Article
Virology
Shibo Li, Jianbo Wu, Weiyu Jiang, Haiyan He, Yunjiao Zhou, Wei Wu, Yidan Gao, Minxiang Xie, Anqi Xia, Jiaying He, Qianqian Zhang, Yuru Han, Nan Wang, Guangqi Zhu, Qiujing Wang, Zheen Zhang, Christian T. Mayer, Kang Wang, Xiangxi Wang, Junqing Wang, Zhenguo Chen, Shibo Jiang, Lei Sun, Rong Xia, Qiao Wang
Summary: Isolation of monoclonal antibodies (mAbs) from a convalescent donor revealed cross-reactivity against both SARS-CoV-1 and SARS-CoV-2, with broad binding capacity and cross-neutralizing potency against various SARS-CoV-2 variants of concern (VOCs). However, these antibodies were ineffective against the Omicron variant and its sublineages, which efficiently evade antibodies cross-reactive against SARS-CoV-1. Evaluation of cross-reactive bNAbs showed a negative correlation between neutralizing activities against SARS-CoV-1 and SARS-CoV-2 Omicron, highlighting the importance of cross-neutralization for the design of pan-sarbecovirus vaccines and bNAbs.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Biochemical Research Methods
Aimee Lehman, Virginia A. Muniz, Ryan Chaney, Joseph Pimentel, John Mattila, Shawn Lawrence
Summary: Neutralizing antibodies are effective in treating infectious diseases, and their development is crucial for combating emerging diseases like COVID-19. Regeneron and Genentech successfully addressed the challenges of process development and technology transfer in a compressed timeline, allowing the clinical manufacturing of casirivimab and imdevimab.
CURRENT OPINION IN BIOTECHNOLOGY
(2022)
Article
Immunology
Collin Jugler, Haiyan Sun, Francisca Grill, Karen Kibler, Adrian Esqueda, Huafang Lai, Yize Li, Douglas Lake, Qiang Chen
Summary: In this study, researchers developed an antibody cocktail against SARS-CoV-2 using Nicotiana benthamiana plants. The cocktail, consisting of two monoclonal antibodies, showed high expression in plants and effectively neutralized multiple variants of the virus. This work demonstrates the potential of using plant-based production for the development of affordable and efficacious mAb cocktails against emerging viral diseases.
Article
Biology
Chunyun Sun, Hang Chi, Fei Yuan, Jing Li, Ji Yang, Aihua Zheng, Fei Wang, Lingling Sun, Yanjing Zhang, Ping Hu, Lihua Jiao, Yongqiang Deng, Liangzhi Xie
Summary: This study developed a new antibody cocktail with potent neutralizing activities against a broad spectrum of SARS-CoV-2 variants. The cocktail showed more effective protection than monotherapy and prevented mutational escape in vitro. However, it lost its potency against the Omicron variant, suggesting the need to search for more conserved epitopes.
SCIENCE CHINA-LIFE SCIENCES
(2023)
Article
Virology
Pragya D. Yadav, Sanjeev Kumar Mendiratta, Sreelekshmy Mohandas, Arun K. Singh, Priya Abraham, Anita Shete, Sanjay Bandyopadhyay, Sanjay Kumar, Aashini Parikh, Pankaj Kalita, Vibhuti Sharma, Hardik Pandya, Chirag G. Patel, Mihir Patel, Swagat Soni, Suresh Giri, Mukul Jain
Summary: A monoclonal antibody cocktail (ZRC-3308) has been developed for COVID-19 treatment, showing neutralizing efficacy against various SARS-CoV-2 variants and demonstrating prophylactic and therapeutic activity in Syrian hamsters.
