Enzymatic methylation of the amide bond

Substrate Plasticity of a Fungal Peptide α-N-Methyltransferase

(2020) Haigang Song et al.   ACS Chemical Biology

Distinct autocatalytic α-N-methylating precursors expand the borosin RiPP family of peptide natural products

(2019) Marissa R. Quijano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Characterization of the Fast and Promiscuous Macrocyclase from Plant PCY1 Enables the Use of Simple Substrates

(2018) Hannes Ludewig et al.   ACS Chemical Biology

Structural basis of ribosomal peptide macrocyclization in plants

(2018) Joel Haywood et al.   eLife

Molecular Basis for Autocatalytic Backbone N-Methylation in RiPP Natural Product Biosynthesis

(2018) Chayanid Ongpipattanakul et al.   ACS Chemical Biology

A molecular mechanism for the enzymatic methylation of nitrogen atoms within peptide bonds

(2018) Haigang Song et al.   Science Advances

Autocatalytic backbone N-methylation in a family of ribosomal peptide natural products

(2017) Niels S van der Velden et al.   Nature Chemical Biology

Characterization of the macrocyclase involved in the biosynthesis of RiPP cyclic peptides in plants

(2017) Jonathan R. Chekan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of a dual function macrocyclase enables design and use of efficient macrocyclization substrates

(2017) Clarissa M. Czekster et al.   Nature Communications

Rule of five in 2015 and beyond: Target and ligand structural limitations, ligand chemistry structure and drug discovery project decisions

(2016) Christopher A. Lipinski   ADVANCED DRUG DELIVERY REVIEWS

Natural supramolecular protein assemblies

(2016) Bas J. G. E. Pieters et al.   CHEMICAL SOCIETY REVIEWS

Gymnopeptides A and B, Cyclic Octadecapeptides from the Mushroom Gymnopus fusipes

(2016) Attila Ványolós et al.   ORGANIC LETTERS

Peptide therapeutics: current status and future directions

(2015) Keld Fosgerau et al.   DRUG DISCOVERY TODAY

Interrupted adenylation domains: unique bifunctional enzymes involved in nonribosomal peptide biosynthesis

(2015) Kristin J. Labby et al.   NATURAL PRODUCT REPORTS

Identification and Characterization of a Welwitindolinone Alkaloid Biosynthetic Gene Cluster in the Stigonematalean CyanobacteriumHapalosiphon welwitschii

(2014) Matthew L. Hillwig et al.   CHEMBIOCHEM

Peptide Macrocyclization Catalyzed by a Prolyl Oligopeptidase Involved in α-Amanitin Biosynthesis

(2014) Hong Luo et al.   CHEMISTRY & BIOLOGY

Opposed Effects of Enzymatic Gliotoxin N- and S-Methylations

(2014) Daniel H. Scharf et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Butelase 1 is an Asx-specific ligase enabling peptide macrocyclization and synthesis

(2014) Giang K T Nguyen et al.   Nature Chemical Biology

N-Methylation of Peptides and Proteins: An Important Element for Modulating Biological Functions

(2012) Jayanta Chatterjee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Architectures, mechanisms and molecular evolution of natural product methyltransferases

(2012) David K. Liscombe et al.   NATURAL PRODUCT REPORTS

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

(2012) Paul G. Arnison et al.   NATURAL PRODUCT REPORTS

The mechanism of patellamide macrocyclization revealed by the characterization of the PatG macrocyclase domain

(2012) Jesko Koehnke et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Tangled Up in Knots: Structures of Inactivated Forms of E. coli Class Ia Ribonucleotide Reductase

(2012) Christina M. Zimanyi et al.   STRUCTURE

N-Methylation of the Amide Bond by Methyltransferase Asm10 in Ansamitocin Biosynthesis

(2011) Yingying Wu et al.   CHEMBIOCHEM

Evolution of a new enzyme for carbon disulphide conversion by an acidothermophilic archaeon

(2011) Marjan J. Smeulders et al.   NATURE

Intramolecular hydrogen bonding to improve membrane permeability and absorption in beyond rule of five chemical space

(2011) Alexander Alex et al.   MedChemComm

Using Marine Natural Products to Discover a Protease that Catalyzes Peptide Macrocyclization of Diverse Substrates

(2009) Jaeheon Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N-Methylation of Peptides: A New Perspective in Medicinal Chemistry

(2008) Jayanta Chatterjee et al.   ACCOUNTS OF CHEMICAL RESEARCH