Article
Polymer Science
Haniyeh Malektaj, Aleksey D. Drozdov, Jesper deClaville Christiansen
Summary: This study investigates the preparation of cross-linked alginate hydrogels using various cations and analyzes their equilibrium swelling and mechanical properties. The results show that the type of cations used in the cross-linking process affects the elastic moduli and equilibrium degree of swelling. Experimental data is fitted with a model that involves two material parameters, and numerical analysis reveals the influence of cations on these quantities. The study also finds that the relationship between the elastic modulus and equilibrium swelling differs from that predicted by conventional theory for covalently cross-linked gels.
Article
Biochemistry & Molecular Biology
Elena Manaila, Gabriela Craciun, Ion Cosmin Calina
Summary: Agriculture is affected by water scarcity and nutrient deficiency, and it also contributes to these issues. Using biodegradable hydrogels as soil conditioners can improve irrigation efficiency, reduce the need for fertilizers, and combat pathogens. This study aimed to create and characterize Sodium Alginate-g-acrylamide/acrylic Acid hydrogels using electron beam irradiation, and investigate their potential as soil conditioners through absorption and release experiments. The hydrogels were obtained through irradiation using a linear accelerator and their physical, chemical, structural, and morphological characteristics were analyzed. Several experiments were performed to test the absorption and release of different nutrient solutions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Polymer Science
Magdalena B. Labowska, Maria Skrodzka, Hanna Sicinska, Izabela Michalak, Jerzy Detyna
Summary: This manuscript presents a kinetic analysis of water evaporation from sodium alginate-based hydrogels under different environmental conditions. The results suggest that lower temperatures and higher humidity contribute to better water retention in the hydrogel structure.
Article
Biochemistry & Molecular Biology
Yudan Yi, Yi Zhang, Bradley Mansel, Ya-Nan Wang, Sujay Prabakar, Bi Shi
Summary: In this study, dialdehyde carboxymethyl cellulose (DCMC) crosslinkers with similar sizes but different aldehyde group contents were prepared. By regulating the structure of the crosslinkers, the pore properties of the collagen matrix were controlled, resulting in enhanced potential for biomedical applications.
Article
Polymer Science
Trevor Gilbert, Matthew A. Campea, Nahieli Preciado Rivera, Michael Majcher, Richard Alsop, Mouhanad Babi, Thomas Kalab, Jose Moran-Mirabal, Maikel Rheinstadter, Todd Hoare
Summary: In this study, injectable PNIPAM/PVP interpenetrating polymer networks were fabricated and characterized. The results show that the internal structure of the injectable IPNs can be controlled by adjusting the PVP molecular weight and degree of thiolation. The PNIPAM gelation drives the formation of domains, with PNIPAM mainly located in the PVP-rich domains and PVP entrapped in the PNIPAM-rich domain. Additionally, the structural reconfiguration of the IPNs can be achieved by heating above the volume phase transition temperature of the PNIPAM phase, which is influenced by the molecular weight and thiolation degree of the PVP precursor polymers.
Article
Nanoscience & Nanotechnology
Maoru Zhao, Chao Ji, Hao Dai, Chengyan Wang, Ruixue Liu, Jiani Xie, Yuguang Wang, Zhanjun Gu
Summary: Oral squamous cell carcinoma (OSCC) is a common oral malignancy, and radiotherapy is the primary noninvasive treatment. A highly efficient and low-toxic radiosensitization strategy was developed using poly(vinyl pyrrolidone)-modified tantalum nanoparticles (Ta@PVP NPs) and mussel inspired catechol-grafted sodium alginate hydrogels for precision radiotherapy. This strategy effectively inhibited OSCC development without facial deformities and damage to surrounding normal tissues.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Polymer Science
Jignesh Trivedi, Arvind Chourasia
Summary: The water absorption properties of a new superabsorbent anionic hydrogel, H-Na-PCMSA-g-PAN, were investigated in water, low-conductivity saline solutions, and simulated urine. The hydrogel showed reduced swelling capacity in the saline solutions compared to water, and the trend of swelling was Na+ > Ca2+ > Al3+ at the same concentration. The swelling capacity decreased with increasing ionic strength of the swelling medium, consistent with experimental results and Flory's equation. The swelling process of the hydrogel followed second-order kinetics in various swelling media.