Article
Immunology
Qing Ye, Mei Wu, Chao Zhou, Xishan Lu, Baoying Huang, Ning Zhang, Hui Zhao, Hang Chi, Xiaojing Zhang, Dandan Ling, Rong-Rong Zhang, Zhuofan Li, Dan Luo, Yi-Jiao Huang, Hong-Ying Qiu, Haifeng Song, Wenjie Tan, Ke Xu, Bo Ying, Cheng-Feng Qin
Summary: This study developed a combined vaccine against COVID-19 and influenza, using the LNP-mRNA vaccine platform, and successfully protected mice from coinfection with SARS-CoV-2 and influenza.
Article
Cell Biology
Kang-Hao Liang, Pao-Yin Chiang, Shih-Han Ko, Yu-Chi Chou, Ruei-Min Lu, Hsiu-Ting Lin, Wan-Yu Chen, Yi-Ling Lin, Mi-Hua Tao, Jia-Tsrong Jan, Han-Chung Wu
Summary: The study showed that six antibodies had varying binding and neutralizing abilities against SARS-CoV-2 variants, with antibody cocktails demonstrating potent neutralizing activities and potential therapeutic and prophylactic effects against multiple variants.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Article
Immunology
Wael Bahnan, Sebastian Wrighton, Martin Sundwall, Anna Blackberg, Olivia Larsson, Urban Hoglund, Hamed Khakzad, Magdalena Godzwon, Maria Walle, Elisabeth Elder, Anna Soderlund Strand, Lotta Happonen, Oscar Andre, Johannes Kumra Ahnlide, Thomas Hellmark, Vidar Wendel-Hansen, Robert PA. Wallin, Johan Malmstom, Lars Malmstrom, Mats Ohlin, Magnus Rasmussen, Pontus Nordenfelt
Summary: The concentration of Spike-specific antibodies can enhance or reduce Spike-bead phagocytosis by monocytes, independent of antibody neutralization potential. The levels of anti-Spike antibodies correlate with the outcome in an experimental SARS-CoV-2 infection model, suggesting that non-neutralizing antibodies could confer protection to SARS-CoV-2 infection by mediating phagocytosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Jonathan L. Torres, Gabriel Ozorowski, Emanuele Andreano, Hejun Liu, Jeffrey Copps, Giulia Piccini, Lorena Donnici, Matteo Conti, Cyril Planchais, Delphine Planas, Noemi Manganaro, Elisa Pantano, Ida Paciello, Piero Pileri, Timothee Bruel, Emanuele Montomoli, Hugo Mouquet, Olivier Schwartz, Claudia Sala, Raffaele De Francesco, Ian A. Wilson, Rino Rappuoli, Andrew B. Ward
Summary: As the COVID-19 pandemic continues, highly potent monoclonal antibodies are needed to combat SARS-CoV-2 variants of concern. This study evaluates the efficacy of mAb J08 against these variants and investigates the binding details using cryo-EM and X-ray crystallography. The results demonstrate that mAb J08 has strong affinity against most variants and binds at a specific location on the receptor binding domain, away from the mutation sites. These findings further support the use of mAb J08 as a monoclonal therapy in ongoing clinical trials.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Antonio Leidi, Flora Koegler, Roxane Dumont, Richard Dubos, Maria-Eugenia Zaballa, Giovanni Piumatti, Matteo Coen, Amandine Berner, Pauline Darbellay Farhoumand, Pauline Vetter, Nicolas Vuilleumier, Laurent Kaiser, Delphine Courvoisier, Andrew S. Azman, Idris Guessous, Silvia Stringhini
Summary: This study found that seroconversion after SARS-CoV-2 infection provides protection against reinfection lasting at least 8 months. These findings could aid global health authorities in prioritizing vaccine allocation.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Ramon Roozendaal, Laura Solforosi, Daniel Stieh, Jan Serroyen, Roel Straetemans, Anna Dari, Muriel Boulton, Frank Wegmann, Sietske K. Rosendahl Huber, Joan E. M. van der Lubbe, Jenny Hendriks, Mathieu le Gars, Liesbeth Dekking, Dominika N. Czapska-Casey, Nuria Guimera, Sarah Janssen, Sarah Tete, Abishek Chandrashekar, Noe Mercado, Jingyou Yu, Wouter Koudstaal, Juan J. Perez-Ruixo, Jerry Sadoff, Dan H. Barouch, Hanneke Schuitemaker, Roland Zahn
Summary: The study examines the immune response and protection provided by the Ad26.COV2.S vaccine in rhesus macaques, finding that the levels of Spike-binding and neutralizing antibodies can predict durable protection against SARS-CoV-2 replication in the lungs. The results suggest that CoP could help predict the durability of protection in humans vaccinated with Ad26.COV2.S.
