Spatial Multiplexing of Fluorescent Reporters for Imaging Signaling Network Dynamics

Kinase-targeted cancer therapies: progress, challenges and future directions

(2018) Khushwant S. Bhullar et al.   Molecular Cancer

Visualizing Dynamics of Cell Signaling In Vivo with a Phase Separation-Based Kinase Reporter

(2018) Qiang Zhang et al.   MOLECULAR CELL

A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters

(2018) Kiryl D. Piatkevich et al.   Nature Chemical Biology

cAMPr: A single-wavelength fluorescent sensor for cyclic AMP

(2018) Christopher R. Hackley et al.   Science Signaling

Red fluorescent cAMP indicator with increased affinity and expanded dynamic range

(2018) Yusaku Ohta et al.   Scientific Reports

Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes

(2018) Jia-Ren Lin et al.   eLife

cAMPr: A single-wavelength fluorescent sensor for cyclic AMP

(2018) Christopher R. Hackley et al.   Science Signaling

Single-fluorophore biosensors for sensitive and multiplexed detection of signalling activities

(2018) Sohum Mehta et al.   NATURE CELL BIOLOGY

Programmable design of orthogonal protein heterodimers

(2018) Zibo Chen et al.   NATURE

TrackMate: An open and extensible platform for single-particle tracking

(2017) Jean-Yves Tinevez et al.   METHODS

Proteins evolve on the edge of supramolecular self-assembly

(2017) Hector Garcia-Seisdedos et al.   NATURE

Phosphorylation of Ser1928mediates the enhanced activity of the L-type Ca2+channel Cav1.2 by the β2-adrenergic receptor in neurons

(2017) Hai Qian et al.   Science Signaling

Phosphorylation of Ser1928mediates the enhanced activity of the L-type Ca2+channel Cav1.2 by the β2-adrenergic receptor in neurons

(2017) Hai Qian et al.   Science Signaling

Principles Governing the Self-Assembly of Coiled-Coil Protein Nanoparticles

(2016) Giuliana Indelicato et al.   BIOPHYSICAL JOURNAL

Erratum: Corrigendum: Design of a hyperstable 60-subunit protein icosahedron

(2016) Yang Hsia et al.   NATURE

The coming of age of de novo protein design

(2016) Po-Ssu Huang et al.   NATURE

Protein-retention expansion microscopy of cells and tissues labeled using standard fluorescent proteins and antibodies

(2016) Paul W Tillberg et al.   NATURE BIOTECHNOLOGY

Multiplexed and scalable super-resolution imaging of three-dimensional protein localization in size-adjustable tissues

(2016) Taeyun Ku et al.   NATURE BIOTECHNOLOGY

De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity

(2016) S. E. Boyken et al.   SCIENCE

Accurate design of megadalton-scale two-component icosahedral protein complexes

(2016) J. B. Bale et al.   SCIENCE

Multiplexed Epitope-Based Tissue Imaging for Discovery and Healthcare Applications

(2016) Bernd Bodenmiller   Cell Systems

Designing and defining dynamic protein cage nanoassemblies in solution

(2016) Y.-T. Lai et al.   Science Advances

Simple, Scalable Proteomic Imaging for High-Dimensional Profiling of Intact Systems

(2015) Evan Murray et al.   CELL

Ratiometric biosensors based on dimerization-dependent fluorescent protein exchange

(2015) Yidan Ding et al.   NATURE METHODS

Design of ordered two-dimensional arrays mediated by noncovalent protein-protein interfaces

(2015) S. Gonen et al.   SCIENCE

Expansion microscopy

(2015) F. Chen et al.   SCIENCE

The Molecular and Systems Biology of Memory

(2014) Eric R. Kandel et al.   CELL

TNF and IL-1 exhibit distinct ubiquitin requirements for inducing NEMO–IKK supramolecular structures

(2014) Nadine Tarantino et al.   JOURNAL OF CELL BIOLOGY

A Set of Computationally Designed Orthogonal Antiparallel Homodimers that Expands the Synthetic Coiled-Coil Toolkit

(2014) Christopher Negron et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Accurate design of co-assembling multi-component protein nanomaterials

