CRL4DCAF8 dependent opposing stability control over the chromatin remodeler LSH orchestrates epigenetic dynamics in ferroptosis

Ferroptosis as a target for protection against cardiomyopathy

(2019) Xuexian Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic regulation of ferroptosis by H2B monoubiquitination and p53

(2019) Yufei Wang et al.   EMBO REPORTS

NRF2 and the Hallmarks of Cancer

(2018) Montserrat Rojo de la Vega et al.   CANCER CELL

Tethering of Lsh at the Oct4 locus promotes gene repression associated with epigenetic changes

(2018) Jianke Ren et al.   Epigenetics

TRAF-interacting protein with forkhead-associated domain (TIFA) transduces DNA damage–induced activation of NF-κB

(2018) Jingxuan Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vpr Targets TET2 for Degradation by CRL4 VprBP E3 Ligase to Sustain IL-6 Expression and Enhance HIV-1 Replication

(2018) Lei Lv et al.   MOLECULAR CELL

BAP1 links metabolic regulation of ferroptosis to tumour suppression

(2018) Yilei Zhang et al.   NATURE CELL BIOLOGY

Emerging roles of linker histones in regulating chromatin structure and function

(2017) Dmitry V. Fyodorov et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TOP2A , HELLS , ATAD2 , and TET3 Are Novel Prognostic Markers in Renal Cell Carcinoma

(2017) Dong Chen et al.   UROLOGY

EGLN1/c-Myc Induced Lymphoid-Specific Helicase Inhibits Ferroptosis through Lipid Metabolic Gene Expression Changes

(2017) Yiqun Jiang et al.   Theranostics

DDM1 and Lsh remodelers allow methylation of DNA wrapped in nucleosomes

(2017) David B Lyons et al.   eLife

Chromatin Remodeling Factor LSH Drives Cancer Progression by Suppressing the Activity of Fumarate Hydratase

(2016) Xiaozhen He et al.   CANCER RESEARCH

Epigenetic Mechanisms of Longevity and Aging

(2016) Payel Sen et al.   CELL

Ferroptosis is an autophagic cell death process

(2016) Minghui Gao et al.   CELL RESEARCH

Tumour hypoxia causes DNA hypermethylation by reducing TET activity

(2016) Bernard Thienpont et al.   NATURE

De novo DNA methylation drives 5hmC accumulation in mouse zygotes

(2016) Rachel Amouroux et al.   NATURE CELL BIOLOGY

Nucleation of DNA repair factors by FOXA1 links DNA demethylation to transcriptional pioneering

(2016) Yu Zhang et al.   NATURE GENETICS

Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

Gene-expression analysis of gleason grade 3 tumor glands embedded in low- and high-risk prostate cancer

(2016) A. Marije Hoogland et al.   Oncotarget

Mammalian lipoxygenases and their biological relevance

(2015) Hartmut Kuhn et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death

(2015) Min-Young Kwon et al.   Oncotarget

Chromatin remodelers HELLS and UHRF1 mediate the epigenetic deregulation of genes that drive retinoblastoma tumor progression

(2015) Claudia A. Benavente et al.   Oncotarget

Tumor Suppression by the Fbw7 Ubiquitin Ligase: Mechanisms and Opportunities

(2014) Ryan J. Davis et al.   CANCER CELL

Cellular mechanisms and physiological consequences of redox-dependent signalling

(2014) Kira M. Holmström et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mutation of HELLS, a Chromatin Remodeling Gene, Gastric and Colorectal Cancers

(2014) Youn Jin Choi et al.   PATHOLOGY & ONCOLOGY RESEARCH

The Arabidopsis Nucleosome Remodeler DDM1 Allows DNA Methyltransferases to Access H1-Containing Heterochromatin

(2013) Assaf Zemach et al.   CELL

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Dynamic Readers for 5-(Hydroxy)Methylcytosine and Its Oxidized Derivatives

(2013) Cornelia G. Spruijt et al.   CELL

FOXA1 mediates p16INK4a activation during cellular senescence

(2013) Qian Li et al.   EMBO JOURNAL

TET enzymes, TDG and the dynamics of DNA demethylation

(2013) Rahul M. Kohli et al.   NATURE

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

The SNF2 family ATPase LSH promotes phosphorylation of H2AX and efficient repair of DNA double-strand breaks in mammalian cells

(2012) Joe Burrage et al.   JOURNAL OF CELL SCIENCE

Physiological Roles of Mitochondrial Reactive Oxygen Species

(2012) Laura A. Sena et al.   MOLECULAR CELL

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

Epigenetics and the environment: emerging patterns and implications

(2012) Robert Feil et al.   NATURE REVIEWS GENETICS

ΔNp63α Is an Oncogene that Targets Chromatin Remodeler Lsh to Drive Skin Stem Cell Proliferation and Tumorigenesis

(2011) William M. Keyes et al.   Cell Stem Cell

The SNF2-like helicase HELLS mediates E2F3-dependent transcription and cellular transformation

(2011) Björn von Eyss et al.   EMBO JOURNAL

Linking expression of FOXM1, CEP55 and HELLS to tumorigenesis in oropharyngeal squamous cell carcinoma

(2011) Jeffrey R. Janus et al.   LARYNGOSCOPE

Curing APL through PML/RARA degradation by As2O3

(2011) Valerie Lallemand-Breitenbach et al.   TRENDS IN MOLECULAR MEDICINE

LSH and G9a/GLP complex are required for developmentally programmed DNA methylation

(2010) K. Myant et al.   GENOME RESEARCH

CRL4Cdt2 Regulates Cell Proliferation and Histone Gene Expression by Targeting PR-Set7/Set8 for Degradation

(2010) Tarek Abbas et al.   MOLECULAR CELL

Downstream targets of FOXM1: CEP55 and HELLS are cancer progression markers of head and neck squamous cell carcinoma

(2010) Ahmad Waseem et al.   ORAL ONCOLOGY

Histone modification levels are predictive for gene expression

(2010) R. Karlic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial reactive oxygen species regulate hypoxic signaling

(2009) Robert B Hamanaka et al.   CURRENT OPINION IN CELL BIOLOGY

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

(2009) Teresa A. Soucy et al.   NATURE

FOXM1 Upregulation Is an Early Event in Human Squamous Cell Carcinoma and it Is Enhanced by Nicotine during Malignant Transformation

(2009) Emilios Gemenetzidis et al.   PLoS One

Lsh Participates in DNA Methylation and Silencing of Stem Cell Genes

(2009) Sichuan Xi et al.   STEM CELLS

CRL4s: the CUL4-RING E3 ubiquitin ligases

(2009) Sarah Jackson et al.   TRENDS IN BIOCHEMICAL SCIENCES

Combinatorial patterns of histone acetylations and methylations in the human genome

(2008) Zhibin Wang et al.   NATURE GENETICS

Depletion of Human Histone H1 Variants Uncovers Specific Roles in Gene Expression and Cell Growth

(2008) Mónica Sancho et al.   PLoS Genetics