NATURE COMMUNICATIONS
(2021)
Article
Biology
Jiao Chen, Fei Wu, Dan Lin, Weikang Kong, Xueting Cai, Jie Yang, Xiaoyan Sun, Peng Cao
Summary: This study optimized antibodies through virtual scanning and molecular dynamics simulations, identifying two mutants with higher binding affinities against SARS-CoV-2 and potential neutralizing activity against the variant N501Y.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Virology
Yuanyuan Qu, Xueyan Zhang, Meiyu Wang, Lina Sun, Yongzhong Jiang, Cheng Li, Wei Wu, Zhen Chen, Qiangling Yin, Xiaolin Jiang, Yang Liu, Chuan Li, Jiandong Li, Tianlei Ying, Dexin Li, Faxian Zhan, Youchun Wang, Wuxiang Guan, Shiwen Wang, Mifang Liang
Summary: The study identified two high-affinity antibodies generated from convalescent donors that showed effective neutralization against SARS-CoV-2, including variants such as B.1.1.7 and B.1.351. The cocktail of these antibodies demonstrated broad neutralizing activity and potential therapeutic basis against emerging SARS-CoV-2 variants.
Article
Infectious Diseases
Hiroaki Sasaki, Nobuyuki Miyata, Yukihiro Yoshimura, Natsuo Tachikawa
Summary: This study evaluated the antibody titers among COVID-19 patients treated with REGN-COV. The results showed an elevation of IgG(SP) after REGN-COV administration, which was correlated with the reciprocal of ideal body weight.
Article
Microbiology
Opeyemi S. Adeniji, Leila B. Giron, Mansi Purwar, Netanel F. Zilberstein, Abhijeet J. Kulkarni, Maliha W. Shaikh, Robert A. Balk, James N. Moy, Christopher B. Forsyth, Qin Liu, Harsh Dweep, Andrew Kossenkov, David B. Weiner, Ali Keshavarzian, Alan Landay, Mohamed Abdel-Mohsen
Summary: The study suggests that qualitative differences in SARS-CoV-2-specific antibody-mediated innate immune functions may contribute to COVID-19 severity, with higher ADCD associated with higher inflammation and higher ADCP associated with lower inflammation. Understanding these qualitative features of antibodies could be crucial for developing effective and safe COVID-19 therapeutics and vaccines.
Article
Gastroenterology & Hepatology
Liang-Jie Tang, Gang Li, Mohammed Eslam, Pei-Wu Zhu, Sui-Dan Chen, Howard Ho-Wai Leung, Ou-Yang Huang, Grace Lai-Hung Wong, Yu-Jie Zhou, Morten Karsdal, Diana Julie Leeming, Pei Jiang, Cong Wang, Hai-Yang Yuan, Christopher D. Byrne, Giovanni Targher, Jacob George, Vincent Wai-Sun Wong, Ming-Hua Zheng
Summary: This study developed a novel sequential algorithm based on PRO-C3 to identify liver inflammation and fibrosis in MAFLD patients. The algorithm performed well in high-risk patients and can be used to screen high-risk MAFLD patients for clinical trials and emerging pharmacotherapies.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Immunology
Xuan Luo, Xunyao Wu, Anqi Wang, Yingying Chen, Yu Peng, Chuiwen Deng, Lidan Zhao, Huaxia Yang, Jiaxin Zhou, Linyi Peng, Qingjun Wu, Mengtao Li, Yan Zhao, Xiaofeng Zeng, Wen Zhang, Yunyun Fei
Summary: This study revealed that B cells from patients with pSS are more metabolically active than those from healthy controls. The glycolysis pathway and mTORC1-GLUT1 pathway were identified as major drivers of B cell hyperactivation and autoantibody production in pSS patients.
Review
Oncology
Luxi Yin, Haozhe Li, Linlin Shi, Keda Chen, Hongming Pan, Weidong Han
Summary: The systematic treatment of colorectal cancer still has room for improvement. Nanomaterials as carriers can enhance the bioavailability of anticancer drugs and enable precise targeted delivery. They can also produce synergistic effects with anticancer drugs. Modified nanocarriers can activate the immune microenvironment and have therapeutic potential in CRC treatment. Nanodrugs regulating microbial function have also been explored as an anticancer strategy.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Surgery
Lang Shi, Zhixia Song, Yuzhen Li, Jing Huang, Fan Zhao, Yanwen Luo, Juan Wang, Fangjing Deng, Halinuer Shadekejiang, Mingjiao Zhang, Shengyu Dong, Xiongfei Wu, Jiefu Zhu
Summary: Ischemia/reperfusion injury (IRI) often occurs after kidney transplantation, causing delayed graft function (DGF). MicroRNAs, especially miR-20a-5p, play a significant role in the development of ischemia/reperfusion-induced acute kidney injury and DGF. This study discovered that miR-20a-5p is upregulated in acute kidney injury mice and DGF patients' kidneys. The experiment also showed that the mimic of miR-20a-5p could attenuate IRI and renal fibrosis, while the inhibitor of miR-20a-5p aggravated the injuries. Moreover, the study found that miR-20a-5p is a negative regulator of ACSL4, which is involved in ferroptosis, a type of cell death, suggesting a potential therapeutic application in kidney transplantation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Immunology
Yanwen Luo, Jiefu Zhu, Fan Zhao, Lang Shi, Yuzhen Li, Xiongfei Wu
Summary: This study investigated the role of PIM1 in renal ischemia-reperfusion injury (IRI) and its downstream regulatory mechanism. The study found that PIM1 expression was significantly upregulated in renal IRI mouse model and in renal tubular cell HR model. Overexpression of PIM1 ameliorated renal IRI, possibly through the ASK1-MAPK pathway. Therefore, PIM1 may be a potential therapeutic target for renal IRI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yifei Wang, Hengshuo Ge, Naveed Ahmad, Jia Li, Yijin Wang, Xinyi Liu, Weican Liu, Xiaowei Li, Nan Wang, Fawei Wang, Yuanyuan Dong
Summary: This study identified MADS-box transcription factors in safflower and characterized a putative CtMADS24 gene during vegetative and reproductive growth. The CtMADS24 gene was found to play an important regulatory role in floral organ development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Rongli Li, Yingying Chen, Shangzhu Zhang, Linyi Peng, Jiaxin Zhou, Yunyun Fei, Wen Zhang, Yan Zhao, Xiaofeng Zeng
Summary: This study aimed to investigate the clinical characteristics, potential risk factors, and long-term outcomes in EGPA patients with gastrointestinal (GI) involvement. The results showed that EGPA patients with GI involvement had higher levels of hs-CRP, higher grades of BVAS and FFS scores compared to those without GI involvement. During the follow-up period, EGPA patients with GI involvement had lower cumulative survival rate, lower long-term remission rate, and higher cumulative relapse rate.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Surgery
Xu Zhu, Yijie Shao, Yun Lu, Jiajia Sun, Jie Chen
Summary: This study compared the efficacy of four different posterior approaches for treating type A thoracolumbar fractures. It was found that all four approaches were effective, but each had its own advantages and disadvantages. Proper selection of the approach is crucial for patient outcomes.
