☆ 4.7 Article

Rational design of an oxygen-enriching nanoemulsion for enhanced near-infrared laser activatable photodynamic therapy against hypoxic tumors

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

Journal

COLLOIDS AND SURFACES B-BIOINTERFACES

Volume 198, Issue -, Pages -

Publisher

ELSEVIER

DOI: 10.1016/j.colsurfb.2020.111500

Keywords

Hypoxia; Photodynamic therapy; Nanoemulsion; Near-infrared light; Delivery system

Funding

National Natural Science Foundation of China [61525503, 61835009, 61722508, 61935012, 61620106016]
(Key) Project of Department of Education of Guangdong Province [2016KCXTD007]
Instrumental Analysis Center of Shenzhen University

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Abstract

The novel nanoplatform IR780-P/VV NE developed in this study improves the water solubility and stability of IR780, enhances the efficiency of near-infrared light triggered PDT by increasing reactive oxygen species generation, and has the potential to be a universal platform for loading hydrophobic photosensitizers and improving therapeutic efficacy. The developed nanoemulsions show promising potential for mitigating tumor hypoxia and enhancing the efficiency of oxygen-dependent therapies such as PDT, sonodynamic therapy, and radiotherapy.

Photodynamic therapy (PDT) has emerged as one of the most promising modalities to treat cancers. However, the hypoxic microenvironment in tumors severely limits the efficiency of PDT. IR780 is a near-infrared light activatable photosensitizer for PDT. It has attracted intensive attention owing to its intriguing properties such as mitochondria-targeting ability and fluorescence imaging capability. Nevertheless, its application in tumor treatment is hampered by its low aqueous solubility and poor stability. To address these obstacles, here we designed a novel hierarchical nanoplatform containing a uniquely stable high loading capacity oxygen carrier (perfluoropolyether, in short, PFPE) and IR780. This nanoplatform (IR780-P/VV NE, in abbreviation for IR780-PFPE-in-water nanoemulsion) has no detectable dark cytotoxicity. It not only improves the aqueous solubility and stability of IR780, but also transports oxygen to relieve hypoxia and boosts the efficiency of near-infrared light triggered PDT via augmentation of reactive oxygen species generation. Particularly, the innovative nano-sized oxygen carrier developed in this research, P/W NE, is a potential universal platform for loading hydrophobic photosensitizers (including but not limited to IR780), sonosensitizers, or radiosensitizers, and simultaneously improving the therapeutic efficacy. Our results highlight the intriguing potential of the developed nanoemulsions for mitigating tumor hypoxia and enhancing the efficiencies of oxygen-dependent therapies including PDT, sonodynamic therapy, radiotherapy, and so on.

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Orthogonal Optimization, Characterization, and In Vitro Anticancer Activity Evaluation of a Hydrogen Peroxide-Responsive and Oxygen-Reserving Nanoemulsion for Hypoxic Tumor Photodynamic Therapy

Liang Hong, Jianman Wang, Yi Zhou, Guofu Shang, Tao Guo, Hailong Tang, Jiangmin Li, Yali Luo, Xiangyu Zeng, Zhu Zeng, Zuquan Hu

Summary: Tumor hypoxia can reduce the effectiveness of photodynamic therapy (PDT). Two approaches, in situ oxygen generation and oxygen delivery, have been developed to address this issue. In situ oxygen generation involves using catalysts to decompose excess H2O2 produced by tumors, while oxygen delivery uses substances with high oxygen solubility to transport oxygen. To combine the benefits of both approaches, we developed a nanoemulsion system called CCIPN. CCIPN can store oxygen generated by catalysts for use in PDT, and it shows promise as an oxygen-supplementing PDT nanomaterial.

CANCERS (2023)