Article
Biochemistry & Molecular Biology
Masoumeh Mohamadhoseini, Zahra Mohamadnia
Summary: The mechanical properties of self-healing hydrogels based on host-guest interaction can be enhanced by employing the dual cross-linking method. The alginate-based hydrogels with porous structure and improved mechanical properties were obtained through modification with beta-cyclodextrin and adamantane groups. The incorporation of Ca2+ ions and dual cross-linking methodology further improved the mechanical properties of the hydrogels, making them suitable for various applications such as 3D printing and tissue engineering.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Polymer Science
Svetlana A. Glukhova, Vyacheslav S. Molchanov, Boris V. Lokshin, Andrei V. Rogachev, Alexey A. Tsarenko, Timofey D. Patsaev, Roman A. Kamyshinsky, Olga E. Philippova
Summary: This study investigates the rheological properties of nanocomposite hydrogels, incorporating percolating halloysite nanotubes in a rigid network embedded in a soft alginate network cross-linked by calcium ions. The research reveals a pronounced shear-thinning behavior and significant viscosity drop, emphasizing the role of polymer cross-linking in enhancing the shear-thinning properties and viscosity recovery.
Article
Biochemistry & Molecular Biology
Shiliang Liu, Qinglin Wu, Xiuxuan Sun, Yiying Yue, Brenda Tubana, Rongjie Yang, Huai N. Cheng
Summary: Novel nanocomposite hydrogels with unique structure and high water retention capacity showed good sensitivity to different solutions and achieved precise NPK release, making them suitable for drought-prone and/or fertilizer-loss regions.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Multidisciplinary
E. Baigorria, S. Souza dos Santos, M. R. de Moura, L. F. Fraceto
Summary: In this study, 3D printing of bioinks was used to develop nanocomposite hybrid adsorbent hydrogels. By adding clay to the biopolymer matrix, the resulting hydrogels showed improved rheological, mechanical, thermal, and porous properties. The SA-B30 bioink and corresponding 3D-printed device were found to be the best systems for adsorption of the pesticide paraquat. The synthesized eco-friendly, biodegradable, and low-cost materials can contribute to a circular economy and ensuring safe water for human consumption.
MATERIALS TODAY CHEMISTRY
(2023)
Article
Polymer Science
Ayesha Mahmood, Asif Mahmood, Mohamed A. Ibrahim, Zahid Hussain, Muhammad Umar Ashraf, Mounir M. Salem-Bekhit, Ibrahim Elbagory
Summary: This research aimed to develop a pH-responsive polymeric system for targeted drug delivery of Diloxanide furoate. Sodium alginate (Na-Alg) and Carbopol 934P were used as building blocks and SCH1-SCH12 were created with different polymer ratios. Positive outcomes were observed in swelling and release profiles at higher pH levels. Hydrogel formation, component compatibility, thermal stability, and Diloxanide furoate loading were all validated. The results showed the potential of this polymeric system for pH-dependent localized and regulated drug delivery.
Article
Chemistry, Multidisciplinary
Bin Li, Aolin Wu, Wenrui Hao, Jizhen Liu, Zhigang Hu, Ying Wang
Summary: Deep eutectic solvent (DES) was synthesized from urea, acrylamide and choline chloride, and SA/P(U-AM-ChCl) composite hydrogel was prepared using thermal initiation frontal polymerization (FP) with sodium alginate as filler. The composite hydrogels were characterized by FTIR and SEM. The addition of SA greatly enhanced the swelling properties, mechanical properties, and self-healing properties of the hydrogels. The tensile strength of the hydrogel increased with increasing SA content, and the self-healing efficiency also improved with the increase of SA.
Article
Biochemistry & Molecular Biology
Shengbo Li, Xuemei Wang, Jing Chen, Jiahe Guo, Meng Yuan, Gui Wan, Chengqi Yan, Wenqing Li, Hans-Guenther Machens, Yuval Rinkevich, Xiaofan Yang, Heng Song, Zhenbing Chen
Summary: Chronic non-healing diabetic wounds and ulcers are a major challenge in the medical field. In this study, a hydrogel with pro-angiogenesis and antibacterial properties was developed, showing potential clinical application in refractory wounds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Katarzyna Bialik-Was, Klaudia Pluta, Dagmara Malina, Mateusz Barczewski, Katarzyna Malarz, Anna Mrozek-Wilczkiewicz
Summary: The study demonstrates that increasing glycerin content significantly decreases gel fraction and thermal resistance, while also reducing water absorption capacity. However, it does not affect cytotoxicity and elongation properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Polymer Science
Reza Hosseinpourpia, Arantxa Eceiza, Stergios Adamopoulos
Summary: This study investigated the performance of polyurethane adhesives with different combinations and found that the addition of MS can improve the thermal behavior, rheological performance, and tensile shear strength of the adhesives. The adhesive with Gly polyol and a higher content of MS exhibited the highest shear strength under dry conditions.
