Article
Radiology, Nuclear Medicine & Medical Imaging
Halil Komek, Canan Can, Ihsan Kaplan, Cihan Gundogan, Ferat Kepenek, Huseyin Karaoglan, Aykut Demirkiran, Senar Ebinc, Yunus Guzel, Ebubekir Gundes
Summary: [(68) Ga]Ga-DOTA-FAPI-04 PET/CT demonstrates higher sensitivity and specificity in the evaluation of primary lesions and metastases in patients with colorectal cancer.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yue Zhang, Yushan Zhou, Rong Tian, Minggang Su
Summary: The physiological uptake of Ga-68-labeled fibroblast activation protein inhibitor (FAPI) in normal breast tissue has certain characteristics, including diffuse symmetrical uptake and uptake levels related to menstrual status. These findings contribute to the improvement of breast cancer staging accuracy.
MOLECULAR IMAGING AND BIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ruohua Chen, Xinlan Yang, Xiaofeng Yu, Xiang Zhou, Yee Ling Ng, Yumei Chen, Lianghua Li, Yun Zhou, Gang Huang, Jianjun Liu
Summary: Ultra-early and fast imaging showed equivalent tumor detection and lesion uptake compared to traditional [(68) Ga]Ga-FAPI-04 imaging. This method could meet clinical diagnostic requirements for patients with intolerance to prolonged horizontal positioning and waiting time.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Caner Civan, Serkan Kuyumcu, Duygu Has Simsek, Oner Sanli, Emine Goknur Isik, Zeynep Gozde Ozkan, Ozge Hurdogan, Yasemin Sanli
Summary: This study investigates the role of [Ga-68]Ga-FAPI-04 PET/CT in patients with renal cell carcinoma (RCC) and demonstrates its potential utility in providing valuable information for the diagnosis and prognosis of RCC. The results suggest that [Ga-68]Ga-FAPI-04 PET/CT may have promising applications in selected patients.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Guokun Wang, Qinqin Yang, Shengyong Wu, Xudong Xu, Xiao Li, Siyu Liang, Guixia Pan, Changjing Zuo, Xianxian Zhao, Chao Cheng, Suxuan Liu
Summary: [(68) Ga]Ga-FAPI-04 PET/CT can monitor early cardiac fibrosis in pressure overload heart failure and predict the deterioration of cardiac function.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xin Zhou, Shuailiang Wang, Xiaoxia Xu, Xiangxi Meng, Huiyuan Zhang, Annan Zhang, Yufei Song, Hua Zhu, Zhi Yang, Nan Li
Summary: This study compared the clinical staging performance of [(68) Ga]Ga-DOTA-FAPI-04 PET/CT and 2-[F-18]FDG PET/CT in non-small cell lung cancer (NSCLC) patients. The results showed that [(68) Ga]Ga-DOTA-FAPI-04 PET/CT had better staging performance in NSCLC patients, especially in localized disease.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Ihsan Kaplan, Canan Can, Yunus Guzel, Ulas Alabalik, Halil Komek
Summary: F-18-FDG PET/CT and Ga-68-FAPI 04 PET/CT were used for restaging in a 16-year-old boy with malignant mixed germ cell tumor. Results showed that Ga-68-FAPI-04 PET/CT was superior to F-18-FDG PET/CT in the evaluation of metastases in the testicular tumor.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Oncology
Huipan Liu, Zhi Hu, Xiao Yang, Tianyang Dai, Yue Chen
Summary: The study found that [Ga-68]Ga-DOTA-FAPI-04 PET/CT has better diagnostic performance in detecting primary and metastatic lesions of esophageal cancer compared to [F-18]FDG PET/CT. The technology showed higher accuracy in detecting lesions in treatment-naive patients and had higher sensitivity for primary tumors, lymph nodes, and bone and visceral metastases.
FRONTIERS IN ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Goksel Alcin, Esra Arslan, Tamer Aksoy, Merve Cin, Ozge Erol Fenercioglu, Ediz Beyhan, Nurhan Ergul, Tevfik Fikret Cermik
Summary: In this study, the PET findings of F-18-FDG PET/CT were compared with Ga-68-FAPI-04 PET/CT findings in breast cancer patients with low F-18-FDG uptake. The results showed that Ga-68-FAPI-04 PET/CT has higher sensitivity in detecting primary tumors and provides higher SUVmax values. Additionally, this method can contribute to increased detection of lymph node involvement and aid in patient management.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zijun Chen, Yining Wang, Xinlan Yang, Lianghua Li, Yanmiao Huo, Xiaofeng Yu, Xiuying Xiao, Chenpeng Zhang, Yumei Chen, Haitao Zhao, Yun Zhou, Gang Huang, Jianjun Liu, Ruohua Chen
Summary: This study aimed to explore the effect of half-dose [Ga-68]Ga-FAPI-04 on image quality and tumor detectability in oncology patients. The results showed that with a reduced acquisition time of 120 s, half-dose [Ga-68]Ga-FAPI-04 in total-body PET/CT imaging achieved acceptable subjective image quality and 100% tumor detection rate.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Bingxin Gu, Xin Liu, Shuoer Wang, Xiaoping Xu, Xiaosheng Liu, Silong Hu, Wangjun Yan, Zhiguo Luo, Shaoli Song
Summary: This study evaluated the diagnostic value of [(68)Ga]Ga-DOTA-FAPI-04 PET/CT for recurrent soft tissue sarcoma (STS) and compared it with [F-18]FDG PET/CT. The results showed that [(68)Ga]Ga-DOTA-FAPI-04 PET/CT was more accurate than [F-18]FDG PET/CT in detecting recurrent lesions of liposarcoma, MSFT, and IDCS.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Liming Chen, Xiaolin Zhong, Limin Li, Xue Li, Ya Liu, Chunmei Guo, Yue Chen, Zhanwen Huang
Summary: The efficacy of [Ga-68]Ga-FAPI-04 PET/CT in identifying lesions and assessing the progression of Crohn's disease (CD) was evaluated, and the technique was found to be highly sensitive in detecting different classes of lesions in all intestinal segments.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Peipei Wang, Chen Li, Guozhu Hou, Zhaohui Li, Hongli Jing, Wen Zhang, Fang Li
Summary: The study demonstrates that PET/CT is useful in evaluating patients with SAPHO syndrome, a rare inflammatory disorder affecting bone, joints, and skin.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Aleksander Kosmala, Sebastian E. Serfling, Wiebke Schlotelburg, Thomas Lindner, Kerstin Michalski, Andreas Schirbel, Takahiro Higuchi, Philipp E. Hartrampf, Andreas K. Buck, Alexander Weich, Rudolf A. Werner
Summary: The purpose of this study was to compare the impact of FAPI-directed molecular imaging with GCI on staging and therapeutic management in patients with digestive system tumors. The results showed that 68Ga-FAPI-04 PET/CT resulted in staging changes in 46.9% of patients and therapeutic modifications in 25.0% of patients. These findings may favor a more widespread adoption of FAP-directed imaging, especially in patients with HCC and PDAC.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jie Ding, Jiangdong Qiu, Zhixin Hao, Hua Huang, Qiaofei Liu, Wenjing Liu, Chao Ren, Marcus Hacker, Taiping Zhang, Wenming Wu, Li Huo, Xiang Li
Summary: The study aimed to assess the prognostic value of [(68) Ga]Ga-FAPI-04 PET uptake in PDAC and evaluate its correlation with pathological characteristics. The results showed a significant correlation between PET imaging and laboratory findings and pathological characteristics. PET imaging has the potential for postoperative prognostication of PDAC.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
