SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells

The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2

(2020) Liang Chen et al.   CARDIOVASCULAR RESEARCH

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Patch-Seq Links Single-Cell Transcriptomes to Human Islet Dysfunction in Diabetes

(2020) Joan Camunas-Soler et al.   Cell Metabolism

COVID-19 in People With Diabetes: Urgently Needed Lessons From Early Reports

(2020) Matthew C. Riddle et al.   DIABETES CARE

Decreased pancreatic acinar cell number in type 1 diabetes

(2020) Jordan J. Wright et al.   DIABETOLOGIA

Phenotypic characteristics and prognosis of inpatients with COVID-19 and diabetes: the CORONADO study

(2020) Bertrand Cariou et al.   DIABETOLOGIA

Coronavirus Infections and Type 2 Diabetes—Shared Pathways with Therapeutic Implications

(2020) Daniel J Drucker   ENDOCRINE REVIEWS

Pancreatic injury patterns in patients with COVID-19 pneumonia

(2020) Fan Wang et al.   GASTROENTEROLOGY

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

(2020) Jun Lan et al.   NATURE

SARS-COV-2 associated acute pancreatitis: Cause, consequence or epiphenomenon?

(2020) Glenn Kunnath Bonney et al.   PANCREATOLOGY

Cell entry mechanisms of SARS-CoV-2

(2020) Jian Shang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes

(2020) Ruochen Zang et al.   Science Immunology

Newly diagnosed diabetes and diabetic ketoacidosis precipitated by COVID-19 infection

(2020) Ashley I. Heaney et al.   AMERICAN JOURNAL OF EMERGENCY MEDICINE

Shedding Light on COVID-19

(2020) Brittany Schreiber et al.   AMERICAN JOURNAL OF THERAPEUTICS

A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids

(2020) Liuliu Yang et al.   Cell Stem Cell

High prevalence of COVID-19-associated diabetic ketoacidosis in UK secondary care

(2020) Nina Goldman et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Diabetic ketoacidosis precipitated by Covid-19 in a patient with newly diagnosed diabetes mellitus

(2020) Ying Jie Chee et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Fasting blood glucose at admission is an independent predictor for 28-day mortality in patients with COVID-19 without previous diagnosis of diabetes: a multi-centre retrospective study

(2020) Sufei Wang et al.   DIABETOLOGIA

Mild Pancreatic Enzyme Elevations in COVID-19 Pneumonia: Synonymous with Injury or Noise?

(2020) Aditya Ashok et al.   GASTROENTEROLOGY

Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19)

(2020) W. Joost Wiersinga et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Pancreatic injury in the course of coronavirus disease 2019: A not‐so‐rare occurrence

(2020) Giuseppe Bruno et al.   JOURNAL OF MEDICAL VIROLOGY

The protein expression profile of ACE2 in human tissues

(2020) Feria Hikmet et al.   Molecular Systems Biology

Extrapulmonary manifestations of COVID-19

(2020) Aakriti Gupta et al.   NATURE MEDICINE

COVID-19 presenting as acute pancreatitis: Lessons from a patient in Iran

(2020) Sedighe Karimzadeh et al.   PANCREATOLOGY

Practical recommendations for the management of diabetes in patients with COVID-19

(2020) Stefan R Bornstein et al.   Lancet Diabetes & Endocrinology

COVID-19 in people with diabetes: understanding the reasons for worse outcomes

(2020) Matteo Apicella et al.   Lancet Diabetes & Endocrinology

Risk factors for COVID-19-related mortality in people with type 1 and type 2 diabetes in England: a population-based cohort study

(2020) Naomi Holman et al.   Lancet Diabetes & Endocrinology

Associations of type 1 and type 2 diabetes with COVID-19-related mortality in England: a whole-population study

(2020) Emma Barron et al.   Lancet Diabetes & Endocrinology

The MERS-CoV Receptor DPP4 as a Candidate Binding Target of the SARS-CoV-2 Spike

(2020) Yu Li et al.   iScience

SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

(2020) Thomas Mandel Clausen et al.   CELL

Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus Macaques

(2020) Malika Aid et al.   CELL

New-Onset Type 1 Diabetes in Children During COVID-19: Multicenter Regional Findings in the U.K.

(2020) Rebecca Unsworth et al.   DIABETES CARE

Beta cell dysfunction in diabetes: the islet microenvironment as an unusual suspect

(2020) Joana Almaça et al.   DIABETOLOGIA

Targeted therapy strategies against SARS-CoV-2 cell entry mechanisms: A systematic review of in vitro and in vivo studies

(2020) Simin Seyedpour et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Tissue-specific and interferon-inducible expression of nonfunctional ACE2 through endogenous retroelement co-option

(2020) Kevin W. Ng et al.   NATURE GENETICS

Interferons and viruses induce a novel truncated ACE2 isoform and not the full-length SARS-CoV-2 receptor

(2020) Olusegun O. Onabajo et al.   NATURE GENETICS

COVID-19 and diabetes: a co-conspiracy?

(2020) The Lancet Diabetes & Endocrinology   Lancet Diabetes & Endocrinology

Impact of Comorbidities on SARS-CoV-2 Viral Entry-Related Genes

(2020) Joshua Breidenbach et al.   Journal of Personalized Medicine

Expression of SARS-CoV-2 Entry Factors in the Pancreas of Normal Organ Donors and Individuals with COVID-19

(2020) Irina Kusmartseva et al.   Cell Metabolism

Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells

(2019) Gopika G. Nair et al.   NATURE CELL BIOLOGY

NIH Initiative to Improve Understanding of the Pancreas, Islet, and Autoimmunity in Type 1 Diabetes: The Human Pancreas Analysis Program (HPAP)

(2019) Klaus H. Kaestner et al.   DIABETES

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

The Pericyte of the Pancreatic Islet Regulates Capillary Diameter and Local Blood Flow

(2018) Joana Almaça et al.   Cell Metabolism

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes

(2018) Marcela Brissova et al.   Cell Reports

Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling

(2017) Chunhua Dai et al.   JOURNAL OF CLINICAL INVESTIGATION

Single-cell sequencing reveals dissociation-induced gene expression in tissue subpopulations

(2017) Susanne C van den Brink et al.   NATURE METHODS

Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function

(2016) H. Efsun Arda et al.   Cell Metabolism

Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes

(2016) Åsa Segerstolpe et al.   Cell Metabolism

A Single-Cell Transcriptomic Map of the Human and Mouse Pancreas Reveals Inter- and Intra-cell Population Structure

(2016) Maayan Baron et al.   Cell Systems

Droplet Barcoding for Single-Cell Transcriptomics Applied to Embryonic Stem Cells

(2015) Allon M. Klein et al.   CELL

Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets

(2015) David M. Blodgett et al.   DIABETES

Islet Microenvironment, Modulated by Vascular Endothelial Growth Factor-A Signaling, Promotes β Cell Regeneration

(2014) Marcela Brissova et al.   Cell Metabolism

Full-length RNA-seq from single cells using Smart-seq2

(2014) Simone Picelli et al.   Nature Protocols

Binding of SARS coronavirus to its receptor damages islets and causes acute diabetes

(2009) Jin-Kui Yang et al.   ACTA DIABETOLOGICA

Viral Trigger for Type 1 Diabetes: Pros and Cons

(2008) C. M. Filippi et al.   DIABETES