Article
Pharmacology & Pharmacy
Kizkitza Gonzalez, Izaskun Larraza, Garazi Berra, Arantxa Eceiza, Nagore Gabilondo
Summary: Starch-based tablets with tailored releases were prepared using 3D printing, and the importance of excipient origin as well as the effect of tablet geometry on drug release were analyzed. Different origins of starch influenced the rheological properties of inks, resulting in tablets with different microporous structures and compression and swelling behaviors. Tablets combining different starches and geometries were able to tailor the drug release and demonstrate applicability in personalized therapies.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Polymer Science
Tamara Calvo-Correas, Miriam Benitez, Izaskun Larraza, Lorena Ugarte, Cristina Pena-Rodriguez, Arantxa Eceiza
Summary: Different ways to valorise discarded TPU ear tags from the livestock sector were studied, including mechanical processing and 3D printing. The results showed that these methods were effective in recycling TPU waste and obtaining materials suitable for printing and electrospinning.
POLYMER DEGRADATION AND STABILITY
(2022)
Article
Chemistry, Applied
Julen Vadillo, Izaskun Larraza, Tamara Calvo-Correas, Nagore Gabilondo, Christophe Derail, Arantxa Eceiza
Summary: This study explores the preparation of a bioactive ink suitable for direct ink writing (DIW) 3D printing by adding extract obtained from Salvia officinalis L. during the synthesis of a waterborne polyurethane urea (WBPUU). The addition of cellulose nanocrystals (CNC) improves the printing performance. The study also confirms the bioactive capacity of the ink through the testing of scaffolds against bacteria.
REACTIVE & FUNCTIONAL POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Raquel Olmos-Juste, Sheila Olza, Nagore Gabilondo, Arantxa Eceiza
Summary: In this study, personalized mesh implants made of alginate and waterborne-polyurethane (A-WBPU) were developed using 3D printing technology. The optimal mesh formulation for different types of hernias was determined through rheological characterization and mechanical analysis. Additionally, an antibiotic-loaded formulation was developed to prevent infection.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Chemistry, Applied
Stefano Torresi, Tamara Calvo-Correas, Senda Basasoro, Olatz Guaresti, Ana Alonso-Varona, Nagore Gabilondo, Arantxa Eceiza
Summary: A biobased polyurethane formulation containing furan was synthesized and functionalized via reaction. The formulation was processed into nanofiber membranes using electrospinning. The polymer has the advantages of being catalyst-free, having high renewable content, and being easily producible. The membranes are highly hydrophobic, allowing for functionalization reactions in water with minimal impact on membrane integrity. The material also exhibits good biocompatibility, making it suitable for biomedical tissue applications.
REACTIVE & FUNCTIONAL POLYMERS
(2022)
Article
Engineering, Environmental
Eider Mendiburu-Valor, Gurutz Mondragon, Nekane Gonzalez, Galder Kortaberria, Loli Martin, Arantxa Eceiza, Cristina Pena-Rodriguez
Summary: This study investigates the degradation of PET samples from urban and marine wastes and evaluates the impact of degradation on the chemical recycling process. The results show that all PET residues were degraded, and the initial degradation of PET wastes increases the monomer content in the glycolyzed samples.
RESOURCES CONSERVATION AND RECYCLING
(2022)
Article
Polymer Science
Izaskun Larraza, Julen Vadillo, Tamara Calvo-Correas, Alvaro Tejado, Loli Martin, Aitor Arbelaiz, Arantxa Eceiza
Summary: Waterborne, polyurethane-urea (WBPUU) based inks with cellulose nanofibers (CNF) as a rheological modulator were prepared by two methods: ex situ and in situ. In situ addition allows proximity of WBPUU particles and CNF, favoring interactions and chemical bonds formation.
Article
Polymer Science
Pablo Ramos, Tamara Calvo-Correas, Arantxa Eceiza, Javier Gonzalez-Benito
Summary: Nonwoven mats made of submicrometric fibers of thermally responsive biopolyurethanes modified with multiwalled carbon nanotubes were prepared using solution blow spinning. The addition of different amounts of MWCNT had an impact on the morphology, structure, thermal behavior, and electrical properties of the materials. As the MWCNT content increased, the fiber diameter increased, and the relative amount of fibers increased, resulting in a more compact microstructure with lower porosity.