(2014) Neil P. King et al.   NATURE

Structure of a designed protein cage that self-assembles into a highly porous cube

(2014) Yen-Ting Lai et al.   Nature Chemistry

Independent optical excitation of distinct neural populations

(2014) Nathan C Klapoetke et al.   NATURE METHODS

Noninvasive optical inhibition with a red-shifted microbial rhodopsin

(2014) Amy S Chuong et al.   NATURE NEUROSCIENCE

Computational design of water-soluble α-helical barrels

(2014) Andrew R. Thomson et al.   SCIENCE

High thermodynamic stability of parametrically designed helical bundles

(2014) Po-Ssu Huang et al.   SCIENCE

Intermingled cAMP, cGMP and calcium spatiotemporal dynamics in developing neuronal circuits

(2014) Stefania Averaimo et al.   Frontiers in Cellular Neuroscience

AKAP-Anchored PKA Maintains Neuronal L-type Calcium Channel Activity and NFAT Transcriptional Signaling

(2014) Jonathan G. Murphy et al.   Cell Reports

The roles of protein kinases in learning and memory

(2013) K. P. Giese et al.   LEARNING & MEMORY

Visualization of an endogenous retinoic acid gradient across embryonic development

(2013) Satoshi Shimozono et al.   NATURE

Ultrasensitive fluorescent proteins for imaging neuronal activity

(2013) Tsai-Wen Chen et al.   NATURE

Design of a single-chain polypeptide tetrahedron assembled from coiled-coil segments

(2013) Helena Gradišar et al.   Nature Chemical Biology

An Improved Ras Sensor for Highly Sensitive and Quantitative FRET-FLIM Imaging

(2013) Ana F. Oliveira et al.   PLoS One

Squaring the Circle in Peptide Assembly: From Fibers to Discrete Nanostructures by de Novo Design

(2012) Aimee L. Boyle et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Computational Design of Self-Assembling Protein Nanomaterials with Atomic Level Accuracy

(2012) N. P. King et al.   SCIENCE

Structure of a 16-nm Cage Designed by Using Protein Oligomers

(2012) Y.-T. Lai et al.   SCIENCE

The Cyclic AMP Pathway

(2012) P. Sassone-Corsi   Cold Spring Harbor Perspectives in Biology

A Basis Set of de Novo Coiled-Coil Peptide Oligomers for Rational Protein Design and Synthetic Biology

(2012) Jordan M. Fletcher et al.   ACS Synthetic Biology

Reporting from the Field: Genetically Encoded Fluorescent Reporters Uncover Signaling Dynamics in Living Biological Systems

(2011) Sohum Mehta et al.   Annual Review of Biochemistry

Cross-talk between calcium and protein kinase A in the regulation of cell migration

(2011) Alan K Howe   CURRENT OPINION IN CELL BIOLOGY

A de novo peptide hexamer with a mutable channel

(2011) Nathan R Zaccai et al.   Nature Chemical Biology

Computational Design of Virus-Like Protein Assemblies on Carbon Nanotube Surfaces

(2011) G. Grigoryan et al.   SCIENCE

Organization of Intracellular Reactions with Rationally Designed RNA Assemblies

(2011) C. J. Delebecque et al.   SCIENCE

Visualization of PKA activity in plasma membrane microdomains

(2010) Charlene Depry et al.   Molecular BioSystems

GABAB Receptors Modulate NMDA Receptor Calcium Signals in Dendritic Spines

(2010) Jason R. Chalifoux et al.   NEURON

Local and Long-Range Reciprocal Regulation of cAMP and cGMP in Axon/Dendrite Formation

(2010) M. Shelly et al.   SCIENCE

An Autoinhibited Coiled-Coil Design Strategy for Split-Protein Protease Sensors

(2009) Sujan S. Shekhawat et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The role of membrane microdomains in shaping β2-adrenergic receptor-mediated cAMP dynamics

(2009) Lisa M. DiPilato et al.   Molecular BioSystems

Genetically encoded FRET sensors to monitor intracellular Zn2+ homeostasis

(2009) Jan L Vinkenborg et al.   NATURE METHODS

A genetically encoded fluorescent reporter of ATP:ADP ratio

(2009) Jim Berg et al.   NATURE METHODS