Cryo-EM snapshots of the human spliceosome reveal structural adaptions for splicing regulation

Molecular architecture of the human 17S U2 snRNP

(2020) Zhenwei Zhang et al.   NATURE

RNAs in the spliceosome: Insight from cryoEM structures

(2019) Lingdi Zhang et al.   Wiley Interdisciplinary Reviews-RNA

Structural Insights into Nuclear pre-mRNA Splicing in Higher Eukaryotes

(2019) Berthold Kastner et al.   Cold Spring Harbor Perspectives in Biology

A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation

(2019) Sebastian M. Fica et al.   SCIENCE

Structures of the human spliceosomes before and after release of the ligated exon

(2019) Xiaofeng Zhang et al.   CELL RESEARCH

Mechanism of 5ʹ splice site transfer for human spliceosome activation

(2019) Clément Charenton et al.   SCIENCE

A unified mechanism for intron and exon definition and back-splicing

(2019) Xueni Li et al.   NATURE

Smu1 and RED are required for activation of spliceosomal B complexes assembled on short introns

(2019) Sandra Keiper et al.   Nature Communications

RNA Splicing by the Spliceosome

(2019) Max E. Wilkinson et al.   Annual Review of Biochemistry

Splicing Kinetics and Coordination Revealed by Direct Nascent RNA Sequencing through Nanopores

(2019) Heather L. Drexler et al.   MOLECULAR CELL

Structure and Conformational Dynamics of the Human Spliceosomal B act Complex

(2018) David Haselbach et al.   CELL

Structure of the human activated spliceosome in three conformational states

(2018) Xiaofeng Zhang et al.   CELL RESEARCH

SNRP-27, the C. elegans homolog of the tri-snRNP 27K protein, has a role in 5' splice site positioning in the spliceosome

(2018) Alan M. Zahler et al.   RNA

Structure of a human catalytic step I spliceosome

(2018) Xiechao Zhan et al.   SCIENCE

Structures of the fully assembledSaccharomyces cerevisiaespliceosome before activation

(2018) Rui Bai et al.   SCIENCE

Prespliceosome structure provides insights into spliceosome assembly and regulation

(2018) Clemens Plaschka et al.   NATURE

Emerging Roles of Ubiquitin-like Proteins in Pre-mRNA Splicing

(2018) Sittinan Chanarat et al.   TRENDS IN BIOCHEMICAL SCIENCES

Structures of the human pre-catalytic spliceosome and its precursor spliceosome

(2018) Xiechao Zhan et al.   CELL RESEARCH

Structure of a pre-catalytic spliceosome

(2017) Clemens Plaschka et al.   NATURE

Structure of a spliceosome remodelled for exon ligation

(2017) Sebastian M. Fica et al.   NATURE

Cryo-EM structure of a human spliceosome activated for step 2 of splicing

(2017) Karl Bertram et al.   NATURE

Mechanistic insights into precursor messenger RNA splicing by the spliceosome

(2017) Yigong Shi   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cryo-electron microscopy snapshots of the spliceosome: structural insights into a dynamic ribonucleoprotein machine

(2017) Sebastian M Fica et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A new role for FBP21 as regulator of Brr2 helicase activity

(2017) Lisa M. Henning et al.   NUCLEIC ACIDS RESEARCH

Postcatalytic spliceosome structure reveals mechanism of 3′–splice site selection

(2017) Max E. Wilkinson et al.   SCIENCE

Cryo-electron microscopy snapshots of the spliceosome: structural insights into a dynamic ribonucleoprotein machine

(2017) Sebastian M Fica et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CryoEM structures of two spliceosomal complexes: starter and dessert at the spliceosome feast

(2016) Thi Hoang Duong Nguyen et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Å resolution

(2016) Thi Hoang Duong Nguyen et al.   NATURE

Cryo-EM structure of the spliceosome immediately after branching

(2016) Wojciech P. Galej et al.   NATURE

Structure of a yeast activated spliceosome at 3.5 A resolution

(2016) C. Yan et al.   SCIENCE

A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity

(2016) Carsten Boesler et al.   Nature Communications

The RNA helicase Aquarius exhibits structural adaptations mediating its recruitment to spliceosomes

(2015) Inessa De et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The RNA helicase Aquarius exhibits structural adaptations mediating its recruitment to spliceosomes

(2015) Inessa De et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Context-dependent control of alternative splicing by RNA-binding proteins

(2014) Xiang-Dong Fu et al.   NATURE REVIEWS GENETICS

Evidence for a group II intron–like catalytic triplex in the spliceosome

(2014) Sebastian M Fica et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNA catalyses nuclear pre-mRNA splicing

(2013) Sebastian M. Fica et al.   NATURE

Crystal structure of Prp8 reveals active site cavity of the spliceosome

(2013) Wojciech P. Galej et al.   NATURE

Rearrangements within human spliceosomes captured after exon ligation

(2013) J. O. Ilagan et al.   RNA

Alternative Splicing of RNA Triplets Is Often Regulated and Accelerates Proteome Evolution

(2012) Robert K. Bradley et al.   PLOS BIOLOGY

Exon and intron definition in pre-mRNA splicing

(2012) Laura De Conti et al.   Wiley Interdisciplinary Reviews-RNA

Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AF

(2011) Cameron D. Mackereth et al.   NATURE

Exon Definition Complexes Contain the Tri-snRNP and Can Be Directly Converted into B-like Precatalytic Splicing Complexes

(2010) Marc Schneider et al.   MOLECULAR CELL

Invariant U2 snRNA Nucleotides Form a Stem Loop to Recognize the Intron Early in Splicing

(2010) Rhonda Perriman et al.   MOLECULAR CELL

Expansion of the eukaryotic proteome by alternative splicing

(2010) Timothy W. Nilsen et al.   NATURE

Human PRP4 kinase is required for stable tri-snRNP association during spliceosomal B complex formation

(2010) Marc Schneider et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Pre-mRNA Processing Reaches Back toTranscription and Ahead to Translation

(2009) Melissa J. Moore et al.   CELL

The Spliceosome: Design Principles of a Dynamic RNP Machine

(2009) Markus C. Wahl et al.   CELL

Alternative isoform regulation in human tissue transcriptomes

(2008) Eric T. Wang et al.   NATURE

Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome

(2008) Rebecca Mathew et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY