Switching between biologics in severe asthma patients. When the first choice is not proven to be the best

Antibodies targeting the interleukin-5 signaling pathway used as add-on therapy for patients with severe eosinophilic asthma: a review of the mechanism of action, efficacy, and safety of the subcutaneously administered agents, mepolizumab and benralizumab

(2020) Georgios Hillas et al.   Expert Review of Respiratory Medicine

Safety of Eosinophil-Depleting Therapy for Severe, Eosinophilic Asthma: Focus on Benralizumab

(2020) David J. Jackson et al.   DRUG SAFETY

Biologics in severe asthma: The overlap endotype - Opportunities and challenges

(2020) A Bakakos et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Efficacy of benralizumab for patients with severe eosinophilic asthma: a retrospective, real-life study

(2020) Takanori Numata et al.   BMC Pulmonary Medicine

Disseminated herpes zoster following treatment with benralizumab

(2019) Ajay Kumar Mishra et al.   Clinical Respiratory Journal

The clinical benefit of mepolizumab replacing omalizumab in uncontrolled severe eosinophilic asthma

(2019) Kenneth R. Chapman et al.   ALLERGY

Pregnancy Outcomes in the Omalizumab Pregnancy Registry and a Disease-matched Comparator Cohort

(2019) Jennifer A. Namazy et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Efficacy of Mepolizumab in patients with previous Omalizumab treatment failure: real life observation

(2019) Diego Bagnasco et al.   ALLERGY

Combination biologic therapy for severe persistent asthma

(2019) Gilbert Ortega et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

How to treat patients with chronic spontaneous urticaria with omalizumab: Questions and answers

(2019) Murat Türk et al.   Journal of Allergy and Clinical Immunology-In Practice

New paradigm in asthma management: switching between biologics!

(2019) Manali Mukherjee et al.   ALLERGY

Safety of Reslizumab in Uncontrolled Asthma with Eosinophilia: A Pooled Analysis from 6 Trials

(2019) J. Christian Virchow et al.   Journal of Allergy and Clinical Immunology-In Practice

Update: Mepolizumab treatment in patients with severe eosinophilic asthma and prior omalizumab use

(2019) Frank C. Albers et al.   ALLERGY

ERS/TSANZ Task Force Statement on the Management of Reproduction and Pregnancy in Women with Airways Diseases

(2019) Peter G. Middleton et al.   EUROPEAN RESPIRATORY JOURNAL

Weight-adjusted Intravenous Reslizumab in Severe Asthma with Inadequate Response to Fixed-Dose Subcutaneous Mepolizumab

(2018) Manali Mukherjee et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mepolizumab use

(2018) Mariel R. Benjamin et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma

(2018) Klaus F. Rabe et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma

(2018) Mario Castro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Benralizumab: From the Basic Mechanism of Action to the Potential Use in the Biological Therapy of Severe Eosinophilic Asthma

(2018) Corrado Pelaia et al.   Biomed Research International

Omalizumab Effectiveness by Biomarker Status in Patients with Asthma: Evidence From PROSPERO, A Prospective Real-World Study

(2018) Thomas B. Casale et al.   Journal of Allergy and Clinical Immunology-In Practice

Baseline Patient Factor Impact on the Clinical Efficacy of Benralizumab for Severe Asthma

(2018) Eugene R. Bleecker et al.   EUROPEAN RESPIRATORY JOURNAL

Anti–IL-5 treatments in patients with severe asthma by blood eosinophil thresholds: Indirect treatment comparison

(2018) William Busse et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Reslizumab Compared with Benralizumab in Patients with Eosinophilic Asthma: A Systematic Literature Review and Network Meta-Analysis

(2018) Thomas B. Casale et al.   Journal of Allergy and Clinical Immunology-In Practice

Role of Biologics in Asthma

(2018) Mary Clare McGregor et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Severe uncontrolled eosinophilic asthma, which responded to benralizumab after failure to respond to mepolizumab

(2018) Motohiro Kurosawa et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Matching-adjusted indirect comparison of benralizumab versus interleukin-5 inhibitors for the treatment of severe asthma: a systematic review

(2018) Arnaud Bourdin et al.   EUROPEAN RESPIRATORY JOURNAL

Assessment of the long-term safety of mepolizumab and durability of clinical response in patients with severe eosinophilic asthma

(2018) Sumita Khatri et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial

(2018) William W Busse et al.   Lancet Respiratory Medicine

Biologic agents for severe asthma patients: clinical perspectives and implications

(2017) Massimo Caruso et al.   Internal and Emergency Medicine

Oral Glucocorticoid–Sparing Effect of Benralizumab in Severe Asthma

(2017) Parameswaran Nair et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy of mepolizumab add-on therapy on health-related quality of life and markers of asthma control in severe eosinophilic asthma (MUSCA): a randomised, double-blind, placebo-controlled, parallel-group, multicentre, phase 3b trial

(2017) Geoffrey L Chupp et al.   Lancet Respiratory Medicine

Overlap of atopic, eosinophilic, and TH2-high asthma phenotypes in a general population with current asthma

(2016) Trung N. Tran et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Benralizumab, an anti-interleukin-5 receptor α monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA): a randomised, double-blind, placebo-controlled phase 3 trial

(2016) J Mark FitzGerald et al.   LANCET

Oral Glucocorticoid-Sparing Effect of Mepolizumab in Eosinophilic Asthma

(2014) Elisabeth H. Bel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma

(2014) Hector G. Ortega et al.   NEW ENGLAND JOURNAL OF MEDICINE

Exploring the Effects of Omalizumab in Allergic Asthma

(2013) Nicola A. Hanania et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Effects of benralizumab on airway eosinophils in asthmatic patients with sputum eosinophilia

(2013) Michel Laviolette et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Inhibiting Interleukin-4 and Interleukin-13 in Difficult-to-Control Asthma

(2013) Michael E. Wechsler   NEW ENGLAND JOURNAL OF MEDICINE

Dupilumab in Persistent Asthma with Elevated Eosinophil Levels

(2013) Sally Wenzel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma

(2009) Pranabashis Haldar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mepolizumab for Prednisone-Dependent Asthma with Sputum Eosinophilia

(2009) Parameswaran Nair et al.   NEW ENGLAND JOURNAL OF MEDICINE

The use of omalizumab in the treatment of severe allergic asthma: A clinical experience update

(2009) Stephen Holgate et al.   RESPIRATORY MEDICINE