Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection

A new coronavirus associated with human respiratory disease in China

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A pneumonia outbreak associated with a new coronavirus of probable bat origin

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A Novel Coronavirus from Patients with Pneumonia in China, 2019

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Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

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Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies

(2020) Daniel Wrapp et al.   CELL

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

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A Mouse Model of SARS-CoV-2 Infection and Pathogenesis

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Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion

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A human neutralizing antibody targets the receptor binding site of SARS-CoV-2

(2020) Rui Shi et al.   NATURE

Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody

(2020) Dora Pinto et al.   NATURE

Structures of the portal vertex reveal essential protein-protein interactions for Herpesvirus assembly and maturation

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Architecture of the herpesvirus genome-packaging complex and implications for DNA translocation

(2020) Yunxiang Yang et al.   Protein & Cell

Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies

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Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike

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A thermostable, closed SARS-CoV-2 spike protein trimer

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Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies

(2020) Alina Baum et al.   SCIENCE

Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model

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Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody

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Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability

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Broad neutralization of SARS-related viruses by human monoclonal antibodies

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Serotype specific epitopes identified by neutralizing antibodies underpin immunogenic differences in Enterovirus B

(2020) Kang Wang et al.   Nature Communications

Structures of Echovirus 30 in complex with its receptors inform a rational prediction for enterovirus receptor usage

(2020) Kang Wang et al.   Nature Communications

Structure-based development of human antibody cocktails against SARS-CoV-2

(2020) Nan Wang et al.   CELL RESEARCH

Architecture of African swine fever virus and implications for viral assembly

(2019) Nan Wang et al.   SCIENCE

Structural basis for neutralization of Japanese encephalitis virus by two potent therapeutic antibodies

(2018) Xiaodi Qiu et al.   Nature Microbiology

Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site

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Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Pre-fusion structure of a human coronavirus spike protein

(2016) Robert N. Kirchdoerfer et al.   NATURE

Structure, Function, and Evolution of Coronavirus Spike Proteins

(2016) Fang Li   Annual Review of Virology

Quantifying the local resolution of cryo-EM density maps

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Towards automated crystallographic structure refinement withphenix.refine

(2012) Pavel V. Afonine et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Prevention of overfitting in cryo-EM structure determination

(2012) Sjors H W Scheres et al.   NATURE METHODS

UCSF Chimera, MODELLER, and IMP: An integrated modeling system

(2011) Zheng Yang et al.   JOURNAL OF STRUCTURAL BIOLOGY

MolProbity: all-atom structure validation for macromolecular crystallography

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