Recent advances in dissecting the demethylation reactions in natural product biosynthesis

Novel caffeine degradation gene cluster is mega-plasmid encoded in Paraburkholderia caffeinilytica CF1

(2020) Di Sun et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Metabolism and Biological Activities of 4-Methyl-Sterols

(2019) Sylvain Darnet et al.   MOLECULES

The Biosynthesis of Norsesquiterpene Aculenes Requires Three Cytochrome P450 Enzymes to Catalyze a Stepwise Demethylation Process

(2019) Chi-Fang Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biosynthetic Study of Cephalosporin P1 Reveals a Multifunctional P450 Enzyme and a Site-Selective Acetyltransferase

(2019) Zhi-Qin Cao et al.   ACS Chemical Biology

A Single-Turnover Kinetic Study of DNA Demethylation Catalyzed by Fe(II)/α-Ketoglutarate-Dependent Dioxygenase AlkB

(2019) Lyubov Yu. Kanazhevskaya et al.   MOLECULES

Diverging Mechanisms: Cytochrome-P450-Catalyzed Demethylation and γ-Lactone Formation in Bacterial Gibberellin Biosynthesis

(2018) Raimund Nagel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Probing the specificity of CYP112 in bacterial gibberellin biosynthesis

(2018) Raimund Nagel et al.   BIOCHEMICAL JOURNAL

DFT investigation on the metabolic mechanisms of theophylline by cytochrome P450 monooxygenase

(2018) Fan Rao et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Syntheses of Gibberellins A15 and A24, the Key Metabolites in Gibberellin Biosynthesis

(2018) David J.-Y. D. Bon et al.   JOURNAL OF ORGANIC CHEMISTRY

C-4 sterol demethylation enzymes distinguish bacterial and eukaryotic sterol synthesis

(2018) Alysha K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage

(2018) Gao-Qian Wang et al.   Nature Communications

Do two oxidants (ferric-peroxo and ferryl-oxo species) act in the biosynthesis of estrogens? A DFT calculation

(2018) Xiang-Yun Wang et al.   RSC Advances

Glycine Betaine Monooxygenase, an Unusual Rieske-Type Oxygenase System, Catalyzes the Oxidative N -Demethylation of Glycine Betaine in Chromohalobacter salexigens DSM 3043

(2018) Ya-Hui Shao et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Biosynthesis of clinically used antibiotic fusidic acid and identification of two short-chain dehydrogenase/reductases with converse stereoselectivity

(2018) Zhiqin Cao et al.   Acta Pharmaceutica Sinica B

The crystal structure of a new O -demethylase from Sphingobium sp. strain SYK-6

(2017) Ayaka Harada et al.   FEBS Journal

Structure of arylO-demethylase offers molecular insight into a catalytic tyrosine-dependent mechanism

(2017) Amanda C. Kohler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacterial catabolism of lignin-derived aromatics: New findings in a recent decade: Update on bacterial lignin catabolism

(2017) Naofumi Kamimura et al.   Environmental Microbiology Reports

Biosynthesis of helvolic acid and identification of an unusual C-4-demethylation process distinct from sterol biosynthesis

(2017) Jian-Ming Lv et al.   Nature Communications

Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases

(2016) Louise J. Walport et al.   Nature Communications

Sterol Synthesis in Diverse Bacteria

(2016) Jeremy H. Wei et al.   Frontiers in Microbiology

Papaverine 7-O-demethylase, a novel 2-oxoglutarate/Fe2+-dependent dioxygenase from opium poppy

(2015) Scott C. Farrow et al.   FEBS LETTERS

Cytochrome P450 3A Enzymes Catalyze theO6-Demethylation of Thebaine, a Key Step in Endogenous Mammalian Morphine Biosynthesis

(2015) Valerie M. Kramlinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Theoretical study on the N-demethylation mechanism of theobromine catalyzed by P450 isoenzyme 1A2

(2015) Jing Tao et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

A Century of Gibberellin Research

(2015) Peter Hedden et al.   JOURNAL OF PLANT GROWTH REGULATION

Estrogen Formation via H-Abstraction from the O–H Bond of gem-Diol by Compound I in the Reaction of CYP19A1: Mechanistic Scenario Derived from Multiscale QM/MM Calculations

(2015) Kai Xu et al.   ACS Catalysis

Mechanism of the Third Oxidative Step in the Conversion of Androgens to Estrogens by Cytochrome P450 19A1 Steroid Aromatase

(2014) Francis K. Yoshimoto et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

O-Demethylations Catalyzed by Rieske Nonheme Iron Monooxygenases Involve the Difficult Oxidation of a Saturated C–H Bond

(2013) Wenzhi Jiang et al.   ACS Chemical Biology

Mechanism and Catalytic Diversity of Rieske Non-Heme Iron-Dependent Oxygenases

(2013) Sarah M. Barry et al.   ACS Catalysis

Genetic, molecular, and biochemical basis of fungal tropolone biosynthesis

(2012) J. Davison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Steroid-transforming enzymes in fungi

(2011) Katja Kristan et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Biochemistry and occurrence of O-demethylation in plant metabolism

(2011) Jillian M. Hagel   Frontiers in Physiology

Peroxo−Iron Mediated Deformylation in Sterol 14α-Demethylase Catalysis

(2010) Kakali Sen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy

(2010) Jillian M Hagel et al.   Nature Chemical Biology

Dissecting the sterol C-4 demethylation process in higher plants. From structures and genes to catalytic mechanism

(2010) Alain Rahier   STEROIDS