Article
Nutrition & Dietetics
Arantzazu Valdes, Gurutz Mondragon, Maria Carmen Garrigos, Arantxa Eceiza, Alfonso Jimenez
Summary: This study developed a microwave-assisted extraction method for extracting cellulose nanocrystals from almond shell waste. The new method was found to be more time and energy efficient, as well as more environmentally friendly, compared to the conventional approach. The extracted nanocrystals showed great potential for applications in food packaging, biological, medical, and photoelectric materials.
FRONTIERS IN NUTRITION
(2023)
Article
Green & Sustainable Science & Technology
Eider Mendiburu-Valor, Tamara Calvo-Correas, Loli Martin, Isabel Harismendy, Cristina Pena-Rodriguez, Arantxa Eceiza
Summary: This paper focuses on the synthesis of sustainable thermoplastic polyurethanes (TPU) using a recycled bis(2-hydroxyethyl) terephthalate (BHET) monomer obtained from marine polyethylene terephthalate (PET) litter and a renewable castor oil-derived macrodiol. The TPUs were synthesized in bulk without catalysts, with different BHET contents as chain extenders. Extensive characterization of the BHET monomer and TPUs was conducted. The TPUs synthesized in this work, consisting of at least three quarters of biobased and recycled components, exhibited favorable thermal, thermomechanical, and mechanical properties.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Polymer Science
Irati Barandiaran, Joseba Gomez-Hermoso-de-Mendoza, Junkal Gutierrez, Agnieszka Tercjak, Galder Kortaberria
Summary: A biobased diglycidyl ether of vanillin (DGEVA) epoxy resin was nanostructured using poly(ethylene oxide-b-propylene oxide-b-ethylene oxide) (PEO-PPO-PEO) triblock copolymer. Different morphologies were obtained depending on the amount of triblock copolymer. A hexagonally packed cylinder morphology was maintained at 30 wt% of PEO-PPO-PEO content, while a complex three-phase morphology with worm-like PPO domains surrounded by two different phases was obtained at 50 wt%. UV-vis measurements showed a reduction in transmittance with increased triblock copolymer content, possibly due to the presence of PEO crystals detected by calorimetry.
Article
Biochemistry & Molecular Biology
Julen Diaz-Ramirez, Senda Basasoro, Kizkitza Gonzalez, Arantxa Eceiza, Alona Retegi, Nagore Gabilondo
Summary: This study successfully utilized grape pomace agricultural waste to prepare antioxidant Pickering emulsions. Rod-like bacterial cellulose nanocrystals with lengths up to 1.5 μm and widths of 5-30 nm were obtained through enzymatic hydrolysis. The polyphenolic extract obtained through ultrasound-assisted hydroalcoholic solvent extraction showed excellent antioxidant properties. The combination of nanocellulose and polyphenolic extract improved the colloidal stability and antioxidant activity of the emulsions.
Article
Polymer Science
I. Razquin, A. Iregui, M. Cobos, J. Latasa, A. Eceiza, K. Gonzales, L. Martin, A. J. Muller, A. Gonzalez, L. Irusta
Summary: Epoxy/polycaprolactone (PCL) blends with cationic photo-initiator were prepared by solution and melt blending, and processed using various techniques including solvent casting, solution electrospinning, melt electrowriting, and Fused Deposition Modeling (FDM) 3D printing. The shape memory properties varied depending on the processing technique, with electrospun fibers showing optimal fixity and recovery ratios. AFM images revealed different morphologies for different processing techniques, with electrospun mats exhibiting Shish-Kebab-type crystalline morphology and superior solvent resistance properties. The electrospun mats also showed high affinity towards chloroform, suggesting potential applications as chloroform sensors.
Review
Polymer Science
Piedad Ganan, Jaime Barajas, Robin Zuluaga, Cristina Castro, Daniel Marin, Agnieszka Tercjak, Daniel H. Builes
Summary: This work uses bibliometric analysis to study the evolution and current state of unsaturated polyester resin (UPR) biocomposites. The study examines 531 published papers from 1982 to July 2022 and provides insights into the most commonly used natural fibers as reinforcements, fiber treatments, and composite design parameters. The findings offer valuable information for future research in this field.
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
