prenatal Days E7.5 to E18.5

(2017) Vivian S. Chen et al.   TOXICOLOGIC PATHOLOGY

An updated assessment of microglia depletion: current concepts and future directions

(2017) Jinming Han et al.   Molecular Brain

The development and maintenance of resident macrophages

(2016) Elisa Gomez Perdiguero et al.   NATURE IMMUNOLOGY

Origin, fate and dynamics of macrophages at central nervous system interfaces

(2016) Tobias Goldmann et al.   NATURE IMMUNOLOGY

Specification of tissue-resident macrophages during organogenesis

(2016) E. Mass et al.   SCIENCE

4D atlas of the mouse embryo for precise morphological staging

(2015) Michael D. Wong et al.   DEVELOPMENT

Progressive Differentiation and Instructive Capacities of Amniotic Fluid and Cerebrospinal Fluid Proteomes following Neural Tube Closure

(2015) Kevin F. Chau et al.   DEVELOPMENTAL CELL

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

Recruitment of Beneficial M2 Macrophages to Injured Spinal Cord Is Orchestrated by Remote Brain Choroid Plexus

(2013) Ravid Shechter et al.   IMMUNITY

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

(2013) Katrin Kierdorf et al.   NATURE NEUROSCIENCE

The Function of the Conserved Regulatory Element within the Second Intron of the Mammalian Csf1r Locus

(2013) Kristin A. Sauter et al.   PLoS One

CSF1R mutations in hereditary diffuse leukoencephalopathy with spheroids are loss of function

(2013) Clare Pridans et al.   Scientific Reports

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids

(2011) Rosa Rademakers et al.   NATURE GENETICS

Absence of Colony Stimulation Factor-1 Receptor Results in Loss of Microglia, Disrupted Brain Development and Olfactory Deficits

(2011) Bryna Erblich et al.   PLoS One

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE