Safety of Eosinophil-Depleting Therapy for Severe, Eosinophilic Asthma: Focus on Benralizumab

Blood Eosinophil Counts in Clinical Trials for Chronic Obstructive Pulmonary Disease

(2020) Dave Singh et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Disseminated herpes zoster following treatment with benralizumab

(2019) Ajay Kumar Mishra et al.   Clinical Respiratory Journal

Activated Eosinophils Exert Antitumorigenic Activities in Colorectal Cancer

(2019) Hadar Reichman et al.   Cancer Immunology Research

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease: The GOLD Science Committee Report 2019

(2019) Dave Singh et al.   EUROPEAN RESPIRATORY JOURNAL

Benralizumab for PDGFRA-Negative Hypereosinophilic Syndrome

(2019) Fei Li Kuang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Benralizumab for the Prevention of COPD Exacerbations

(2019) Gerard J. Criner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting IL-5 in COPD

(2019) Dharani K. Narendra et al.   International Journal of Chronic Obstructive Pulmonary Disease

2094-P: Decreased Human Adipose Tissue-Resident Eosinophils in Obese Subjects Is Associated with Increased Insulin Resistance

(2019) JAMES D. HERNANDEZ et al.   DIABETES

Management of Severe Asthma: a European Respiratory Society/American Thoracic Society Guideline

(2019) Fernando Holguin et al.   EUROPEAN RESPIRATORY JOURNAL

P221 BENRALIZUMAB TREATMENT IS NOT ASSOCIATED WITH ORAL CORTICOSTEROID–LIKE INCREASES IN WEIGHT AND BLOOD PRESSURE

(2019) J. Kreindler et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Two-year integrated steroid-sparing analysis and safety of benralizumab for severe asthma

(2019) Arnaud Bourdin et al.   JOURNAL OF ASTHMA

Mepolizumab use

(2018) Mariel R. Benjamin et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Eosinophils from Physiology to Disease: A Comprehensive Review

(2018) Giuseppe A. Ramirez et al.   Biomed Research International

Inhaled corticosteroids and risk of upper respiratory tract infection in patients with asthma: a meta-analysis

(2018) Mingjin Yang et al.   INFECTION

Assessment of the long-term safety of mepolizumab and durability of clinical response in patients with severe eosinophilic asthma

(2018) Sumita Khatri et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A systematic review of the adverse events and economic impact associated with oral corticosteroids in asthma

(2018) Khalid Al Efraij et al.   JOURNAL OF ASTHMA

Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial

(2018) William W Busse et al.   Lancet Respiratory Medicine

Changes in eosinophil count during bacterial infection: revisiting an old marker to assess the efficacy of antimicrobial therapy

(2017) B. Davido et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Eosinophils Promote Antiviral Immunity in Mice Infected with Influenza A Virus

(2017) Amali E. Samarasinghe et al.   JOURNAL OF IMMUNOLOGY

Oral Glucocorticoid–Sparing Effect of Benralizumab in Severe Asthma

(2017) Parameswaran Nair et al.   NEW ENGLAND JOURNAL OF MEDICINE

Severe eosinophilic asthma: from the pathogenic role of interleukin-5 to the therapeutic action of mepolizumab

(2017) Corrado Pelaia et al.   Drug Design Development and Therapy

Long-term Safety and Efficacy of Reslizumab in Patients with Eosinophilic Asthma

(2017) Kevin Murphy et al.   Journal of Allergy and Clinical Immunology-In Practice

Eosinophils: The unsung heroes in cancer?

(2017) Gilda Varricchi et al.   OncoImmunology

Targeting Inflammation in Cancer Prevention and Therapy

(2016) J. Todoric et al.   Cancer Prevention Research

Eosinophils in Cancer: Favourable or Unfavourable?

(2016) Samy Sakkal et al.   CURRENT MEDICINAL CHEMISTRY

Lung-resident eosinophils represent a distinct regulatory eosinophil subset

(2016) Claire Mesnil et al.   JOURNAL OF CLINICAL INVESTIGATION

Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting β2-agonists (SIROCCO): a randomised, multicentre, placebo-controlled phase 3 trial

(2016) Eugene R Bleecker et al.   LANCET

Benralizumab, an anti-interleukin-5 receptor α monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA): a randomised, double-blind, placebo-controlled phase 3 trial

(2016) J Mark FitzGerald et al.   LANCET

Reductions in eosinophil biomarkers by benralizumab in patients with asthma

(2016) Tuyet-Hang Pham et al.   RESPIRATORY MEDICINE

Eosinophils in Helminth Infection: Defenders and Dupes

(2016) Lu Huang et al.   TRENDS IN PARASITOLOGY

Severe eosinophilic asthma treated with mepolizumab stratified by baseline eosinophil thresholds: a secondary analysis of the DREAM and MENSA studies

(2016) Hector G Ortega et al.   Lancet Respiratory Medicine

The infiltration and functional regulation of eosinophils induced by TSLP promote the proliferation of cervical cancer cell

(2015) Feng Xie et al.   CANCER LETTERS

Interleukin-5 Facilitates Lung Metastasis by Modulating the Immune Microenvironment