FRONTIERS IN SURGERY
(2023)
Article
Environmental Sciences
Xiangping Chen, Siyu Liu, Yan Luo
Summary: This study evaluated the health risks of arsenic-contaminated substances in drinking water and wheat-based food intake in the Guanzhong Plain, China. The results showed that a high percentage of water samples exceeded the drinking water limit, and a small percentage of wheat samples exceeded the food limit for arsenic. Probabilistic health risk assessment was found to be more reliable than deterministic assessment. The study concluded that drinking water and consumption of arsenic-containing wheat increased both cancer and non-cancer risks.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Engineering, Civil
Yun Zhou, Zhangyan Chen, Genquan Zhong
Summary: A Damped Masonry Infill Wall (DMIW) configuration is developed by subdividing the traditional masonry infill wall (MIW) horizontally and introducing a damping layer joint (DLJ) into the wall. The optimized material for the DLJ is determined through shear-hysteretic testing. Quasi-static testing shows that DMIW can reduce damage levels, lateral force, and stiffness, proving its potential for improving the seismic performance of frame structures.
ENGINEERING STRUCTURES
(2023)
Article
Virology
Dan Li, Hai-Tao Lu, Yu-Zhen Ding, Hong-Jiang Wang, Jing-Long Ye, Cheng-Feng Qin, Zhong-Yu Liu
Summary: The regulatory mechanisms of genome cyclization in yellow fever virus (YFV) are not fully understood. This study found that a group of cis-acting RNA elements balance genome cyclization to govern efficient viral RNA replication in YFV, highlighting the importance of RNA-based regulatory mechanisms in viral replication.
JOURNAL OF VIROLOGY
(2023)
Article
Dermatology
Xiao-Jia Liu, Ying Lei, Michael H. Gold, Jun Tan
Summary: The study aimed to investigate the efficacy and safety of pulsed dye laser (PDL) combined with fractional CO2 laser in treating burn scars in pediatric patients. A total of 60 pediatric patients with burn scars were enrolled in the study. The combination treatment showed good efficacy in improving scar condition with high patient satisfaction and no severe complications.
LASERS IN SURGERY AND MEDICINE
(2023)
Article
Endocrinology & Metabolism
Jianhua Li, Jing Chen, Shuang Tian, Tingting Jiao, Jianye Wang, Yan Wei, Yanbin Cheng, Ye Xu, Ri-Cheng Chian, Youzhu Li, Shuiwen Zhang
Summary: This study evaluated the embryonic development and clinical outcomes of different sperm sources in cycles of in vitro maturation-intracytoplasmic sperm injection (IVM-ICSI). The results showed that the sperm sources, including ejaculated sperm, percutaneous epididymal sperm aspiration (PESA), and testicular sperm aspiration (TESA), did not affect the fertilization rate, cleavage rate, embryo quality, implantation rate, clinical pregnancy rate, and live birth rate in IVM-ICSI cycles.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Oncology
Danhua Zhu, Xiaoxi Ouyang, Yanhong Zhang, Xiaopeng Yu, Kunkai Su, Lanjuan Li
Summary: Long noncoding RNAs (lncRNAs) are noncoding RNAs with a length of more than 200 nucleotides. Dysregulation of lncRNAs is involved in various diseases, and is closely associated with patient clinical features. EGFR-AS1, a lncRNA, is aberrantly expressed in many types of cancers and is associated with multiple clinical characteristics. It regulates various cellular activities, making it a promising marker for cancer management.
FRONTIERS IN ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Yongwei Liu, Yan Li, Jing Xie
Summary: A systematic pharmacological study was conducted to uncover the potential pharmacological targets of baweixiaoyaosan for treating major depressive disorder (MDD). Through data mining and evaluation systems, 133 potential active compounds were identified. The target prediction model based on random forest and support vector machine methods was used to identify the targets of these compounds. Herbal ingredient-target networks and target-disease networks were constructed, and gene ontology enrichment analysis, tissue location analysis, and pathway analysis were performed on potential targets. The study revealed the multi-directional treatment methods and the specific functions of different herbs in the formula.
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2023)
