Article
Dermatology
S. J. Park, J. W. Park, G. R. Ahn, S. Y. Choi, K. H. Yoo, K. Li, B. J. Kim
Summary: This study reviewed the clinical and microbiological features of patients with filler-induced skin necrosis, identifying injection sites at the nasolabial fold, nasal dorsum, and nasal tip. The true culture-positive rate was found to be 50% after cases of contamination were excluded. To avoid permanent sequelae, all physicians should be aware of possible secondary infections when treating filler-induced skin necrosis.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Danny J. Soares
Summary: Biocompatible hyaluronic acid gel implants have revolutionized surgery and medicine, particularly in cosmetic applications. However, the increased use of injectable dermal fillers has led to a rise in complications, including vascular occlusion. This article reviews the mechanisms and treatment strategies for filler-induced vascular occlusion, as well as recent advances in prevention and management.
Review
Dermatology
Jameson Loyal, Nina Hartman, Sabrina G. Fabi, Kimberly J. Butterwick, Mitchel P. Goldman
Summary: This article reviews the literature on the treatment of vascular occlusions threatening skin barrier integrity and provides a step-wise treatment guide. The use of high-dose, pulsed hyaluronidase is crucial, and other therapies lacking evidence are also highlighted.
DERMATOLOGIC SURGERY
(2022)
Article
Surgery
Congying Li, Wei Zhang
Summary: Hyaluronic acid filler injection is commonly used for facial shaping and filling. However, occasional incidents, such as alopecia at the injected site, have been reported. This case study reports the successful recovery of skin necrosis and alopecia in the left temple region through treatment with hyaluronidase and minoxidil.
JOURNAL OF CRANIOFACIAL SURGERY
(2023)
Article
Dermatology
Sun Young Choi, Sun Hye Shin, Joon Seok, Kwang Ho Yoo, Beom Joon Kim
Summary: This study aimed to assess the clinical prognosis of hyaluronic acid (HA) filler vascular complications based on post-procedural management and clinical findings. The findings showed that early recognition and prompt hyaluronidase injection were crucial in preventing further damage and improving prognosis. This case series highlights the importance of early detection and appropriate management of HA filler complications, and further studies are warranted to confirm these findings and refine treatment strategies.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Dermatology
Murad Alam, Rohit Kakar, Jeffrey S. Dover, Vishnu Harikumar, Bianca Y. Kang, Hoi Ting Wan, Emily Poon, Derek H. Jones
Summary: In this cohort study, injections with either needles or cannulas for skin fillers were associated with a low risk of intravascular occlusion events. Using cannulas was found to be associated with a lower occlusion risk, and most occlusions resolved without long-term sequelae. Dermatologists may consider using cannulas in filler injection to further minimize the risk of occlusion when appropriate.
Article
Surgery
Can Zheng, Qiang Fu, Gui-wen Zhou, Lin-ying Lai, Li-xia Zhang, De-quan Zhang, Guo-jie Chen, Li-ming Liang, Min-liang Chen
Summary: Percutaneous facial or supratrochlear arterial hyaluronidase injection is an effective treatment for skin necrosis and ptosis caused by HA filler embolism.
AESTHETIC SURGERY JOURNAL
(2022)
Article
Engineering, Environmental
Peng Xu, Min Xing, Huizhen Huang, Ke Xue, Jiang Chang, Kai Liu
Summary: The study demonstrates that the composite hydrogel of calcium silicate incorporated into human serum albumin hydrogel can improve skin flap survival by attenuating vascular endothelial cell apoptosis and inflammation. This bioactive composite hydrogel shows great potential for clinical applications.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Surgery
Marcelo Germani Vieira, Daniel Augusto Machado-Filho, Allan Rafael Alcantara, Adriana Mendonca, Jun Ho Kim, Arthur Rodriguez Gonzalez Cortes
Summary: This report presents an alternative approach using a high dose of hyaluronidase to treat severe nasal skin necrosis related to HA injection, showing promising results in reversing the necrotic process.
JOURNAL OF CRANIOFACIAL SURGERY
(2021)
Review
Dentistry, Oral Surgery & Medicine
Francois Gorostidi, Nicolas Glasson, Victoria Salati, Kishore Sandu
Summary: Vascular anomalies are rare lesions that can affect the head and neck region, potentially causing obstruction in the upper airway. The evaluation and management of airway risk are of utmost importance before etiologic treatment. Prenatal diagnosis requires specialized teams experienced in managing compromised feto-neonatal airways. Even after birth, the airway remains central in the patient's overall management. Treatment should be tailored to the specific patient and lesion, aiming to improve symptoms and avoid complications. Maintaining reasonable expectations is crucial for successful management, as cure is achievable for small, localized lesions, while symptom relief is the goal for large, complex lesions.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2022)
Article
Surgery
Robert E. George, Eric T. Elwood, Glyn E. Jones
Summary: This study compares the accuracy of indocyanine green angiography and multispectral reflectance imaging in predicting tissue viability and postoperative necrosis. The results showed that indocyanine green angiography tends to overpredict necrosis, while multispectral reflectance imaging has higher accuracy in predicting tissue viability.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Surgery
Allan Rafael Alcantara, Daniel Augusto Machado-Filho, Renato Goulart Provenzano, Leonardo Caldas Vieira, Jun Ho Kim, Arthur Rodriguez Gonzalez Cortes
Summary: The use of hyaluronic acid fillers in lip augmentation is widely used, but incorrect technique can lead to severe complications. There is no consensus on the treatment protocol for vascular complications. This case study suggests that high doses of hyaluronidase with additional multimodal treatment may be a promising approach in treating severe vascular complications caused by hyaluronic acid filling.
JOURNAL OF CRANIOFACIAL SURGERY
(2022)
Review
Endocrinology & Metabolism
Jie Wang, Mengjie Xiao, Jie Wang, Shudong Wang, Jingjing Zhang, Yuanfang Guo, Yufeng Tang, Junlian Gu
Summary: This review summarizes recent advances in targeting NRF2-related epigenetic modifications for the treatment of cardiac and vascular complications associated with diabetes mellitus. It also discusses potential agonists that could regulate NRF2-associated epigenetic mechanisms.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Dermatology
Qicheng Lan, Kaitao Wang, Zhefeng Meng, Hang Lin, Taotao Zhou, Yi Lin, Zhikai Jiang, Jianpeng Chen, Xuao Liu, Yuting Lin, Dingsheng Lin
Summary: This study investigated the effects of RXD on the survival of random skin flaps. The results showed that RXD promoted flap survival, increased angiogenesis, and decreased inflammation and oxidative stress.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Immunology
Christian Girbardt, Catharina Busch, Mayss Al-Sheikh, Jeanne Martine Gunzinger, Alessandro Invernizzi, Alba Xhepa, Jan Darius Unterlauft, Matus Rehak
Summary: This retrospective case series describes six cases of retinal vascular events shortly after receiving mRNA or adenoviral-vectored COVID-19 vaccines. The short time span between vaccination and the occurrence of these events raises questions about a potential direct correlation with the vaccines.