(2015) R. Zaynagetdinov et al.   CANCER RESEARCH

The Eosinophil in Infection

(2015) Karen A. Ravin et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Inflammation Fuels Tumor Progress and Metastasis

(2015) Jingyi Liu et al.   CURRENT PHARMACEUTICAL DESIGN

IL-1β in eosinophil-mediated small intestinal homeostasis and IgA production

(2015) Y Jung et al.   Mucosal Immunology

Sputum eosinophilia is a determinant of FEV1 decline in occupational asthma: results of an observational study

(2015) D. Talini et al.   BMJ Open

Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicentre, parallel, double-blind, randomised, placebo-controlled, phase 3 trials

(2015) Mario Castro et al.   Lancet Respiratory Medicine

Blood eosinophil count and prospective annual asthma disease burden: a UK cohort study

(2015) David B Price et al.   Lancet Respiratory Medicine

The Global Burden of Cancer 2013

(2015) Christina Fitzmaurice et al.   JAMA Oncology

Eosinophils and Type 2 Cytokine Signaling in Macrophages Orchestrate Development of Functional Beige Fat

(2014) Yifu Qiu et al.   CELL

Importance of concomitant local and systemic eosinophilia in uncontrolled asthma

(2014) F. N. Schleich et al.   EUROPEAN RESPIRATORY JOURNAL

Eosinophilic inflammation in COPD: prevalence and clinical characteristics: Table 1–

(2014) Dave Singh et al.   EUROPEAN RESPIRATORY JOURNAL

Eosinophils Promote Generation and Maintenance of Immunoglobulin-A-Expressing Plasma Cells and Contribute to Gut Immune Homeostasis

(2014) Van Trung Chu et al.   IMMUNITY

Asthma and infections: Is the risk more profound than previously thought?

(2014) William W. Busse et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Risks for infection in patients with asthma (or other atopic conditions): Is asthma more than a chronic airway disease?

(2014) Young J. Juhn   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Incidence of malignancy in patients with moderate-to-severe asthma treated with or without omalizumab

(2014) Aidan Long et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Eosinophil Deficiency Compromises Parasite Survival in Chronic Nematode Infection

(2014) V. Fabre et al.   JOURNAL OF IMMUNOLOGY

A Transient Increase in Eosinophils Is Associated with Prolonged Survival in Men with Metastatic Castration-Resistant Prostate Cancer Who Receive Sipuleucel-T

(2014) D. G. McNeel et al.   Cancer Immunology Research

Anti-IL5 therapy for asthma and beyond

(2014) Manali Mukherjee et al.   World Allergy Organization Journal

The consequences of not having eosinophils

(2013) G. J. Gleich et al.   ALLERGY

Activated mouse eosinophils protect against lethal respiratory virus infection

(2013) C. M. Percopo et al.   BLOOD

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

(2013) K. F. Chung et al.   EUROPEAN RESPIRATORY JOURNAL

Effects of benralizumab on airway eosinophils in asthmatic patients with sputum eosinophilia

(2013) Michel Laviolette et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Increased Risk of Herpes Zoster in Children with Asthma: A Population-Based Case-Control Study

(2013) Bong-Seong Kim et al.   JOURNAL OF PEDIATRICS

Induction of Malignant Plasma Cell Proliferation by Eosinophils

(2013) Tina W. Wong et al.   PLoS One

Streptococcus pyogenes upper respiratory infection and atopic conditions other than asthma: a retrospective cohort study

(2012) Young J Juhn et al.   Primary Care Respiratory Journal

Increased risk of pertussis in patients with asthma

(2011) Conrad R. Capili et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Identification of Innate IL-5-Producing Cells and Their Role in Lung Eosinophil Regulation and Antitumor Immunity

(2011) M. Ikutani et al.   JOURNAL OF IMMUNOLOGY

Interleukin-5 and IL-5 receptor in health and diseases

(2011) Kiyoshi TAKATSU   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Host-derived Interleukin-5 Promotes Adenocarcinoma-induced Malignant Pleural Effusion

(2010) Georgios T. Stathopoulos et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Eosinophils in health and disease: the LIAR hypothesis

(2010) J. J. Lee et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Eosinophils as antigen-presenting cells in allergic upper airway disease

(2010) Praveen Akuthota et al.   Current Opinion in Allergy and Clinical Immunology

MEDI-563, a humanized anti–IL-5 receptor α mAb with enhanced antibody-dependent cell-mediated cytotoxicity function

(2010) Roland Kolbeck et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Eosinopenia: Is it a good marker of sepsis in comparison to procalcitonin and C-reactive protein levels for patients admitted to a critical care unit in an urban hospital?

(2010) Hamid Shaaban et al.   JOURNAL OF CRITICAL CARE

Filarial Parasites Develop Faster and Reproduce Earlier in Response to Host Immune Effectors That Determine Filarial Life Expectancy

(2010) Simon A. Babayan et al.   PLOS BIOLOGY

Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma

(2009) Pranabashis Haldar et al.   NEW ENGLAND JOURNAL OF MEDICINE